Li Wang

Institute of Chemistry and Materials, Lutetia Parisorum, Île-de-France, France

Are you Li Wang?

Claim your profile

Publications (867)2431.41 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Flag leaf is the most essential organ for photosynthesis in rice and its size plays an important role in rice breeding for ideal plant-type. Flag leaf size affect photosynthesis to a certain extent, thereby influencing rice production. Several genes controlling leaf size and shape have been identified with mutants. Although a number of quantitative trait loci (QTLs) for leaf size and shape have been detected on 12 chromosomes with different populations of rice, few of them were cloned. The pair-wise correlation analysis was conducted on length, width and length-width ratio of the flag leaf, and yield per plant in the core recombinant inbred lines of Liang-You-Pei-Jiu (LYP9) developed in Hainan and Hangzhou. There were significant correlations among the three flag leaf size and shape traits. Interestingly, a positive correlation was found between flag leaf width and yield per plant. Based on the high-resolution linkage map we constructed before, 43 QTLs were detected for three flag leaf size and shape traits and yield per plant, among which 31 QTLs were unreported so far. Seven QTLs were identified common in two environments. And qFLW7.2, a new major QTL for flag leaf width, was fine mapped within 27.1 kb region on chromosome 7. Both qFLW7.2 and qPY7 were located in the interval of 45.30 ~ 53.34 cM on chromosome 7, which coincided with the relationship between yield per plant (PY) and flag leaf width (FLW). qFLW7.2, which explained 14% of the phenotypic variation, increased flag leaf width with 93-11 allele. Two candidate genes were selected based on sequence variation and expression difference between two parents, which facilitated further QTL cloning and molecular breeding in super rice.
    Rice 12/2015; 8(1). DOI:10.1186/s12284-014-0039-9 · 2.45 Impact Factor
  • Kun He, Hongliang Zhu, Li Wang
    [Show abstract] [Hide abstract]
    ABSTRACT: Inspired by energy storage systems for peak load shifting (PLS), this study proposes a PLS utilization mode of electricity-generating coal gas resources for the steel industry in China. The proposed mode can help the steel industry save electricity bills (2.4%) through the introduction of a time-of-use tariff. Data of a steel enterprise are used to prove the economic benefit of the coal gas utilization mode. Given that China produces more than half of converter steel of the total production worldwide, their coal gas resources are abundant. The PLS utilization mode will have a great effect on balancing the power grid. A simulated operation model for PLS coal-fired power units is used to calculate the energy conservation and emission reduction effect of coal-fired power plants under different scenarios. The annual coal savings are 1.7–3.1%, and the annual SO2 and NOX emission reductions are 2.9–12.4% and 44.6–14.1% of the total reduction amount of the steel industry in China, respectively.
    Applied Energy 09/2015; 154:644-650. DOI:10.1016/j.apenergy.2015.05.022 · 5.26 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We investigated whether the MDR1 (multidrug resistance 1) gene single nucleotide polymorphism (SNP) and haplotype variants were associated with the susceptibility to diffuse large B-cell lymphoma (DLBCL). A total of 129 DLBCL patients and 208 healthy controls from Jiangsu Han population were enrolled in this study. They were genotyped by polymerase chain reaction-allele specific primers (PCR-ASP) method or DNA direct sequencing at three common loci: C1236T, G2677T/A and C3435T. At locus G2677T/A, allele G and genotype GT were significantly more common in DLBCL (G: OR = 1.48, 95% CI: 1.08–2.02, Pc = 0.03; GT: OR = 1.96, 95% CI: 1.25–3.07, Pc < 0.01), while genotype AT in this locus seemed to be protective (OR = 0.29, 95% CI: 0.02–0.72, Pc = 0.03). TT genotype at locus C3435T showed a risk factor in DLBCL (OR = 2.38, 95% CI: 1.52–3.74, Pc < 0.01). The frequency of T-G-T haplotype was significantly increased in DLBCL group (OR = 5.21, 95% CI: 2.58–10.54, Pc < 0.01); haplotype of G-T in 2677–3435 and diplotype of 2677GT/3435TT were significantly more frequent in DLBCL group (G-T: OR = 3.97, 95% CI: 2.31–6.85, Pc < 0.01; 2677GT/3435TT: OR = 4.55, 95% CI: 2.02–10.22, Pc < 0.01). Our findings demonstrate that G, GT at locus G2677T/A, and TT at locus C3435T might contribute to the susceptibility to DLBCL, as well as haplotype of T-G-T, G-T in 2677–3435 and diplotype of 2677GT/3435TT, while AT at locus G2677T/A might be a protective genotype. These findings could provide evidence that the MDR1 SNPs may modify the susceptibility to DLBCL and shade new lights in disease association studies.
    Biomedecine [?] Pharmacotherapy 07/2015; 73:24-28. DOI:10.1016/j.biopha.2015.05.005 · 2.11 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To characterize the clinical features of IgG4-related disease (IgG4-RD) in China. A prospective cohort study of IgG4-RD was carried out in Peking Union Medical College Hospital between 2011 and 2013. Patients with newly diagnosed IgG4-RD were enrolled. A total of 118 patients with IgG4-RD were enrolled, including 82 males and 36 females, aged 53.1 (s.d. 13.6) years. The most common symptom at onset was lacrimal gland swelling (38/32.2%). A range of organs were involved: 77 patients (65.3%) had lymphadenopathy, 76 (64.4%) had sialadenitis, 60 (50.8%) had dacryoadenitis, 45 (38.1%) had autoimmune pancreatitis, 32 (27.1%) had pulmonary involvement, 31 (26.3%) had periaortitis/retroperitoneal fibrosis, 29 (35.4% of male patients) had prostatitis and 29 (24.6%) had renal involvement. In addition, there were 21 (17.8%) cases of sclerosing cholangitis, 15 (12.7%) of sinusitis and 10 (8.5%) of inflammatory pseudotumour. Uncommon manifestations included mediastinal fibrosis, skin involvement, sclerosing thyroiditis, hypophysitis, orchitis and colitis. Multiple organ involvement was observed in 93 patients, whereas only 4.2% had only a single organ involved. A history of allergy was reported in 73 (61.9%) patients. The serum IgG4 level was elevated in 97.5% and was correlated with the number of organs involved. Most patients were treated with glucocorticoids alone or in combination with immunosuppressive drugs, and the majority usually improved within 3 months. IgG4-RD is a systemic inflammatory and sclerosing disease. Parotid and lacrimal involvement (formerly called Mikulicz's disease), lymphadenopathy and pancreatitis are the most common manifestations. Patients with IgG4-RD showed favourable responses to treatment with glucocorticoids and immunosuppressive agents. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email:
    Rheumatology (Oxford, England) 06/2015; DOI:10.1093/rheumatology/kev203 · 4.44 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A hydrothermal process of zinc oxide (ZnO), which was suitable for both planar surfaces and non-planar surfaces, was proposed to obtain nanopillars in this work. The effects of process parameters including the growth time and solution concentration on the morphological properties of ZnO nanorods were investigated by experiments. After process optimization, the ZnO arrays were well patterned in large area with vertically aligned orientation. This developed process of ZnO was then introduced to combine with other techniques to obtain various hierarchical structures on different substrates. Furthermore, the superhydrophobicity and self-cleaning effect were respectively verified on the plexiglass tube with ZnO nanopillars and the tin–bronze surface with hierarchical architectures.
    Microelectronic Engineering 06/2015; 141. DOI:10.1016/j.mee.2015.01.015 · 1.34 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel glucose biosensor was developed by immobilizing glucose oxidase (GOD) on a three-dimensional (3D) porous kenaf stem-derived carbon (3D-KSC) which was firstly proposed as novel supporting materials to load biomolecules for electrochemical biosensing. Here, an integrated 3D-KSC electrode was prepared by using a whole piece of 3D-KSC to load the GOD molecules for glucose biosensing. The morphologies of integrated 3D-KSC and 3D-KSC/GOD electrode were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The SEM results revealed 3D honeycomb macroporous structure of integrated 3D-KSC electrode. The TEM results showed some microporosities and defects in the 3D-KSC electrode. The electrochemical behaviors and electrocatalytic performance of integrated 3D-KSC/GOD electrode were evaluated by cyclic voltammetry and electrochemical impedance spectroscopy. The effects of pH and scan rate on the electrochemical response of biosensor have been studied in detail. The glucose biosensor showed a wide linear range from 0.1 mM to 14.0 mM with a high sensitivity of 1.73 μA mM-1 and a low detection limit of 50.75 μM. Furthermore, the glucose biosensor exhibited high selectivity, good repeatability and reproducibility, and nice stability.
    The Analyst 06/2015; DOI:10.1039/C5AN00200A · 3.91 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In clinical practical work, a rare kind of chronic pancreatic inflammatory granuloma which is caused by the foreign body of gastrointestinal perforation could be misdiagnosed and treated as pancreatic neoplasm sometimes, and even brings irreparable harm to patients. Here, we depict a male presenting recurrent upper abdominal pain and gradual weight loss, besides, the computer tomography suggested pancreatic tumor strongly. Fortunately, it has been proved to be a chronic pancreatic inflammatory granuloma caused by fish bone through laparotomy finally. To our knowledge, this case is the first case about the chronic pancreatic inflammatory granuloma caused by foreign body which successfully avoids unnecessary pancreatectomy. Copyright © 2015. Published by Elsevier B.V.
    Pancreatology 06/2015; DOI:10.1016/j.pan.2015.05.474 · 2.50 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study was to explore the characteristics of anemia in Castleman disease (CD). Clinical data were collected retrospectively to analyze the prevalence and characteristics of CD with anemia were analysed retrospectively, and different types of anemia and their therapeutic effects were evaluated. Anemia was observed in 13/33(39%) newly diagnosed CD patients, most of them was mild and normocytic. Incidence of anemia in multicentric CD (MCD) was higher than that in unicentric CD (UCD) (85% vs 10%, P < 0.001). Most of CD patients with anemia presented systematic manifestations; moreover, they had higher levels of erythrocyte sedimentation and inflammatory indices, higher incidence of polyclonal hyperimmunoglobulinemia, and higher positive rate of autoantibodies than those without anemia (P < 0.05). Except for 2 cases of autoimmune hemolytic anemia (AIHA) and 1 case of anemia secondary to hypersplenism, the anemia in the other 10 patients exhibited features similar to anemia of chronic disease (ACD), whose hemoglobin levels were negatively correlated with the serum levels of C reactive protein and fibrinogen (r -0.917 and -0.717, respectively, P < 0.001). Anemia in UCD was cured by the removal of tumor. Yet, anemia in MCD was improved after systemic treatment with immunotherapy and/or chemotherapy. anemia with an inflammatory and immunologic mechanism presents as a common symptom in MCD, but also can be observed in UCD. In addition to occasional AIHA, anemia associated with CD mainly presents characteristics of ACD. Treatment for anemia in CD is mainly based on the control of primary disease.
    Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology 06/2015; 23(3):696-701.
  • PLoS ONE 05/2015; 10(5):e0128763. DOI:10.1371/journal.pone.0128763 · 3.53 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The role of 18F-2-fluoro-2-deoxy-D-glucose (FDG) uptake of bone marrow (BM) on positron emission tomography/computed tomography (PET/CT) in patients with lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH) remains uncertain. In this retrospective study, we included 34 LA-HLH patients underwent both PET/CT and comprehensive BM examinations prior to treatment. Comparison between PET/CT and BM examinations for the assessment of bone marrow involvement (BMI) indicated statistical difference (P=0.039). The specificity of PET/CT in detecting BMI was 11.1% compared to BM examinations. However, we found a significant correlation between PET parameters of BM and laboratory parameters associated with HLH, such as C-reactive protein, ferritin, fibrinogen and soluble CD25. By multivariate analysis, PET parameters of marrow were significantly associated with overall survival. Our findings suggest that FDG uptake of marrow might fail to detect lymphomatous BMI, but reflected the level of cytokines storm to a certain extent and might be as prognostic factor in patients with LA-HLH.
    Leukemia & lymphoma 05/2015; DOI:10.3109/10428194.2015.1048442 · 2.61 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Bulk hierarchical nanoporous palladium (BHNPP) materials composing both bimodal porous structure and monolithic porous structure were fabricated by chemical dealloying of Pd20Al80 alloy with sub-micrometer grain size via mechanical alloying and spark plasma sintering process (MA-SPS). The different nanoporous structures were formed in the regions where the microstructure was heterogeneous. Monolithic porous structure were formed after dealloyed of monolithic grain structure mainly composed of PdAl3 phase, and bimodal porous structure with both larger pore of hundreds nanometers and smaller pore of a few nanometers were obtained after dealloyed of nanocrystalline structure consist of PdAl3 and Al phases, respectively. Effects of dealloying time, concentration of dealloying solutions and chloride ion (Cl−) on the evolution of the microstructure of BHNPP were also studied. Ligament of BHNPP can be facility coarsen by add chloride rather than only raise the concentration of HCl solution. Moreover, the cyclic voltammetry results reveal that the BHNPP materials have superior ethanol oxidation ability.
    Microporous and Mesoporous Materials 05/2015; 208. DOI:10.1016/j.micromeso.2015.01.017 · 3.21 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Two-dimensional materials such as MoS2 have attracted much attention in recent years due to their fascinating optoelectronic properties. Dielectric property of MoS2 is desired for the optoelectronic application. In this paper, terahertz (THz) time-domain spectroscopy and ellipsometry technology are employed to investigate the dielectric response of MoS2 crystal in THz and visible region. The real and imaginary parts of the complex dielectric constant of MoS2 crystal are found to follow a Drude model in THz region, which is due to the intrinsic carrier absorption. In visible region, the general trend of the complex dielectric constant is found to be described with a Lorentz model, while two remarkable peaks are observed at 1.85 and 2.03 eV, which have been attributed to the splitting arising from the combined effect of interlayer coupling and spin-orbit coupling. This work affords the fundamental dielectric data for the future optoelectronic applications with MoS2.
  • [Show abstract] [Hide abstract]
    ABSTRACT: ChgA has recently been identified as the autoantigen for diabetogenic CD4(+) T cells in NOD mice and T1D patients. However, autoreactive CD8(+) T-cell responses targeting ChgA haven't been studied yet. Here several HLA-A*0201-restricted peptides derived from mChgA and hChgA were selected by an integrated computational prediction approach, followed by an HLA-A*0201 binding assay. MChgA10-19 and mChgA43-52 peptides, which bound well with HLA-A*0201 molecule, induced significant proliferation and IFN-γ-releasing of splenocytes from diabetic NOD.β2m(null).HHD mice. Notably, flowcytometry analysis found mChgA10-19 and mChgA43-52 stimulated the production of IFN-γ, perforin, and IL-17 by splenic CD8(+) T cells of diabetic NOD.β2m(null.)HHD mice. Furthermore, hChgA10-19 and hChgA43-52-induced IFN-γ releasing by specific CD8(+) T cells were frequently detected in recent-onset HLA-A*0201-positive T1D patients. Thus, this study demonstrated autoreactive CD8(+) T cells targeting ChgA were present in NOD.β2m(null).HHD mice and T1D patients, and might contribute to pathogenesis of T1D through secreting proinflammatory cytokines and cytotoxic molecules. Copyright © 2015. Published by Elsevier Inc.
    Clinical Immunology 05/2015; 159(1). DOI:10.1016/j.clim.2015.04.017 · 3.99 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In the present study, porous hollow palladium particles with uniform size distribution have been successfully prepared by templating method with silica sphere as template materials. Experimental results show that hydrazine hydrate is a preferable reducing regent to prepare pure palladium layer by electroless plating rather than sodium hypophosphite. Silica sphere templates can be easily removed after eroded in alkali solutions, and then palladium particle with hollow structure and a specific surface area of ∼10.26 m2/g can be prepared. Furthermore, electrochemical properties of the porous hollow palladium were also investigated and the results reveal that it has superior ethanol oxidation ability.
    Journal of Alloys and Compounds 05/2015; 632. DOI:10.1016/j.jallcom.2015.01.065 · 2.73 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The pathophysiological role of influenza infection is poorly understood. In this study, one non-neurovirulent virus (IAV/Aichi/2/68/H3N2) strain was used to infect intra-nasally mice at different age to investigate the mechanism of cerebral edema formation and lower activities of mitochondria enzymes after influenza A virus (IAV) infection. Mice suffered 46.4% mortality in newborn compared with 96.0% in weanling, 100% in adult on day 7, respectively. IAV-RNA was easily detected in the brain of newborn mice. Significant production of endothelin-1 and inducible nitric oxide syntheses were increased on the 3rd and 5th day after IAV infection, associated with increasing blood-brain barrier permeability, brain edema formation and the higher mortality of animals. Production of tumor necrosis factor-α was related to inhibition of mitochondrial enzyme activities, suggesting that over expression of inflammatory cytokines and lower enzyme activities in mitochondria after IAV infection.
    Pakistan journal of pharmaceutical sciences 05/2015; 28(3 Suppl):1109-14. · 0.95 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Capsaicin is an active component of chili peppers, having diverse effects. However, the effects of capsaicin on intestinal motility are still controversial. The present study aimed to investigate the effects of capsaicin on intestinal motility disorder and uncover related mechanisms. A rat model with intestinal motility disorder was established in vitro through adding different stimuli into tissue bath; in vivo using constipation and diarrhea model respectively. Capsaicin exerted dual effects on intestinal motility, i.e., the relaxation and contraction of jejunum induced by corresponding stimulus were respectively regulated to be normal contraction by capsaicin. The mechanisms underlined capsaicin induced dual effects were investigated using Western blotting, qRT-PCR, and whole cell patch clamp respectively. Results showed that cholinergic excitatory nerves, adrenergic nerves, and neurons containing nitric oxide synthase which are the main muscle motor neurons in enteric nervous system (ENS) are involved in capsaicin-induced dual effects. The competition for regulation of Ca(2+) influx by capsaicin induced the interaction with components of the ENS. Capsaicin significantly increased MLCK expression and myosin phosphorylation extent in jejunal segments of constipation-prominent rats and significantly decreased MLCK expression and myosin phosphorylation extent in jejunal segments of diarrhea-prominent rats. In summary, capsaicin alleviates abnormal intestinal motility through regulating enteric motor neurons and MLCK activity, which is beneficial for the treatment of gastrointestinal motility disorders. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Molecular Nutrition & Food Research 05/2015; DOI:10.1002/mnfr.201500039 · 4.91 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the clinical features of patients with microscopic polyangiitis (MPA) and alveolar hemorrhage (AH), so as to raise the physicians' understanding of this condition. The clinical data of 15 MPA patients combined with AH, who were hospitalized in Peking Union Medical College Hospital from January 2008 to January 2014, were retrospectively analyzed. These 15 subjects accounted for 18.1% of all MPA patients, including 4 males and 11 females with mean age of (59.4±17.9) years old and mean disease duration of 7.5 (1-48) months. Hemoptysis or bloody sputum (14/15) and dyspnea (11/15) were predominant pulmonary manifestations. Hypoxemia appeared in 6 patients (40.0%). An average 8-46 (22.7±4.4) g/L drop of hemoglobin level was seen in all 15 patients. Imaging revealed new bilateral infiltrations or opacities in 13 cases, and bloody bronchoalveolar lavage fluid were found in 6 cases. Compared with MPA patients without AH, the incidence of myalgia [2/15 vs 50.0%(34/68); P=0.009, OR=0.154] and hemoglobin level [(83.2±21.0) g/L vs (102.5±18.7) g/L; P=0.001] were statistically lower in MPA patients with AH. There were no statistical differences in age, sex, interstitial lung disease, renal involvement, peripheral neuropathy and the five factor score between two groups. The proportion of patients who received corticosteroid pulse treatment in MPA with AH group was significantly higher than that of MPA patients without AH [9/15 vs 19.1%(13/68); P=0.003, OR=6.346]. After treatment, 13 cases achieved remission, while 2 died. As an important pulmonary manifestation of MPA, AH could be insidious but fatal. The treatment with steroid, cyclophosphamide and plasma exchange could improve the prognosis.
    Zhonghua nei ke za zhi [Chinese journal of internal medicine] 05/2015; 54(5):416-419.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Here, we investigated the pathogenesis of primary biliary cirrhosis (PBC) by using 2D-DIGE to analyze serological differences between anti-mitochondrial antibody (AMA)-positive and -negative PBC patients. The study comprised 30 patients with PBC; 20 AMA-positive and 10 AMA-negative patients matched for age, sex, and pathological stage. A screening group (four AMA-positive and four AMA-negative patients) was used for 2D-DIGE. Protein spots that were differently abundant between the two groups were identified via dye intensity and MS. Nine candidate proteins were identified from these spots. Western blotting was used to verify two of the identified proteins, serum amyloid P-component (SAP) and vitronectin (VN). VN levels were significantly higher in the sera of AMA-negative PBC patients (p < 0.01), whereas no significant difference was found between the two groups for SAP. To our knowledge, this is the first study to use serological comparative proteomics to explore differences between AMA-positive and -negative PBC patients. VN levels were higher in AMA-negative PBC patients, and this finding could be related to the more severe bile duct destruction observed in this group. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Electrophoresis 04/2015; DOI:10.1002/elps.201400342 · 3.16 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A carbapenem-nonsusceptible Enterobacter aerogenes strain named 3-SP was isolated from a human case of pneumonia in a Chinese teaching hospital. NDM-1 carbapenemase is produced by a pNDM-BJ01-like conjugative plasmid designated p3SP-NDM to account for carbapenem resistance of 3-SP. p3SP-NDM was fully sequenced and compared with all publically available pNDM-BJ01-like plasmids. The genetic differences between p3SP-NDM and pNDM-BJ01 include only 18 single nucleotide polymorphisms, a 1 bp deletion and a 706 bp deletion. p3SP-NDM and pNDM-BJ01 harbor an identical Tn125 element organized as ISAba125, bla NDM-1, ble MBL, ΔtrpF, dsbC, cutA, ΔgroES, groEL, ISCR27, and ISAba125. The bla NDM-1 surrounding regions in these pNDM-BJ01-like plasmids have a conserved linear organization ISAba14-aphA6-Tn125-unknown IS, with considerable genetic differences identified within or immediately downstream of Tn125. All reported pNDM-BJ01-like plasmids are exclusively found in Acinetobacter, whereas this is the first report of identification of a pNDM-BJ01-like plasmid in Enterobacteriaceae.
    Frontiers in Microbiology 04/2015; 6. DOI:10.3389/fmicb.2015.00294 · 3.94 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The efficacy and safety of sirolimus (SIR)-based graft-versus-host disease (GVHD) prophylaxis in patients who were subjected to allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain to be clarified; this meta-analysis was conducted to evaluate these factors. Data from original research were obtained from PubMed, Embase, and Cochrane central register of controlled trials databases. Randomized controlled trials (RCTs) evaluating the efficacy of SIR-based prophylaxis in allo-HSCT were included. The risk ratio (RR), with a 95% confidence interval (CI), was used to pool data. The random effects model was used, irrespective of the presence or absence of heterogeneity. Five RCTs were included in the meta-analysis. SIR was observed to significantly decrease the incidence of Grade II to IV acute GVHD (aGVHD; RR, 0.65; 95% CI, 0.47-0.89). However, the incidence of Grade III to IV aGVHD and chronic GVHD was not decreased (RR, 0.91; 95% CI, 0.59-1.40; RR, 1.04; 95% CI, 0.88-1.23, respectively). An analysis of the toxic effects of SIR revealed that SIR effected a significant increase in the incidence of sinusoidal obstructive syndrome (RR, 2.24; 95% CI, 1.26-4.01), while that of thrombotic microangiopathy was not significantly increased (RR, 2.48; 95% CI, 0.87-7.06). Moreover, SIR did not improve event-free survival and overall survival (RR, 0.97; 95% CI, 0.85-1.10; and RR, 0.92; 95% CI, 0.82-1.02, respectively). This meta-analysis indicated that the SIR-based regimen is an effective and safe alternative prophylaxis strategy for GVHD. © 2015 AABB.
    Transfusion 04/2015; DOI:10.1111/trf.13110 · 3.57 Impact Factor

Publication Stats

8k Citations
2,431.41 Total Impact Points


  • 2015
    • Institute of Chemistry and Materials
      Lutetia Parisorum, Île-de-France, France
    • Nanjing University of Aeronautics & Astronautics
      • College of Mechanical and Electrical Engineering
      Nan-ching, Jiangsu Sheng, China
    • University of North Carolina at Chapel Hill
      • Department of Biochemistry and Biophysics
      North Carolina, United States
  • 2013–2015
    • Hangzhou Normal University
      Hang-hsien, Zhejiang Sheng, China
    • Shangqiu Normal University
      Zhuji, Henan Sheng, China
    • Inner Mongolia University
      Suiyüan, Inner Mongolia, China
    • Beijing University of Posts and Telecommunications
      • Department of Communication Engineering
      Peping, Beijing, China
    • First People's Hospital Chenzhou
      Chenchow, Hunan, China
    • Guilin University of Electronic Technology
      Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China
    • Capital Medical University
      • Department of Pathophysiology
      Peping, Beijing, China
    • Xuzhou Medical College
      Suchow, Jiangsu Sheng, China
  • 2012–2015
    • Shanxi Medical University
      • Department of Physiology
      Yangkü, Shanxi Sheng, China
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
    • Chongqing University of Technology
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2011–2015
    • Xi'an Jiaotong University
      • • School of Mechanical Engineering
      • • State Key Laboratory for Mechanical Behavior of Materials
      • • School of Medicine
      • • State Key Laboratory for Manufacturing Systems Engineering
      Ch’ang-an, Shaanxi, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Chongqing Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Jilin Normal University
      Yung-chi, Jilin Sheng, China
    • Nantong University
      Tungchow, Jiangsu Sheng, China
    • Tsinghua University
      • State Key Joint Laboratory of Environmental Simulation and Pollution
      Peping, Beijing, China
    • Huazhong University of Science and Technology
      • State Key Laboratory of Digital Manufacturing Equipment and Technology
      Wu-han-shih, Hubei, China
    • Soochow University (PRC)
      Wu-hsien, Jiangsu Sheng, China
    • Southwest Petroleum University
      Hua-yang, Sichuan, China
    • Southwest University in Chongqing
      Pehpei, Chongqing Shi, China
  • 2010–2015
    • Lanzhou University
      • • School of Physical Science and Technology
      • • School of Life Science
      Kao-lan-hsien, Gansu Sheng, China
    • Hefei University of Technology
      • School of Materials Science and Engineering
      Luchow, Anhui Sheng, China
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
    • Hebei University of Science and Technology
      Chentow, Hebei, China
    • Tohoku University
      • Department of Applied Chemistry
      Miyagi, Japan
    • China Agriculture University-East
      Peping, Beijing, China
  • 2009–2015
    • Nanjing Medical University
      • • Department of Oncology
      • • Department of Hematology
      Nan-ching, Jiangsu Sheng, China
    • Henan Provincial People’s Hospital
      Cheng, Henan Sheng, China
    • Peking University
      • Institute of Urology
      Beijing, Beijing Shi, China
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Wuhan University
      Wu-han-shih, Hubei, China
  • 2008–2015
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
    • Jiangxi Normal University
      Nan-ch’ang-shih, Jiangxi Sheng, China
  • 2005–2015
    • Sichuan University
      • • Department of Material Science
      • • State Key Laboratory of Biotherapy
      • • Analytical Center
      • • Department of Chemistry
      • • College of Life Sciences
      Hua-yang, Sichuan, China
    • Chinese Academy of Medical Sciences
      • Institute of Basic Medical Sciences (IBMS)
      Peping, Beijing, China
    • Beijing Hospital
      Peping, Beijing, China
    • University of Connecticut
      Storrs, Connecticut, United States
    • Institute of Genetics and Developmental Biology, CAS
      Peping, Beijing, China
  • 2002–2015
    • Third Military Medical University
      • • Southwest Hospital
      • • Department of Physiology
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2014
    • Nanjing University of Traditional Chinese Medicine
      Nan-ching, Jiangsu Sheng, China
    • Beijing Jiaotong University
      • School of Traffic and Transportation
      Peping, Beijing, China
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • University of Toronto
      • Department of Materials Science and Engineering
      Toronto, Ontario, Canada
    • Chongqing University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • China National Rice Research Institute
      Hang-hsien, Zhejiang Sheng, China
    • Qingdao University of Science and Technology
      Tsingtao, Shandong Sheng, China
    • McMaster University
      • Department of Anesthesia
      Hamilton, Ontario, Canada
  • 2013–2014
    • China Agricultural University
      • State Key Laboratory for Agrobiotechnology
      Peping, Beijing, China
    • Zhejiang Normal University
      Jinhua, Zhejiang Sheng, China
  • 2012–2014
    • Tianjin University
      • School of Science
      T’ien-ching-shih, Tianjin Shi, China
  • 2011–2014
    • Shanghai Jiao Tong University
      • Department of Anesthesiology
      Shanghai, Shanghai Shi, China
    • Dalian Medical University
      • • College of Pharmacy
      • • School of Pharmacy
      • • Department of Pharmacology
      Lü-ta-shih, Liaoning, China
  • 2010–2014
    • Zhengzhou University
      Cheng, Henan Sheng, China
    • Broad Institute of MIT and Harvard
      Cambridge, Massachusetts, United States
  • 2009–2014
    • Beijing University of Aeronautics and Astronautics (Beihang University)
      • School of Economics and Management
      Peping, Beijing, China
  • 2006–2014
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
    • Beijing University of Technology
      Peping, Beijing, China
  • 2005–2014
    • Jilin University
      • • State Key Laboratory of Supramolecular Structure and Materials
      • • Department of Phathogenobiology
      • • State Key Laboratory of Inorganic Synthesis and Preparative
      • • Department of Immunology
      • • College of Chemistry
      Yung-chi, Jilin Sheng, China
    • Peking Union Medical College Hospital
      • Department of Rheumatology
      Peping, Beijing, China
  • 2002–2014
    • Shandong University
      • • Department of Electronic Information Engineering
      • • School of Life Science
      • • School of Environmental Science and Engineering
      • • Key Laboratory for Cardiovascular Remodelling and Function Research
      • • Key Laboratory for Liquid Structure and Heredity of Materials
      Chi-nan-shih, Shandong Sheng, China
  • 2012–2013
    • Shandong University of Science and Technology
      Tsingtao, Shandong Sheng, China
  • 2011–2013
    • Yangzhou University
      • College of Horticulture and Plant Protection
      Peping, Beijing, China
  • 2010–2013
    • Inner Mongolia Agricultural University
      Suiyüan, Inner Mongolia, China
    • University of Southampton
      • Faculty of Physical and Applied Sciences
      Southampton, England, United Kingdom
  • 2009–2013
    • Fourth Military Medical University
      • • Department of Neurology
      • • Department of Biochemistry and Molecular Biology
      • • State Key Laboratory of Cancer Biology
      • • Department of Medical Genetics and Developmental Biology
      Xi’an, Liaoning, China
  • 2004–2013
    • Fudan University
      • • Department of Chemistry
      • • Institute of Biodiversity Science
      • • School of Computer Science
      • • School of Life Sciences
      Shanghai, Shanghai Shi, China
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • National Space Science
      Peping, Beijing, China
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
    • Anhui Normal University
      Wu-hu-shih, Anhui Sheng, China
  • 2003–2013
    • Chinese Academy of Sciences
      • • Institute of Physics
      • • Institute of Genetics and Developmental Biology
      • • Laboratory of Molecular and Developmental Biology
      • • State Key Laboratory of Electroanalytical Chemistry
      Peping, Beijing, China
  • 2011–2012
    • Chengdu University Of Traditional Chinese Medicine
      Hua-yang, Sichuan, China
  • 2008–2012
    • Beijing Fuwai Hospital
      Peping, Beijing, China
  • 2008–2011
    • Shanghai Center for Bioinformation Technology
      Shanghai, Shanghai Shi, China
  • 2009–2010
    • Kunming Medical College
      • Department of Pathology
      Yün-nan, Yunnan, China
  • 2008–2010
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
  • 2007–2010
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • West China School of Medicine
      Hua-yang, Sichuan, China
    • Eli Lilly
      • Lilly Research Laboratories
      Indianapolis, Indiana, United States
  • 2008–2009
    • University of Science and Technology, Beijing
      Peping, Beijing, China
  • 2005–2007
    • Shanghai University of Engineering Science
      Shanghai, Shanghai Shi, China