Lei Wang

Peking University, Peping, Beijing, China

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Publications (895)2497.45 Total impact

  • ChemInform 11/2014; 45(44).
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    ABSTRACT: Solvothermal reactions of tetrabromoterephthalic (H2tbtpa) acid and different bis-imidazoles with cadmium nitrate provided four new Cd(II) coordination polymers (CPs), namely, {[Cd(bip)(tbtpa)]•H2O}n (1), {[Cd2(bibp)(tbtpa)2(H2O)4]•H2O}n (2), {[Cd(1,2-mbix)(tbtpa)]•H2O}n (3) [Cd(1,2-mbix)(tbtpa)]n (4), (bip = 1,4-di(1H-imidazol-1-yl)benzene, bibp = 1,1'-(2,5-dimethyl-1,4-phenylene)bis(1H-imidazole), 1,2-mbix = 1,2-bis((2-methyl-1H-imidazol-1-yl)methyl)benzene, H2tbtpa = tetrabromoterephthalic acid). All of the compounds have been structurally characterized by single-crystal X-ray diffraction analyses and further characterized by elemental analyses, IR spectroscopy, powder X-ray diffraction (PXRD), and thermogravimetric analyses (TGA). Single crystal X-ray diffraction analysis reveals that compound 1 exhibits a 3D diamond-type (dia, 66) framework of 3-fold interpenetration. Compound 2 displays a noninterpenetrated 3D network with the classical pcu topology. Compound 3 exhibits a polyrotaxane-like 2D + 2D → 2D layer with 44-sql topology and the 2D sheets were further formed a 3D framework by π•••π interaction. Compound 4 is a 2D 44-sql network and the adjacent 2D networks are packed parallel in a •••ABAB••• fashion. Moreover, the thermal stability and photoluminescence properties of the compounds were investigated.
    RSC Advances 10/2014; · 3.71 Impact Factor
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    ABSTRACT: IntroductionThe onset of distal metastasis, which underlies the high mortality of breast cancers, warrants substantial studies to depict its molecular basis. Nuclear factor of activated T cells 5 (NFAT5) is upregulated in various malignancies and is critically involved in migration and invasion of neoplastic cells. Nevertheless, the metastasis-related events potentiated by this transcriptional factor and the mechanism responsible for NFAT5 elevation in carcinoma cells remain to be fully elucidated.Methods The correlation of NFAT5 with breast cancer invasiveness was investigated in vitro and clinically. The genes transcriptionally activated by NFAT5 were probed and their roles in breast cancer progression were dissected. The upstream regulators of NFAT5 were studied with particular attempt to explore the involvement of non-coding RNAs, and the mechanism underlying the maintenance of NFAT5 expression was deciphered.ResultsIn metastatic breast cancers, NFAT5 promotes epithelial-mesenchymal transition (EMT) and invasion of cells by switching on the expression of the calcium binding protein S100A4, and facilitates the angiogenesis of breast epithelial cells and thus the development of metastases by transcriptionally activating vascular endothelial growth factor C (VEGF-C). NFAT5 is directly targeted by miR-568, which is in turn suppressed by the long non-coding RNA, Hotair, via a documented in trans gene silencing pattern, that is recruitment of the polycomb complex (Polycomb Repressive Complex 2; PRC2) and LSD1, and consequently methylation of histone H3K27 and demethylation of H3K4 on the miR-568 loci.Conclusion This study unravels a detailed role of NFAT5 in mediating metastatic signaling, and provides broad insights into the involvement of Hotair, in particular, by transcriptionally regulating the expression of microRNA(s), in the metastasis of breast cancers.
    Breast cancer research: BCR 10/2014; 16(5):454. · 5.87 Impact Factor
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    ABSTRACT: Most patients with low-grade gliomas (LGGs) experience epileptic seizures as an initial symptom. However, the mechanism of LGG-related epilepsy is poorly understood. Genetic changes in brain tumors influence epileptic seizures, but few biomarkers have been associated with LGG-related seizures. We investigated the association between LGG-related epilepsy and tumor-specific molecular changes.
    Journal of Cancer Research and Clinical Oncology 10/2014; · 2.91 Impact Factor
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    ABSTRACT: The determination of trace analytes based on membrane filtration–enrichment and diffuse reflectance spectroscopic technique has gained increasing concern in the past decade due to its simplicity, rapidity and high sensitivity. However, poor repeatability primarily attributed to the distinction between membrane filters limits the development of this technique. In the current study, a simple and effective multichannel device is specially designed for the membrane filtration–enrichment process. The device is able to enrich six samples simultaneously on different positions of a membrane filter and allows to fulfil the spectroscopic measurement of six samples with only one membrane filter. The proposed approach avoided the effects caused by the nonuniform membrane filters on the performance of the enrichment process. Accuracy and repeatability have been improved significantly for the subsequent on-line spectroscopic detection. A case study was carried out to assess this method utilizing the carcinogenic dye rhodamine B (RhB) as a model analyte. Under the optimal conditions, linearity of calibration curve based on the Kubelka-Munk function was achieved in the concentration range of 2 – 30 μg L-1 with the correlation coefficient (R2) of 0.9924. Good repeatability was achieved with three average relative standard deviation (RSD) values of 3.6%, 3.8% and 3.8% corresponding to the solutions of 30, 10 and 5 μg L-1 RhB, respectively. The presented method was successfully employed to quantify RhB in soft drink and river water samples.
    RSC Advances 10/2014; · 3.71 Impact Factor
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    ABSTRACT: A new protocol for Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates was firstly established that allows the efficient construction of phthalide skeleton. Interestingly, this reaction underwent a decarboxylative process, in which only divinylation was observed and the subsequent cyclization led to the formation of phthalides.
    Chemical Communications 10/2014; · 6.38 Impact Factor
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    ABSTRACT: A highly efficient Pd-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was developed. A variety of anilides reacted with aryl acylperoxides to afford the corresponding ortho-arylation products. Meanwhile, the reaction of N-methoxyarylamides with aryl acylperoxides generated the phenanthridinones through an arylation-cyclization sequence process.
    Chemical Communications 10/2014; · 6.38 Impact Factor
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    ABSTRACT: Neonates (including human infants) require L-glutamine (Gln) for optimal intestinal health. This study tested the hypothesis that Gln enhances enterocyte growth via both mammalian target of rapamycin (mTOR) and AMP-activated kinase (AMPK) signaling pathways. Intestinal porcine epithelial cells (IPEC-1) were cultured for 3 days in Gln-free Dulbecco's modified Eagle medium containing 0 or 2 mM Gln. To determine the role of mTOR and AMPK on cell growth, additional experiments were conducted where medium contained 2 mM Gln and 10 nM rapamycin (Rap, an inhibitor of mTOR) or 1 μM compound C (an inhibitor of AMPK). IPEC-1 cell growth increased with increasing concentrations of Gln from 0 to 2 mM. Compared with 0 mM Gln, 2 mM Gln increased (P < 0.05) the amounts of phosphorylated 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70S6 kinase) proteins but did not affect abundances of total or phosphorylated AMPK protein. Gln also increased mRNA levels for Bcl-2, mTOR, p70S6 kinase, 4E-BP1, COX7C, ASCT2, ODC, SGLT-1, CFTR, Na(+)/K(+)-ATPase, HSP70, and ZO-1. Similarly, cells cultured with Rap and Gln exhibited higher (P < 0.05) abundances of phosphorylated 4E-BP1 and p70S6 kinase proteins than the Rap-only group, whereas abundances of phosphorylated mTOR and 4E-BP1 proteins were increased when AMPK was inhibited by compound C. Conversely, the amount of phosphorylated AMPK increased when mTOR was inhibited by Rap, suggesting a negative cross-talk between mTOR and AMPK. Collectively, these results indicate that Gln stimulates enterocyte growth by activating the mTOR signaling pathway independently of AMPK.
    Amino Acids 10/2014; · 3.91 Impact Factor
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    ABSTRACT: Left-sided malignant colonic obstruction is one of the most difficult clinical problems; however, no studies compared the two most common used surgical approach laparoscopic and open colorectomy till now. The purpose of this study was to investigate the short- and long-term outcomes of laparoscopy and open colorectomy for left-sided malignant colonic obstruction. A total of 193 colorectal carcinoma patients (55 patients who underwent laparoscopic colorectomy and 138 who underwent open colorectomy) with left-sided colonic obstruction and surgical therapy, between May 2007 and March 2012, are included in the study. The short-term and long-term outcomes including curative resection rate, hospital stay time, complications, 1-, 3- and 5-year survival rates and recurrence rate, as well as recurrence-free survival rate were analyzed retrospectively. No significant difference was found between the laparoscopic and open groups about the short-term outcomes, such as the curative resection rate (81.82 vs. 78.99 %, P = 0.658), hospital stay time (24.22 ± 17.09 vs. 24.19 ± 14.76 day, P = 0.990), the overall and respective complications (32.73 vs. 39.63 %, P = 0.674). Long-term outcomes, including 1-, 3- and 5-year survival rates (P = 0.518), recurrence rates (P = 0.320), and recurrence-free survival rates (P = 0.988), were also indicated no significant differences between the two patient groups. Laparoscopy might not have advantages on left-sided malignant colonic obstruction compared with open colorectal resection in both short-term and long-term outcomes.
    Medical oncology (Northwood, London, England). 10/2014; 31(10):213.
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    ABSTRACT: Shigella adhesion to host cells is a transitional stage from an extracellular to an intracellular environment. However, the dynamic adaptations of Shigella during adhesion are poorly understood. To address this, we performed the first transcriptome analysis of Shigella flexneri 2457T during adhesion. A total of 1,757 genes were differentially regulated (>twofold). The majority of plasmid-borne ipa-mxi-spa locus genes were downregulated, indicating these virulence genes were strictly regulated after successful adhesion. Altered expression of genes involved in stress response indicates that adherent S. flexneri encountered envelope stress and oxidative stress. Shigella flexneri also experienced reduced energy production during adherence. Transcript profiling and cell culture assays using glpD and glpK mutants showed that enhancement of glycerol catabolism were related with adhesion ability of S. flexneri. In addition, regulation of expression of some ionic transport system may be required for S. flexneri adhesion. Expression levels of 26 genes were further examined using qRT-PCR, which were congruent with transcriptome data. A comparison with expression profile during intracellular growth revealed major differences in genes involved in translation, surface modification, and utilization of carbon and iron. These results contribute to the knowledge of the adaptation mechanisms of S. flexneri during adhesion.
    Journal of Basic Microbiology 10/2014; · 1.20 Impact Factor
  • ChemInform 09/2014; 45(40).
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    ABSTRACT: The nerve growth factor receptor (NGFR/p75) is a potential tumor suppressor, but its role in colorectal cancer (CRC) is unknown. Here, the hypermethylation status, biological function, and clinical relevance were determined for p75NGFR in CRC. The methylation status and expression of p75NGFR were assessed in CRC cell lines and clinical tissues by bisulfate genomic sequencing (BGS), qRT-PCR and immunoblot assay. Methylation of p75NGFR was frequently found in CRC, leading to its silencing or down-regulation, and it was effectively restored by a demethylation agent. The overexpression of p75NGFR in multiple CRC cell model systems significantly inhibited cell proliferation (concomitant with G1-phase arrest), invasion, and colony formation and induced cell apoptosis. In contrast, p75NGFR knockdown significantly promoted proliferative and invasive phenotypes. Importantly, p75NGFR methylation was observed in the majority of primary CRC specimens and was associated with histological grade and preoperative serum CA19-9 levels. Multivariate analysis indicated that patients who lack p75NGFR have reduced overall survival (OS; 64% vs. 75%, p=0.028) and disease-free survival (DFS; 61% vs. 72%, p=0.034) compared with p75NGFR-positive patients. In conclusion, p75NGFR is predominantly silenced or down-regulated in CRC, and its biological activities are consistent with it being a relevant tumor suppressor. Implications: p75NGFR is a candidate tumor suppressor and has independent prognostic potential in CRC.
    Molecular cancer research : MCR. 09/2014;
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    ABSTRACT: The supramolecular reactions of tetrabromoterephthalic acid (H2-TBTA) with a series of N-heterocycles afford eight new complexes, namely, [(H2-BTAH)2·(TBTA)·(H2-TBTA)] (1), [(H2-Bim)2·(TBTA)·(H2-TBTA)·2H2O] (2), [(H-8-HQ)2·(TBTA)·3H2O] (3), [(5-NO2-phen)2·(H2-TBTA)] (4), [(4,6-DHP)2·(H2-TBTA)·2H2O] (5), [(H2-2,4-DMI)2·(TBTA)·(H2-TBTA)2] (6), [(H2-3,5-DMP)2·(TBTA)] (7), and [(H-4-CNpy)2·(TBTA)·(H2-TBTA)] (8) (H-BTAH = 1H-Benzotriazole, H-Bim = 1H-Benzimidazole, 8-HQ = 8-Hydroxyquinoline, 5-NO2-phen = 5-Nitro-1,10-phenanthroline, 4,6-DHP = 4,6-Dihydroxypyrimidine, H-2,4-DMI = 2,4-Dimethylimidazole, H-3,5-DMP = 3,5-Dimethylpyrazole, and 4-CNpy = 4-Cyanopyridine), which have been prepared under mild and identical reaction conditions in a mixture of distilled water and ethanol. All the complexes were fully characterized by single crystal X-ray diffraction analysis, elemental analysis, infrared spectroscopy (IR), and thermogravimetric analysis (TGA). Combining the various N-containing ligands and the diversity of the hydrogen bonds, the eight crystals display amusing structural characteristics. Of this, complex 3 forms three-dimensional (3D) network through the C–H···Br, whilst the O–H···Br consist in the 3D construction of compound 2. Complexes 4-8 generate a 3D supramolecular structure by large amounts of hydrogen bonds. In crystal 1, the π–π stacking interactions play an important part in the 3D network. The thermal stability of crystals 1-8 has been investigated by thermogravimetric analysis (TGA) of mass loss.
    RSC Advances 09/2014; · 3.71 Impact Factor
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    ABSTRACT: Epidermal growth factor receptor (EGFR), which is overexpressed in psoriatic lesions, has been proven to contribute to the hyperproliferation of keratinocytes in psoriasis. Single nucleotide polymorphisms (SNPs) involved in miRNAs that can regulate the expression of EGFR could potentially influence the development of psoriasis. The present study investigated the association between a functional SNP of rs2910164 in miR-146a and the risk of psoriasis in the Chinese Han population. A total of 521 Han Chinese patients with psoriasis and 582 healthy controls were recruited in this study. The miR-146a rs2910164 SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Overall, a significantly increased risk of psoriasis was associated with the rs2910164 miR-146a CG and GG genotypes (adjusted OR, 1.38; 95% CI, 1.06-1.80). Furthermore, the rs2910164G allele in miR-146a attenuated its inhibitory regulation on the expression of EGFR as well as the proliferation of human keratinocytes, and lowered the level of miR-146a in the psoriatic lesions. These findings indicate that the rs2910164G allele in miR-146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR, which may account for the increased risk of psoriasis in this study population.
    Journal of Cellular and Molecular Medicine 09/2014; · 4.75 Impact Factor
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    ABSTRACT: Although conscientiousness was commonly viewed as a type of personal resource to help individuals reduce strain or mitigate the impacts of stressors, empirical research demonstrated mixed results. Based on the personal resource allocation perspective, we posited that rather than functioning as personal resource per se, conscientiousness may act as a key factor influencing how individuals allocate their personal resources. The current study examined the moderating roles of conscientiousness in the relationships that work stressors (i.e., challenge stressors and hindrance stressors) have with employee psychological strain and job performance by using multi-source, time-lagged data collected from 250 employees working at two companies. The results showed that both challenge stressors and hindrance stressors were positively related to psychological strain. Conscientiousness moderated the relationships between both stressors and psychological strain, such that the positive relationships were stronger for individuals with high conscientiousness. Conscientiousness also moderated the relationship between challenge stressors and performance, such that the relationship was positive for individuals with high conscientiousness but negative for those with low conscientiousness. Altogether, the findings suggest that conscientiousness acts as a double-edged sword that both promotes performance and exacerbates the stress reaction of employees when they are confronted with stressful situations. Copyright © 2014 John Wiley & Sons, Ltd.
    Journal of Organizational Behavior 09/2014; · 3.85 Impact Factor
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    ABSTRACT: Big data benchmark suites must include a diversity of data and workloads to be useful in fairly evaluating big data systems and architectures. However, using truly comprehensive benchmarks poses great challenges for the architecture community. First, we need to thoroughly understand the behaviors of a variety of workloads. Second, our usual simulation-based research methods become prohibitively expensive for big data. As big data is an emerging field, more and more software stacks are being proposed to facilitate the development of big data applications, which aggravates hese challenges. In this paper, we first use Principle Component Analysis (PCA) to identify the most important characteristics from 45 metrics to characterize big data workloads from BigDataBench, a comprehensive big data benchmark suite. Second, we apply a clustering technique to the principle components obtained from the PCA to investigate the similarity among big data workloads, and we verify the importance of including different software stacks for big data benchmarking. Third, we select seven representative big data workloads by removing redundant ones and release the BigDataBench simulation version, which is publicly available from http://prof.ict.ac.cn/BigDataBench/simulatorversion/.
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    ABSTRACT: Cyclic dinucleotides are a newly expanded class of second messengers that contribute to the regulation of multiple different pathways in bacterial, eukaryotic, and archaeal cells. The recently identified Vibrio cholerae dinucleotide cyclase (DncV, the gene product of VC0179) can generate three different cyclic dinucleotides and preferentially synthesize a hybrid cyclic-GMP-AMP. Here, we report the crystal structural and functional studies of DncV. We unexpectedly observed a 5-methyltetrahydrofolate diglutamate (5MTHFGLU2) molecule bound in a surface pocket opposite the nucleotide substrate-binding groove of DncV. Subsequent mutagenesis and functional studies showed that the enzymatic activity of DncV is regulated by folate-like molecules, suggesting the existence of a signaling pathway that links folate-like metabolism cofactors to the regulation of cyclic dinucleotide second messenger synthesis. Sequence analysis showed that the residues involved in 5MTHFGLU2 binding are highly conserved in DncV orthologs, implying the presence of this regulation mechanism in a wide variety of bacteria.
    Molecular Cell 09/2014; · 15.28 Impact Factor
  • Lin Yu, Min Wang, Lei Wang
    Tetrahedron. 09/2014; 70(35):5391–5397.
  • Lei Wang, Tianwen Gao, Gang Wang
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    ABSTRACT: Background Verrucous hemangioma is a rare form of vascular malformation. Previous studies have reported positive expression of Wilms tumor 1 (WT-1) and Glut-1 and negative expression of lymphatic markers such as D2-40 and Prox1 in verrucous hemangioma cases. However, the sample sizes of these studies were usually small.Methods We analyzed 74 cases of verrucous hemangioma diagnosed in a single dermatology department and performed immunohistochemical analysis of vascular and lymphatic markers in all cases.ResultsVerrucous hemangioma was usually located on the extremities. Most lesions presented as solitary or multiple hyperkeratotic plaques or nodules with various diameters. Histopathologically, the lesions showed proliferation of small- to medium-sized vessels from the papillary dermis to subcutaneous tissue. The density of the proliferated vessels varied between cases. The vessels were positive for CD31 in 74 cases, focally positive for Prox1 in 63 cases, focally positive for D2-40 in 10 cases, negative for lymphatic vessel endothelial hyaluronan receptor-1 in 74 cases, negative for WT-1 in 60 cases, and positive for Glut-1 in 49 cases.Conclusion Verrucous hemangioma is a vascular malformation with an incomplete lymphatic immunophenotype, as indicated by positive staining for Prox1 and negative staining for WT-1 in the majority of instances.
    Journal of Cutaneous Pathology 09/2014; · 1.77 Impact Factor
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    ABSTRACT: The aim of the present study was to investigate the abnormal calcium re-uptake function of myocardium sarcoplasmic reticulum (SR) in rabbits with heart failure, as well as potential mechanisms. Heart failure model was established in rabbits through aortic insufficiency and constriction of abdominal aorta. The SR Ca(2+) re-uptake function was measured with a calcium imaging device. The activity of myocardium SR calcium adenodine triphosphatase 2a (SERCA2a) was measured by inorganic phosphate. The protein expressions of SERCA2a, CaMKII, PKA, PP1α, phospholamban (PLB), PLB-Ser(16) and PLB-Thr(17) were evaluated by Western blot. The activities of PKA and CaMKII were detected by γ-(32)P substrate incorporation. The results showed that, compared with the sham operation group, the heart failure group exhibited reduced Ca(2+) re-uptake amount (P < 0.01) and the expression and activity of SERCA2a (P < 0.05 or P < 0.01), decreased expression of PLB and its phosphorylation status in sites of Ser(16) and Thr(17) (P < 0.05), increased expressions and activities of PKA and CaMKII (P < 0.05 or P < 0.01), and increased expression of PP1α (P < 0.05). These results suggest that the abnormal Ca(2+) re-uptake function in heart failure is related with reduced expression and activities of SERCA2a, as well as reduced expression of PLB and its phosphorylation status. Both PLB-Ser(16) and -Thr(17) may be involved in the regulation of myocardium SR calcium pump activity in heart failure.
    Sheng li xue bao: [Acta physiologica Sinica] 08/2014; 66(4):483-8.

Publication Stats

5k Citations
2,497.45 Total Impact Points


  • 2014
    • Peking University
      Peping, Beijing, China
    • Universität Heidelberg
      • V. Medicine Clinic
      Heidelburg, Baden-Württemberg, Germany
    • The Northwest Normal University
      Kao-lan-hsien, Gansu Sheng, China
    • University of Science and Technology of China
      • School of Life Sciences
      Luchow, Anhui Sheng, China
  • 2013–2014
    • Hebei Medical University
      Chentow, Hebei, China
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
    • Beijing Centers for Disease Control and Prevention
      Peping, Beijing, China
    • Northwest University
      Ch’ang-an, Shaanxi, China
    • Chinese Academy of Tropical Agricultural Sciences
      Hoihau, Hainan, China
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
    • Zhengzhou Tobacco Institute
      Chen-chu-shan, Jiangxi Sheng, China
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • China-Japan Friendship Hospital
      Peping, Beijing, China
    • Anhui Agricultural University (AHAU)
      Luchow, Anhui Sheng, China
    • Liaoning Universtity of Traditional Chinese Medicine
      Feng-t’ien, Liaoning, China
    • Zhengzhou University
      Cheng, Henan Sheng, China
    • Southern Medical University
      Shengcheng, Guangdong, China
    • Shenzhen Second People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
  • 2011–2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
    • Beijing University of Chemical Technology
      • College of Materials Science and Engineering (SMSE)
      Peping, Beijing, China
    • Soochow University (PRC)
      • • Department of Polymer Science and Engineering
      • • Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application
      • • Department of Materials Science and Engineering
      Wu-hsien, Jiangsu Sheng, China
    • Yangzhou University
      Chiang-tu, Jiangsu Sheng, China
    • Harbin Engineering University
      • College of Science
      Harbin, Heilongjiang Sheng, China
    • University of New South Wales
      • School of Biotechnology and Biomolecular Sciences (BABS)
      Kensington, New South Wales, Australia
    • University Town of Shenzhen
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Shenyang Ligong University
      Feng-t’ien, Liaoning, China
    • Anhui Medical University
      Luchow, Anhui Sheng, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
    • National Institute for the Control of Pharmaceutical and Biological Products
      Peping, Beijing, China
  • 2010–2014
    • Shanghai Jiao Tong University
      • • Bio-X Institute
      • • School of Agriculture and Biology
      Shanghai, Shanghai Shi, China
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China
    • Cold Spring Harbor Laboratory
      Cold Spring Harbor, New York, United States
    • Zhejiang University
      • Institute for Thermal Power Engineering
      Hangzhou, Zhejiang Sheng, China
    • Jiangsu Academy of Agricultural Sciences
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2008–2014
    • Qingdao University of Science and Technology
      Tsingtao, Shandong Sheng, China
    • University of Hawaiʻi at Hilo
      • Department of Natural Science
      Hilo, HI, United States
    • Hawaii Agriculture Research Center
      Honolulu, Hawaii, United States
    • Imperial College London
      Londinium, England, United Kingdom
    • GNS Science
      Lower Hutt City, Wellington, New Zealand
    • University of Hawai'i System
      Honolulu, Hawaii, United States
  • 2007–2014
    • Queen's University Belfast
      • School of Pharmacy
      Béal Feirste, N Ireland, United Kingdom
    • Chinese Academy of Sciences
      • • Institute of Process Engineering
      • • Key Laboratory of Organic Solids
      Peping, Beijing, China
  • 2006–2014
    • Sun Yat-Sen University
      • Proteomics Lab
      Shengcheng, Guangdong, China
  • 2005–2014
    • Nanjing Medical University
      • Key Laboratory of Reproductive Medicine
      Nan-ching, Jiangsu Sheng, China
    • Tsinghua University
      • • Department of Basic Medical Sciences
      • • Department of Biomedical Engineering
      • • School of Environment
      Peping, Beijing, China
    • Fourth Military Medical University
      • • Department of Dermatology
      • • Department of Biochemistry and Molecular Biology
      Xi’an, Liaoning, China
    • National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
      Peping, Beijing, China
    • Robert Koch Institut
      • ZBS 3: Microbial Toxins
      Berlín, Berlin, Germany
    • Freie Universität Berlin
      Berlín, Berlin, Germany
  • 2004–2014
    • Huaibei Normal University
      Hua-pei-ts’un, Shanxi Sheng, China
    • Nankai University
      • • Department of Genetics and Cell Biology
      • • TEDA School of Biological Science and Biotechnology
      • • College of Life Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • Shandong University
      • • School of Pharmaceutical Sciences
      • • Department of Chemical Engineering
      • • State Key Laboratory for Crystal Materials
      Chi-nan-shih, Shandong Sheng, China
  • 1999–2014
    • Sun Yat-Sen University of Medical Sciences
      Shengcheng, Guangdong, China
    • University of Melbourne
      • Department of Microbiology and Immunology
      Melbourne, Victoria, Australia
  • 2011–2013
    • Beijing Tiantan Hospital
      Peping, Beijing, China
    • Jiangnan University
      • School of Food Science and Technology
      Wuxi, Jiangsu Sheng, China
  • 2010–2013
    • Wuhan Polytechnic University
      Wu-han-shih, Hubei, China
  • 2009–2013
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
    • Lanzhou University
      • State Key Laboratory of Applied and Organic Chemistry
      Kao-lan-hsien, Gansu Sheng, China
    • Tongji University
      • Department of Material Science and Engineering
      Shanghai, Shanghai Shi, China
    • Capital Medical University
      • Department of Otorhinolaryngology Head and Neck Surgery
      Peping, Beijing, China
  • 2008–2013
    • Heilongjiang University
      • School of Chemistry and Materials Science
      Charbin, Heilongjiang Sheng, China
  • 2007–2013
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 1998–2013
    • University of Sydney
      • School of Molecular Bioscience
      Sydney, New South Wales, Australia
  • 2012
    • Dalian University of Technology
      Lü-ta-shih, Liaoning, China
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
    • Nanjing University of Information Science & Technology
      Nan-ching, Jiangsu Sheng, China
    • General Hospital of Jinan Military Region
      Chi-nan-shih, Shandong Sheng, China
    • Shanghai Municipal Center for Disease Control and Prevention
      Shanghai, Shanghai Shi, China
    • Northeast Agricultural University
      Charbin, Heilongjiang Sheng, China
    • Beijing Institute Of Technology
      Peping, Beijing, China
    • Carl von Ossietzky Universität Oldenburg
      Oldenburg, Lower Saxony, Germany
    • Fred Hutchinson Cancer Research Center
      • Division of Clinical Research
      Seattle, Washington, United States
  • 2011–2012
    • Guangzhou University of Traditional Chinese Medicine
      Shengcheng, Guangdong, China
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
  • 2010–2012
    • Jinan University (Guangzhou, China)
      • School of Medicine
      Shengcheng, Guangdong, China
  • 2008–2012
    • Queen's University
      • • Division of Rheumatology
      • • Department of Medicine
      Kingston, Ontario, Canada
  • 2007–2012
    • China Pharmaceutical University
      • Department of Phytochemistry
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2006–2012
    • Huazhong University of Science and Technology
      • • Key Laboratory of Organ Transplantation , MOE
      • • Department of Electronic Science and Technology
      Wu-han-shih, Hubei, China
  • 2005–2012
    • Russian Academy of Sciences
      • Zelinsky Institute of Organic Chemistry
      Moscow, Moscow, Russia
  • 2002–2012
    • China Agricultural University
      • • Department of Applied Chemistry
      • • College of Resources and Environmental Sciences
      • • Department of Microbiology and Immunology
      • • College of Biological Sciences
      Beijing, Beijing Shi, China
  • 2006–2011
    • Northeast Institute of Geography and Agroecology
      • • Dalian Institute of Chemical Physics
      • • Key Laboratory of Agro-ecological Processes in Subtropical Region
      • • State Key Laboratory of Organometallic Chemistry
      • • Institute of Computing Technology
      Beijing, Beijing Shi, China
  • 2004–2011
    • Jilin University
      • • College of Physics
      • • State Key Laboratory of Inorganic Synthesis and Preparative
      Jilin, Jilin Sheng, China
  • 2006–2010
    • Tianjin University of Science and Technology
      • Faculty of Food Engineering and Biotechnology
      T’ien-ching-shih, Tianjin Shi, China