L. J. Fernandez

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Publications (3)0 Total impact

  • Conference Proceeding: A TWO CHAMBER SU8 LABONACHIP WITH INTEGRATED BURST VALVE FOR SAMPLE PREPARATION, SAMPLE CONCENTRATION AND PCR
    Verónica Calvo, M. Agirregabiria, L.J. Fernandez, A. Ezkerra, J. Berganzo, J. Elizalde
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    ABSTRACT: This paper reports on a novel two-chamber SU8 LabonaChip (LoC) for sample concentration, purification and Polymerase Chain Reaction (PCR). This typical sequence of reactions demands highly integrated microfluidic control. The burst valve concept presented in this work aims at addressing this problem, providing an integrated solution based on the controlled rupture of a vertical SU-8 wall. Owing to its vertical construction, the valve can be readily integrated into any geometry with low increase in footprint. A valve regulated double-chamber device for DNA concentration has been successfully fabricated and a full DNA concentration, elution and transportation protocol has been carried out.
    microTAS, Groningen (The Netherlands); 10/2010
  • Article: Fabrication and testing of a SU-8 thermal flow sensor
    R. Vilares, C. Hunter, I. Ugarte, I. Aranburu, J. Berganzo, J. Elizalde, L. J. Fernandez
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    ABSTRACT: In this work, a microthermal flow sensor integrated in a completely polymeric based microfluidic chip is presented. The fabrication process is based on photolithography of SU-8 layers to pattern the fluidic channels, surface treatment processes in order to improve adhesion of metal layer on top of the polymer, and the use of an adhesive bonding of two patterned SU-8 layers, allowing an easy packaging and integration with other SU-8 based devices like micropumps, microvalves, etc. Characterization of the device shows its successful performance detecting flows in the order of tens of μl/min, working at heater temperatures from 60 °C down to 40 °C. Moreover, the sensor exhibits a linear response at flows below 25 μl/min and the detection of volumes in the range of nanoliters. Such characteristics of the sensor are of great interest for its use in biological applications.
    Sensors and Actuators B: Chemical. 01/2010; 147(2):411 - 417.
  • Article: Fabrication and testing of a SU-8 thermal flow sensor
    R. Vilares, C. Hunter, I. Ugarte, I. Aranburu, J. Berganzo, J. Elizalde, L.J. Fernandez
    [show abstract] [hide abstract]
    ABSTRACT: In this work, a microthermal flow sensor integrated in a completely polymeric based microfluidic chip is presented. The fabrication process is based on photolithography of SU-8 layers to pattern the fluidic channels, surface treatment processes in order to improve adhesion of metal layer on top of the polymer, and the use of an adhesive bonding of two patterned SU-8 layers, allowing an easy packaging and integration with other SU-8 based devices like micropumps, microvalves, etc. Characterization of the device shows its successful performance detecting flows in the order of tens of μl/min, working at heater temperatures from 60 °C down to 40 °C. Moreover, the sensor exhibits a linear response at flows below 25 μl/min and the detection of volumes in the range of nanoliters. Such characteristics of the sensor are of great interest for its use in biological applications.
    Sensors and Actuators B: Chemical.
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