Lei Wang

University of Science and Technology of China, Luchow, Anhui Sheng, China

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Publications (865)2414.83 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Left-sided malignant colonic obstruction is one of the most difficult clinical problems; however, no studies compared the two most common used surgical approach laparoscopic and open colorectomy till now. The purpose of this study was to investigate the short- and long-term outcomes of laparoscopy and open colorectomy for left-sided malignant colonic obstruction. A total of 193 colorectal carcinoma patients (55 patients who underwent laparoscopic colorectomy and 138 who underwent open colorectomy) with left-sided colonic obstruction and surgical therapy, between May 2007 and March 2012, are included in the study. The short-term and long-term outcomes including curative resection rate, hospital stay time, complications, 1-, 3- and 5-year survival rates and recurrence rate, as well as recurrence-free survival rate were analyzed retrospectively. No significant difference was found between the laparoscopic and open groups about the short-term outcomes, such as the curative resection rate (81.82 vs. 78.99 %, P = 0.658), hospital stay time (24.22 ± 17.09 vs. 24.19 ± 14.76 day, P = 0.990), the overall and respective complications (32.73 vs. 39.63 %, P = 0.674). Long-term outcomes, including 1-, 3- and 5-year survival rates (P = 0.518), recurrence rates (P = 0.320), and recurrence-free survival rates (P = 0.988), were also indicated no significant differences between the two patient groups. Laparoscopy might not have advantages on left-sided malignant colonic obstruction compared with open colorectal resection in both short-term and long-term outcomes.
    Medical oncology (Northwood, London, England). 10/2014; 31(10):213.
  • ChemInform 09/2014; 45(40).
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    ABSTRACT: The supramolecular reactions of tetrabromoterephthalic acid (H2-TBTA) with a series of N-heterocycles afford eight new complexes, namely, [(H2-BTAH)2·(TBTA)·(H2-TBTA)] (1), [(H2-Bim)2·(TBTA)·(H2-TBTA)·2H2O] (2), [(H-8-HQ)2·(TBTA)·3H2O] (3), [(5-NO2-phen)2·(H2-TBTA)] (4), [(4,6-DHP)2·(H2-TBTA)·2H2O] (5), [(H2-2,4-DMI)2·(TBTA)·(H2-TBTA)2] (6), [(H2-3,5-DMP)2·(TBTA)] (7), and [(H-4-CNpy)2·(TBTA)·(H2-TBTA)] (8) (H-BTAH = 1H-Benzotriazole, H-Bim = 1H-Benzimidazole, 8-HQ = 8-Hydroxyquinoline, 5-NO2-phen = 5-Nitro-1,10-phenanthroline, 4,6-DHP = 4,6-Dihydroxypyrimidine, H-2,4-DMI = 2,4-Dimethylimidazole, H-3,5-DMP = 3,5-Dimethylpyrazole, and 4-CNpy = 4-Cyanopyridine), which have been prepared under mild and identical reaction conditions in a mixture of distilled water and ethanol. All the complexes were fully characterized by single crystal X-ray diffraction analysis, elemental analysis, infrared spectroscopy (IR), and thermogravimetric analysis (TGA). Combining the various N-containing ligands and the diversity of the hydrogen bonds, the eight crystals display amusing structural characteristics. Of this, complex 3 forms three-dimensional (3D) network through the C–H···Br, whilst the O–H···Br consist in the 3D construction of compound 2. Complexes 4-8 generate a 3D supramolecular structure by large amounts of hydrogen bonds. In crystal 1, the π–π stacking interactions play an important part in the 3D network. The thermal stability of crystals 1-8 has been investigated by thermogravimetric analysis (TGA) of mass loss.
    RSC Advances 09/2014; · 3.71 Impact Factor
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    ABSTRACT: Epidermal growth factor receptor (EGFR), which is overexpressed in psoriatic lesions, has been proven to contribute to the hyperproliferation of keratinocytes in psoriasis. Single nucleotide polymorphisms (SNPs) involved in miRNAs that can regulate the expression of EGFR could potentially influence the development of psoriasis. The present study investigated the association between a functional SNP of rs2910164 in miR-146a and the risk of psoriasis in the Chinese Han population. A total of 521 Han Chinese patients with psoriasis and 582 healthy controls were recruited in this study. The miR-146a rs2910164 SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Overall, a significantly increased risk of psoriasis was associated with the rs2910164 miR-146a CG and GG genotypes (adjusted OR, 1.38; 95% CI, 1.06-1.80). Furthermore, the rs2910164G allele in miR-146a attenuated its inhibitory regulation on the expression of EGFR as well as the proliferation of human keratinocytes, and lowered the level of miR-146a in the psoriatic lesions. These findings indicate that the rs2910164G allele in miR-146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR, which may account for the increased risk of psoriasis in this study population.
    Journal of Cellular and Molecular Medicine 09/2014; · 4.75 Impact Factor
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    ABSTRACT: Although conscientiousness was commonly viewed as a type of personal resource to help individuals reduce strain or mitigate the impacts of stressors, empirical research demonstrated mixed results. Based on the personal resource allocation perspective, we posited that rather than functioning as personal resource per se, conscientiousness may act as a key factor influencing how individuals allocate their personal resources. The current study examined the moderating roles of conscientiousness in the relationships that work stressors (i.e., challenge stressors and hindrance stressors) have with employee psychological strain and job performance by using multi-source, time-lagged data collected from 250 employees working at two companies. The results showed that both challenge stressors and hindrance stressors were positively related to psychological strain. Conscientiousness moderated the relationships between both stressors and psychological strain, such that the positive relationships were stronger for individuals with high conscientiousness. Conscientiousness also moderated the relationship between challenge stressors and performance, such that the relationship was positive for individuals with high conscientiousness but negative for those with low conscientiousness. Altogether, the findings suggest that conscientiousness acts as a double-edged sword that both promotes performance and exacerbates the stress reaction of employees when they are confronted with stressful situations. Copyright © 2014 John Wiley & Sons, Ltd.
    Journal of Organizational Behavior 09/2014; · 3.85 Impact Factor
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    ABSTRACT: Big data benchmark suites must include a diversity of data and workloads to be useful in fairly evaluating big data systems and architectures. However, using truly comprehensive benchmarks poses great challenges for the architecture community. First, we need to thoroughly understand the behaviors of a variety of workloads. Second, our usual simulation-based research methods become prohibitively expensive for big data. As big data is an emerging field, more and more software stacks are being proposed to facilitate the development of big data applications, which aggravates hese challenges. In this paper, we first use Principle Component Analysis (PCA) to identify the most important characteristics from 45 metrics to characterize big data workloads from BigDataBench, a comprehensive big data benchmark suite. Second, we apply a clustering technique to the principle components obtained from the PCA to investigate the similarity among big data workloads, and we verify the importance of including different software stacks for big data benchmarking. Third, we select seven representative big data workloads by removing redundant ones and release the BigDataBench simulation version, which is publicly available from http://prof.ict.ac.cn/BigDataBench/simulatorversion/.
  • Lin Yu, Min Wang, Lei Wang
    Tetrahedron. 09/2014; 70(35):5391–5397.
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    ABSTRACT: The aim of the present study was to investigate the abnormal calcium re-uptake function of myocardium sarcoplasmic reticulum (SR) in rabbits with heart failure, as well as potential mechanisms. Heart failure model was established in rabbits through aortic insufficiency and constriction of abdominal aorta. The SR Ca(2+) re-uptake function was measured with a calcium imaging device. The activity of myocardium SR calcium adenodine triphosphatase 2a (SERCA2a) was measured by inorganic phosphate. The protein expressions of SERCA2a, CaMKII, PKA, PP1α, phospholamban (PLB), PLB-Ser(16) and PLB-Thr(17) were evaluated by Western blot. The activities of PKA and CaMKII were detected by γ-(32)P substrate incorporation. The results showed that, compared with the sham operation group, the heart failure group exhibited reduced Ca(2+) re-uptake amount (P < 0.01) and the expression and activity of SERCA2a (P < 0.05 or P < 0.01), decreased expression of PLB and its phosphorylation status in sites of Ser(16) and Thr(17) (P < 0.05), increased expressions and activities of PKA and CaMKII (P < 0.05 or P < 0.01), and increased expression of PP1α (P < 0.05). These results suggest that the abnormal Ca(2+) re-uptake function in heart failure is related with reduced expression and activities of SERCA2a, as well as reduced expression of PLB and its phosphorylation status. Both PLB-Ser(16) and -Thr(17) may be involved in the regulation of myocardium SR calcium pump activity in heart failure.
    Sheng li xue bao: [Acta physiologica Sinica] 08/2014; 66(4):483-8.
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    ABSTRACT: Getting the most out of available nutrients is a key challenge that all organisms face. Little is known about how they optimize and balance the simultaneous utilization of multiple elemental resources. We investigated the effects of long-term phosphate limitation on carbon metabolism of the model organism Escherichia coli using chemostat cultures. We profiled metabolic changes in the growth medium over time and found evidence for an increase in fermentative metabolism despite the aerobic conditions. Using full-genome sequencing and competition experiments, we found that fitness under phosphate-limiting conditions was reproducibly increased by a mutation preventing flux through succinate in the tricarboxylic acid cycle. In contrast, these mutations reduced competitive ability under carbon limitation, and thus reveal a conflicting metabolic benefit in the role of the TCA cycle in environments limited by inorganic phosphate and glucose.
    Molecular BioSystems 08/2014; · 3.35 Impact Factor
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    ABSTRACT: Spermiogenesis is a complex process of terminal differentiation that is necessary to produce mature sperm. Using protein expression profiles of mouse and human testes generated from our previous studies, we chose to examine the actions of lamin A/C in the current investigation. Lamin A and lamin C are isoforms of the A-type lamins that are encoded by the Lmna gene. Our results showed that lamin A/C was expressed in the mouse testis throughout different stages of spermatogenesis and in mature sperm. Lamin A/C was also expressed in mouse haploid germ cells and was found to be localized to the acroplaxome from round spermatids to mature spermatozoa. The decreased expression of lamin A/C following injections of siRNA against Lmna caused a significant increase in caudal sperm head abnormalities when compared to negative controls. These abnormalities were characterized by increased fragmentation of the acrosome and abnormal vesicles, which failed to fuse to the developing acrosome. This fragmentation also caused significant alterations in nuclear elongation and acrosome formation. Furthermore, we found that lamin A/C interacted with the microtubule plus-end-tracking protein CLIP-170. These results suggest that lamin A/C is critical for proper structural and functional development of the sperm acrosome and head shape.
    Reproduction (Cambridge, England). 08/2014;
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    ABSTRACT: Three new mixed-ligand metal–organic coordination networks based on tetrabromoterephthalic acid and different bis-imidazole or bis-triazole ligands, [Zn2(bmib)(tbtpa)2·2H2O]n (1), [Cd(ditb)(tbtpa)(H2O)2·2H2O]n (2), and [Zn(ditp)(tbtpa)]n (3) (bmib = 1,4-bis(2-methyl-1H-imidazol-1-yl)butane, ditb = 1,4-di(1H-1,2,4-triazol-1-yl)butane, ditp = 1,3-di(1H-1,2,4-triazol-1-yl)propane, H2tbtpa = tetrabromoterephthalic acid), have been synthesized under solvothermal conditions and structurally characterized by single-crystal X-ray diffraction analyses, infrared spectroscopy (IR), elemental analyses, powder X-ray diffraction (PXRD) and thermogravimetric analyses (TGA). Single-crystal X-ray diffraction analysis reveals that 1 features a 4-fold class IIIa interpenetrated dia framework strengthened by BrBr halogen bonds. Complex 2 possesses an infinite 2D layer structure with a 44-sql topology, and the 2D sheets were further packed into the 3D supramolecular framework in an –ABAB– fashion which is reinforced by hydrogen bonds and BrBr halogen bonds. Complex 3 is a 2D 63-hcb network incorporating [Zn2(tbtpa)2] cyclic subunits, and the 2D layers were further extended to a 3D supramolecular framework incorporating ππ interactions and BrBr and BrO halogen bonds. In 1–3, all flexible N-donor ligands and dicarboxylates are 2-connected linkers, but networks with diverse topologies are formed, which indicates the coordination preferential geometries of the central metal ion and that the coordination conformations and modes of the ligands have important influences on the resultant structures. Furthermore, there is no solid-state photoluminescence observed for 1–3 at 298 K, and only 2 and 3 are emissive when cooled to liquid nitrogen temperature. The nanosecond range of lifetimes of 2 and 3 in the solid state at 77 K reveals that their emission is fluorescent in nature.
    CrystEngComm 08/2014; · 3.88 Impact Factor
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    ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs that, by targeting certain messenger RNAs (mRNAs) for translational repression or cleavage, can regulate the expression of these genes. In addition, miRNAs may also function as oncogenes and tumor-suppressor genes, as the abnormal expression of miRNAs is associated with various human tumors. However, the effects of the expression of miR-124 in breast cancer remain unclear. The present study was conducted to study the expression of miR-124 in breast cancer, paying particular attention to miR-124's relation to the proliferation, invasion, and apoptosis in breast cancer cell MCF-7 and MDA-MB-231. Real-time quantitative RT-PCR (qRT-PCR) was performed to identify miR-124 that was down-regulated in breast cancer tissues. We also showed E26 transformation specific-1 (Ets-1) and miR-124 expression levels in breast cancer tissues that were associated with lymph node metastases. With transfected synthetic miR-124 agomir into MCF-7 and MDA-MB-231, a significant reduction (P < 0.05) in MCF-7 and MDA-MB-231 cell proliferation and colony forming potential was observed after treatment with miR-124. Apoptosis and migration rates were found to be significantly higher in two breast-derived cell lines transfected with a miR-124 agomir (P < 0.05). Luciferase reporter assay and Western blot were used to verify Ets-1 as a potential major target gene of miR-124, and the result showed that miR-124 can bind to putative binding sites within the Ets-1 mRNA 3' untranslated region (UTR) to reduce its expression. Based on these findings, we propose that miR-124 and Ets-1 may serve as a therapeutic agent in breast cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 08/2014;
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    ABSTRACT: This trail was conducted to study the effect of L-proline on the growth performance, and blood parameter in the weaned lipopolysaccharide (LPS)-challenged pigs. Thirty six pigs (9.13±0.85 kg) were assigned randomly to dietary treatments in a 2×3 factorial arrangement in a 20-d growth assay. Factors were intraperitoneal injection with saline or LPS, and three dietary L-proline supplement levels (0%, 0.5%, or 1.0%). On d 10, blood samples were collected at 3 h after LPS (100 μg LPS/kg body weight [BW]) or saline injection. On d 20 of the trial, all pigs were orally administrated D-xylose (0.1 g/kg BW) at 2 h, and blood samples were collected at 3 h after LPS or saline injection. As a result, dietary supplementation with 0.5% proline had a tendency to increase average daily gain (ADG) in piglets during d 10 to 20 (p = 0.088). Without LPS challenge, dietary supplementation with 1.0% proline had no effect on growth hormone (GH) concentrations on d 10 (p>0.05), but decreased it after LPS challenge (p<0.05). There was LPS challenge×proline interaction for GH concentrations on d 10 (p<0.05). Dietary supplementation with 1.0% proline decreased glucagon concentration on d 10 after LPS challenge (p<0.05). In addition, dietary supplementation with proline increased superoxide dismutase (SOD) activity significantly on d 10 and 20 (p<0.05), and 1.0% proline increased heat shock proteins-70 concentration on d 10 (p<0.05). Moreover, proline supplementation increased diamine oxidase (DAO) concentrations after LPS challenge (p<0.05). There was LPS challenge×proline interaction for DAO (p<0.05). Furthermore, dietary supplementation with 1.0% proline increased the D-xylose level when no LPS challenge (p<0.05). These results indicate that proline supplementation could improve growth performance, increase SOD activities, and has a positive effect on the gastrointestinal tract digestibility in early weaned pigs.
    Asian Australasian Journal of Animal Sciences 08/2014; 27(8):1150-6. · 0.64 Impact Factor
  • Lei Wang, Gang Wang, Tianwen Gao
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    ABSTRACT: Onychomatricoma is a rare tumor originating from the nail matrix, and, in rare conditions, from the ventral aspect of the proximal nailfold. Here we report a rare case of a 51-year-old man presenting with melanonychia mainly involving the distal nail plate. Histopathologic examination showed typical findings of onychomatricoma mainly involving the nail bed, while the nail matrix was largely uninvolved. We also identified fungal infection in a focal area of the distal nail plate. Our findings indicate that onychomatricoma can develop in the surrounding epithelial tissue of the nail unit, including the nail bed, and suggest that fungal infection may represent a secondary phenomenon of onychomatricoma.
    Journal of Cutaneous Pathology 07/2014; · 1.77 Impact Factor
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    ABSTRACT: Mature mitochondria with high oxidative phosphorylation undergo fission and fusion and morphogenesis to become immature mitochondria during iPS induction from somatic cells. Dynamin-related protein 1 (Drp1) is involved in mitochondria fission and biogenesis in somatic cells. We tested the role of Drp1 in the induction and maintenance of pluripotency. We show that Drp1 band shift occurs in ES cells and iPS cells induced from fibroblasts, in association with mitochondrial morphogenesis. However, knockdown of Drp1 by shRNA does not abrogate mitochondria morphogenesis and induction of iPS cells from fibroblasts. Also, knockdown of Drp1 affects neither mitochondria fission and function as shown by normal mitochondrial membrane potential, nor proliferation and pluripotency of ES cells. Nonetheless, Drp1 knockdown negatively influences terminal differentiation of ES cells, particularly in the lineage of neurogenesis in vitro and in vivo, coincident with delayed reduction of Oct4 and Nanog during mid-differentiation. Our data suggest that Drp1 is not critical for mitochondria biogenesis in stem cell proliferation but required for neurogenesis likely by down-regulation of pluripotency-associated genes Nanog and Oct4. ES cell differentiation model could be used to model role of Drp1 in neuron development and diseases.
    Stem cells and development. 06/2014;
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    ABSTRACT: A new strategy for accurate and reversible modulation of protein activity via simple conjugation of the sulfhydryl modifier and polymer with the introduced Cys residue in protein was developed in this study. With Escherichia coli inorganic pyrophosphatase (PPase) as a model protein, we used site-directed mutagenesis to generate a mutant PPase (PPC) with a substituted Cys residue at the specific Lys-148 site, which is within a conserved sequence near the active site and exposed to the surface of the PPC for chemical reaction. The site-specific conjugation of the mutated Cys residue in PPC with sulfhydryl modifier p-chloromercuribenzoate (PCMB) and pyridyl disulfide-functionalized poly(2-hydroxyethyl methacrylate) (pHEMA) resulted in obvious decrease or complete loss of the catalytic activity of PPC, due to the conformational change of PPC. Compared with the effect of small molecule modification (PCMB), the pHEMA conjugation led to greater inhibitory effect on protein activity due to the significant change of the tertiary structure of PPC after conjugation. Moreover, the protein activity can be restored to different extents by the treatment with different amount of reductive reagents, which can result in the dissociation between PPC and PCMB or pHEMA to recover the protein conformation. This study provides a new strategy for efficient control of protein activity at different levels by site-specific conjugation of a small molecule and polymer.
    Bioconjugate Chemistry 06/2014; · 4.58 Impact Factor
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    ABSTRACT: Oxygen electrochemistry has been intensely studied in the pursuit of sustainable and efficient energy conversion and storage solutions. Over the years, developing oxygen electrode catalysts with high activity and low cost remains a great challenge despite tremendous efforts. Here, NixCo1-x(OH)2 is used as a bi-functional electrocatalyst for both oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). The effect of its compositions (x = 1, 0.55, 0) and morphologies (including both multi-layer and single-layer NixCo1-x(OH)2) on catalytic activity is studied systematically in order to optimize the oxygen-electrochemical performance of 3d-M (M=Ni and Co) metal hydroxides. Our results show that the compositions of NixCo1-x(OH)2 has a great influence on overpotentials by comparing multi-layer Co(OH)2, Ni0.55Co0.45(OH)2, and Ni(OH)2 for OER. Multi-layer Ni(OH)2 exhibits the lowest overpotential of 324 mV at the current density of 5 mA/cm2. Moreover, the overpotential could be greatly lowered by using single-layer NixCo1-x(OH)2. Single-layer Ni(OH)2 nanosheet manifests 71 mV overpotential decrease (5 mA/cm2) and a factor of 14 turnover frequency increase as compared to multi-layer Co(OH)2 for OER. As for ORR, multi-layer Co(OH)2 shows the best activity among multi-layer NixCo1-x(OH)2. Similar to OER, single-layer NixCo1-x(OH)2 demonstrates enhanced ORR activity over multi-layer NixCo1-x(OH)2. Single-layer Co(OH)2 exhibits the best catalytic activity and 3.7 electrons are transferred during oxygen reduction process. The successful identification of the composition and morphology effect of 3d-metal hydroxides on electrocatalytic performance provides the foundation for rational design of active sites for high-performance catalyst for both OER and ORR.
    ACS Applied Materials & Interfaces 06/2014; · 5.01 Impact Factor
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    ABSTRACT: A novel and efficient n-Bu4NI/TBHP-catalyzed direct amination of allylic and benzylic C(sp(3))-H with anilines to form N-substituted anilines under metal-free conditions has been developed.
    Chemical communications (Cambridge, England). 06/2014;
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    ABSTRACT: We demonstrate that surface-emitting second-harmonic generation is an effective technique for evaluating domains of periodically-poled lithium niobate waveguide: domain period, linear taper, and poling depth. Such a method reaches nanoscale spatial resolution of 0.5 nm.
    CLEO: QELS_Fundamental Science; 06/2014
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    ABSTRACT: We have observed enhancements of forward and backward anti-Stokes Raman signals generated in lithium niobate waveguides by one order of magnitude. Forward and backward exhibit different spectral features, unique for two configurations.
    CLEO: Applications and Technology; 06/2014

Publication Stats

5k Citations
2,414.83 Total Impact Points


  • 2014
    • University of Science and Technology of China
      • School of Life Sciences
      Luchow, Anhui Sheng, China
    • Universität Heidelberg
      • V. Medicine Clinic
      Heidelburg, Baden-Württemberg, Germany
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
  • 2013–2014
    • Hebei Medical University
      Chentow, Hebei, China
    • Chinese Academy of Tropical Agricultural Sciences
      Hoihau, Hainan, China
    • Beijing Centers for Disease Control and Prevention
      Peping, Beijing, China
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
    • China-Japan Friendship Hospital
      Peping, Beijing, China
    • Zhengzhou Tobacco Institute
      Chen-chu-shan, Jiangxi Sheng, China
    • Northwest University
      Ch’ang-an, Shaanxi, China
    • Shenzhen Second People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • Liaoning Universtity of Traditional Chinese Medicine
      Feng-t’ien, Liaoning, China
    • Anhui Agricultural University (AHAU)
      Luchow, Anhui Sheng, China
    • Zhengzhou University
      Cheng, Henan Sheng, China
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • Southern Medical University
      Shengcheng, Guangdong, China
  • 2011–2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
    • Beijing University of Chemical Technology
      • College of Materials Science and Engineering (SMSE)
      Peping, Beijing, China
    • Soochow University (PRC)
      • • Department of Polymer Science and Engineering
      • • Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application
      • • Department of Materials Science and Engineering
      Wu-hsien, Jiangsu Sheng, China
    • Yangzhou University
      Chiang-tu, Jiangsu Sheng, China
    • Harbin Engineering University
      • College of Science
      Harbin, Heilongjiang Sheng, China
    • University of New South Wales
      • School of Biotechnology and Biomolecular Sciences (BABS)
      Kensington, New South Wales, Australia
    • University Town of Shenzhen
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Shenyang Ligong University
      Feng-t’ien, Liaoning, China
    • Anhui Medical University
      Luchow, Anhui Sheng, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
    • Beijing Tiantan Hospital
      Peping, Beijing, China
    • National Institute for the Control of Pharmaceutical and Biological Products
      Peping, Beijing, China
  • 2010–2014
    • Shanghai Jiao Tong University
      • • Bio-X Institute
      • • School of Agriculture and Biology
      Shanghai, Shanghai Shi, China
    • Zhejiang University
      • Institute for Thermal Power Engineering
      Hangzhou, Zhejiang Sheng, China
    • Jiangsu Academy of Agricultural Sciences
      Nan-ching-hsü, Jiangxi Sheng, China
    • Cold Spring Harbor Laboratory
      Cold Spring Harbor, New York, United States
  • 2008–2014
    • Qingdao University of Science and Technology
      Tsingtao, Shandong Sheng, China
    • GNS Science
      Lower Hutt City, Wellington, New Zealand
    • Imperial College London
      Londinium, England, United Kingdom
    • Hawaii Agriculture Research Center
      Honolulu, Hawaii, United States
    • University of Hawai'i System
      Honolulu, Hawaii, United States
    • University of Hawaiʻi at Hilo
      • Department of Natural Science
      Hilo, HI, United States
  • 2007–2014
    • Queen's University Belfast
      • School of Pharmacy
      Béal Feirste, N Ireland, United Kingdom
    • Chinese Academy of Sciences
      • • Institute of Process Engineering
      • • Key Laboratory of Organic Solids
      Peping, Beijing, China
  • 2006–2014
    • Sun Yat-Sen University
      • Proteomics Lab
      Shengcheng, Guangdong, China
  • 2005–2014
    • Tsinghua University
      • • Department of Basic Medical Sciences
      • • Department of Biomedical Engineering
      • • School of Environment
      Peping, Beijing, China
    • Fourth Military Medical University
      • • Department of Dermatology
      • • Department of Biochemistry and Molecular Biology
      Xi’an, Liaoning, China
    • Nanjing Medical University
      • Key Laboratory of Reproductive Medicine
      Nan-ching, Jiangsu Sheng, China
    • National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
      Peping, Beijing, China
    • Robert Koch Institut
      • ZBS 3: Microbial Toxins
      Berlín, Berlin, Germany
    • Freie Universität Berlin
      Berlín, Berlin, Germany
  • 2004–2014
    • Huaibei Normal University
      Hua-pei-ts’un, Shanxi Sheng, China
    • Nankai University
      • • Department of Genetics and Cell Biology
      • • TEDA School of Biological Science and Biotechnology
      • • College of Life Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • Shandong University
      • • School of Pharmaceutical Sciences
      • • Department of Chemical Engineering
      • • State Key Laboratory for Crystal Materials
      Chi-nan-shih, Shandong Sheng, China
  • 2011–2013
    • Jiangnan University
      • School of Food Science and Technology
      Wuxi, Jiangsu Sheng, China
  • 2010–2013
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China
    • Wuhan Polytechnic University
      Wu-han-shih, Hubei, China
  • 2009–2013
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
    • Capital Medical University
      • Department of Otorhinolaryngology Head and Neck Surgery
      Peping, Beijing, China
    • Tongji University
      • Department of Material Science and Engineering
      Shanghai, Shanghai Shi, China
  • 2008–2013
    • Heilongjiang University
      • School of Chemistry and Materials Science
      Charbin, Heilongjiang Sheng, China
  • 2007–2013
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 1999–2013
    • Sun Yat-Sen University of Medical Sciences
      Shengcheng, Guangdong, China
    • University of Melbourne
      • Department of Microbiology and Immunology
      Melbourne, Victoria, Australia
  • 1998–2013
    • University of Sydney
      • School of Molecular Bioscience
      Sydney, New South Wales, Australia
  • 2012
    • Nanjing University of Information Science & Technology
      Nan-ching, Jiangsu Sheng, China
    • Dalian University of Technology
      Lü-ta-shih, Liaoning, China
    • Northeast Agricultural University
      Charbin, Heilongjiang Sheng, China
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
    • Shanghai Municipal Center for Disease Control and Prevention
      Shanghai, Shanghai Shi, China
    • Beijing Institute Of Technology
      Peping, Beijing, China
    • Fred Hutchinson Cancer Research Center
      • Division of Clinical Research
      Seattle, Washington, United States
    • Carl von Ossietzky Universität Oldenburg
      Oldenburg, Lower Saxony, Germany
    • General Hospital of Jinan Military Region
      Chi-nan-shih, Shandong Sheng, China
  • 2011–2012
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
    • Guangzhou University of Traditional Chinese Medicine
      Shengcheng, Guangdong, China
  • 2010–2012
    • Jinan University (Guangzhou, China)
      • School of Medicine
      Shengcheng, Guangdong, China
  • 2008–2012
    • Queen's University
      • • Division of Rheumatology
      • • Department of Medicine
      Kingston, Ontario, Canada
  • 2007–2012
    • China Pharmaceutical University
      • Department of Phytochemistry
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2006–2012
    • Huazhong University of Science and Technology
      • • Key Laboratory of Organ Transplantation , MOE
      • • Department of Electronic Science and Technology
      Wu-han-shih, Hubei, China
  • 2005–2012
    • Russian Academy of Sciences
      • Zelinsky Institute of Organic Chemistry
      Moscow, Moscow, Russia
  • 2002–2012
    • China Agricultural University
      • • Department of Applied Chemistry
      • • College of Resources and Environmental Sciences
      • • Department of Microbiology and Immunology
      • • College of Biological Sciences
      Beijing, Beijing Shi, China
  • 2006–2011
    • Northeast Institute of Geography and Agroecology
      • • Dalian Institute of Chemical Physics
      • • Key Laboratory of Agro-ecological Processes in Subtropical Region
      • • State Key Laboratory of Organometallic Chemistry
      • • Institute of Computing Technology
      Beijing, Beijing Shi, China
  • 2004–2011
    • Jilin University
      • • College of Physics
      • • State Key Laboratory of Inorganic Synthesis and Preparative
      Jilin, Jilin Sheng, China
  • 2009–2010
    • Lanzhou University
      • State Key Laboratory of Applied and Organic Chemistry
      Lanzhou, Gansu Sheng, China
  • 2006–2010
    • Tianjin University of Science and Technology
      • Faculty of Food Engineering and Biotechnology
      T’ien-ching-shih, Tianjin Shi, China