Publications (6)0.69 Total impact

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    ABSTRACT: Seven female subjects in whom thyroid hemiagenesis was suspected on the basis of clinical findings and scintiscanning before and after TSH administration were studied with ultrasound. Ultrasonic scanning confirmed true hemiagenesis in only three cases. In the other four it revealed a nonfunctional hypoplastic lobe contralateral to the assumed single lobe.
    Journal of Clinical Ultrasound 11/1985; 13(8):561-3. DOI:10.1002/1097-0096(199010)13:83.0.CO;2-X · 0.69 Impact Factor
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    ABSTRACT: Previous reports demonstrate a circadian rhythm of the free thyroid hormones in healthy subjects. In this study we evaluated circadian variation of FT3 and FT4 in hyperthyroid and hypothyroid states. We considered six hyperthyroid patients, six hypothyroid patients and six control subjects. Blood samples were taken two hours apart from a catherterized arm vein. Data were evaluated by Halberg's cosinor analysis. The results show that FT3 and FT4 exhibit a circadian rhythm in healthy subjects, not evident in hyperthyroid and hypothyroid patients.
    Bollettino della Società italiana di biologia sperimentale 02/1983; 59(1):33-5.
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    ABSTRACT: The clinical significance of T3 assay is related to the discovery of T3 thyrotoxicosis, a form of hyperthyroidism caused by an overproduction of alone T3 with normal value of T4. We evaluated the prevalence and the clinical features of this form in a group of 850 subjects who were submitted to clinical examination and hormonal thyroid assay. We showed that T3 thyrotoxicosis is a mild condition of hyperthyroidism.
    Bollettino della Società italiana di biologia sperimentale 07/1982; 58(11):660-2.
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    ABSTRACT: TRH-test is an usefull tool for diagnostic purpose in thyroid disease. We challenged with TRH 4 groups of patients (1 degrees non toxic diffuse goitre, 2 degrees nodular goitre (Plummer's disease), 3 degrees euthyroid ophthalmic Graves' disease, 4 degrees hemithyroidectomy) with different thyroid affections who showed no symptoms and presented normal values of total thyroid hormones, in comparison with a control group. These groups displayed normal and pathological (blunted or absent and exaggerated) responses of TSH to TRH. Therefore TRH-test ra presents a good mean to recognize subclinical forms both hyperthyroidism and hypothyroidism.
    Bollettino della Società italiana di biologia sperimentale 07/1982; 58(11):663-5.
  • Bollettino della Società italiana di biologia sperimentale 02/1982; 58(1-2):76-9.
  • P De Remigis · L Vianale · A Damiani · M D'Angelo · S Sensi
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    ABSTRACT: The PRL response to TRH constitutes an important clinical tool for diagnosing forms of hyperprolactinemic syndrome. Hence it is important to establish the characteristics of the circadian variation in the response of PRL to TRH to improve the diagnostic value of the test. Six male subjects, ranging in age from 23 to 24 years, participated in this study. All were considered healthy on the basis of clinical examination, biochemical and hormonal tests. Six TRH tests were performed on each subject, one test every other day during a total span of 12 days. Each test was performed at a different clock hour: 0000, 0400, 0800, 1200, 1600, 2000. For the test, subjects received 200 microgram TRH intravenously. Blood samples were drawn from a catheterized arm vein before the TRH injection (basal value) and 20, 30, 60 and 120 min after injection. At each timepoint 5 endpoints were determined for PRL on each subject. The population mean cosinor, according to Halberg, was used to investigate the circadian rhythm in each of the endpoints. All the 5 endpoints for PRL are consistent on showing p values near 0.5 and acrophase estimates before midnight (while basal value displays acrophase at 0400). Further investigations are necessary to clarify these circadian rhythms and the shift of the acrophases.
    Chronobiologia 01/1982; 9(2):127-32.