Li Wang

Tianjin Medical University Cancer Institute and Hospital, T’ien-ching-shih, Tianjin Shi, China

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Publications (240)484.98 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are responsible for the progression and recurrence of GBM after conventional therapy. Morusin possesses anti-cancer activity in vitro. The purpose of this study is to confirm the growth inhibition effect of morusin on human GSCs growth in vitro and in vivo and to explore the possible mechanism of its activity. Human GSCs were enriched under nonadhesive culture system, and characterized through neurosphere formation, toluidine blue staining, immunofluorescence staining, Western blotting analysis of stemness markers of CD133, nestin, Sox2 and Oct4, and tumorigenecity in vivo; the growth inhibition effect of morusin on human GSCs in vitro and in vivo were tested by cell cytotoxicity, neurosphere formation inhibition, adipogenic differentiation, apoptosis induction, and tumor growth inhibition in vivo assays. The potential molecular mechanisms underlying the growth inhibition effect of morusin on GSCs in vitro and in vivo were investigated with Western blotting evaluation of stemness, adipogenic, and apoptotic proteins in morusin treated GSCs and tumor tissues. GSCs enriched under nonadhesive culture system possess stemness characterstics; Morusin inhibited GSCs growth in vitro and in vivo, it reduced stemness of GSCs, induced them adipocyte-like transdifferention and apoptosis. Morusin has the potential to inhibit human GSCs growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction. © 2014 Wiley Periodicals, Inc.
    Molecular Carcinogenesis 12/2014; · 4.27 Impact Factor
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    ABSTRACT: Microspheres assembled using cryptomelane-type KMn8O16 nanorods are synthesized via a facile template-free, single-step hydrothermal technique. The synthesized KMn8O16 generates nanorods 10-20 nm in diameter and approximately 300-1000 nm long. The rods self-assemble to form microspheres of 2-6 μm in diameters. The electron transfer number for KMn8O16 during the ORR is approximately 3.98 at 0.5 V vs. Hg/HgO, and the H2O2 percentage is 0.66%. Moreover, a direct methanol fuel cell (DMFC) is built using KMn8O16 as cathodic catalyst, PtRu/C alloy as the anodic catalyst and a polymer fiber membrane (PFM) instead of a conventional polymer electrolyte membrane (PEM). The peak power densities (43.3 mW cm-2 and 153.9 mW cm-2) have been achieved at 25 °C and 70 °C, respectively. KMn8O16 shows good electrocatalytic activity and stability during oxygen reduction in alkaline solutions and demonstrates tolerance toward methanol poisoning.
    Journal of Power Sources 12/2014; 267:33–38. · 5.21 Impact Factor
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    ABSTRACT: The effect of polycomb chromobox (Cbx) proteins in cancer is context-dependent. The Chromobox homolog 8 (CBX8) was originally characterized as a transcriptional repressor, which inhibits cell proliferation in Ink4a-Arf-dependent and -independent manner. However, the role of CBX8 in colorectal cancer remains unknown. Here, we found that high CBX8 expression was associated with a low rate of distant metastasis and good prognosis in CRC patients, even though CBX8 was up-regulated in CRC cell lines and clinical samples. Knockdown of CBX8 inhibited CRC proliferation in vitro and in vivo, mostly by increasing p53 and its downstream effectors. However, knockdown of CBX8 enhanced CRC migration, invasion and metastasis in vitro and in vivo, in part through direct up-regulation of integrin β4 (ITGB4) that in turn decreased RhoA activity. Collectively, the knockdown of CBX8 inhibited CRC proliferation, while promoting its metastasis, thus exerting paradoxical effects in CRC progression.
    Oncotarget 10/2014; · 6.63 Impact Factor
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    ABSTRACT: Magnetic iron oxide nanoparticles (IONPs) have been widely used for various biomedical applications such as magnetic resonance imaging and drug delivery. However, their potential toxic effects, including genotoxicity, need to be thoroughly understood. In the present study, the genotoxicity of IONPs with different particle sizes (10, 30 nm) and surface coatings (PEG, PEI) were assessed using three standard genotoxicity assays, the Salmonella typhimurium reverse mutation assay (Ames test), the in vitro mammalian chromosome aberration test, and the in vivo micronucleus assay. In the Ames test, SMG-10 (PEG coating, 10 nm) showed a positive mutagenic response in all the five test bacterial strains with and without metabolic activation, whereas SEI-10 (PEI coating, 10 nm) showed no mutagenesis in all tester strains regardless of metabolic activation. SMG-30 (PEG coating, 30 nm) was not mutagenic in the absence of metabolic activation, and became mutagenic in the presence of metabolic activation. In the chromosomal aberration test, no increase in the incidence of chromosomal aberrations was observed for all three IONPs. In the in vivo micronucleus test, there was no evidence of increased micronuclei frequencies for all three IONPs, indicating that they were not clastogenic in vivo. Taken together, our results demonstrated that IONPs with PEG coating exhibited mutagenic activity without chromosomal and clastogenic abnormalities, and smaller IONPs (SMG-10) had stronger mutagenic potential than larger ones (SMG-30); whereas, IONPs with SEI coating (SEI-10) were not genotoxic in all three standard genotoxicity assays. This suggests that the mutagenicity of IONPs depends on their particle size and surface coating.
    Nanotechnology 10/2014; 25(42):425101. · 3.67 Impact Factor
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    ABSTRACT: Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4% to 1.3% has been reported in literature. The primary malignancies that most commonly metastasize to the breast are leukemia, lymphoma, and malignant melanoma. In this report, two cases of pulmonary metastasis to the breast were presented. A 40-year-old female manifested a right breast mass of 2-month duration. After physical examination was performed, a poorly defined mass was noted in the upper outer quadrant of the right breast. Another 49-year-old female manifested right breast mass of 5-day duration. A poorly defined mass was noted in the lower inner quadrant of the right breast. Mammography results also revealed breast cancer. The patients underwent local excision. After histological and immunohistochemical analyses were conducted, a primary lung carcinoma that metastasized to the breast was diagnosed. An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.
    Cancer biology & medicine. 09/2014; 11(3):208-15.
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    ABSTRACT: An ultrasensitive and selective electrochemical immunosensor was developed for the detection of Epstein Barr virus nuclear antigen 1 (EBNA-1). Firstly, a suspension of graphene sheets (GS) and multi-walled carbon nanotubes (MWCNTs) was prepared with the aid of chitosan (CS) solution and then modified on a glassy carbon electrode (GCE). Gold nanoparticles (AuNPs) were then electrodeposited onto the surface of the GS–MWCNTs film by cyclic voltammetry (CV) to immobilize the captured antibodies. After that, specific sandwich immunoreactions were formed among the captured antibody, EBNA-1, and secondary antibody, DNA-coated carboxyl multi-wall carbon nanotubes (DNA–MWCNTs–Ab2). DNA initiator strands (S0) and secondary antibodies linked to the MWCNTs and double-helix DNA polymers were obtained by hybridization chain reaction (HCR), and here S0 on the MWCNTs propagates a chain reaction of hybridization events between two alternating hairpins to form a nicked double-helix. Finally, electroactive indicator doxorubicin hydrochloride was intercalated into the CG–GC steps between the HCR products and could produce an electrochemical signal, which was monitored by differential pulse voltammetry (DPV). Under optimum conditions, the amperometric signal increased linearly with the target concentrations (0.05–6.4 ng mL−1), and the immunosensor exhibited a detection limit as low as 0.7 pg mL−1 (S/N=3). The proposed method showed acceptable stability and reproducibility, as well as favorable recovery for EBNA-1 in human serum. The proposed immunosensor provides a novel avenue for signal amplification and potential applications in bioanalysis and clinical diagnostics.
    Biosensors & Bioelectronics 08/2014; 58:68–74. · 6.45 Impact Factor
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    ABSTRACT: A novel electrochemical aptasensor was developed for ultrasensitive detecting staphylococcal enterotoxin B (SEB) by combining signal amplification and target-induced aptamer release strategy. Target SEB could efficiently induce the release of aptamers from the eletrode surface, thus leading to substantial enzyme-amplified electrochemical signal in the presence of H2O2.
    Colloids and surfaces B: Biointerfaces 08/2014; · 4.28 Impact Factor
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    ABSTRACT: Glioma stem cells (GSCs) are believed to contribute to glioblastoma multiforme (GBM) propagation and treatment resistance. Tanshinone IIA possesses anticancer and anti-inflammatory activities. This study aimed to determine the inhibitory effect of tanshinone IIA on human GSCs in vitro and in vivo and to explore the underlying mechanisms. In the present study, human GBM neurospheres (GBMS) were isolated from adherent GBM cells in serum-free medium, and the cells from the GBMS displayed characteristics of GSCs. Results from the MTT, neurosphere formation and in vivo inhibition assays revealed that tanshinone IIA had a significant inhibitory effect on human GSCs in vitro and in vivo. Furthermore, tanshinone IIA increased the expression of differentiation and neural lineage markers including GFAP and β-tubulin, decreased expression of GSC markers including CD133 and nestin, and induced GSC apoptosis in vitro and in vivo in a dose‑dependent manner. Inflammatory cytokines and signaling pathways are believed to play key roles in maintaining the stem-like properties in human glioma cells. In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. This result indicated that disturbance of the IL6/STAT3 signaling axis by tanshinone IIA is closely related to the growth inhibition of GSCs. Taken together, our results indicate that tanshinone IIA has the potential to target and kill GSCs through suppression of proliferation, attenuation of stemness and induction of apoptosis. Its mechanism of activity may be associated with attenuation of the IL6/STAT3 signaling pathway.
    Oncology reports. 06/2014;
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    ABSTRACT: Knowledge is limited about the relationship between chemotherapy and prognosis among the subtypes of axillary node-negative breast cancer (ANNBC). In this study, a population including 2,236 primary and operable ANNBC patients, with a median age of 53, were included. All breast tumors were classified into five immunohistochemically defined subtypes-luminal A, luminal B, luminal human epidermal growth factor receptor 2 (HER2), HER2 overexpression, and triple negative. With a median follow-up of 73.6 months, the rate of relapse was lowest in luminal A (6.5 %) and highest in HER2 overexpression subtype (16.4 %). Multivariate analysis indicated that the risks of relapse and death were enhanced in HER2 overexpression and triple-negative (TN) subtypes, and these two subtypes were independent predictors of relapse and death. Luminal A patients with risk factors could benefit from chemotherapy in terms of relapse-free survival (RFS). The relapse rate of TN patients after chemotherapy with taxanes was lower compared with that after chemotherapy without taxanes. In conclusion, women with ANNBC were at higher risks of relapse and death if suffering from HER2 overexpression or TN diseases. Chemotherapy could reduce the recurrence rate of luminal A patients with risk factors. TN patients may benefit from adjuvant chemotherapy containing taxanes.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 05/2014;
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    ABSTRACT: The role of [-2]proPSA (p2PSA) based diagnostic tests for the detection of aggressive prostate cancer (PCa) has not been fully evaluated. We conducted a meta-analysis to evaluate the diagnostic performance of p2PSA/free PSA (%p2PSA) and prostate health index (Phi) tests for PCa and to evaluate their ability in discriminating between aggressive and non-aggressive PCa. A total of 16 articles were included in this meta-analysis. For the detection of PCa, the pooled sensitivity, specificity, and AUC were 0.86 (95% CI, 0.84-0.87), 0.40 (95% CI, 0.39-042) and 0.72 (95% CI, 0.67-0.77) for %p2PSA respectively, and were 0.85 (95% CI, 0.83-0.86), 0.45 (95% CI, 0.44-0.47) and 0.70 (95% CI = 0.65-0.74) for Phi, respectively. In addition, the sensitivity for discriminating PCa between higher Gleason score (≥7) and lower Gleason score (<7) was 0.96 (95% CI, 0.93-0.98) and 0.90 (95% CI, 0.87-0.92) for %p2PSA and Phi respectively, and the specificity was low, only 0.09 (95% CI, 0.06-0.12) and 0.17 (95% CI, 0.14-0.19) for %p2PSA and Phi, respectively. Phi and %p2PSA have a high diagnostic accuracy rates and can be used in PCa diagnosis. Phi and %p2PSA may be useful as tumor markers in predicating patients harboring more aggressive disease and guiding biopsy decisions.
    Scientific Reports 05/2014; 4:5012. · 5.08 Impact Factor
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    ABSTRACT: Abstract Objective: To first describe laparoscopic nephrectomy (LN) for patients with acute blunt Grade 4 renal injuries using a retroperitoneal approach. Patients and Methods: Three patients (2 males and 1 female) with acute blunt renal trauma underwent retroperitoneal LN successfully. The revised American Association for Surgery of Trauma grading system was used to grade renal injuries. All three patients with Grade 4 renal injuries required blood transfusions preoperatively and angiographic embolization because of hemodynamic instability. Given the severity of the renal injuries, failure of angiographic embolization, and persistent blood loss, surgical intervention was used. We performed retroperitoneal LN using four trocars within 24 hours after trauma for the patients. Results: Pure retroperitoneal LN was successfully performed in all 3 patients without requiring hand-assisted or open surgery. The renal hematoma dimension for the patients was 7.5, 8.4, and 9.2 cm, respectively. Operative time was 80, 110, and 130 minutes, respectively. Estimated blood loss was 100, 140, and 300 mL, respectively. The incision size was 4.2, 4.2, and 4.5 cm, respectively. The average hospital stay was 6 days. Pathology showed renal injuries without incidental renal tumors. Conclusions: Despite the technical challenges, LN for patients with acute blunt Grade 4 renal injuries using a retroperitoneal approach is safe and feasible in carefully selected patients if conservative measures and angiographic embolization fail. However, it is important to note that one should keep a low threshold for open conversion or the hand-assisted approach whenever necessary.
    Journal of Laparoendoscopic & Advanced Surgical Techniques 05/2014; · 1.19 Impact Factor
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    ABSTRACT: Objective To evaluate the production and utilization of Cochrane systematic reviews(CSRs) and to analyze its influential factors, so as to improve the capacity of translating CSRs into practice.Methods All CSRs and protocols were retrieved from the Cochrane Library ISSUE 2, 2011 and citation data were retrieved from SCI database. Citation analysis was used to analyze the situation of CSRs production and utilization.ResultsCSR publication had grown from an annual average of 32 to 718 documents. Only one developing country was among the ten countries with the largest amount of publications. High income countries accounted for 83% of CSR publications and 90.8% of cited counts. 34.7% of CSRs had a cited count of 0, while only 0.9% had been cited more than 50 times. Highly cited CSRs were published in England, Australia, Canada, USA and other high income countries. The countries with a Cochrane center or a Cochrane methodology group had a greater capability of CSRs production and citing than others. The CSRs addressing the topics of diseases were more than those targeted at public health issues. There was a big gap in citations of different interventions even for the same topic.Conclusion The capability of CSR production and translation grew rapidly, but varied among countries and institutions, which was affected by several factors such as the capability of research, the resourcesand the applicability of the evidence. It is important to improve evidence translation through educating, training and prioritizing the problems based on real demands of end user.This article is protected by copyright. All rights reserved.
    Journal of Evidence-Based Medicine 05/2014;
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    ABSTRACT: Recent genome-wide association studies have identified 14 genetic variants associated with bladder cancer in Caucasians. The effects of these risk variants and their cumulative effects in Asian populations are unknown. We genotyped these newly identified variants in a case-control study of 1,050 patients diagnosed with bladder cancer and 1,404 controls in the Chinese population. Odds rations (ORs) and 95% confidence intervals (CIs) were computed by logistic regression, and cumulative effect of risk alleles were evaluated. Overall, seven of the 14 variants were significantly associated with bladder cancer risk (P = 9.763 × 10-3 for rs9642880 at 8q24.21, P = 3.004 × 10-3 for rs2294008 at 8q24.3, P = 0.012 for rs798766 at 4p16.3, P = 0.034 for rs1495741 at 8p22, P = 2.306 × 10-4 for GSTM1, P = 8.507 × 10-8 for rs17674580 at 18q12.3, P = 7.179 × 10-4 for rs10936599 at 3q26.2), and the Odds Ratios (ORs) ranged from 1.13 to 1.65. Moreover, there were a significant increased risk for bladder cancer positively correlated numbers of risk alleles and smoking status (Ptrend = 7.060 × 10-16). However, no allelic interaction effects on bladder cancer risk were observed between cumulative effects of variants and clinical characteristics. These findings suggest that seven bladder cancer risk-associated variants (rs9642880, rs2294008, rs798766, rs1495741, GSTM1 null, rs17674580, and rs10936599) may be used, collectively, to effectively measure inherited risk for bladder cancer. © 2014 Wiley Periodicals, Inc.
    International Journal of Cancer 04/2014; · 6.20 Impact Factor
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    ABSTRACT: The stochastic transportation problem involves in many areas such as production scheduling, facility location, resource allocation, logistics management. Constructing an operable solving method has important theoretical and practical value. In this paper, we first analyze the characteristic and deficiencies of the existing stochastic programming methods, such as higher computation complexity. We then give the concept of reliability coefficient and a quasi-linear processing pattern based on expectation and variance. We further analyze the relationship between reliability coefficient and reliability degree, also give the selecting strategy of reliability coefficient. Based on that, we establish a quasi-linear programming model for stochastic transportation problem, and we analyze its performance by a case-based example. The results indicate that this model has good interpretability and operability. It can effectively solve the transportation problem under complex stochastic environment or with incomplete information.
    Applied Mathematical Modelling 04/2014; 38(s 7–8):1919–1928. · 2.16 Impact Factor
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    ABSTRACT: Lithocarpus polystachyus leaves have been used as tea beverage and folk medicine for healthy care in the Southwest of China. The purpose of this study is to investigate the anticancer activity of Lithocarpus polystachyus Rehd leaf aqueous extract (LPAE) and to explore the possible mechanism of its activity. Growth inhibition effects of LPAE breast cancer were tested in vitro and in vivo. The possible mechanism of its activity was analyzed with cell biological and molecular biological assays. After LPAE treatment, the proliferation and colony formation of cancer cells decreased; apoptotic cells increased; DNA fragmentations were evident; mRNA and protein expressions of PPARγ, Bax, and caspase-3 genes increased and expressions of cyclin D1 and Bcl-2 genes decreased; in vivo experiment, LPAE inhibited human beast cancer growth. The findings in this experimental study suggested that LPAE has potential cytotoxic and apoptotic effects on human breast cancer cells in vitro and inhibits the cancer growth in vivo, and its mechanism of activity might be associated with apoptosis induction of cancer cells through upregulation of the mRNA and protein expressions of PPARγ, Bax, and capase-3 genes and downregulation of the expressions of cyclin D1 and Bcl-2 genes.
    Nutrition and Cancer 03/2014; · 2.70 Impact Factor
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    ABSTRACT: OBJECTIVES To describe our pure retroperitoneal laparoscopic radical nephrectomy (LRN) with thrombectomy for right renal masses with renal vein (RV) and inferior vena cava (IVC) thrombus. METHODS Five right renal masses with RV and IVC thrombus underwent pure retroperitoneal LRN. Three patients had a history of abdominal surgery. In one patient with a RV thrombus, the RV was ligated and dissected with Hem-o-lok clips; in 4 patients with IVC thrombus, the IVC was partially occluded with a laparoscopic vascular clamp and incised distal to its junction with the right RV, and the thrombus was delivered intact. The IVC was closed with a running 3-zero polypropylene suture. RESULTS Pure retroperitoneal LRN with thrombectomy was successfully performed for all the patients without hand-assisted or open conversion. The mean tumor size was 6.2cm and mean thrombus length was 2.8cm; Four thrombus extended 0.6-1.0cm into the IVC and the mean operative time was 127 minutes with the average estimated blood loss at 148 ml. The mean hospital stay was 5 days. Histology revealed 2 renal cell carcinomas (RCC), 1 angiomylipoma (AML), 1 renal pelvic transitional cell carcinoma (TCC) and 1 renal infarction. All the surgical margins were negative. With a mean follow-up of 35 months, no patients developed metastatic diseases. CONCLUSIONS Despite the technical challenges, pure retroperitoneal LRN for right renal masses with a RV and IVC thrombus is safe and feasible in appropriately selected patients using a retroperitoneal approach. In patients with minimal caval involvement, our surgical approach provided an alternative treatment option, especially when the patients had a history of abdominal surgery.
    Journal of endourology / Endourological Society 03/2014; · 1.75 Impact Factor
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    ABSTRACT: An ultrasensitive and specific electrochemical biosensor for the determination of mecA gene, which is associated with methicillin resistant strains, was successfully developed. Capture probes were immobilized on the surface of a gold nanoparticle modified glassy carbon electrode. After target probes were hybridized with capture probes, dual labeled gold nanoparticles with alkaline phosphatase and detection probes were hybridized with target probes for sensitive detection of mecA gene fragments. Dual labeled gold nanoparticles, which acted as a high-efficiency signal amplification strategy, were successfully prepared. The gold nanoparticles and dual labeled gold nanoparticles were characterized by transmission electron microscopy. Different concentrations of gene fragments were detected to inspect the specificity and sensitivity of the proposed biosensor. This biosensor displayed outstanding selectivity and a remarkable sensitivity (LOD = 23 pM, S/N = 3). Good linearity over the range of 50 pM to 250 pM was demonstrated. Moreover, the measurement process required less than 2 hours. This device was employed for the successful determination of mecA gene from methicillin resistant Staphylococcus aureus.
    Analytical Letters 03/2014; 47(4). · 0.98 Impact Factor
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    ABSTRACT: Finding a way to improve students' learning performance is a crucial concern in education reform. Many researchers have investigated possible predictors of student learning performance, including personality traits, learning styles, self-efficacy, and so on. Nevertheless, there is limited research that examines the effectiveness of the interaction between students and teachers, achievement sharing, and the classroom environment. This study investigates the impact of effective communication between students and teachers, achievement sharing, and a positive classroom environment on learning performance through an empirical analysis. We found that when teachers create a sense of community, respond to students and foster positive relationships, students are more engaged and enthusiastic about learning and tend to perform better academically. Copyright © 2014 John Wiley & Sons, Ltd.
    Behavioral Science 03/2014;
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    ABSTRACT: Objective: Efforts have been made by tissue engineers to create a permissive environment for neural regeneration, and to enhance the efficiency of neural stem cell (NSC) transplantation. However, to acquire sufficient number of seed cells on the material appears to be the main obstacle to constructing functional transplantable NSC-biomaterial complexes. A culture system has been optimized in the current study to maintain the specific characteristics of NSCs/neural progenitor cells (NPCs) on the material and achieve sustaining increased multipotent seed cells. Methods: The PHBHHx film was selected as biomaterial and the surface was firstly modified with NaOH treatment. The NSCs/NPCs isolated from the cerebral cortex of rat embryos were cultured on the treated PHBHHx films in growth medium containing 1%, 5%, and 10% fetal bovine serum (FBS). Then the attachment, survival, proliferation, and differentiation of NSCs/NPCs were assessed. Results: NaOH treatment significantly increased the hydrophilicity of PHBHHx and enhanced NSCs/NPCs attachment. On the treated PHBHHx film, NSCs/NPCs survived well and actively proliferated in the medium containing 1% FBS. After 7-14 days in culture, approximately two-thirds of cells remained as nestin and Sox2 positive NSCs/NPCs. However, in the medium containing 5% and 10% FBS, NSCs/NPCs proliferation was reduced and differentiation, particularly glial differentiation was significantly promoted. Conclusion: Growth medium containing low concentration of FBS is favorable for maintaining the characteristics, in terms of self-renewal and multiple differentiation, of NSCs/NPCs on NaOH-treated PHBHHx films. This could be a useful method to construct functional transplantable NSCs/NPCs-biomaterial complex.
    Neurological Research 03/2014; 36(3):207-14. · 1.45 Impact Factor
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    ABSTRACT: Employee turnover is costly in terms of direct costs and indirect costs faced by organizations. Thus, researchers have investigated turnover for more than two decades. Different methods have been proposed to identify employee turnover risk. However, reducing and preventing employee turnover is still one of the biggest challenges to organizations. Quality function deployment (QFD) method is a systems approach to quality engineering. Employee turnover risk identification mainly involves employee turnover risk factors modelling, identifying risk factors' index, and determining index weights. In this paper, we propose a multi-level employee turnover risk identification model using modified QFD method. This study contributes to the QFD and employee turnover research literature and provides practical guidance to business practitioners. Copyright © 2014 John Wiley & Sons, Ltd.
    Behavioral Science 03/2014;

Publication Stats

807 Citations
484.98 Total Impact Points


  • 2014
    • Tianjin Medical University Cancer Institute and Hospital
      T’ien-ching-shih, Tianjin Shi, China
    • Xi'an Jiaotong University
      • State Key Laboratory for Mechanical Behavior of Materials
      Ch’ang-an, Shaanxi, China
    • Beijing Jiaotong University
      • School of Traffic and Transportation
      Peping, Beijing, China
  • 2013–2014
    • Wake Forest School of Medicine
      • Center for Cancer Genomics
      Winston-Salem, North Carolina, United States
    • Wake Forest University
      Winston-Salem, North Carolina, United States
    • Fourth Military Medical University
      Xi’an, Liaoning, China
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
    • Changhai Hospital, Shanghai
      Shanghai, Shanghai Shi, China
  • 2012–2014
    • Chongqing Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Sun Yat-Sen University Cancer Center
      Shengcheng, Guangdong, China
    • Beijing Medical University
      • Department of Pathophysiology
      Peping, Beijing, China
  • 2010–2014
    • Beijing University of Aeronautics and Astronautics (Beihang University)
      • School of Economics and Management
      Peping, Beijing, China
  • 2005–2014
    • Sichuan University
      • • Analytical Center
      • • Department of Chemistry
      • • College of Life Sciences
      Hua-yang, Sichuan, China
  • 2011–2012
    • Chengdu University Of Traditional Chinese Medicine
      Hua-yang, Sichuan, China
    • McMaster University
      Hamilton, Ontario, Canada
  • 2007–2011
    • West China School of Medicine
      Hua-yang, Sichuan, China
    • Shanghai Jiao Tong University
      • Department of Cardiology (Renji)
      Shanghai, Shanghai Shi, China
  • 2009
    • University of Queensland 
      • School of Biomedical Sciences
      Brisbane, Queensland, Australia
    • Prince Henry's Institute
      Melbourne, Victoria, Australia
    • Northeast Institute of Geography and Agroecology
      • Shanghai Institutes for Biological Sciences
      Peping, Beijing, China
    • Agricultural University Of Hebei
      Pao-ting-shih, Hebei, China
    • Shanghai Institute of Measurement and Testing Technology
      Shanghai, Shanghai Shi, China
    • China Pharmaceutical University
      • Department of Pharmaceutical Analysis
      Nanjing, Jiangxi Sheng, China
  • 2004–2009
    • Huazhong Agricultural University
      • College of Life Science and Technology
      Wuhan, Hubei, China