Lei Wang

Anhui Agricultural University (AHAU), Luchow, Anhui Sheng, China

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Publications (831)2044.87 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Low-loss planar and channel waveguides in ${rm Pr}^{3+}$ -doped yttrium orthosilicate single crystals were fabricated using 6-MeV oxygen ion implantation. The fabricated surface guiding structure was characterized by the prism coupling method. The relationship between the implantation induced index change and the implantation fluence has been investigated. The photoluminescence properties of the implanted samples were found to be well preserved with respect to the bulk, exhibiting possible applications for integrated quantum memory and laser generation devices.
    Journal of Lightwave Technology 06/2015; 33(11):2263-2267. DOI:10.1109/JLT.2015.2410276 · 2.86 Impact Factor
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    ABSTRACT: Hemolin belongs to the immunoglobulin superfamily and plays an important role in innate immune response of insects. In this study, a hemolin-like cDNA of 1418bp was obtained from Antheraea pernyi (Ap-hemolin-like). Sequence analysis revealed Ap-hemolin-like was homologous to those hemolins from other insect species. Recombinant Ap-hemolin-like protein was expressed in Escherichia coli cells, and polyclonal antibodies were produced against the recombinant proteins. Real-time PCR and western blot analysis showed that the Ap-hemolin-like was expressed in hemolymph, Malpighian tubules, midgut, epidermis and fat body, with the highest expression level in hemolymph. To investigate its role in the immune response against microorganisms, fifth instar larvae were challenged by injecting nucleopolyhedrovirus (NPV), E. coli, or Beauveria bassiana. The results showed that the expression of Ap-hemolin-like in hemolymph and fat body was obviously induced by microorganisms. In addition, the recombinant Ap-hemolin-like protein promoted the agglutination of E. coli in the presence of calcium, which was confirmed by agglutination assay. These results suggested that the Ap-hemolin-like protein was involved in innate immune response of A. pernyi against pathogens. Copyright © 2015 Elsevier B.V. All rights reserved.
    International immunopharmacology 05/2015; 26(1). DOI:10.1016/j.intimp.2015.03.010 · 2.71 Impact Factor
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    ABSTRACT: Intravascular lymphoma is a rare type of lymphoma that frequently affects the skin and is usually of B-cell origin. This lymphoma type is very rare and not recognized as a separate entity in the 2008 World Health Organization classification of hematopoietic and lymphoid tissue tumors. We reported 5 cases of intravascular NK/T cell lymphoma with cutaneous manifestation and reviewed 12 published cases involving Chinese patients with similar characteristics. All 5 patients were adults who exhibited red or brown patches or plaques on the lower extremities or trunk; 4 cases were associated with B symptoms; 1 case developed subsequent to a lymphoma on the face (possibly extranodal NK/T cell lymphoma, nasal type). Histopathologically, all patients exhibited abnormal, medium-sized intravascular lymphocytes in the dermis and subcutaneous tissues. All patients were positive for CD2, CD3ε, CD56, and cytotoxic proteins. All cases were Epstein-Barr virus (EBV) positive. Four of 5 patients died of lymphoma within a few months of diagnosis. Intravascular NK/T-cell lymphoma is a rare highly aggressive and EBV-associated lymphoma that is prone to develop in Chinese patients. The relationship between intravascular NK/T-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type, requires clarification. This article is protected by copyright. All rights reserved.
    Journal of Cutaneous Pathology 04/2015; DOI:10.1111/cup.12515 · 1.56 Impact Factor
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    ABSTRACT: This study was designed to evaluate the utility of expression and DNA methylation patterns of the sine oculis homeobox homolog 2 (SIX2) gene in early diagnosis and prognosis of Wilms' tumor (WT). Methylation-specific polymerase chain reaction (MSP), real-time quantitative polymerase chain reaction (qRT-PCR), receiver operating characteristic (ROC), and survival curve analyses were utilized to measure the expression and DNA methylation patterns of SIX2 in a cohort of WT tissues, with a view to assessing their diagnostic and prognostic value. Relative expression of SIX2 mRNA was higher, while the promoter methylation level was lower in the WT than control group (P < 0.05) and closely associated with poor survival prognosis of WT children (P < 0.05). Increased expression and decreased methylation of SIX2 were correlated with increasing tumor size, clinical stage, vascular invasion, and unfavorable histological differentiation (P < 0.05). ROC curve analysis showed areas under the curve (AUCs) of 0.579 for methylation and 0.917 for expression in WT venous blood, indicating higher diagnostic yield of preoperative SIX2 expression. The preoperative venous blood SIX2 expression level serves as an underlying biomarker for early diagnosis of WT. SIX2 overexpression and concomitantly decreased promoter methylation are significantly associated with poor survival of WT children.
    Tumor Biology 04/2015; DOI:10.1007/s13277-015-3456-5 · 2.84 Impact Factor
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    ABSTRACT: The assessment of acute pancreatitis severity on admission currently remains a challenge to clinicians. A single, rapid biochemical marker would be preferable to clinical and radiological scoring systems. The aim of this study was to undertake a meta-analysis on the value of carboxypeptidase-B activation peptide (CAPAP) in predicting severity of acute pancreatitis on admission. Major databases and trial registries were searched to identify all relevant studies from January 1998 to March 2015. Pooled sensitivity, specificity and the diagnostic odds ratios (DORs) with 95% confidence interval (CI) were calculated for each study and were compared to other biomarkers, if included, within the same study. Summary receiver-operating curves (ROC) were conducted and the area under the curve (AUC) was evaluated. In total, six studies were included. At the time of admission, the AUC of serum CAPAP for predicting severity of acute pancreatitis was 0.86 with pooled sensitivity, specificity and DORs were 0.90, 0.70 and 19.08, respectively. When serum CAPAP was compared with urinary CAPAP, the AUC, pooled sensitivity, specificity and DOR were 0.69 vs. 0.88, 0.90 vs. 0.81, 0.68 vs. 0.77 and 17.96 vs. 18.58, respectively. Similarly, the AUC, pooled sensitivity, specificity and DOR of serum CAPAP vs maximal serum C-reactive protein within the first 3 days of admission were found to be 0.97 vs. 0.82, 0.92 vs. 0.88, 0.81 vs. 0.68 and 37.90 vs. 18.80, respectively. Both serum and urinary CAPAP have the potential to act as a stratification marker on admission in predicting severity of acute pancreatitis. Copyright © 2015. Published by Elsevier Inc.
    Clinical biochemistry 04/2015; DOI:10.1016/j.clinbiochem.2015.04.018 · 2.23 Impact Factor
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    ABSTRACT: Using polynomial regressions and response-surface methodology, this study examined the congruence effect of employee received and desired communication frequency with supervisors on communication quality and communication relationship satisfaction. Findings showed that both communication quality and relationship satisfaction are higher when employees' actual communication frequency with their supervisors met their expectations.
    the 30th Annual Conference of the Society for Industrial and Organizational Psychology, Philadelphia, PA; 04/2015
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    Wenqi Wei, Jingjing Ma, Lei Wang
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    ABSTRACT: The concrete experience of physical warmth has been demonstrated to promote interpersonal warmth. This well-documented link, however, tells only half of the story. In the current study, we thus examined whether physical coldness can also increase interpersonal warmth under certain circumstances. We conducted three experiments to demonstrate that the relationship between the experience of physical temperature and interpersonal outcomes is context dependent. Experiment 1 showed that participants touching cold (vs. warm) objects were more willing to forgive a peer's dishonest behaviour. Experiment 2 demonstrated the fully interactive effect of temperature and context on interpersonal warmth: Participants touching cold (vs. warm) objects were less likely to assist an individual who had provided them with good service (positive social context), but more likely to assist an individual who had provided them with poor service (negative social context). Experiment 3 replicated the results of Experiment 2 using the likelihood to complain, a hostility-related indicator, as the dependent variable: In a pleasant queue (positive social context), participants touching cold objects were more likely to complain and those touching warm objects were less likely to complain compared with the control group. This pattern was reversed in an annoying queue (negative social context). © 2015 The Authors. British Journal of Social Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.
    British Journal of Social Psychology 04/2015; DOI:10.1111/bjso.12108 · 1.76 Impact Factor
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    ABSTRACT: Biomarkers for predicting chemotherapy response are important to treatment of colorectal cancer (CRC) patients. Cryptochrome 2 (CRY2) is a circadian clock protein involved in cell cycle, but the biological consequences of this activity in cancer are poorly understood. We set up biochemical and cell biology analyses to analyze CRY2 expression and chemoresistance. Here we report that CRY2 is overexpressed in chemoresistant CRC samples, and CRY2 overexpression is correlated with poor patient survival. Knockdown CRY2 increased colorectal cancer sensitivity to oxaliplatin in colorectal cancer cell. We also identify FBXW7 as a novel E3 ubiquitin ligase for targeting CRY2 through proteasomal degradation. Mechanistic studies show that CRY2 is regulated by FBXW7, in which FBXW7 binds directly to phosphorylated Thr300 of CRY2. Furthermore, FBXW7 expression leads to degradation of CRY2 through enhancing CRY2 ubiquitination and accelerating CRY2's turnover rate. High expressed FBXW7 downregulates CRY2 and increases colorectal cancer cells sensitivity to chemotherapy. Low FBXW7 expression is correlated with high CRY2 expression in CRC patient samples. Also, low FBXW7 expression is correlated with poor patient survival. Taken together, our findings indicate that the upregulation of CRY2 caused by downregulation of FBXW7 may be a novel prognostic biomarker and may represent a new therapeutic target in colorectal cancer. Copyright © 2015, American Association for Cancer Research.
    Molecular Cancer Therapeutics 04/2015; DOI:10.1158/1535-7163.MCT-15-0030 · 6.11 Impact Factor
  • PLoS ONE 04/2015; 10(4):e0121296. DOI:10.1371/journal.pone.0121296 · 3.53 Impact Factor
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    ABSTRACT: Down-regulated expression of the putative tumor suppressor gene spleen tyrosine kinase (SYK) is strongly associated with the development of various cancers, including colorectal cancer (CRC). SYK gene promoter polymorphisms have been shown to be involved in the pathogenesis of multiple malignant tumors. In this study, we investigated associations of SYK gene promoter polymorphisms with the susceptibility to colorectal cancer development in a Southern Han Chinese population. SNPs in the promoter region of the human SYK gene were identified using in silico analysis tools, linkage disequilibrium analysis, and a search for likely transcription factor binding sites via TFSEARCH in the NCBI SNP database (gene ID: 6850). Based on this information, -803A > T and -534T > C were selected as candidates for further analysis. TaqMan-MGB probe analyses were performed in 567 CRC patients and 569 age- and gender-matched healthy controls for SYK gene promoter genotyping. Associations between CRC risk and SNPs were estimated using an unconditional logistic regression model, and environmental risk factors were included in a multivariate logistic regression model for correction. The frequencies of the TA and TT genotypes and the T allele of the -803A > T SNP were found to be significantly higher in the CRC patients compared to the healthy individuals of the control group (P = 0.020, 0.023, and 0.013, respectively). Synergistic effects between -803A > T genotypes (i.e., TA + TT) and age (≤60 years; P = 0.039), male gender (P = 0.011), smoking (P = 0.005), drinking alcohol (P = 0.002), and high BMI (≥24.0 kg/m(2); P = 0.009) were found to increase the risk to develop CRC by stratified analyses. The SYK -803 A > T genotypes TA and TT are independent risk factors for CRC development in Han Chinese in Southern China, and an association with TA + TT genotypes appears predominant among younger patients, male patients, patients with a high BMI, and patients who smoke or drink alcohol.
    04/2015; 38(2):165-72. DOI:10.1007/s13402-014-0208-2
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    ABSTRACT: Scutellarin (SCU), a flavonoid from a traditional Chinese medicinal plant. Our previous study has demonstrated that SCU relaxes mouse aortic arteries mainly in an endothelium-depend-ent manner. In the present study, we investigated the vasoprotective effects of SCU against HR-induced endothelial dysfunction (ED) in isolated rat CA and the possible mechanisms involving cyclic guanosine monophosphate (cGMP) dependent protein kinase (PKG). The isolated endothelium-intact and endothelium-denuded rat CA rings were treated with HR injury. Evaluation of endothelium-dependent and -independent vasodilation relaxation of the CA rings were performed using wire myography and the protein expressions were assayed by Western blotting. SCU (10-1 000 μmol·L(-1)) could relax the endothelium-intact CA rings but not endothelium-denuded ones. In the intact CA rings, the PKG inhibitor, Rp-8-Br-cGMPS (PKGI-rp, 4 μmol·L(-1)), significantly blocked SCU (10-1 000 μmol·L(-1))-induced relaxation. The NO synthase (NOS) inhibitor, NO-nitro-L-arginine methylester (L-NAME, 100 μmol·L(-1)), did not significantly change the effects of SCU (10-1 000 μmol·L(-1)). HR treatment significantly impaired ACh-induced relaxation, which was reversed by pre-incubation with SCU (500 μmol·L(-1)), while HR treatment did not altered NTG-induced vasodilation. PKGI-rp (4 μmol·L(-1)) blocked the protective effects of SCU in HR-treated CA rings. Additionally, HR treatment reduced phosphorylated vasodilator-stimulated phosphoprotein (p-VASP, phosphorylated product of PKG), which was reversed by SCU pre-incubation, suggesting that SCU activated PKG phosphorylation against HR injury. SCU induces CA vasodilation in an endothelium-dependent manner to and repairs HR-induced impairment via activation of PKG signaling pathway. Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
    04/2015; 13(4):264-73. DOI:10.1016/S1875-5364(15)30013-3
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    ABSTRACT: The KRAS gene frequently mutates in colorectal cancer (CRC). Here we investigated the prognostic and predictive role of KRAS mutation in patients with stage II or III CRC. A consecutive cohort of patients with stage II or III CRC from a single center database was studied. The association between KRAS status, adjuvant FOLFOX therapy, and 3-year disease-free survival (3-y DFS) was analyzed. Of our 433 patients, 166 (38.3%) exhibited the KRAS mutation. Among the 190 patients who did not receive adjuvant therapy, those with KRAS mutation tumors had a worse 3-y DFS (hazard ratio [HR], 1.924; 95% confidence interval [CI], 1.078-3.435; P = 0.027). Among patients who received adjuvant chemotherapy, KRAS mutation was not correlated with worse 3-y DFS (HR, 1.083; 95% CI, 0.618-1.899; P = 0.781). Adjuvant chemotherapy improved 3-y DFS only among patients with KRAS mutant tumors (78.0% vs 69.2%) on multivariate analysis adjusted for age, stage, grade, site, vessel invasion, and carcinoembryonic antigen level (HR, 0.454; 95% CI, 0.229-0.901; P = 0.024). In contrast, there was no benefit of adjuvant chemotherapy in the KRAS wild-type group (84.3% vs 82.0%). KRAS mutation indicates poor prognosis. FOLFOX adjuvant chemotherapy benefits patients with stage II or III colorectal cancer with KRAS mutant tumors and is worth further investigation. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
    Molecular oncology 03/2015; DOI:10.1016/j.molonc.2015.03.006 · 5.94 Impact Factor
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    Bin Yang, Lu Feng, Fang Wang, Lei Wang
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    ABSTRACT: Enterohemorrhagic Escherichia coli (EHEC) is an important foodborne pathogen that infects humans by colonizing the large intestine. Here we identify a virulence-regulating pathway in which the biotin protein ligase BirA signals to the global regulator Fur, which in turn activates LEE (locus of enterocyte effacement) genes to promote EHEC adherence in the low-biotin large intestine. LEE genes are repressed in the high-biotin small intestine, thus preventing adherence and ensuring selective colonization of the large intestine. The presence of this pathway in all nine EHEC serotypes tested indicates that it is an important evolutionary strategy for EHEC. The pathway is incomplete in closely related small-intestinal enteropathogenic E. coli due to the lack of the Fur response to BirA. Mice fed with a biotin-rich diet show significantly reduced EHEC adherence, indicating that biotin might be useful to prevent EHEC infection in humans.
    Nature Communications 03/2015; 6:6592. DOI:10.1038/ncomms7592 · 10.74 Impact Factor
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    ABSTRACT: Fifteen novel homocamptothecin derivatives with α-OMe substituted E-rings were designed and synthesized. All of the derivatives exhibited similar or superior cytotoxicities compared with that of SN-38, and they inhibited Topo I activity in a cell-free assay in a manner similar to that of SN-38, confirming that they represent a new class of Topo I inhibitors. Notably, the water soluble compound 36o (1.2mg/mL) exhibited increased lactone stability, and at 0.5mg/kg and 3.0mg/kg, it demonstrated significant antitumor activity in mice bearing a xenograft model using human colon cancer cell line HT-29. On the basis of these positive results, further development of 36o-related compounds as potential anticancer clinical trial candidates is definitely warranted. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Bioorganic & medicinal chemistry 03/2015; 23(9). DOI:10.1016/j.bmc.2015.03.031 · 2.95 Impact Factor
  • Journal of Managerial Psychology 03/2015; 30(2):169-182. DOI:10.1108/JMP-12-2012-0404 · 1.25 Impact Factor
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    ABSTRACT: Understanding the effects of strong static magnetic fields (SMFs) on living organisms is significant in health risk assessment, but underlying mechanisms are largely unknown. In the present study, we determined developmental abnormalities induced by 8.5Tesla (T) SMFs in a well-established in vivo model organism, Caenorhabditis elegans (C. elegans). Exposure of C. elegans eggs to 8.5 T SMF resulted in a time-dependent lifespan decrease, whereas only slight changes were observed upon exposure to 5 T SMF. Although SMF exposure did not alter brood size, development rate and stages were significantly modified by 8.5 T SMF. Germ cell apoptosis dramatically increased upon exposure to 8.5 T SMF in adult worms, as confirmed by ced-3 and ced-4 mutants, and could be prevented by concurrent treatment with a free radical scavenger, dimethyl sulfoxide. Compared to wild-type worms, shorter lifespan and greater numbers of apoptotic cells were observed in abnormal methyl viologen sensitivity-1 (mev-1(kn1)) nematodes with increased sensitivity to oxidative damage. Furthermore, exposure to 8.5 T SMF increased expression of superoxide dismutase-3 (sod-3), which is thought to protect against oxidative stress. However, 8.5 T SMF had minimal effects on lifespans of daf-2 and daf-16 mutants, which have compromised insulin/IGF-1 (insulin-like growth factors-1) mediated signaling pathways; this finding was consistent with the expression of these genes in wild-type worms. Our results indicate that developmental toxicity induced by strong SMF in C. elegans is mediated by oxidative stress and may be regulated by the insulin-like receptor pathway. Bioelectromagnetics. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Bioelectromagnetics 03/2015; 36(3). DOI:10.1002/bem.21906 · 1.86 Impact Factor
  • Lei Wang, Tianwen Gao, Gang Wang
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    ABSTRACT: Neoplasms originating from nail matrix keratinocytes are very rare. Onychomatricoma and onychocytic matricoma are benign tumors arising from nail matrix keratinocytes. Only one case of onychocytic carcinoma, the malignant counterpart of onychocytic matricoma, has been reported in the literature. Herein, we describe a case of invasive onychocytic carcinoma. Two biopsy specimens of the tumor, obtained at early and invasive stages, were examined histopathologically. The first biopsy specimen showed a retiform proliferation of eosinophilic and basophilic cells in the nail matrix. The second biopsy specimen showed a retiform basophilic cell proliferation with focal keratinization. Similar to normal nail matrix keratinocytes, the proliferating basophilic cells failed to express cytokeratin (CK)1, CK6, and CK10. Focal expression of hair-specific keratins, including K31, K85, and K86, was observed. Based on these findings, the tumor was identified as an invasive malignant tumor originating from nail matrix keratinocytes. This article is protected by copyright. All rights reserved.
    Journal of Cutaneous Pathology 03/2015; DOI:10.1111/cup.12476 · 1.56 Impact Factor
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    ABSTRACT: Laser welded DP steel joints are used widely in the automotive industry for weight reduction. Understanding the deformation and fracture behavior of the base metal (BM) and its welded joint (WJ), especially at high strain rates, is critical for the design of vehicle structures. This paper is concerned with the effects of strain rate on the tensile properties, deformation and fracture behavior of the laser welded DP780 steel joint. Quasi-static and dynamic tensile tests were performed on the WJ and BM of the DP780 steel using an electromechanical universal testing machine and a high-speed tensile testing machine over a wide range of strain rate (0.0001-1142 s−1). The microstructure change and microhardness distribution of the DP780 steel after laser welding were examined. Digital image correlation (DIC) and high-speed photography were employed for the strain measurement of the DP780 WJ during dynamic tensile tests. The DP780 WJ is a heterogeneous structure with hardening in fusion zone (FZ) and inner heat-affected zone (HAZ), and softening in outer HAZ. The DP780 BM and WJ exhibit positive strain rate dependence on the YS and UTS, which is smaller at lower strain rates and becomes larger with increasing strain rate, while ductility in terms of total elongation (TE) tends to increase under dynamic loading. Laser welding leads to an overall reduction in the ductility of the DP780 steel. However, the WJ exhibits a similar changing trend of the ductility to that of the BM with respect to the strain rate over the whole strain rate range. As for the DP780 WJ, the distance of tensile failure location from the weld centerline decreases with increasing strain rate. The typical ductile failure characteristics of the DP780 BM and WJ do not change with increasing strain rate. DIC measurements reveal that the strain localization starts even before the maximum load is attained in the DP780 WJ and gradual transition from uniform strains to severely localized strains occurs at high strain rates. The diffuse necking of the DP780 WJ occurs earlier during the tensile deformation process at higher strain rates under dynamic loadings.
    Materials Science and Engineering A 03/2015; 627:296-305. DOI:10.1016/j.msea.2014.12.103 · 2.41 Impact Factor
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    ABSTRACT: The vitellogenin receptor (VgR) plays a key role on embryonic development in oviparous animals. Here, we cloned a VgR gene, which was identified from the wild silkworm Bombyx mandarina (BmaVgR) using reverse transcriptase polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE). Sequence analysis revealed that BmaVgR is 5,861 bp long with an open reading frame encoded by 1,811 amino acid residues. The predicted amino acid sequence has 99.7 and 98.2% identity with the VgRs of Actias selene and Bombyx mori, respectively. The class B domain sequence of BmaVgR was cloned and expressed in Escherichia coli, and purified by a Ni-NTA column. Polyclonal antibodies were produced against the purified recombinant protein, and titer of the antibody was about 1:12,800 measured by enzyme-linked immunosorbent assay (ELISA). Western blot and RT-qPCR showed that BmaVgR was expressed in the ovary and fat body of female larvae and the ovary of moth, and the expression level was highest at the third day and then declined from third day to seventh in fat body of pupa. After knockdown of the BmaVgR gene through RNA interference (RNAi), other three BmaVgR-related genes (Vg, egg-specific protein, and low molecular weight lipoprotein LP gene) were all downregulated significantly. © 2015 Wiley Periodicals, Inc.
    Archives of Insect Biochemistry and Physiology 03/2015; DOI:10.1002/arch.21235 · 1.16 Impact Factor
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    ABSTRACT: Serine protease inhibitors (SPIs) play a key role in physiological responses by controlling proteases activities. In this study, we studied the biochemical functions of serpin-15, an SPI, from Bombyx mori (Bmserpin-15). Recombinant Bmserpin-15 was expressed in Escherichia coli cells and used to raise rabbit anti-Bmserpin-15 polyclonal antibodies. Bmserpin-15 mRNA and protein expression was detected in all tested tissues, particularly in the fat body and silk gland. After challenge with four different microorganisms (Escherichia coli, Beauveria bassiana, Micrococcus luteus and B. mori nuclearpolyhedrosis virus), the expressions of Bmserpin-15 mRNA and protein were induced significantly, particularly by B. bassiana and M. luteus. Recombinant Bmserpin-15 inhibited prophenoloxidase activation, but did not affect phenoloxidase activity, in B. mori hemolymph. Injection of recombinant Bmserpin-15 into B. mori larvae reduced significantly the transcript levels of antimicrobial peptides in fat body. Our results suggested that Bmserpin-15 plays an important role in innate immunity of B. mori. Copyright © 2015. Published by Elsevier Ltd.

Publication Stats

7k Citations
2,044.87 Total Impact Points

Institutions

  • 2014–2015
    • Anhui Agricultural University (AHAU)
      Luchow, Anhui Sheng, China
    • Universität Heidelberg
      • V. Medicine Clinic
      Heidelburg, Baden-Württemberg, Germany
    • Henan University
      • Laboratory of Photovoltaic Materials
      K’ai-feng-shih, Henan Sheng, China
    • University of Science and Technology of China
      • School of Life Sciences
      Luchow, Anhui Sheng, China
    • East China University of Science and Technology
      Shanghai, Shanghai Shi, China
    • Xuzhou Medical College
      Suchow, Jiangsu Sheng, China
    • Nanjing Medical University
      • Key Laboratory of Reproductive Medicine
      Nan-ching, Jiangsu Sheng, China
    • Jiangsu Provincial Center for Disease Control and Prevention
      Chiang-tu, Jiangsu Sheng, China
  • 2013–2015
    • Jiangsu University
      • School of Chemistry and Chemical Engineering
      Chenkiang, Jiangsu Sheng, China
    • Harbin Institute of Technology
      • Department of Transportation Engineering
      Charbin, Heilongjiang Sheng, China
    • Central South University
      • State Key Laboratory of Powder Metallurgy
      Ch’ang-sha-shih, Hunan, China
    • Yunnan University
      Yün-nan, Yunnan, China
    • Kunming University of Science and Technology
      Yün-nan, Yunnan, China
    • The American Society for Biochemistry and Molecular Biology
      SCE, Pennsylvania, United States
    • King Faisal University
      • College of Agricultural and Food Sciences
      Al Hadā, Makkah, Saudi Arabia
    • Beijing University of Technology
      Peping, Beijing, China
    • Chinese Academy of Agricultural Sciences
      Peping, Beijing, China
    • China Agricultural University
      • Ministry of Agriculture Key Laboratory of Plant Nutrition
      Peping, Beijing, China
    • Northwest University
      Ch’ang-an, Shaanxi, China
  • 2009–2015
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
    • Shandong University
      • • Department of Chemical Engineering
      • • State Key Laboratory for Crystal Materials
      Chi-nan-shih, Shandong Sheng, China
    • Capital Medical University
      • Department of Otorhinolaryngology Head and Neck Surgery
      Peping, Beijing, China
  • 2008–2015
    • Fourth Military Medical University
      • • Department of Dermatology
      • • School of Pharmacy
      • • Department of Biochemistry and Molecular Biology
      Xi’an, Liaoning, China
    • Huazhong University of Science and Technology
      Wu-han-shih, Hubei, China
    • Government of the People's Republic of China
      Peping, Beijing, China
    • Hawaii Agriculture Research Center
      Honolulu, Hawaii, United States
    • Imperial College London
      Londinium, England, United Kingdom
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Mechnikov Research Institute of Vaccines and Sera
      Moskva, Moscow, Russia
    • Fuzhou University
      Min-hou, Fujian, China
  • 2005–2015
    • Shanghai Research Institute of Chemical Industry
      Shanghai, Shanghai Shi, China
    • N. D. Zelinsky Institute of Organic Chemistry
      Moskva, Moscow, Russia
  • 2004–2015
    • Sun Yat-Sen University
      • • Department of Medical Oncology
      • • Department of Oral and Maxillofacial Surgery
      • • Department of Biochemistry
      Shengcheng, Guangdong, China
    • Nankai University
      • • TEDA School of Biological Science and Biotechnology
      • • College of Life Sciences
      T’ien-ching-shih, Tianjin Shi, China
  • 2013–2014
    • Northwest University
      KYL, Florida, United States
    • East China Normal University
      • Department of Chemistry
      Shanghai, Shanghai Shi, China
  • 2011–2014
    • Zhengzhou University
      Cheng, Henan Sheng, China
    • Soochow University (PRC)
      • • Department of Polymer Science and Engineering
      • • Department of Materials Science and Engineering
      Wu-hsien, Jiangsu Sheng, China
    • Jinan University (Guangzhou, China)
      • School of Medicine
      Shengcheng, Guangdong, China
    • Tsinghua University
      • • Department of Basic Medical Sciences
      • • Department of Chemical Engineering
      Peping, Beijing, China
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
    • Sichuan University
      • • Department of Respiratory Medicine
      • • Department of Integrated Traditional Chinese and Western Medicine
      Hua-yang, Sichuan, China
    • Zhongshan Entry-Exit Inspection and Quarantine Bureau
      中山, Guangdong, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Jiangnan University
      • School of Food Science and Technology
      Wu-hsi, Jiangsu Sheng, China
    • Shenyang Ligong University
      Feng-t’ien, Liaoning, China
    • University of Macau
      • Institute of Chinese Medical Sciences
      Macao, Macau, Macao
    • Russian Academy of Sciences
      • Zelinsky Institute of Organic Chemistry
      Moscow, Moscow, Russia
    • Beijing University of Chemical Technology
      Peping, Beijing, China
    • Guangzhou University of Traditional Chinese Medicine
      Shengcheng, Guangdong, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
  • 2010–2014
    • Huaibei Normal University
      Hua-pei-ts’un, Shanxi Sheng, China
    • Shanghai Jiao Tong University
      • • Bio-X Institute
      • • Department of Plant Sciences
      • • School of Agriculture and Biology
      Shanghai, Shanghai Shi, China
    • Qingdao University of Science and Technology
      Tsingtao, Shandong Sheng, China
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China
    • Jiangsu Academy of Agricultural Sciences
      Nan-ching-hsü, Jiangxi Sheng, China
    • University Joseph Fourier - Grenoble 1
      • Laboratoire Adaptation et Pathogénie des Microorganismes
      Grenoble, Rhône-Alpes, France
    • Shenyang University of Technology
      Feng-t’ien, Liaoning, China
    • University of Lodz
      • Department of Immunobiology of Bacteria
      Łódź, Łódź Voivodeship, Poland
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
    • Florida State University
      • Center for Advanced Power Systems (CAPS)
      Tallahassee, Florida, United States
    • Taiyuan University of Technology
      Yangkü, Shanxi Sheng, China
  • 2006–2014
    • Peking University
      • Department of Psychology
      Peping, Beijing, China
    • Beijing Centers for Disease Control and Prevention
      Peping, Beijing, China
  • 2004–2014
    • Chinese Academy of Sciences
      • • Shenzhen Institutes of Advanced Technology
      • • State Key Laboratory of Catalysis
      • • Laboratory of DES
      • • Key Laboratory of Computer System and Architecture
      • • Laboratory of Photosynthesis and Environmental Biology
      • • Institute of Semiconductors
      Peping, Beijing, China
  • 1999–2014
    • Sun Yat-Sen University of Medical Sciences
      • Department of Surgery
      Shengcheng, Guangdong, China
  • 2012–2013
    • Saudi Academy
      Ar Riyāḑ, Ar Riyāḑ, Saudi Arabia
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
  • 2011–2013
    • University Town of Shenzhen
      Shen-ch’üan-shih, Zhejiang Sheng, China
  • 2010–2013
    • Beijing Genomics Institute
      Bao'an, Guangdong, China
  • 2010–2012
    • Nanjing University of Information Science & Technology
      Nan-ching, Jiangsu Sheng, China
    • Zhejiang University
      • Institute of Insect Sciences
      Hangzhou, Zhejiang Sheng, China
  • 2008–2012
    • Queen's University
      • • Division of Rheumatology
      • • Department of Chemistry
      Kingston, Ontario, Canada
  • 2005–2012
    • Northeastern University (Shenyang, China)
      • Key Laboratory for Anisotropy and Texture of Materials
      Feng-t’ien, Liaoning, China
  • 2010–2011
    • Northeastern University
      Boston, Massachusetts, United States
    • Northeast Forestry University
      • Key Laboratory of Plant Ecology, Ministry of Education
      Charbin, Heilongjiang Sheng, China
  • 2009–2011
    • Tongji University
      Shanghai, Shanghai Shi, China
  • 2009–2010
    • Shenyang Institute of Technology
      Feng-t’ien, Liaoning, China
  • 2008–2010
    • Tianjin University of Science and Technology
      • Faculty of Food Engineering and Biotechnology
      T’ien-ching-shih, Tianjin Shi, China
  • 2007–2010
    • Harbin Engineering University
      • College of Automation
      Charbin, Heilongjiang Sheng, China
    • Bundesinstitut für Risikobewertung
      Berlín, Berlin, Germany
    • Heilongjiang University
      • School of Chemistry and Materials Science
      Harbin, Heilongjiang Sheng, China
    • University of Victoria
      • Department of Psychology
      Victoria, British Columbia, Canada
  • 2007–2009
    • China Pharmaceutical University
      • Department of Phytochemistry
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2003–2008
    • Jilin University
      • State Key Laboratory of Inorganic Synthesis and Preparative
      Yung-chi, Jilin Sheng, China
  • 2004–2005
    • Nanfang Hospital
      Shengcheng, Guangdong, China
  • 1996–2004
    • University of Sydney
      • School of Molecular Bioscience
      Sydney, New South Wales, Australia
    • Toyohashi University of Technology
      • Department of Production Systems Engineering
      Toyohasi, Aichi, Japan
  • 2000–2003
    • Tottori University
      • Department of Mechanical Engineering
      TTJ, Tottori, Japan