Lingling Wang

Nanjing Medical University, Nan-ching, Jiangsu Sheng, China

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Publications (5)9.02 Total impact

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    ABSTRACT: Objectives: This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia. Methods: We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry. Results: The frequency of B7-H3(+) cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34(+) cases and high risk karyotypes. Conclusions: Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.
    Hematology (Amsterdam, Netherlands) 08/2014; 20(4). DOI:10.1179/1607845414Y.0000000186 · 1.25 Impact Factor
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    Yixin Hu · Ji Xu · Lingling Wang · Jianyong Li · Hongxia Qiu · Sujiang Zhang
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    ABSTRACT: The goal of this study was to observe the therapeutic efficacy of cyclophosphamide, vincristine and prednisone combined chemotherapy (COP) in treating adult haemophagocytic lymphohistiocytosis (HLH). Fifteen cases diagnosed with HLH were enrolled in our study. Each of them was treated with the COP regimen. Two of the fifteen patients had autoimmune disease-associated HLH (13.3%), 2/15 had lymphoma-associated HLH (13.3%), 7/15 had infection-associated HLH (IAHLH) (46.7%), and the remaining 4/15 developed the disease in the absence of apparent underlying disease (26.7%). A complete response (CR) was achieved in 7/15 patients (46.7%), while a partial response (PR) was achieved in 5/15 patients (33.3%). With a mean follow-up of 72.5 weeks, the one-year overall survival was 66.7%. HLH of varying aetiology exhibited differing sensitivity and response to the COP regimen. In combination with aetiological and supportive treatment, the COP regimen as a mild and cost-effective chemotherapy is especially favourable for IAHLH, autoimmune disease-associated HLH, and disease severity precluding intensive treatment.
    Schweizerische medizinische Wochenschrift 02/2012; 142:w13512. DOI:10.4414/smw.2012.13512 · 2.09 Impact Factor
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    ABSTRACT: To investigate the situation of anaplasmosis in Yiyuan county, Shandong Province. A total of 26 blood samples from febrile patients suspected of anaplasmosis, 48 blood samples from healthy farmers, 8 from dogs, and 10 from goats and 170 ticks were collected in the same area during 2005-2007, and detected by serological and molecular methods. Eight confirmed cases and 6 probable cases were determined using serologic and molecular methods. The seroprevalence of Anaplasma phagocytophilum (A. phagocytophilum) was 26.7% in healthy cases. Nine out of 10 sheep samples and 7 out of 8 dog samples reacted positively to the A. phagocytophilum antigen. PCR amplification and sequencing of the 16SrRNA of A. phagocytophilum gene showed that some samples from patients, goats and ticks were 100% identical. The seroprevalence of Rickettsia typhi was 22.9%, Orientia tsutsugamushi 6.3%, Rickettsia sibirica 27.1%, Coxiella burnetii 18.8%, Bartonella henselae 31.3%, and Borrelia burgdorferi 41.6%. It is important to make differential diagnosis of febrile patients and to apply treatment with specific antibiotics. It is needed to enforce essential prevention and control measures including tick control and to improve sanitation conditions.
    Asian Pacific Journal of Tropical Medicine 07/2011; 4(7):568-72. DOI:10.1016/S1995-7645(11)60148-X · 0.93 Impact Factor
  • Leukemia & lymphoma 03/2011; 52(7):1360-2. DOI:10.3109/10428194.2011.566394 · 2.89 Impact Factor
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    Lijuan Zhang · Feng Cui · Lingling Zhang · Lingling Wang
    International Journal of Infectious Diseases 08/2009; 13. DOI:10.1016/S1201-9712(09)60591-9 · 1.86 Impact Factor