Lei Wang

University of Science and Technology of China, Luchow, Anhui Sheng, China

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Publications (868)2327.74 Total impact

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    ABSTRACT: In this work, a series of new metal phosphonates were hydrothermally synthesized and structurally characterized based on m-xylylenediphosphonic acids (H4L), including [M(H2L)(bpy)] (M = Mn 1, Co 2), [MH2L)(phen)] (M = Co 3, Cu 4), and [Cu2(H2L)2(bpy″)2] 5 (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, bpy″ = 4,4′-dimethyl-2,2′-bipyridine). X-ray diffraction indicated that compounds 1 and 2 were isomorphic. Complexes 3 and 4 were shown to crystallize in different space groups but had similar crystallographic units. In the complexes, H4L was seen to partially deprotonate to afford H2L2−. The H2L2− ligands in 1–4 functioned as tetradentate ligands with each phosphonate group adopting bidentate coordination mode with two M centers to generate a 2D layer. In addition, the H2L2− anions in 5 functioned as tridentate ligands with one phosphonate group adopting the bidentate mode and another phosphonate group adopti ng the monodentate mode, thus linking three Cu atoms to provide a 1D chain. The IR and thermal stabilities of these compounds were subsequently examined.
    Chinese Science Bulletin 12/2014; 59(34). · 1.37 Impact Factor
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    ABSTRACT: Gastric cancer (GC) is one of the most threatening diseases. The symptoms of GC are complex and hard to detect, which also contribute to the poor prognosis of GC. Besides, the current diagnosis for GC is expensive and invasive. Thus, a fast, noninvasive biomarker is urgently needed for GC screening. MicroRNAs (miRNAs) are small noncoding RNAs, which are involved in a great variety of pathological processes, particularly carcinogenesis. MiRNAs are stable in gastric juice, plasma as well as serum, which facilitate it to be a promising biomarker for cancer. In this study, we selected three novel miRNAs, i.e., miR-233, miR-16, and miR-100, to investigate their potential diagnostic value in GC screening. A total of 50 GC patients and 47 healthy controls were involved in this study. Blood serum samples were collected; RNAs were extracted and normalized with U6 snRNA as the internal control; qRT-PCR was performed for relative expression of target miRNAs. Levels of miRNAs expression were compared by Student's t test for the comparison between two groups, and one-way ANOVA was used for multiple comparisons. The expression of miR-223, miR-16, and miR-100 was all significantly higher in GC patients than controls (all P < 0.001). All the tested miRNAs were manifested to be valuable biomarkers for GC. Relative expression of these miRNAs was significantly correlated with clinical characteristics of GC patients, such as TNM stage (P = 0.036 for miR-223; P < 0.001 for miR-100), metastatic status (P = 0.045 for miR-223; P = 0.031 for miR-16; P = 0.006 for miR-100), tumor size (P = 0.042 for miR-223; P = 0.031 for miR-16; P < 0.001 for miR-100), and differentiation grade (P = 0.036 for miR-223; P = 0.030 for miR-16; P = 0.034 for miR-100). However, in T classification, which considered both tumor size and direct extent of primary tumor, the difference in target miRNAs expression was not significant. In summary, we confirmed the diagnostic value of serum miR-223, miR-16, and miR-100 in GC. Significantly elevated expression of the three miRNAs was also observed in advanced GC patients, which suggested their availability in cancer staging.
    Medical oncology (Northwood, London, England). 12/2014; 31(12):298.
  • Lei Wang, Tianwen Gao, Gang Wang
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    ABSTRACT: CD8+ cytotoxic T-cell lymphoma involving the skin represents a heterogeneous group of diseases that include subcutaneous panniculitis-like T-cell lymphoma, primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, and ‘type D’ lymphomatoid papulosis. In this report, we describe a case of CD8+ cytotoxic T-cell lymphoma involving both the epidermis and subcutis. The patient was a 6-year-old girl who presented with a 3-year history of multiple plaques on her trunk and legs. The lesions had relapsed twice but responded well to prednisone. Histopathologic examination showed the proliferation of atypical lymphocytes in the epidermis, dermis, and subcutaneous tissue. On immunohistochemical analysis, the atypical lymphocytes were positive for βF1, CD3, CD8, perforin, granzyme B, and TIA-1, but negative for T-cell receptor (TCR) γ, CD4, CD30 and CD56. It was difficult to classify this tumor in terms of the known types of cutaneous lymphoma, and this case should be differentiated with subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma.
    Journal of Cutaneous Pathology 12/2014; · 1.77 Impact Factor
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    ABSTRACT: Background Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorectal cancer (CRC).Methods The mRNA levels of RFC4 were assessed in 30 paired primary CRC tissues and matched normal colonic tissues by quantitative PCR. The protein expression levels of RFC4 were evaluated by western blotting (n =16) and immunohistochemistry (IHC; n =49), respectively. Clinicopathological features and survival data were correlated with the expression of RFC4 by IHC analysis in a tissue microarray comprising 331 surgically resected CRC. The impact of RFC4 on cell proliferation and the cell cycle was assessed using CRC cell lines.Results RFC4 expression was significantly increased in CRC specimens as compared to adjacent normal colonic tissues (P <0.05). High levels of RFC4, determined on a tissue microarray, were significantly associated with differentiation, an advanced stage by the Tumor-Node-Metastasis (TNM) staging system, and a poor prognosis, as compared to low levels of expression (P <0.05). However, in multivariate analysis, RFC4 was not an independent predictor of poor survival for CRC. In vitro studies, the loss of RFC4 suppressed CRC cell proliferation and induced S-phase cell cycle arrest.Conclusion RFC4 is frequently overexpressed in CRC, and is associated with tumor progression and worse survival outcome. This might be attributed to the regulation of CRC cell proliferation and cell cycle arrest by RFC4.
    Journal of translational medicine. 11/2014; 12(1):320.
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    ABSTRACT: Members of Myxozoa, a parasitic metazoan taxon, have considerable detrimental effects on fish hosts and also have been associated with human food-borne illness. Little is known about their biology and metabolism. Analysis of the genome of Thelohanellus kitauei and comparative analysis with genomes of its two free-living cnidarian relatives revealed that T. kitauei has adapted to parasitism, as indicated by the streamlined metabolic repertoire and the tendency towards anabolism rather than catabolism. T. kitauei mainly secretes proteases and protease inhibitors for nutrient digestion (parasite invasion), and depends on endocytosis (mainly low-density lipoprotein receptors-mediated type) and secondary carriers for nutrient absorption. Absence of both classic and complementary anaerobic pathways and gluconeogenesis, the lack of de novo synthesis and reduced activity in hydrolysis of fatty acids, amino acids, and nucleotides indicated that T. kitauei in this vertebrate host-parasite system has adapted to inhabit a physiological environment extremely rich in both oxygen and nutrients (especially glucose), which is consistent with its preferred parasitic site, i.e., the host gut submucosa. Taking advantage of the genomic and transcriptomic information, twenty-three potential nutrition-related T. kitauei-specific chemotherapeutic targets were identified. This first genome sequence of a myxozoan will facilitate development of potential therapeutics for efficient control of myxozoan parasites and ultimately prevent myxozoan-induced fish-borne illnesses in humans.
    Genome Biology and Evolution 11/2014; · 4.76 Impact Factor
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    ABSTRACT: Salmonella, a genus that is closely related to Escherichia coli, includes many pathogens of humans and other animals. A notable feature that distinguishes Salmonella from E. coli is lactose negativity, because the lac operon is lost in most Salmonella genomes. Here, we expressed the lac operon in Salmonella enterica serovar Typhimurium and compared the virulence of the Lac(+) strain to that of the wild-type strain in a murine model, invasion assays, and macrophage replication assays. We showed that the Lac(+) strain is attenuated in vivo and the attenuation of virulence is caused by its defect in epithelial cell invasion. However, the invasion-defective phenotype is unrelated to lactose utilization. Through sequencing and the comparison of the transcriptome profile between the Lac(+) and wild-type strains during invasion, we found that most flagellar genes were markedly downregulated in the Lac(+) strain, while other genes associated with invasion, such as the majority of genes encoded in Salmonella pathogenicity island 1, were not differentially expressed. Moreover, we discovered that lacA is the major repressor of flagellar gene expression in the lac operon. In conclusion, these data demonstrate that the lac operon decreases Salmonella invasion of epithelial cells through repression of flagellar biosynthesis. As the ability to invade epithelial cells is a critical virulence determinant of Salmonella, our results provide important evidence that the loss of the lac operon contributes to the evolution of Salmonella pathogenicity.
    Current microbiology. 11/2014;
  • Lei Wang, Gang Wang, Tianwen Gao
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    ABSTRACT: Primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoma (SMPTCL) is an indolent form of cutaneous lymphoma that usually presents in solitary fashion and is histopathologically characterized by nodular infiltration of small to medium-sized pleomorphic T-cells. We report the case of a patient who presented with a 5-year history of acneiform lesions on his face. Histopathologic examination of two lesions revealed a nodular infiltrate of small to medium-sized lymphocytes with necrosis in the dermis. The proliferating cells were positive for CD2, CD3, and CD4 and negative for CD8, CD30, and CD56. They were positive for TIA-1 and negative for perforin and granzyme B. The Ki67 proliferation index was approximately 10%. The neoplastic cells expressed programmed death-1 (PD-1) and lacked expression of CXCL-13, bcl-6, and CD10. In situ hybridization for Epstein-Barr virus–encoded RNA (EBER) yielded a negative result. T-cell receptor (TCR) gene rearrangement showed identical T-lymphocyte monoclonality in both lesions. In brief, we report a rare case of acneiform SMPTCL with prominent necrosis.
    Journal of Cutaneous Pathology 11/2014; · 1.77 Impact Factor
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    ABSTRACT: Our results showed that 70.6% and 65.7% of the colorectal cancer tissues had positive HLA-G or HLA-E expression.•Cox multivariate analysis showed that only HLA-G expression can serve as independent factor for OS.•Our results also showed that the expression of HLA-E was significantly correlated with tumor metastasis.
    Cellular Immunology. 10/2014;
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    ABSTRACT: The aim of the present study was to investigate whether the expression of Brain-Derived Neurotrophic Factor (BDNF) and its receptor Tropomyosin-related kinase B (TrkB) is correlated with the clinical progression of salivary adenoid cystic carcinoma (SACC) and whether the BDNF/TrkB axis is associated with the induction of epithelial-mesenchymal transition (EMT) in SACC cells. The expression of BDNF, TrkB, and E-cadherin (an EMT biomarker) in 76 primary SACC specimens and 20 normal salivary gland tissues was analyzed by immunohistochemistry. Additionally, the expression of BDNF, TrkB, and E-cadherin in SACC cell lines (SACC-83 and SACC-LM) was analyzed by RT-PCR and Western blotting. The biological role of the BDNF/TrkB axis in the EMT progression of SACC was evaluated after treatment with increased levels of BDNF and by inhibiting TrkB activity in SACC-83 cell line. The progression of SACC cells through EMT was assessed by RT-PCR, Western blotting, photography, migration and invasion assays. Elevated expression of TrkB (92.1%) and BDNF (89.5%), and downregulated expression of E-cadherin (47.4%) was found in SACC specimens, which was significantly correlated with the invasion and metastasis in SACC (P<0.05). The high expression of TrkB and the low expression of E-cadherin was significantly correlated with the poor prognosis of SACC patients (P<0.05). The expression of TrkB was inversely correlated with the expression of E-cadherin in both SACC cases and cell lines (P<0.05). Increasing BDNF levels after treatment with exogenous recombinant human BDNF (rhBDNF) at 100ng/ml significantly promoted the activation of TrKB and the progression of EMT in SACC cells. While obstruction of TrkB by its inhibitor, k252a (100nM), significantly inhibited the EMT progression of SACC cells. These results suggest that BDNF-mediated TrkB activation contributes to the EMT progression and the poor prognosis in SACC. The present study demonstrated that the BDNF/TrkB axis promotes the migration and invasion of SACC cells via EMT in vitro. Targeting the inactivation of the BDNF/TrkB axis may be a potential strategy for the treatment of SACC. Copyright © 2014. Published by Elsevier Ltd.
    Oral oncology. 10/2014;
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    ABSTRACT: Structure-based prediction for the site of metabolism (SOM) of a compound metabolized by human cytochrome P450s (CYPs) is highly beneficial in drug discovery and development. However, the flexibility of the CYPs' active site remains a huge challenge for accurate SOM prediction. Compared with other CYPs, the active site of CYP2A6 is relatively small and rigid. To address the impact of the flexibility of CYP2A6 active site residues on the SOM prediction for substrates, in this work, molecular dynamics (MD) simulations and molecular docking were used to predict the SOM of 96 CYP2A6 substrates. Substrates with known SOM were docked into the snapshot structures from MD simulations and the crystal structures of CYP2A6. Compared to the crystal structures, the protein structures obtained from MD simulations showed more accurate prediction for SOM. Our results indicated that the flexibility of the active site of CYP2A6 significantly affects the SOM prediction results. Further analysis for the 40 substrates with definite Km values showed that the prediction accuracy for the low Km substrates is comparable to that by ligand-based methods. Copyright © 2014 Elsevier Inc. All rights reserved.
    Journal of Molecular Graphics and Modelling. 10/2014; 54:90–99.
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    ABSTRACT: Solvothermal reactions of tetrabromoterephthalic (H2tbtpa) acid and different bis-imidazoles with cadmium nitrate provided four new Cd(II) coordination polymers (CPs), namely, {[Cd(bip)(tbtpa)]•H2O}n (1), {[Cd2(bibp)(tbtpa)2(H2O)4]•H2O}n (2), {[Cd(1,2-mbix)(tbtpa)]•H2O}n (3) [Cd(1,2-mbix)(tbtpa)]n (4), (bip = 1,4-di(1H-imidazol-1-yl)benzene, bibp = 1,1'-(2,5-dimethyl-1,4-phenylene)bis(1H-imidazole), 1,2-mbix = 1,2-bis((2-methyl-1H-imidazol-1-yl)methyl)benzene, H2tbtpa = tetrabromoterephthalic acid). All of the compounds have been structurally characterized by single-crystal X-ray diffraction analyses and further characterized by elemental analyses, IR spectroscopy, powder X-ray diffraction (PXRD), and thermogravimetric analyses (TGA). Single crystal X-ray diffraction analysis reveals that compound 1 exhibits a 3D diamond-type (dia, 66) framework of 3-fold interpenetration. Compound 2 displays a noninterpenetrated 3D network with the classical pcu topology. Compound 3 exhibits a polyrotaxane-like 2D + 2D → 2D layer with 44-sql topology and the 2D sheets were further formed a 3D framework by π•••π interaction. Compound 4 is a 2D 44-sql network and the adjacent 2D networks are packed parallel in a •••ABAB••• fashion. Moreover, the thermal stability and photoluminescence properties of the compounds were investigated.
    RSC Advances 10/2014; · 3.71 Impact Factor
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    ABSTRACT: IntroductionThe onset of distal metastasis, which underlies the high mortality of breast cancers, warrants substantial studies to depict its molecular basis. Nuclear factor of activated T cells 5 (NFAT5) is upregulated in various malignancies and is critically involved in migration and invasion of neoplastic cells. Nevertheless, the metastasis-related events potentiated by this transcriptional factor and the mechanism responsible for NFAT5 elevation in carcinoma cells remain to be fully elucidated.Methods The correlation of NFAT5 with breast cancer invasiveness was investigated in vitro and clinically. The genes transcriptionally activated by NFAT5 were probed and their roles in breast cancer progression were dissected. The upstream regulators of NFAT5 were studied with particular attempt to explore the involvement of non-coding RNAs, and the mechanism underlying the maintenance of NFAT5 expression was deciphered.ResultsIn metastatic breast cancers, NFAT5 promotes epithelial-mesenchymal transition (EMT) and invasion of cells by switching on the expression of the calcium binding protein S100A4, and facilitates the angiogenesis of breast epithelial cells and thus the development of metastases by transcriptionally activating vascular endothelial growth factor C (VEGF-C). NFAT5 is directly targeted by miR-568, which is in turn suppressed by the long non-coding RNA, Hotair, via a documented in trans gene silencing pattern, that is recruitment of the polycomb complex (Polycomb Repressive Complex 2; PRC2) and LSD1, and consequently methylation of histone H3K27 and demethylation of H3K4 on the miR-568 loci.Conclusion This study unravels a detailed role of NFAT5 in mediating metastatic signaling, and provides broad insights into the involvement of Hotair, in particular, by transcriptionally regulating the expression of microRNA(s), in the metastasis of breast cancers.
    Breast cancer research: BCR 10/2014; 16(5):454. · 5.87 Impact Factor
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    ABSTRACT: Most patients with low-grade gliomas (LGGs) experience epileptic seizures as an initial symptom. However, the mechanism of LGG-related epilepsy is poorly understood. Genetic changes in brain tumors influence epileptic seizures, but few biomarkers have been associated with LGG-related seizures. We investigated the association between LGG-related epilepsy and tumor-specific molecular changes.
    Journal of Cancer Research and Clinical Oncology 10/2014; · 2.91 Impact Factor
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    ABSTRACT: The determination of trace analytes based on membrane filtration–enrichment and diffuse reflectance spectroscopic technique has gained increasing concern in the past decade due to its simplicity, rapidity and high sensitivity. However, poor repeatability primarily attributed to the distinction between membrane filters limits the development of this technique. In the current study, a simple and effective multichannel device is specially designed for the membrane filtration–enrichment process. The device is able to enrich six samples simultaneously on different positions of a membrane filter and allows to fulfil the spectroscopic measurement of six samples with only one membrane filter. The proposed approach avoided the effects caused by the nonuniform membrane filters on the performance of the enrichment process. Accuracy and repeatability have been improved significantly for the subsequent on-line spectroscopic detection. A case study was carried out to assess this method utilizing the carcinogenic dye rhodamine B (RhB) as a model analyte. Under the optimal conditions, linearity of calibration curve based on the Kubelka-Munk function was achieved in the concentration range of 2 – 30 μg L-1 with the correlation coefficient (R2) of 0.9924. Good repeatability was achieved with three average relative standard deviation (RSD) values of 3.6%, 3.8% and 3.8% corresponding to the solutions of 30, 10 and 5 μg L-1 RhB, respectively. The presented method was successfully employed to quantify RhB in soft drink and river water samples.
    RSC Advances 10/2014; · 3.71 Impact Factor
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    ABSTRACT: A new protocol for Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates was firstly established that allows the efficient construction of phthalide skeleton. Interestingly, this reaction underwent a decarboxylative process, in which only divinylation was observed and the subsequent cyclization led to the formation of phthalides.
    Chemical Communications 10/2014; · 6.38 Impact Factor
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    ABSTRACT: A highly efficient Pd-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was developed. A variety of anilides reacted with aryl acylperoxides to afford the corresponding ortho-arylation products. Meanwhile, the reaction of N-methoxyarylamides with aryl acylperoxides generated the phenanthridinones through an arylation-cyclization sequence process.
    Chemical Communications 10/2014; · 6.38 Impact Factor
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    ABSTRACT: Left-sided malignant colonic obstruction is one of the most difficult clinical problems; however, no studies compared the two most common used surgical approach laparoscopic and open colorectomy till now. The purpose of this study was to investigate the short- and long-term outcomes of laparoscopy and open colorectomy for left-sided malignant colonic obstruction. A total of 193 colorectal carcinoma patients (55 patients who underwent laparoscopic colorectomy and 138 who underwent open colorectomy) with left-sided colonic obstruction and surgical therapy, between May 2007 and March 2012, are included in the study. The short-term and long-term outcomes including curative resection rate, hospital stay time, complications, 1-, 3- and 5-year survival rates and recurrence rate, as well as recurrence-free survival rate were analyzed retrospectively. No significant difference was found between the laparoscopic and open groups about the short-term outcomes, such as the curative resection rate (81.82 vs. 78.99 %, P = 0.658), hospital stay time (24.22 ± 17.09 vs. 24.19 ± 14.76 day, P = 0.990), the overall and respective complications (32.73 vs. 39.63 %, P = 0.674). Long-term outcomes, including 1-, 3- and 5-year survival rates (P = 0.518), recurrence rates (P = 0.320), and recurrence-free survival rates (P = 0.988), were also indicated no significant differences between the two patient groups. Laparoscopy might not have advantages on left-sided malignant colonic obstruction compared with open colorectal resection in both short-term and long-term outcomes.
    Medical Oncology 10/2014; 31(10):213. · 2.15 Impact Factor
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    ABSTRACT: Shigella adhesion to host cells is a transitional stage from an extracellular to an intracellular environment. However, the dynamic adaptations of Shigella during adhesion are poorly understood. To address this, we performed the first transcriptome analysis of Shigella flexneri 2457T during adhesion. A total of 1,757 genes were differentially regulated (>twofold). The majority of plasmid-borne ipa-mxi-spa locus genes were downregulated, indicating these virulence genes were strictly regulated after successful adhesion. Altered expression of genes involved in stress response indicates that adherent S. flexneri encountered envelope stress and oxidative stress. Shigella flexneri also experienced reduced energy production during adherence. Transcript profiling and cell culture assays using glpD and glpK mutants showed that enhancement of glycerol catabolism were related with adhesion ability of S. flexneri. In addition, regulation of expression of some ionic transport system may be required for S. flexneri adhesion. Expression levels of 26 genes were further examined using qRT-PCR, which were congruent with transcriptome data. A comparison with expression profile during intracellular growth revealed major differences in genes involved in translation, surface modification, and utilization of carbon and iron. These results contribute to the knowledge of the adaptation mechanisms of S. flexneri during adhesion.
    Journal of Basic Microbiology 10/2014; · 1.20 Impact Factor
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    ABSTRACT: Spermatogonial stem cells (SSCs) are undifferentiated cells that are required to maintain spermatogenesis throughout the reproductive life of mammals. Although SSC transplantation and culture provide a powerful tool to identify the mechanisms regulating SSC function, the precise signalling mechanisms governing SSC self-renewal and specific surface markers for purifying SSCs remain to be clearly determined. In the present study, we established a steady SSC culture according to the method described by Shinohara's lab. Fertile progeny was produced after transplantation of cultured SSCs into infertile mouse testis, and the red fluorescence exhibited by the culture cell membranes was stably and continuously transmitted to the offspring. Next, via advanced mass spectrometry and an optimized proteomics platform, we constructed the proteome profile, with 682 proteins expressed in SSCs. Furthermore bioinformatics analysis showed that the list contained several known molecules that are regulated in SSCs. Several nucleoproteins and membrane proteins were chosen for further exploration using immunofluorescence and RT-PCR. The results showed that SALL1, EZH2, and RCOR2 are possibly involved in the self-renewal mechanism of SSCs. Furthermore, the results of tissue-specific expression analysis showed that Gpat2 and Pld6 were uniquely and highly expressed in mouse testes and cultured SSCs. The cellular localization of PLD6 was further explored and the results showed it was primarily expressed in the spermatogonial membrane of mouse testes and cultured SSCs. The proteins identified in this study form the basis for further exploring the molecular mechanism of self-renewal in SSCs and for identifying specific surface markers of SSCs.
    Journal of Cellular and Molecular Medicine 10/2014; · 4.75 Impact Factor
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    ABSTRACT: Ubiquitin ligase Nrdp1 (neuregulin receptor degradation protein 1) plays important roles in multiple physiological process because it can ubiquitinate various substrates such as ErbB3, BRUCE, MyD88, C/EBPβ, and Parkin, and so forth. In addition to the physiological function, it was also found to be involved in tumor progression. It has been shown that loss of Nrdp1 enhances breast cancer cell growth. Up to now, the role of Nrdp1 in glioma has not been elucidated. Here, we reported that Nrdp1 as well as cleaved caspase 3 was lower expressed in human glioma tissues comparing with the nontumorous. And then we found that the expression of Nrdp1 and cleaved caspase 3 was increased in the treatment of Temozolomide (TMZ), a drug for glioma chemotherapy. Further investigation indicated that transient transfection of Nrdp1 significantly promoted cell apoptosis by aggravating the degradation of BRUCE and activation of caspase 3. In addition, overexpression of Nrdp1 augmented TMZ induced apoptosis by evaluating the degradation of BRUCE and the activation of caspase 3, while silencing of Nrdp1 reduced the sensitivity to the TMZ by inhibiting the degradation of BRUCE and the activation of caspase 3 in human glioma cells. These observations show that Nrdp1 is a pro-apoptotic protein in human glioma and lower expression of Nrdp1 in human glioma may promote tumor progression by reducing apoptosis, suggesting that Nrdp1 may be an important regulator in the development of human glioma. © 2014 IUBMB Life, 2014
    International Union of Biochemistry and Molecular Biology Life 10/2014; · 2.79 Impact Factor

Publication Stats

6k Citations
2,327.74 Total Impact Points

Institutions

  • 2014
    • University of Science and Technology of China
      • School of Life Sciences
      Luchow, Anhui Sheng, China
  • 2013–2014
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
    • Hebei Medical University
      Chentow, Hebei, China
    • Chinese Academy of Tropical Agricultural Sciences
      Hoihau, Hainan, China
    • Northwest University
      Ch’ang-an, Shaanxi, China
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • Zhengzhou Tobacco Institute
      Chen-chu-shan, Jiangxi Sheng, China
    • Anhui Agricultural University (AHAU)
      Luchow, Anhui Sheng, China
    • Shenzhen Second People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
  • 2011–2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
    • Soochow University (PRC)
      • • Department of Polymer Science and Engineering
      • • Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application
      • • Department of Materials Science and Engineering
      Wu-hsien, Jiangsu Sheng, China
    • Jiangnan University
      • • School of Biotechnology
      • • School of Food Science and Technology
      Wu-hsi, Jiangsu Sheng, China
    • Yangzhou University
      Chiang-tu, Jiangsu Sheng, China
    • Shenyang Ligong University
      Feng-t’ien, Liaoning, China
    • University of New South Wales
      • School of Biotechnology and Biomolecular Sciences (BABS)
      Kensington, New South Wales, Australia
    • University Town of Shenzhen
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • National Institute for the Control of Pharmaceutical and Biological Products
      Peping, Beijing, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Government of the People's Republic of China
      Peping, Beijing, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
    • Anhui Medical University
      Luchow, Anhui Sheng, China
    • Guangzhou University of Traditional Chinese Medicine
      Shengcheng, Guangdong, China
    • Northeastern University (Shenyang, China)
      • Key Laboratory for Anisotropy and Texture of Materials
      Feng-t’ien, Liaoning, China
  • 2010–2014
    • Shanghai Jiao Tong University
      • • Bio-X Institute
      • • Antai College of Economics and Management
      • • School of Agriculture and Biology
      Shanghai, Shanghai Shi, China
    • Jiangsu Academy of Agricultural Sciences
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2008–2014
    • Qingdao University of Science and Technology
      Tsingtao, Shandong Sheng, China
    • Hawaii Agriculture Research Center
      Honolulu, Hawaii, United States
    • GNS Science
      Lower Hutt City, Wellington, New Zealand
    • Imperial College London
      Londinium, England, United Kingdom
    • University of Hawai'i System
      Honolulu, Hawaii, United States
    • University of Hawaiʻi at Hilo
      • Department of Natural Science
      Hilo, HI, United States
  • 2007–2014
    • Chinese Academy of Sciences
      • • Institute of Process Engineering
      • • Key Laboratory of Organic Solids
      • • Key Laboratory of Computer System and Architecture
      Peping, Beijing, China
    • University of Victoria
      • Department of Psychology
      Victoria, British Columbia, Canada
  • 2006–2014
    • Sun Yat-Sen University
      • Proteomics Lab
      Shengcheng, Guangdong, China
    • Peking University
      • Department of Psychology
      Peping, Beijing, China
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
  • 2005–2014
    • Nanjing Medical University
      • Key Laboratory of Reproductive Medicine
      Nan-ching, Jiangsu Sheng, China
    • Fourth Military Medical University
      • • Department of Dermatology
      • • Department of Biochemistry and Molecular Biology
      Xi’an, Liaoning, China
    • Freie Universität Berlin
      Berlín, Berlin, Germany
    • Robert Koch Institut
      • ZBS 3: Microbial Toxins
      Berlín, Berlin, Germany
  • 2004–2014
    • Nankai University
      • • Department of Genetics and Cell Biology
      • • TEDA School of Biological Science and Biotechnology
      • • College of Life Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • Tsinghua University
      • • Department of Basic Medical Sciences
      • • Department of Electronic Engineering
      • • Department of Chemical Engineering
      • • School of Environment
      Peping, Beijing, China
    • Huaibei Normal University
      Hua-pei-ts’un, Shanxi Sheng, China
  • 1999–2014
    • Sun Yat-Sen University of Medical Sciences
      Shengcheng, Guangdong, China
    • University of Melbourne
      • Department of Microbiology and Immunology
      Melbourne, Victoria, Australia
  • 2011–2013
    • Beijing Tiantan Hospital
      Peping, Beijing, China
    • South China University of Technology
      Shengcheng, Guangdong, China
  • 2010–2013
    • Zhengzhou University
      • Division of Pharmacy
      Cheng, Henan Sheng, China
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Shandong University
      • • Key Laboratory for Colloid and Interface Chemistry
      • • Department of Physics
      Chi-nan-shih, Shandong Sheng, China
  • 2009–2013
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
    • National Institute on Alcohol Abuse and Alcoholism
      Maryland, United States
    • Tongji University
      • Department of Material Science and Engineering
      Shanghai, Shanghai Shi, China
    • Indian Institute of Technology Bombay
      • Department of Biosciences & Bioengineering
      Mumbai, State of Maharashtra, India
    • Capital Medical University
      • Department of Otorhinolaryngology Head and Neck Surgery
      Peping, Beijing, China
  • 2008–2013
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • Queen's University Belfast
      • School of Pharmacy
      Belfast, NIR, United Kingdom
  • 2006–2013
    • Northeast Institute of Geography and Agroecology
      • • Institute of Biophysics
      • • Institute of Computing Technology
      Beijing, Beijing Shi, China
  • 1996–2013
    • University of Sydney
      • School of Molecular Bioscience
      Sydney, New South Wales, Australia
  • 2012
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
    • Instituto de Salud Carlos III
      Madrid, Madrid, Spain
    • Northeast Agricultural University
      Charbin, Heilongjiang Sheng, China
    • Shanghai Municipal Center for Disease Control and Prevention
      Shanghai, Shanghai Shi, China
    • General Hospital of Jinan Military Region
      Chi-nan-shih, Shandong Sheng, China
    • Huazhong University of Science and Technology
      • Key Laboratory of Organ Transplantation , MOE
      Wu-han-shih, Hubei, China
    • Fred Hutchinson Cancer Research Center
      • Division of Clinical Research
      Seattle, Washington, United States
  • 2011–2012
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
  • 2010–2012
    • Nanjing University of Information Science & Technology
      Nan-ching, Jiangsu Sheng, China
  • 2008–2012
    • Queen's University
      • • Division of Rheumatology
      • • Department of Medicine
      Kingston, Ontario, Canada
  • 2005–2012
    • Russian Academy of Sciences
      • Zelinsky Institute of Organic Chemistry
      Moscow, Moscow, Russia
  • 2002–2012
    • China Agricultural University
      • • Department of Applied Chemistry
      • • College of Resources and Environmental Sciences
      • • Department of Microbiology and Immunology
      • • College of Biological Sciences
      Beijing, Beijing Shi, China
  • 2005–2011
    • National Institutes of Health
      • • Laboratory of Liver Diseases
      • • Laboratory of Physiologic Studies
      Bethesda, MD, United States
  • 2008–2010
    • Salk Institute
      • Structural Biology Laboratory
      La Jolla, California, United States
  • 2006–2010
    • Tianjin University of Science and Technology
      • Faculty of Food Engineering and Biotechnology
      T’ien-ching-shih, Tianjin Shi, China
  • 2004–2007
    • Jilin University
      • State Key Laboratory of Inorganic Synthesis and Preparative
      Jilin, Jilin Sheng, China