Hiroshi Mori

Gifu Pharmaceutical University, Gihu, Gifu, Japan

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Publications (29)12.73 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: In the present study, we investigated the effects of some anti-asthmatic drugs on the production of the CC chemokine, macrophage inflammatory protein-1α (MIP-1α), in response to lipopolysaccharide (LPS) by peripheral blood mononuclear cells (PBMC). MIP-1α production was induced by LPS in a concentration-dependent fashion and reached the maximum at 10 µg/ml LPS (27.5±2.3 ng MIP-1α/106 PBMC). At a submaximal concentration of LPS (1 µg/ml), the release of MIP-1α increased with time and reached the maximum 24 h after LPS stimulation. Actinomycin D and cycloheximide inhibited MIP-1α production completely, but glucocorticoids did not completely inhibit MIP-1α production, with a maximum inhibition of 70%. We examined the effect of β-stimulants and phosphodiesterase inhibitors, which upregulate intracellular cyclic AMP levels, on MIP-1α production. When PBMC were treated with β-stimulants alone, β-stimulants showed a slightly inhibitory effect on MIP-1α production. However, the coadministration of roliplam significantly potentiated the inhibitory effect of β-stimulants on MIP-1α production. Moreover, db-cAMP suppressed MIP-1α production dose-dependently. The above data indicate that the production of MIP-1α is regulated by cyclic AMP and that cyclic AMP could provide a useful target for therapeutic treatment in asthmatic diseases and other diseases where MIP-1α is involved in their etiology.
    Pharmacology 01/1998; 56(5):230-236. · 1.60 Impact Factor
  • Anti-cancer Drugs - ANTI-CANCER DRUG. 01/1997; 8(5).
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    ABSTRACT: KE-298 is a new immunomodulatory agent with a chemical structure similar to that of D-penicillamine. We compared the effects of KE-298 on type II collagen-induced arthritis (CIA) in mice with those of prednisolone. KE-298 at a dose of 25 mg/kg showed only a decrease in the progression of foot pad swelling. At doses of 50 and 100 mg/kg, however, KE-298 inhibited the severity and development of the collagen-induced arthritis index, the progression of foot pad swelling, bone damage and histopathological changes. These inhibitory effects were more pronounced at the dose of 50 mg/kg than at 100 mg/kg. KE-298 also significantly inhibited the delayed-type hypersensitivity (DTH) response to type II collagen, but did not affect the production of anti-type II collagen IgG antibody in arthritic mice. To determine the inhibitory mechanism of KE-298, we studied the effect of KE-298 on IL-1β and TNF-α production in mice. We found that KE-298 inhibited bacterial lipopolysaccharide (LPS)-induced IL-1β production at doses of 50 and 100 mg/kg. It inhibited the production of TNF-α at the dose of 50 mg/kg, but not at 100 mg/kg. In summary, at appropriate dosages, KE-298 inhibited CIA and TNF-α production in mice. KE-298 also inhibited the DTH reaction to type II collagen and LPS-induced IL-1β production in a dose-related fashion. These findings suggest that these effects of KE-298 are closely related to its immunomodulatory action.
    Pharmacology 01/1996; 53(3):190-196. · 1.60 Impact Factor
  • Japanese Journal of Pharmacology - JPN J PHARMACOL. 01/1995; 67(2):149-156.
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    ABSTRACT: We studied five new Antartic achondrites, MacAlpine Hills (MAC) 88177, Yamato (Y)74357, Y75274, Y791491 and Elephant Moraine (EET)84302 by mineralogical techniques to gain a better understanding of the mineral assemblages of a group of meteorites with an affinity to Lodran (stony-iron meteorite) and their formation processes. This group is being called lodranites. These meteorites contain major coarse-grained orthopyroxene (Opx) and olivine as in Lodran and variable amounts of FeNi metal and troilite etc. MAC88177 has more augite and less FeNi than Lodran; Y74357 has more olivine and contains minor augite; Y791491 contains in addition plagioclase. EET84302 has an Acapulco-like chondritic mineral assembladge and is enriched in FeNi metal and plagioclase, but one part is enriched in Opx and chromite. The EET84302 and MAC88177 Opx crystals have dusty cores as in Acapulco. EET84302 and Y75274 are more Mg-rich than other members of the lodranite group, and Y74357 is intermediate. Since these meteorites all have coarse-grained textures, similar major mineral assemblages, variable amounts of augite, plagioclase, FeNi metal, chromite and olivine, we suggest that they are related and are linked to a parent body with modified chondritic compositions. The variability of the abundances of these minerals are in line with a proposed model of the surface mineral assemblages of the S asteroids. The mineral assemblages can best be explained by differing degrees of loss or movements of lower temperature partial melts and recrystallization, and reduction. A portion of EET84302 rich in metal and plagioclase may represent a type of component removed from the lodranite group meteorites. Y791058 and Caddo County, which were studied for comparison, are plagioclase-rich silicate inclusions in IAB iron meteorites and may have been derived by similar process but in a different body.
    Meteoritics 12/1994;
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    ABSTRACT: Previous investigations of mineral chemistry and RbSr and SmNd ages indicated that clast,84 from eucrite Yamato 75011 had preserved the pristine nature of its initial crystallization during an early stage of the HED parent body. Microscale mineralogy and39Ar-40Ar ages of this clast, however, revealed local disturbance of micrtextures and partially reset ages. This evidence suggests that, in addition to initial crystallization and rapid cooling, the Y75011,84 clast experienced shock deformation, reheating of short duration at higher temperature, and brecciation. These characteristics suggest two or more impact events. Fe-rich olivine filling fractures in pyroxene may have been introduced during the accompanying shock fracturing. The inferred39Ar-40Ar degassing ages for Y75011 matrix and clast,84 are3.94 ± 0.04 Ga and3.98 ± 0.03 Ga, respectively. The suggested degassing age for a clast from Y790020, believed to be paired with Y75011, is ∼ 4.03 Ga, but could be younger. We consider it likely that all three samples experienced a common degassing event3.95 ± 0.05 Ga ago, but we cannot rule out two or more events spaced over a ∼ 0.1 Ga interval. Higher temperature extractions of the two clast samples show significantly older apparent ages up to ∼ 4.5 Ga and suggest that the time/temperature regime of this event was not sufficient to degas Ar totally. Most likely, the K-Ar ages were reset by thermal metamorphism associated with one or more impact events associated with shock fracturing, formation of Fe-rich olivine veins, and/or meteorite brecciation. The pyroxene annealing that commonly occurs in many eucrites is likely to be a much earlier process than the impact-produced textural changes and reset K-Ar ages observed in these meteorites. The existence of mineralogical and chronological evidence for metamorphism in an otherwise pristine eucrite suggests that the HED parent body experienced an extensive degree of early cratering.
    Earth and Planetary Science Letters. 01/1994;
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    ABSTRACT: It is well known that Corynebacterium parvum activates macrophages to produce tumor necrosis factor (TNF). It is suspected that the activation of macrophages by C. parvum requires T‐cell participation. The purpose of this study was to confirm that T cells participate in the activation of macrophages by C. parvum. TNF production in vitro from the spleen cells of BALB/c‐ + / + mice was abrogated completely by the pre‐treatment of spleen cells with anti‐Ia antiserum and complement, indicating that Ia+ cells are the source of TNF. TNF production was not elicited at all in BALB/c‐nu/nu mice. However, there was an increase in the number of Ia+ cells as well as an increase in the weight of spleen and liver. Supernatant from a culture of spleen cells stimulated with phytohemagglutinin‐P (a PHA‐induced lymphokine) made it possible for BALB/c‐nu/nu mice to produce TNF, associated with an induction of Lyt‐1+ cells and Lyt‐2+ cells. However, treatment with the lymphokine did not augment the increases of Ia+ cells or liver and spleen weights. These results suggest that increasing the number of Ia+ cells is not sufficient to bring about TNF production; Ia+ cells must also be stimulated by T cells or T‐cell lymphokines in order to produce TNF. These results suggest that T cells play an essential role in the activation of Ia+ cells against C. parvum.
    Microbiology and Immunology 01/1994; 38(12). · 1.55 Impact Factor
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    ABSTRACT: Our previous studies indicated that a newly synthesized 5-fluorouridine derivative, 2',3',5'- tris- O-[ N-(2- n-propyl- n-pentanoyl)glycyl]-5-fluorouridine (UK-21), revealed its antitumor activity by being converted to 5-fluorouridine (5-FUR) and showed a low level of immunological side effects. However, the bioavailability of UK-21 given orally did not seem to be good. In the present study, we focused on the antitumor and immunosuppressive activities of UK-21 given i.p. to mice. UK-21 suppressed the growth of L-1210, P388 and EL4 leukemias inoculated i.v. into corresponding syngeneic mice and both the growth of Lewis lung carcinoma transplanted s.c. and its subsequent metastasis to the lung. UK-21 showed antitumor activity at doses almost 10 times lower than those of 5-fluorouracil (5-FU). The side effects of UK-21, especially on immune functions, were examined in comparison with those of 5-FUR, 5-FU, and cyclophosphamide (CY) at doses producing comparable antitumor activity. The suppressive effect of UK-21 on IgM and IgG antibody formation in mice immunized with ovalbumin was clearly weaker than that of 5-FUR, 5-FU, and CY. The suppressive effect of UK-21 on thymus weight was markedly weaker than that of 5-FU and CY. The reduction of WBC counts induced by UK-21 was also lower than that produced by any other agent. The results reported herein suggest the strong possibility of UK-21 being developed as a novel anticancer drug with cytotoxic mechanisms different from those of 5-FU. Our study also points to the chemical modification of 5-FUR as a feasible way of developing new anticancer drugs.
    Cancer Chemotherapy and Pharmacology 01/1994; 34(3):216-224. · 2.80 Impact Factor
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    ABSTRACT: Mineralogy of kirschsteinite exsolution in olivine from Antarctic meteorite LEW86010 has been studied by single crustal X-ray diffraction technique. The LEW86010 olivine crystals have exsolution lamellae of kirschteinite about 15 microns wide. Determination of crystallographic orientation of exsolved kirschsteinite in an olivine grain has been made. Weak reflections of exsolved kirschsteinite share common crystallographic orientation with the host olivine. The cell dimensions of the exsolved phase (a - 4.87 plus or minus 0.05A, b - 11.14 plus or minus 0.10A, c - 6.36 plus or minus 0.05A) and intensities were in well accord with those of kirschsteinite previously reported. Oriented section perpendicular to the a axis shows exsolution lamellae in two directions parallel to (031) and (031). The lamellae are up to 10 microns in width and spacings between them are usually 50-100 microns.
    01/1993;
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    ABSTRACT: Polished thin sections of lunar meteorites EET87521 and Y793274, possibly derived from a mare region of the moon, have been analyzed for the mineral chemistries and textures. Basaltic components in both objects contain strongly zoned Fe-Ca-rich pyroxenes like those found in the VLT basalts. A mesostasis portion found in a basaltic clast of EET87521 consists of ilmenite, minor Cr-Ti spinel mantled by fayalite Fo10-prime, and fine-grained mixtures of hedenbergite and fayalite in contact with a silica mineral. Mg-rich materials are rare in EET87521 but abundant in Y793274. The latter contains the most Mg-rich clast found in lunar samples with orthopyroxene and ilemnite, a gabbroic clast with finely exsolved pigeonite, olivine, and plagioclase, and pyroxene clasts intermediate between those in the basaltic and the Mg-rich clast types. A pyroxene fragment in EET87521 shows exsolution lamellae of augite about 300 nm wide, which is consistent with mare basalt origin.
    01/1992; 22:355-364.
  • Japanese Journal of Pharmacology - JPN J PHARMACOL. 01/1992; 58(3):269-282.
  • Japanese Journal of Pharmacology - JPN J PHARMACOL. 01/1992; 59(4):469-476.
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    Hiromi Ogata, Hiroshi Mori, Hiroshi Takeda
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    ABSTRACT: Y74123 is an olivine-rich, relative unshocked ureilite and contains more interstitial pigeonitic materials than do ureilites which have been reported previously. These materials were studied by optical microscope, electron microprobe, SEM, high-resolution TEM, and analytical TEM to gain a better understanding of their nature and origin. The Y790981, with shock partial melts, has also been examined by the same techniques. Bulk chemical compositions of the interstitial materials in Y74123 are pyroxene-like and have higher CaO and Al2O3 contents than the large pigeonite and olivine core. Interstitial materials at olivine-pigeonite grain boundaries are richer in CaO and Al2O3 than those at olivine-olivine grain boundaries. TEM observations of the interstitial material of Y74123 show that it consists of alternating pigeonite-augite lamellae more than 3.5-micron thick on (001). This texture suggests that the rim material had already crystallized before the parent body breakup. The shock-produced glassy veins in Y790981 cut through the rim materials. These observations are consistent with the idea that the interstitial materials in this ureilite are a mixture of residual liquids of high Ca melts and shock-produced partial melts of olivine and pigeonite. This mixture accumulated along the grain boundaries and some of it is trapped within grains.
    Meteoritics 08/1991; 26:195-201.
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    ABSTRACT: The new lunar meteorite MAC88105 has been studied by mineral-chemical techniques and was compared with the Yamato lunar meteorites. Clast types and pyroxene compositions of MAC88105 indicate that evidence for a pairing with any known lunar meteorites is unlikely. Clast-laden vitric breccia and comminuted mineral fragments in glassy matrix are common components as in other lunar meteorites, but granulitic clasts are not as common as in other lunar meteorites. The large and common granulite-like meta-igneous clasts still preserve lath-shaped plagioclase crystals with fine-grained olivine and pyroxenes in the interstices. Pyroxenes with mg number = Mg × 100/(Mg + Fe) between 70-48 mol% are common, but more Mg-rich pyroxenes and plutonic pyroxenes from nonmare pristine crustal rocks are rare. One basaltic clast contains pyroxenes with zoning trends more Mg-rich than the above mg range and than those of the VLT basalts common in lunar meteorites. MAC88105 preserves true glass in the matrix as observed by a transmission electron microscope (TEM). The preservation of glassy materials indicates that MAC88105 had a metamorphic annealing history different from other lunar meteorites.
    Geochimica et Cosmochimica Acta 01/1991; · 3.88 Impact Factor
  • Hiroshi Mori, Hiroshi Takeda
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    ABSTRACT: A transmission electron microscopic (TEM) study was conducted to investigate the stress-induced transformation mechanisms of pigeonites from two achondrites. In pigeonites from the Allan Hills 77257 ureilite, abundant lamellae of orthopyroxene-pigeonite intergrowth accompanied by minor amounts of blebby augite precipitates were observed. In pigeonites from the Juvinas eucrite, some stacking faults running through the (001) augite lamellae were observed although most of the stacking faults terminated at the host-lamella interface. High resolution TEM observation shows the fringe offset produced by the stacking fault in the Juvinas pigeonites. The magnitude of the mismatch parallel to [001] is approximately c/4, which is related to the formation of the partial edge dislocation near the host-lamella interface. The partial dislocation is imaged as an edge dislocation with an (002) extra-plane. Three partial dislocation mechanisms with distinct displacement vectors are proposed in order to explain the stress-induced transformation textures observed in the achondritic pyroxenes. Further study will be required to determine unequivocally the mechanism of atomic displacements during stress-induced transformation. However, regardless of the actual mechanism of transformation, it is not difficult to convert orthopyroxene to clinopyroxene or vice versa by this transformation from the structural point of view. Low-Ca pyroxenes are deformed without a stress-induced transformation by slip at high temperature and geologically reasonable strain rates. However, meteoritic pyroxenes can be deformed by stress-induced transformation even at high temperature because preterrestrial impact processes will produce a deformation condition with high strain rates. Deformation at high strain rates and high temperature is very important when we interpret the microtexture of meteoritic pyroxenes.
    Physics and Chemistry of Minerals 01/1988; 15(3):252-259. · 1.30 Impact Factor
  • Hiroshi Takeda, Hiroshi Mori, Tokuhei Tagai
    National Institute Polar Research Memoirs. 03/1987;
  • Hiroshi Takeda, Hiroshi Mori, Hiromi Ogata
    01/1987;
  • Hiroshi Takeda, Hiroshi Mori, Tokuhei Tagai
    National Institute Polar Research Memoirs. 07/1986;
  • National Institute Polar Research Memoirs. 01/1984;
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    Hiroshi Takeda, Hiroshi Mori
    Meteoritics 12/1982;

Publication Stats

116 Citations
12.73 Total Impact Points

Institutions

  • 1994
    • Gifu Pharmaceutical University
      • Department of Pharmacology
      Gihu, Gifu, Japan
  • 1988–1992
    • The University of Tokyo
      Edo, Tōkyō, Japan