Lei Wang

University of Science and Technology of China, Luchow, Anhui Sheng, China

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Publications (800)2294.04 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.
    Organic letters. 01/2015;
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    ABSTRACT: Malignant melanoma remains the most life-threatening skin cancer up to date. What makes it worse is the incidence keeps increasing worldwide, including in China. Notably, clinical studies revealed the distinct features in Chinese population differing from those in Caucasians, which give hints to variant mechanisms underlying. Therefore, it is of great importance to generate a cell line with similar background for melanoma research in Chinese even Asian patients. However, most melanoma cell lines in used is from Causasians, thus, we established one novel metastatic melanoma cell line, FLFMM-34, derived from a Han Chinese woman. The cell line showed positive for S100, HMB45, vimentin and melan-A. Chromosome analysis revealed multiple structural aberrations. Gene-mutation analysis identified that FLFMM-34 cells had BRAFV600E mutation and deletions of exon 2 and 3 in p16/CDKN2A. Importantly, two novel mutations including TP53P33R and TP53R142H have been detected. RT-PCR results showed that FLFMM-34 cells expressed a higher mRNA level of cyclinD1 than 3 other melanoma cell lines, WM793B, 1205Lu and A2058. In addition, in vivo mice model demonstrated that the cells could be transplanted into the subcutis of nude mice and produced tumors associated with lymphoid node metastases. In conclusion, these data indicate that FLFMM-34 cell line can be employed as a suitable model for melanoma research in Chinese Han population.
    Cell Biology International 01/2015; · 1.64 Impact Factor
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  • Cell Research 12/2014; · 11.98 Impact Factor
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    ABSTRACT: It has been reported that by regulating PHD3 stability, Siah1 contributes to the abundance of hypoxia-inducible factor (HIF)-1α, thereby playing an important role in the cellular response to hypoxia. However, the expression level and functional significance of Siah1 in human malignant glioma, which is characterized by high migration and invasion potential, have never been investigated. We report here, that Siah1 was expressed highly in human glioma tissues compared with its expression in normal brain tissues and was correlated with advanced tumor status and stage. The knockdown of Siah1 by short-hairpin RNA severely suppressed the migration and invasion of human glioma U251 cells under hypoxia, while overexpression of Siah1 promoted it. Furthermore, we demonstrated that the glioma cell migration and invasion under hypoxia mediated by Siah1 was achieved by reducing the stability of PHD3, which protected the HIF-1α from degradation. These findings suggest that Siah1 plays important roles in the migration and invasion of human glioma cells under hypoxia, which may provide some guidance for the targeted therapy of human glioma based on the interference of the Siah1-PHD3-HIF-1α signaling pathway.
    Oncology Reports 12/2014; · 2.19 Impact Factor
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    ABSTRACT: The majority of patients with low-grade glioma (LGG) experience epileptic seizures as their initial symptom, while the underlying mechanisms of tumor-related seizures are still far from being fully understood. In addition to tumor type and location, genetic changes of LGGs are considered to be influential factors in causing epileptic seizures. Nevertheless, the molecular biomarkers associated with tumor-related epilepsy have rarely been identified. RNA sequence data from 80 patients with histologically confirmed LGG were collected from the Chinese glioma genome atlas database and significant differences in expression levels of 33 genes were found. One of the genes, Very large G-protein-coupled receptor-1 (VLGR1), had been previously associated with seizures. Therefore, we investigated the association between LGG-related epilepsy and VLGR1, which played a role in idiopathic epilepsy. The level of VLGR1 expression was compared between patients with epileptic seizures and those without using the reads per kilobase transcriptome per million method. To evaluate the prognostic role of VLGR1 gene expression, the progression-free survival was determined by the Kaplan-Meier method and a multivariate Cox model. We demonstrated that VLGR1 had a significantly lower expression level in patients with epileptic seizures compared to seizure-free patients (p = 0.003). Furthermore, VLGR1 was highly associated with the presence of seizures in a multivariate statistical model. However, VLGR1 could not serve as an independent prognostic factor to determine progression-free survival of LGG patients. Based on RNA sequence data analysis, our results suggest that low expression of VLGR1 is a significant risk factor of epileptic seizures in patients with LGG.
    Journal of Neuro-Oncology 12/2014; · 3.12 Impact Factor
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    ABSTRACT: Metastasis is the major reason for the death of patients suffering from malignant diseases such as human hepatocellular carcinoma (HCC). Among the complex metastatic process, resistance to anoikis is one of the most important steps. Previous studies demonstrate that microRNA-26a (miR-26a) is an important tumor suppressor that inhibits the proliferation and invasion of HCC cells by targeting multiple oncogenic proteins. However, whether miR-26a can also influence anoikis has not been well established. Here, we discovered that miR-26a promotes anoikis of HCC cells both in vitro and in vivo. With a combinational analysis of bioinformatics and public clinical databases, we predicted that alpha5 integrin (ITGA5), an integrin family member, is a putative target of miR-26a. Furthermore, we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a. Through gain- and loss-of-function studies, we demonstrate that ITGA5 is a functional target of miR-26a-induced anoikis in HCC cells. Collectively, our findings reveal that miR-26a is a novel player during anoikis and a potential therapeutic target for the treatment of metastatic HCC.
    Oncotarget 12/2014; · 6.63 Impact Factor
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    ABSTRACT: Legionella pneumophila has been recognized as the major cause of legionellosis since the discovery of the deadly disease. Legionella spp. other than L. pneumophila were later found to be responsible to many non-pneumophila infections. The non-L. pneumophila infections are likely under-detected because of a lack of effective diagnosis. In this report, we have sequenced the 16S-23S rRNA gene internal transcribed spacer (ITS) of 10 Legionella species and subspecies, including L. anisa, L. bozemanii, L. dumoffii, L. fairfieldensis, L. gormanii, L. jordanis, L. maceachernii, L. micdadei, L. pneumophila subspp. fraseri and L. pneumophila subspp. pasculleii, and developed a rapid oligonucleotide microarray detection technique accordingly to identify 12 most common Legionella spp., which consist of 11 pathogenic species of L. anisa, L. bozemanii, L. dumoffii, L. gormanii, L. jordanis, L. longbeachae, L. maceachernii, L. micdadei, and L. pneumophila (including subspp. pneumophila, subspp. fraseri, and subspp. pasculleii) and one non-pathogenic species, L. fairfieldensis. Twenty-nine probes that reproducibly detected multiple Legionella species with high specificity were included in the array. A total of 52 strains, including 30 target pathogens and 22 non-target bacteria, were used to verify the oligonucleotide microarray assay. The sensitivity of the detection was at 1.0 ng with genomic DNA or 13 CFU/100 mL with Legionella cultures. The microarray detected seven samples of air conditioner-condensed water with 100% accuracy, validating the technique as a promising method for applications in basic microbiology, clinical diagnosis, food safety, and epidemiological surveillance. The phylogenetic study based on the ITS has also revealed that the non-pathogenic L. fairfieldensis is the closest to L. pneumophila than the nine other pathogenic Legionella spp.
    PLoS ONE 12/2014; 9(12):e113863. · 3.53 Impact Factor
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    ABSTRACT: Gastric cancer (GC) is one of the most threatening diseases. The symptoms of GC are complex and hard to detect, which also contribute to the poor prognosis of GC. Besides, the current diagnosis for GC is expensive and invasive. Thus, a fast, noninvasive biomarker is urgently needed for GC screening. MicroRNAs (miRNAs) are small noncoding RNAs, which are involved in a great variety of pathological processes, particularly carcinogenesis. MiRNAs are stable in gastric juice, plasma as well as serum, which facilitate it to be a promising biomarker for cancer. In this study, we selected three novel miRNAs, i.e., miR-233, miR-16, and miR-100, to investigate their potential diagnostic value in GC screening. A total of 50 GC patients and 47 healthy controls were involved in this study. Blood serum samples were collected; RNAs were extracted and normalized with U6 snRNA as the internal control; qRT-PCR was performed for relative expression of target miRNAs. Levels of miRNAs expression were compared by Student's t test for the comparison between two groups, and one-way ANOVA was used for multiple comparisons. The expression of miR-223, miR-16, and miR-100 was all significantly higher in GC patients than controls (all P < 0.001). All the tested miRNAs were manifested to be valuable biomarkers for GC. Relative expression of these miRNAs was significantly correlated with clinical characteristics of GC patients, such as TNM stage (P = 0.036 for miR-223; P < 0.001 for miR-100), metastatic status (P = 0.045 for miR-223; P = 0.031 for miR-16; P = 0.006 for miR-100), tumor size (P = 0.042 for miR-223; P = 0.031 for miR-16; P < 0.001 for miR-100), and differentiation grade (P = 0.036 for miR-223; P = 0.030 for miR-16; P = 0.034 for miR-100). However, in T classification, which considered both tumor size and direct extent of primary tumor, the difference in target miRNAs expression was not significant. In summary, we confirmed the diagnostic value of serum miR-223, miR-16, and miR-100 in GC. Significantly elevated expression of the three miRNAs was also observed in advanced GC patients, which suggested their availability in cancer staging.
    Medical Oncology 12/2014; 31(12):298. · 2.06 Impact Factor
  • Lei Wang, Tianwen Gao, Gang Wang
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    ABSTRACT: CD8+ cytotoxic T-cell lymphoma involving the skin represents a heterogeneous group of diseases that include subcutaneous panniculitis-like T-cell lymphoma, primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, and ‘type D’ lymphomatoid papulosis. In this report, we describe a case of CD8+ cytotoxic T-cell lymphoma involving both the epidermis and subcutis. The patient was a 6-year-old girl who presented with a 3-year history of multiple plaques on her trunk and legs. The lesions had relapsed twice but responded well to prednisone. Histopathologic examination showed the proliferation of atypical lymphocytes in the epidermis, dermis, and subcutaneous tissue. On immunohistochemical analysis, the atypical lymphocytes were positive for βF1, CD3, CD8, perforin, granzyme B, and TIA-1, but negative for T-cell receptor (TCR) γ, CD4, CD30 and CD56. It was difficult to classify this tumor in terms of the known types of cutaneous lymphoma, and this case should be differentiated with subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma.
    Journal of Cutaneous Pathology 12/2014; · 1.56 Impact Factor
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    ABSTRACT: Drawing upon the identity-based perspective, the current research focused on the role of affective commitment and future work self salience (FWSS) in the relationship between abusive supervision and job performance. We expected that affective commitment, which represents the organization-based identities of employees, would mediate the relationship between abusive supervision and job performance. Furthermore, we predicted that employees’ FWSS, which represents the ease of construction and clarity of an individual's hoped-for work-based identity, would amplify the indirect effect of abusive supervision on job performance via affective commitment. Specifically, FWSS was expected to play an amplifying role in the abusive supervision–affective commitment path. Based on a sample of 480 salespersons, the results of a 3-wave study revealed that affective commitment mediated the abusive supervision–sales performance relationship. Moreover, the indirect effect of abusive supervision on sales performance via affective commitment was stronger for employees with higher FWSS. Specifically, the deleterious effect of abusive supervision on affective commitment was amplified by FWSS. This was the case even when emotional exhaustion and leader–member exchange were incorporated as competing mediators. Implications of our findings and future directions are discussed.Practitioner pointsOrganizations should pay greater attention to employees with higher FWSS because they are more vulnerable to abusive supervision in terms of their decreased affective commitment and performance.To maintain affective commitment and job performance of employees with higher FWSS, organizations should train leaders to reduce or eliminate abusive behaviours, especially for those leading teams with a majority of high-FWSS employees.
    Journal of Occupational and Organizational Psychology. 12/2014;
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    ABSTRACT: Background Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorectal cancer (CRC).Methods The mRNA levels of RFC4 were assessed in 30 paired primary CRC tissues and matched normal colonic tissues by quantitative PCR. The protein expression levels of RFC4 were evaluated by western blotting (n =16) and immunohistochemistry (IHC; n =49), respectively. Clinicopathological features and survival data were correlated with the expression of RFC4 by IHC analysis in a tissue microarray comprising 331 surgically resected CRC. The impact of RFC4 on cell proliferation and the cell cycle was assessed using CRC cell lines.Results RFC4 expression was significantly increased in CRC specimens as compared to adjacent normal colonic tissues (P <0.05). High levels of RFC4, determined on a tissue microarray, were significantly associated with differentiation, an advanced stage by the Tumor-Node-Metastasis (TNM) staging system, and a poor prognosis, as compared to low levels of expression (P <0.05). However, in multivariate analysis, RFC4 was not an independent predictor of poor survival for CRC. In vitro studies, the loss of RFC4 suppressed CRC cell proliferation and induced S-phase cell cycle arrest.Conclusion RFC4 is frequently overexpressed in CRC, and is associated with tumor progression and worse survival outcome. This might be attributed to the regulation of CRC cell proliferation and cell cycle arrest by RFC4.
    Journal of Translational Medicine 11/2014; 12(1):320. · 3.99 Impact Factor
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    ABSTRACT: Members of Myxozoa, a parasitic metazoan taxon, have considerable detrimental effects on fish hosts and also have been associated with human food-borne illness. Little is known about their biology and metabolism. Analysis of the genome of Thelohanellus kitauei and comparative analysis with genomes of its two free-living cnidarian relatives revealed that T. kitauei has adapted to parasitism, as indicated by the streamlined metabolic repertoire and the tendency towards anabolism rather than catabolism. T. kitauei mainly secretes proteases and protease inhibitors for nutrient digestion (parasite invasion), and depends on endocytosis (mainly low-density lipoprotein receptors-mediated type) and secondary carriers for nutrient absorption. Absence of both classic and complementary anaerobic pathways and gluconeogenesis, the lack of de novo synthesis and reduced activity in hydrolysis of fatty acids, amino acids, and nucleotides indicated that T. kitauei in this vertebrate host-parasite system has adapted to inhabit a physiological environment extremely rich in both oxygen and nutrients (especially glucose), which is consistent with its preferred parasitic site, i.e., the host gut submucosa. Taking advantage of the genomic and transcriptomic information, twenty-three potential nutrition-related T. kitauei-specific chemotherapeutic targets were identified. This first genome sequence of a myxozoan will facilitate development of potential therapeutics for efficient control of myxozoan parasites and ultimately prevent myxozoan-induced fish-borne illnesses in humans.
    Genome Biology and Evolution 11/2014; · 4.53 Impact Factor
  • Meijin Huang, Jinxin Lin, Yanhong Deng, Liang Kang, Jian Zheng, Biying Yi, Lei Wang, Ping Lan, Jianping Wang
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    ABSTRACT: To evaluate the erectile function of male patients treated by neoadjuvant radiochemotherapy and neoadjuvant chemotherapy alone for mid-low rectal cancer. The clinical data of 66 patients with rectal cancer from March 2011 to March 2013 were prospectively analyzed. Of all the patients, 56 cases were finally included in the study and were randomly allocated to two groups. Thirty patients were treated by neoadjuvant radiochemotherapy followed by surgery (RCS group), and 26 were treated by neoadjuvant chemotherapy followed by surgery (NCS group). The five-item version of the international index of erectile function (IIEF-5) questionnaire were used to determine erectile function before therapy and at least 12 months after surgery. The impacts of age, location, size of tumor, and body mass index on erectile function were analyzed. Total score was decreased significantly at follow-up compared to initial assessment in both RCS and NCS groups (23.4 ± 1.30 vs. 11.7 ± 5.8, t = 10.748, P < 0.01; 23.1 ± 1.3 vs. 15.2 ± 6.7, t = 5.910, P < 0.01, respectively). Score difference was statistically higher in RCS group compared with NCS group (11.7 ± 5.6 vs. 8.0 ± 6.0, t = 2.394, P = 0.020). In terms of tumor location for RCS group, difference was statistically higher in the patients with low rectal cancer compared with those with middle rectal cancer (14.5 ± 3.5 vs. 9.5 ± 6.0, t = 2.894, P = 0.008). The erectile functions of patients treated by neoadjuvant radiochemotherapy followed by surgery are more affected than that of patients treated by neoadjuvant chemotherapy followed by surgery in mid-low rectal cancer. Also low rectal cancer are significantly associated with erectile dysfunction in the patients treated by neoadjuvant radiochemotherapy followed by surgery.
    Zhonghua wai ke za zhi [Chinese journal of surgery]. 11/2014; 52(11):822-5.
  • Lei Wang, Gang Wang, Tianwen Gao
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    ABSTRACT: Primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoma (SMPTCL) is an indolent form of cutaneous lymphoma that usually presents in solitary fashion and is histopathologically characterized by nodular infiltration of small to medium-sized pleomorphic T-cells. We report the case of a patient who presented with a 5-year history of acneiform lesions on his face. Histopathologic examination of two lesions revealed a nodular infiltrate of small to medium-sized lymphocytes with necrosis in the dermis. The proliferating cells were positive for CD2, CD3, and CD4 and negative for CD8, CD30, and CD56. They were positive for TIA-1 and negative for perforin and granzyme B. The Ki67 proliferation index was approximately 10%. The neoplastic cells expressed programmed death-1 (PD-1) and lacked expression of CXCL-13, bcl-6, and CD10. In situ hybridization for Epstein-Barr virus–encoded RNA (EBER) yielded a negative result. T-cell receptor (TCR) gene rearrangement showed identical T-lymphocyte monoclonality in both lesions. In brief, we report a rare case of acneiform SMPTCL with prominent necrosis.
    Journal of Cutaneous Pathology 11/2014; · 1.56 Impact Factor
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    ABSTRACT: Our results showed that 70.6% and 65.7% of the colorectal cancer tissues had positive HLA-G or HLA-E expression.•Cox multivariate analysis showed that only HLA-G expression can serve as independent factor for OS.•Our results also showed that the expression of HLA-E was significantly correlated with tumor metastasis.
    Cellular Immunology 10/2014; · 1.87 Impact Factor
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    ABSTRACT: Structure-based prediction for the site of metabolism (SOM) of a compound metabolized by human cytochrome P450s (CYPs) is highly beneficial in drug discovery and development. However, the flexibility of the CYPs' active site remains a huge challenge for accurate SOM prediction. Compared with other CYPs, the active site of CYP2A6 is relatively small and rigid. To address the impact of the flexibility of CYP2A6 active site residues on the SOM prediction for substrates, in this work, molecular dynamics (MD) simulations and molecular docking were used to predict the SOM of 96 CYP2A6 substrates. Substrates with known SOM were docked into the snapshot structures from MD simulations and the crystal structures of CYP2A6. Compared to the crystal structures, the protein structures obtained from MD simulations showed more accurate prediction for SOM. Our results indicated that the flexibility of the active site of CYP2A6 significantly affects the SOM prediction results. Further analysis for the 40 substrates with definite Km values showed that the prediction accuracy for the low Km substrates is comparable to that by ligand-based methods. Copyright © 2014 Elsevier Inc. All rights reserved.
    Journal of Molecular Graphics and Modelling 10/2014; 54:90–99. · 2.02 Impact Factor
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    ABSTRACT: IntroductionThe onset of distal metastasis, which underlies the high mortality of breast cancers, warrants substantial studies to depict its molecular basis. Nuclear factor of activated T cells 5 (NFAT5) is upregulated in various malignancies and is critically involved in migration and invasion of neoplastic cells. Nevertheless, the metastasis-related events potentiated by this transcriptional factor and the mechanism responsible for NFAT5 elevation in carcinoma cells remain to be fully elucidated.Methods The correlation of NFAT5 with breast cancer invasiveness was investigated in vitro and clinically. The genes transcriptionally activated by NFAT5 were probed and their roles in breast cancer progression were dissected. The upstream regulators of NFAT5 were studied with particular attempt to explore the involvement of non-coding RNAs, and the mechanism underlying the maintenance of NFAT5 expression was deciphered.ResultsIn metastatic breast cancers, NFAT5 promotes epithelial-mesenchymal transition (EMT) and invasion of cells by switching on the expression of the calcium binding protein S100A4, and facilitates the angiogenesis of breast epithelial cells and thus the development of metastases by transcriptionally activating vascular endothelial growth factor C (VEGF-C). NFAT5 is directly targeted by miR-568, which is in turn suppressed by the long non-coding RNA, Hotair, via a documented in trans gene silencing pattern, that is recruitment of the polycomb complex (Polycomb Repressive Complex 2; PRC2) and LSD1, and consequently methylation of histone H3K27 and demethylation of H3K4 on the miR-568 loci.Conclusion This study unravels a detailed role of NFAT5 in mediating metastatic signaling, and provides broad insights into the involvement of Hotair, in particular, by transcriptionally regulating the expression of microRNA(s), in the metastasis of breast cancers.
    Breast cancer research: BCR 10/2014; 16(5):454. · 5.88 Impact Factor
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    ABSTRACT: Most patients with low-grade gliomas (LGGs) experience epileptic seizures as an initial symptom. However, the mechanism of LGG-related epilepsy is poorly understood. Genetic changes in brain tumors influence epileptic seizures, but few biomarkers have been associated with LGG-related seizures. We investigated the association between LGG-related epilepsy and tumor-specific molecular changes.
    Journal of Cancer Research and Clinical Oncology 10/2014; · 3.01 Impact Factor
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    ABSTRACT: The determination of trace analytes based on membrane filtration–enrichment and diffuse reflectance spectroscopic technique has gained increasing concern in the past decade due to its simplicity, rapidity and high sensitivity. However, poor repeatability primarily attributed to the distinction between membrane filters limits the development of this technique. In the current study, a simple and effective multichannel device is specially designed for the membrane filtration–enrichment process. The device is able to enrich six samples simultaneously on different positions of a membrane filter and allows to fulfil the spectroscopic measurement of six samples with only one membrane filter. The proposed approach avoided the effects caused by the nonuniform membrane filters on the performance of the enrichment process. Accuracy and repeatability have been improved significantly for the subsequent on-line spectroscopic detection. A case study was carried out to assess this method utilizing the carcinogenic dye rhodamine B (RhB) as a model analyte. Under the optimal conditions, linearity of calibration curve based on the Kubelka-Munk function was achieved in the concentration range of 2 – 30 μg L-1 with the correlation coefficient (R2) of 0.9924. Good repeatability was achieved with three average relative standard deviation (RSD) values of 3.6%, 3.8% and 3.8% corresponding to the solutions of 30, 10 and 5 μg L-1 RhB, respectively. The presented method was successfully employed to quantify RhB in soft drink and river water samples.
    RSC Advances 10/2014; · 3.71 Impact Factor

Publication Stats

7k Citations
2,294.04 Total Impact Points

Institutions

  • 2014
    • University of Science and Technology of China
      • School of Life Sciences
      Luchow, Anhui Sheng, China
  • 2013–2014
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
    • Hebei Medical University
      Chentow, Hebei, China
    • Northwest University
      Ch’ang-an, Shaanxi, China
    • Chinese Academy of Tropical Agricultural Sciences
      Hoihau, Hainan, China
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • Zhengzhou Tobacco Institute
      Chen-chu-shan, Jiangxi Sheng, China
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • Zhengzhou University
      Cheng, Henan Sheng, China
    • Anhui Agricultural University (AHAU)
      Luchow, Anhui Sheng, China
    • Shenzhen Second People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
  • 2011–2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
    • Yangzhou University
      Chiang-tu, Jiangsu Sheng, China
    • Shenyang Ligong University
      Feng-t’ien, Liaoning, China
    • University of New South Wales
      • School of Biotechnology and Biomolecular Sciences (BABS)
      Kensington, New South Wales, Australia
    • University Town of Shenzhen
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • National Institute for the Control of Pharmaceutical and Biological Products
      Peping, Beijing, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
    • Wuhan University
      • Department of Chemistry
      Wuhan, Hubei, China
    • Guangzhou University of Traditional Chinese Medicine
      Shengcheng, Guangdong, China
    • Anhui Medical University
      Luchow, Anhui Sheng, China
    • Northeastern University (Shenyang, China)
      • Key Laboratory for Anisotropy and Texture of Materials
      Feng-t’ien, Liaoning, China
  • 2010–2014
    • Shanghai Jiao Tong University
      • • Bio-X Institute
      • • Antai College of Economics and Management
      • • School of Agriculture and Biology
      Shanghai, Shanghai Shi, China
    • Jiangsu Academy of Agricultural Sciences
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2007–2014
    • Chinese Academy of Sciences
      • • Institute of Process Engineering
      • • Key Laboratory of Organic Solids
      • • Key Laboratory of Computer System and Architecture
      Peping, Beijing, China
    • University of Victoria
      • Department of Psychology
      Victoria, British Columbia, Canada
  • 2006–2014
    • Peking University
      • Department of Psychology
      Peping, Beijing, China
    • Sun Yat-Sen University
      • Proteomics Lab
      Shengcheng, Guangdong, China
  • 2005–2014
    • Nanjing Medical University
      • Key Laboratory of Reproductive Medicine
      Nan-ching, Jiangsu Sheng, China
    • Fourth Military Medical University
      • • Department of Dermatology
      • • Department of Biochemistry and Molecular Biology
      Xi’an, Liaoning, China
    • Freie Universität Berlin
      Berlín, Berlin, Germany
    • Shanghai Research Institute of Chemical Industry
      Shanghai, Shanghai Shi, China
    • Robert Koch Institut
      • ZBS 3: Microbial Toxins
      Berlín, Berlin, Germany
  • 2004–2014
    • Huaibei Normal University
      Hua-pei-ts’un, Shanxi Sheng, China
    • Tsinghua University
      • • Department of Basic Medical Sciences
      • • Department of Chemical Engineering
      • • Department of Electronic Engineering
      • • School of Environment
      Peping, Beijing, China
    • Nankai University
      • • Department of Genetics and Cell Biology
      • • TEDA School of Biological Science and Biotechnology
      • • College of Life Sciences
      T’ien-ching-shih, Tianjin Shi, China
  • 1999–2014
    • Sun Yat-Sen University of Medical Sciences
      Shengcheng, Guangdong, China
    • University of Melbourne
      • Department of Microbiology and Immunology
      Melbourne, Victoria, Australia
  • 2012–2013
    • Huazhong University of Science and Technology
      • • Wuhan National Laboratory for Optoelectronics
      • • Key Laboratory of Organ Transplantation , MOE
      Wu-han-shih, Hubei, China
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
    • Northeast Agricultural University
      Charbin, Heilongjiang Sheng, China
    • General Hospital of Jinan Military Region
      Chi-nan-shih, Shandong Sheng, China
    • Soochow University (PRC)
      • Department of Materials Science and Engineering
      Suzhou, Jiangsu Sheng, China
    • Instituto de Salud Carlos III
      Madrid, Madrid, Spain
    • Shandong University
      • State Key Laboratory for Microbial Technology
      Jinan, Shandong Sheng, China
    • Fred Hutchinson Cancer Research Center
      • Division of Clinical Research
      Seattle, Washington, United States
    • Shanghai Municipal Center for Disease Control and Prevention
      Shanghai, Shanghai Shi, China
  • 2011–2013
    • Beijing Tiantan Hospital
      Peping, Beijing, China
  • 2010–2013
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Heilongjiang University
      • School of Chemistry and Materials Science
      Charbin, Heilongjiang Sheng, China
  • 2009–2013
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
    • Tongji University
      • Department of Material Science and Engineering
      Shanghai, Shanghai Shi, China
    • Indian Institute of Technology Bombay
      • Department of Biosciences & Bioengineering
      Mumbai, State of Maharashtra, India
    • Capital Medical University
      • Department of Otorhinolaryngology Head and Neck Surgery
      Peping, Beijing, China
  • 2008–2013
    • Queen's University Belfast
      • School of Pharmacy
      Belfast, NIR, United Kingdom
    • Hawaii Agriculture Research Center
      Honolulu, Hawaii, United States
    • GNS Science
      Lower Hutt City, Wellington, New Zealand
    • Imperial College London
      Londinium, England, United Kingdom
    • University of Hawai'i System
      Honolulu, Hawaii, United States
    • University of Hawaiʻi at Hilo
      • Department of Natural Science
      Hilo, HI, United States
  • 2006–2013
    • Northeast Institute of Geography and Agroecology
      • • Institute of Biophysics
      • • Institute of Computing Technology
      Beijing, Beijing Shi, China
  • 1996–2013
    • University of Sydney
      • School of Molecular Bioscience
      Sydney, New South Wales, Australia
  • 2011–2012
    • Jiangnan University
      • • School of Biotechnology
      • • School of Food Science and Technology
      Wu-hsi, Jiangsu Sheng, China
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
  • 2010–2012
    • Nanjing University of Information Science & Technology
      Nan-ching, Jiangsu Sheng, China
  • 2008–2012
    • Queen's University
      • • Division of Rheumatology
      • • Department of Medicine
      Kingston, Ontario, Canada
  • 2005–2012
    • Russian Academy of Sciences
      • Zelinsky Institute of Organic Chemistry
      Moscow, Moscow, Russia
  • 2002–2012
    • China Agricultural University
      • • Department of Applied Chemistry
      • • College of Resources and Environmental Sciences
      • • Department of Microbiology and Immunology
      • • College of Biological Sciences
      Beijing, Beijing Shi, China
  • 2009–2011
    • National Institute on Alcohol Abuse and Alcoholism
      Maryland, United States
  • 2003–2011
    • National Institutes of Health
      • • Laboratory of Liver Diseases
      • • Laboratory of Physiologic Studies
      Bethesda, MD, United States
  • 2008–2010
    • Salk Institute
      • Structural Biology Laboratory
      La Jolla, California, United States
  • 2006–2010
    • Tianjin University of Science and Technology
      • Faculty of Food Engineering and Biotechnology
      T’ien-ching-shih, Tianjin Shi, China
  • 2004–2007
    • Jilin University
      • State Key Laboratory of Inorganic Synthesis and Preparative
      Jilin, Jilin Sheng, China