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ABSTRACT: IntroductionThe European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is a widely used health-related quality of
life instrument. The main aim of this study is to investigate whether there are international differences in response to the
questionnaire that can be explained by cultural factors.
MethodsAnalyses involved a database of 106 separate studies including data from over 28,000 respondents. Differential item functioning
(DIF) analyses using logistic regression were conducted for each item of the EORTC QLQ-C30 with respect to cultural/geographic
group. Results were qualitatively compared with previously reported DIF analyses by translation to explore whether the source
of the DIF was more likely to be linguistic or cultural in nature.
ResultsAlthough most response patterns were similar, there were a number of international differences in how the questionnaire was
answered. The largest variations were found in the results for Eastern Europe and East Asia. Results for the UK, the US and
Australia tended to be similar. Many of the European results followed patterns that were more clearly explained when grouped
by translation than when grouped by geographical region.
DiscussionOur results suggest that, in general, the EORTC QLQ-C30 is suitable for use in a wide variety of countries and settings. Some
response variations that have the potential to affect the results of international studies were identified, but it was not
always clear whether the source of the variation was primarily linguistic or cultural.
Quality of Life Research 04/2012; 16(1):115-129. · 2.30 Impact Factor
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ABSTRACT: There are indications that in cancer patients quality of life is a better predictor of survival than clinical measures such as tumour response and stage of disease. In addition, health care professionals' expectations about the effect of a particular treatment on quality of life often do not correspond with the experience of the patient. These are all reasons for every oncological patient to complete a short questionnaire on quality of life. Using this questionnaire can improve communication between care provider and patient, and also give the care provider insight into the problems that are important to the patient at that time. This insight could subsequently lead to counseling tailored to the patient, and, if necessary, modification of treatment or referral for supportive care. A second aim is to link information on quality of life to clinical pathways and treatment guidelines.
Nederlands tijdschrift voor geneeskunde 01/2011; 155(45):A3749.
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ABSTRACT: The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is a widely used health-related quality of life instrument. The main aim of this study is to investigate whether there are international differences in response to the questionnaire that can be explained by cultural factors.
Analyses involved a database of 106 separate studies including data from over 28,000 respondents. Differential item functioning (DIF) analyses using logistic regression were conducted for each item of the EORTC QLQ-C30 with respect to cultural/geographic group. Results were qualitatively compared with previously reported DIF analyses by translation to explore whether the source of the DIF was more likely to be linguistic or cultural in nature.
Although most response patterns were similar, there were a number of international differences in how the questionnaire was answered. The largest variations were found in the results for Eastern Europe and East Asia. Results for the UK, the US and Australia tended to be similar. Many of the European results followed patterns that were more clearly explained when grouped by translation than when grouped by geographical region.
Our results suggest that, in general, the EORTC QLQ-C30 is suitable for use in a wide variety of countries and settings. Some response variations that have the potential to affect the results of international studies were identified, but it was not always clear whether the source of the variation was primarily linguistic or cultural.
Quality of Life Research 03/2007; 16(1):115-29. · 2.30 Impact Factor
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ABSTRACT: The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is one of the most widely used quality of life instruments for cancer patients. The aim of this study was to assess whether there were linguistic differences in the way an international sample answered the EORTC QLQ-C30 questionnaire. Thirteen translations of the EORTC QLQ-C30, representing 22 countries, were investigated using a database of 27,891 respondents, incorporating 103 separate studies. Differential item functioning (DIF) analyses were conducted using logistic regression to identify items which, after controlling for subscale, were answered differently by language of administration. Both uniform and non-uniform DIF were assessed. Although most languages showed similar results to English, at least one instance of statistically significant DIF was identified for each translation, and a few of these differences were large. In some cases, the patterns were supported by the results of qualitative interviews with bilingual people. Although, overall, there appeared to be good linguistic equivalence for most of the EORTC QLQ-C30 items, several scales showed strongly discrepant results for some translations. Some of these effects are large enough to impact on the results of clinical trials. Based on our experience in this study, we suggest that validation of translations of health-related quality of life instruments should include exploration of DIF.
Quality of Life Research 09/2006; 15(6):1103-15; discussion 1117-20. · 2.30 Impact Factor
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Quality of Life Research 07/2006; 15(6):1119-1120. · 2.30 Impact Factor
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