[show abstract][hide abstract] ABSTRACT: The PIENU experiment is going to be carried out at TRIUMF to measure the ratio of pion decay rates, R = Gamma(pi<sup>+</sup> rarr e<sup>+</sup> nu<sub>e</sub>)/Gamma(pi<sup>+</sup> rarr mu<sup>+</sup> nu<sub>mu</sub>), to an accuracy of 0.1%. In order to achieve this goal, a muon identification with waveform analysis in a target scintillator is necessary. Due to the short lifetime of pions, muon pulses tend to overlap onto the tail of pion pulses. Thus waveform analysis with a high frequency flash-ADC is essential for the identification and separation of muon pulses. We use the 500-MHz flash-ADC of the common pipelined platform for electronics readout system, which was developed at KEK, to readout waveforms from the target scintillator. Muon pulse identification capability of this flash-ADC system was investigated by artificial pulses simulating photomultiplier signals.
IEEE Transactions on Nuclear Science 09/2007; · 1.22 Impact Factor
[show abstract][hide abstract] ABSTRACT: The genomic sequence of the human GCMa/GCM1 gene, a mammalian homologue of Drosophila melanogaster GCM, was determined. Drosophila GCM is a neural transcription factor that regulates glial cell fate. The mammalian homolog however, is a placenta-specific transcription factor that is necessary for placental development. The 22 kb DNA sequence spanning the GCMa gene contains six exons and five introns, encoding a 2.8 kb cDNA. Overall genomic organization is similar for the human and mouse. Several potential binding sites for transcription factors like GATA, Oct-1, and bHLH proteins were found in the 5'-flanking region of the human gene. A DNA motif for GCM protein binding exists in the 5'-flanking region that is highly homologous with that of the mouse gene. The location of this gene was mapped to chromosome 6 using fluorescence in situ hybridization.
Biochemical and Biophysical Research Communications 12/2000; 278(1):134-9. · 2.41 Impact Factor
[show abstract][hide abstract] ABSTRACT: Six4, a member of the homeobox gene subfamily (Six), is expressed in a developmentally regulated fashion, and supposed to be involved in embryogenesis. We cloned the human SIX4 and murine Six4 genomic DNAs and determined their structures. The structure, including the 5' upstream region of both genes, was well conserved suggesting the conserved function and regulation of these genes. Human SIX4 was mapped to chromosome 14q23.
Cytogenetics and cell genetics 02/1999; 87(1-2):108-12.
[show abstract][hide abstract] ABSTRACT: The gastric acid output was studied in the 11 patients of hyperparathyroidism before and after parathyroidectomy. The gastric acid output before operation was almost equal to the normal control in our hospital. After the correction of serum calcium by parathyroidectomy, the gastric acid output and serum gastrin were decreased. The decreased gastric acid output was recovered as the days passed since operation and approached to the preoperative level. The acid output in hyperparathyroidism was less in the case whose activity of alkaline phosphatase was more, which suggested that the calcium deposition on gastric mucosa might damage the parietal cell as the result of long lasting hypercalcemia.
[show abstract][hide abstract] ABSTRACT: The present study was designed to produce the experimental carcinoma of the biliary tract in dogs. Tube cholecystostomy was constructed in 8 mongrel dogs and 5-10 ml of 0.7-1.0 mg/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered through the tube every day for the maximum period of 180 days. As the results: The experiment had to be cut off in 7 dogs (5 dogs: The tube was inadvertently pulled out. 2 dogs: died of general weakness). Pathological changes were observed in one dog given ENNG for 180 days and sacrificed at 372 days after the beginning of the experiment. Macroscopically, scattered foci of flat elevation of the mucosa were observed in the entire mucosal surface of common bile duct and a tiny polypoid lesion at the terminal protion. A tiny polypoid projection was adenocarcinoma confined to the mucosa, and areas of flat elevation showed marked hyperplasia of mucosa with partial atypical proliferation. No remarkable findings were noted in other organs.
[show abstract][hide abstract] ABSTRACT: Remakable progress has recently been made in the gastric punch biopsy under direct vision through the fiberscope, however, some tequnical problems are confronted today so far as usage of the forceps punch biotom. First difficulty to be solved is the mechanical limitations due to the biotom; good speciemens can only be obtained when the gastric mucosa situates at right angle to the forceps of the biotom. To find the sites which satisfy such condition, many X-ray films taken at the biopsy procedures were analysed of the angle between the biotom and the internal gastric wall. Main suitable sites for the biopsy were lesser and greater curvature of lower gastric body, gastric angle and some part of pylorus. From the other part of the gastric mucosa, good speciemens, which should contain muco-muscular layer, were hardly obtained. Even the speciemens taken form the above mentioned suitable biopsy sites, which we termed "Rightangle-biopsy-region," only 50~60% of them were good ones containing muco-muscular layer. Biopsy of pedunculated polyp is especially difficult to get by this procedure. To solve these mechanical limitations of the gastric punch biotom, we have been making effort to develop an aspiration biotom combined with the fiberscope. Another problem is lack of objectiveness in selection of the biopsy site, because only the examiner can see the site through the fiberscope. Inproving this aspect, we combined the fiberscope with the endoscopic television, through which the biopsy site can be recognized by many observers and be recorded in films or video-tapes. We also discussed abut the result of the duodenal fiberscopic biopsy by our newly developed endoscopic device.