K Watanabe

National Cancer Center, Tokyo, Tokyo-to, Japan

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Publications (417)593.99 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study investigated whether normal adults were able to discriminate agency from the perceived traces or trajectories of past actions such as handwritings. Subjects wrote two types of component parts of Chinese characters, either mastered and unmastered, and were later shown various handwritten strokes and judged whether each of them had been written by themselves or by someone else. We found that people tended to answer that the handwritings had been written by others when they saw unmastered types of strokes, while they tended to answer that the handwritings had been written by themselves when they saw mastered types of strokes. This finding suggests a tight interplay among perception, self-consciousness, and memorized action in the motor system and adds to our knowledge about a higher order representation level in the agency recognition. Possible cognitive neuroscientific implications and engineering applications of the finding are also discussed.
    Biometrics and Kansei Engineering (ICBAKE), 2011 International Conference on; 10/2011
  • Clinical Neurophysiology 06/2011; 122. · 3.14 Impact Factor
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    ABSTRACT: This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincristine 1 mg m(-2) on weeks 1, 2, 4, 6 and 8; and doxorubicin 40 mg m(-2) and etoposide 80 mg m(-2) on days 1-3 of weeks 1, 3, 5, 7 and 9. Patients went on to surgery and post-operative radiotherapy of 48 Gy; those with unresectable disease received 60 Gy radiotherapy. total of 23 patients were entered. The main toxicities of the chemotherapy regimen were neutropenia and anaemia, and 57% of patients completed the planned 9 weeks of therapy. There were no toxic deaths. Of the 21 eligible patients, 13 (62%) achieved a partial response (95% confidence interval: 38-82%). Thirteen patients underwent a thoracotomy and nine (39%) underwent complete resection. Progression-free survival at 2 and 5 years was 80 and 43%, respectively. Overall survival at 5 and 8 years was 85 and 69%, respectively. Survival did not seem to be affected by resection. In thymoma patients, weekly dose-dense chemotherapy has activity similar to that of conventional regimens. Although some patients could achieve complete resection, the role of surgery remains unclear.
    British Journal of Cancer 06/2010; 103(1):6-11. · 5.08 Impact Factor
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    ABSTRACT: Purpose: To evaluate the MR appearance of bone marrow during and after multiple fractionated and single-dose irradiation using SE sequences, with histopathological correlation. Material and Methods: the left hind limbs of Wistar rats were irradiated with doses of either 2 GyX10 fractions or 20 Gy as a single dose. MR images of the femora were taken on days 0, 1, 3, 5, 7, 10, 15, 20, 25, 30, 40, 50, 60, 90, 120, 150 and 180. T1-, proton-density- and T2-weighted images were obtained with SE sequences. the rats were sacrificed on days 3, 12, 40 and 180 for histological study. Results: No significant change in the T1 relaxation time was observed in the fractionated group during the first 15 days after irradiation. T2 did not change during the initial 7 days. There were significant differences in T1 and T2 between nonirradiated and fractionated, and between fractionated and single-dose irradiated marrows (p Conclusion: the T1 and T2 relaxation times of bone marrow receiving multiple fractionated irradiation did not change significantly on SE sequences during the early phase. However, dilatation of sinusoids, hemorrhage, decrease in cellularity, and increase in fat content were observed. Single-dose irradiation resulted in marked and early changes in T1 and T2 of the bone marrow.
    Acta Radiologica. 01/2010; 39(6).
  • Clinical Neurophysiology - CLIN NEUROPHYSIOL. 01/2010; 121.
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    ABSTRACT: In order to examine whether FcepsilonRI-dependent degranulation of intestinal mast cells is required for expulsion of intestinal nematode Strongyloides ratti, CD45 exon6-deficient (CD45-/-) mice were inoculated with S. ratti. In CD45-/- mice, egg excretion in feces persisted for more than 30 days following S. ratti larvae inoculation, whereas in wild-type (CD45+/+) mice, the eggs completely disappeared by day 20 post-infection. The number of intestinal mucosal mast cells, which are known effector cells for the expulsion of S. ratti, was 75% lower in CD45-/- mice compared with that in CD45+/+ mice. Adoptive transfer of wild-type T cells from CD45+/+ mice into CD45-/- mice reduced the duration of S. ratti infection to comparable levels observed in CD45+/+ mice, with concomitant increases in intestinal mucosal mast cells. These results showed that CD45 is not involved in the effector function of intestinal mucosal mast cells against S. ratti infection. Since FcepsilonRI-dependent degranulation of mast cells is completely impaired in these CD45 knockout mice, we conclude that FcepsilonRI-dependent degranulation is not required in the protective function of intestinal mucosal mast cells against primary infection of S. ratti.
    Parasite 09/2009; 16(3):209-14. · 0.82 Impact Factor
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    ABSTRACT: Safety and efficacy of intrapericardial (i.p.c.) instillation of bleomycin (BLM) following pericardial drainage in patients with malignant pericardial effusion (MPE) remain unclear. Patients with pathologically documented lung cancer, who had undergone pericardial drainage for MPE within 72 h of enrolment, were randomised to either arm A (observation alone after drainage) or arm B (i.p.c. BLM at 15 mg, followed by additional i.p.c. BLM 10 mg every 48 h). The drainage tube was removed when daily drainage was 20 ml or less. The primary end point was survival with MPE control (effusion failure-free survival, EFFS) at 2 months. Eighty patients were enrolled, and 79 were eligible. Effusion failure-free survival at 2 months was 29% in arm A and 46% in arm B (one-sided P=0.086 by Fisher's exact test). Arm B tended to favour EFFS, with a hazard ratio of 0.64 (95% confidence interval: 0.40-1.03, one-sided P=0.030 by log-rank test). No significant differences in the acute toxicities or complications were observed. The median survival was 79 days and 119 days in arm A and arm B, respectively. This medium-sized trial failed to show statistical significance in the primary end point. Although ipc BLM appeared safe and effective in the management of MPE, the therapeutic advantage seems modest.
    British Journal of Cancer 02/2009; 100(3):464-9. · 5.08 Impact Factor
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    ABSTRACT: This phase II study investigated the recommended dose (RD) of irinotecan (CPT-11) by dose escalation in elderly (>or=70 years) chemotherapy-naive Japanese patients with advanced non-small cell lung cancer. UGT1A1*28 and *6 polymorphisms and pharmacokinetics were also investigated. Thirty-seven patients received the RD, 100 mg/m(2) of intravenous CPT-11, on days 1 and 8 of each 3-week cycle in phase II. The overall response rate was 8.1%. The median survival time was 441 days, and time to progression was 132 days. A significant correlation was observed between the incidence of grade 3/4 neutropenia and area under the time-concentration curve (AUC) values of SN-38. A reduction in AUC ratios (AUC(SN-38G)/AUC(SN-38)) and a rise in incidence of grade 3/4 neutropenia were observed with increase in polymorphism. The regimen was well tolerated and provided good disease control and promising survival effects. An analysis of the influence of UGT1A1*28 and *6 polymorphisms provides useful information for the prediction of CPT-11-related hematological toxicity.
    Clinical Pharmacology &#38 Therapeutics 08/2008; 85(2):149-54. · 6.85 Impact Factor
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    ABSTRACT: Dissociated cells of pineal bodies of new-born rats were cultured to see what cell types would be differentiated during culture in vitro for about 4 weeks. In early stages of culture, about 10 days after inoculation, flattened cells with piliform processes, small round cells and small bubbling cells were distinguishable in the cultures. After about 2 weeks, neuronal cells with axon-like processes and multinuclear muscle-like cells were differentiated. On further culture, the latter cells differentiated into mature striated myotubes. The developmental origin of myotube formed in cell cultures of pineal body is discussed.
    Embryologia 07/2008; 23(3):221 - 227. · 2.21 Impact Factor
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    ABSTRACT: We compared the efficacy and the safety of a carboplatin plus etoposide regimen (CE) vs split doses of cisplatin plus etoposide (SPE) in elderly or poor-risk patients with extensive disease small-cell lung cancer (ED-SCLC). Eligibility criteria included: untreated ED-SCLC; age >/=70 and performance status 0-2, or age <70 and PS 3. The CE arm received carboplatin area under the curve of five intravenously (IV) on day 1 and etoposide 80 mg m(-2) IV on days 1-3. The SPE arm received cisplatin 25 mg m(-2) IV on days 1-3 and etoposide 80 mg m(-2) IV on days 1-3. Both regimens were given with granulocyte colony-stimulating factor support in a 21-28 day cycle for four courses. A total of 220 patients were randomised. Median age was 74 years and 74% had a PS of 0 or 1. Major grade 3-4 toxicities were (%CE/%SPE): leucopenia 54/51, neutropenia 95/90, thrombocytopenia 56/16, infection 7/6. There was no significant difference (CE/SPE) in the response rate (73/73%) and overall survival (median 10.6/9.9 mo; P=0.54). Palliation scores were very similar between the arms. Although the SPE regimen is still considered to be the standard treatment in elderly or poor-risk patients with ED-SCLC, the CE regimen can be an alternative for this population considering the risk-benefit balance.
    British Journal of Cancer 08/2007; 97(2):162-9. · 5.08 Impact Factor
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    ABSTRACT: Among four ethnic groups in a lowland area of Nepal, the prevalences of abnormal haemoglobin, thalassaemia, glucose-6-phosphate-dehydrogenase (G6PD) deficiency, hereditary South-east Asian ovalocytosis (SAO) and Duffy blood-group antigen Fy/Fy were determined and related to each group's habitat. The group that has lived for many decades in a malaria-endemic lowland area, the Danuwar, was found to have a high prevalence of alpha+-thalassaemia (79.4%) and low prevalences of haemoglobin E and G6PD deficiency. Much lower prevalences of alpha+-thalassaemia were observed in the Newar (20.5%), Parbate (16.5%) and Tamang (8.8%), who, until the 1950s, all spent their hot-season nights in malaria-free areas at higher altitudes. No subjects with any other identified abnormal haemoglobin, beta-thalassaemia, SAO or Fy/Fy were detected.
    Annals of Tropical Medicine and Parasitology 04/2007; 101(2):113-22. · 1.31 Impact Factor
  • Lung Cancer 07/2005; 49. · 3.39 Impact Factor
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    ABSTRACT: We propose a new nonvolatile MNOS memory using SiON instead of SiN for embedded application, which has high performance and high reliability due to enhanced gate hole injection during erasure and better control of electron conduction in trapping materials during data retention. The increase in hole injection leads to fast and deep erase, which doubles the read-out current. Moreover, there is no erase degradation during program/erase cycling. The electron-conduction control significantly improves the data-retention characteristics, ensuring a 10-year retention lifetime at 180°C.
    Electron Devices Meeting, 2004. IEDM Technical Digest. IEEE International; 01/2005
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    ABSTRACT: To describe ocular manifestations in patients with microscopic polyangiitis. Two patients with microscopic polyangiitis complained of ocular symptoms and underwent ophthalmologic examinations. An 83-year-old woman (Case 1) was diagnosed with microscopic polyangiitis, according to the general clinical findings and the presence of perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA). She had hypopyon iridocyclitis in the right eye and retinal cotton-wool spots in the left eye. The patient was treated with oral prednisolone and subconjunctival betamethasone. The hypopyon iridocyclitis and retinal cotton-wool spots responded. A 79-year-old man (Case 2) had bilateral scleritis. The diagnosis of microscopic polyangiitis was made based on general clinical findings and the presence of P-ANCA. Scleritis was reduced after corticosteroid treatment. Ophthalmologists should be aware that hypopyon iridocyclitis, cotton-wool spot, and scleritis could occur in patients with microscopic polyangiitis.
    European journal of ophthalmology 01/2005; 15(1):138-42. · 0.91 Impact Factor
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    ABSTRACT: To evaluate the efficacy and safety of treatments for advanced non-small-cell lung cancer in elderly patients aged 75 years or older, we conducted a phase II study of cisplatin and docetaxel administered in three consecutive weekly infusions. The eligibility criteria for the study included the presence of chemotherapy-naive advanced non-small-cell lung cancer, age > or =75 years, Eastern Cooperative Oncology Group performance status of 0 or 1, a measurable lesion, adequate organ functions and signed informed consent. The chemotherapy regimen consisted of cisplatin (25 mg/m(2)) and docetaxel (20 mg/m(2)) on days 1, 8 and 15 every 4 weeks. Between February 2000 and March 2002, 34 elderly patients with non-small-cell lung cancer were enrolled in the study and 33 patients were treated. Two complete responses and 15 partial responses were obtained for an objective response rate of 52% in 33 treated patients. The median survival period was 15.8 months, and the 1-year survival rate was 64%. Toxicities were mild with no grade 4 toxicities. Only grade 3 leukopenia (6%), neutropenia (12%), anemia (3%), hyponatremia (3%) and nausea/vomiting (3%) were observed. Cisplatin and docetaxel administered in three consecutive weekly infusions was safe and effective for the treatment of elderly patients with chemotherapy-naive non-small-cell lung cancer.
    Annals of Oncology 01/2004; 15(1):45-50. · 7.38 Impact Factor
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    ABSTRACT: To determine the role of interleukin-5 (IL-5) and eosinophils in protection against Strongyloides ratti, mice treated with anti-IL-5 monoclonal antibody (mAb) were infected with S. ratti larvae. Strongyloides ratti egg numbers in faeces (EPG) in mAb treated mice were higher than those in control mice on days 6 and 7 after inoculation. The numbers of migrating worms in mAb treated mice 36 h after inoculation were higher than those observed in control mice. Intestinal worm numbers in mAb treated mice 5 days after inoculation were higher than those in control mice. These results show that eosinophils effectively protected the host against S. ratti infection by mainly the larval stage in primary infections. The involvement of eosinophils in protection against secondary infection was also examined. Before secondary infection, mice were treated with anti-IL-5 mAb and infected with S. ratti. Patent infections were not observed in either mAb treated or control Ab treated mice. The numbers of migrating worms in the head and lungs of mAb treated mice increased to 60% of that in primary infected mice. Intestinal worms were not found in mAb treated mice or in control mice after oral implantation of adult worms. Eosinophils were therefore mainly involved in protection against tissue migrating worms in secondary infections.
    Journal of Helminthology 01/2004; 77(4):355-61. · 1.16 Impact Factor
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    ABSTRACT: Negative Bias Temperature Instability (NBTI) of pMOSFETs with direct-tunneling gate dielectrics was studied in detail. By investigating the effects of positive bias stress on pMOSFETs after exposure to NBT stress, the generation of bulk charge traps in the gate dielectrics during NBT stress was clearly demonstrated for the first time. We consider that the bulk trap generation is due to hydrogen atoms released from the interface. Moreover, we investigated the impact of the bulk traps on the SILC and TDDB, and described strong indications that the same mechanism, namely the hydrogen release, is responsible for both NBTI and TDDB of pMOSFETs.
    VLSI Technology, 2003. Digest of Technical Papers. 2003 Symposium on; 07/2003
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    ABSTRACT: The negative bias temperature instability (NBTI) of pMOSFETs with ultra-thin gate dielectrics was investigated from four points of view: basic mechanism of NBTI, dependence of NBTI on gate dielectric thickness, mechanism of NBTI enhancement caused by addition of nitrogen to the gate dielectrics, and possibility of applying SiON gate dielectrics with a high concentration of nitrogen. By investigating the behavior of FET characteristics after NBT stresses were stopped, it was clarified that a portion (60%, in our case) of hydrogen atoms released by the NBT stress remains in the gate dielectric in the case of a 1.85-nm-thick NO-oxynitride gate dielectric. The existence of the hydrogen was shown to lead to the generation of positive fixed charges in the gate dielectric. It was also found that NBTI depends little on gate dielectric thickness. Moreover, we revealed that the origin of NBTI enhancement by incorporating nitrogen into gate dielectrics is the property of attracting H<sub>2</sub>O or OH. We speculate that this property is due to the existence of positive fixed charges induced by undesirable nitrogen. We evaluated NBTI immunity of SiN gate dielectrics with an oxygen-enriched interface (OI-SiN) in which high carrier mobility was obtained by reducing positive fixed charges. OI-SiN gate dielectrics with EOTs of 1.4 and 1.6 nm were found to have sufficient lifetime for practical use under 1 V operation.
    Reliability Physics Symposium Proceedings, 2003. 41st Annual. 2003 IEEE International; 01/2003
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    ABSTRACT: We demonstrate a new mode of Hot-Carrier (HC) degradation of p-MOSFETs. A positive feedback HC degradation caused by positive fixed oxide charge increasing the electric field at the drain edge is observed. When TTL AC stress (HC and NBT stress one after another) is applied, this degradation is enhanced. It is assumed that NBT stress produces positive fixed oxide charges easily (NBT-induced HC degradation). It is also shown that this new degradation can be suppressed by halo design.
    Reliability Physics Symposium Proceedings, 2002. 40th Annual; 02/2002
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    ABSTRACT: We studied the clinical effect of recombinant human erythropoietin (r-huEPO) on anemia induced by two courses of cisplatin-based chemotherapy in patients with non-small cell lung cancer (NSCLC). Seventy-two patients with NSCLC were randomized into three groups, receiving 100, or 200 IU/kg of r-huEPO, or placebo. The r-huEPO and placebo were administered subcutaneously three times a week for 6 weeks, starting 2 weeks after the initiation of chemotherapy. In the 53 evaluable patients, hemoglobin (Hb) levels at the nadir after the second cycle of chemotherapy were significantly elevated compared with the nadir after the first cycle in both r-huEPO treated groups, while this level was decreased in the placebo group. Hb levels at the end of the second course of chemotherapy (week 8) in both r-huEPO groups were higher than that in the placebo groups. No adverse drug reaction attributable to r-huEPO was observed. Serum erythropoietin levels after the administration of r-huEPO were higher than those after placebo administration. r-huEPO had an effect in preventing anemia in patients with NSCLC who had cisplatin-based chemotherapy.
    International Journal of Clinical Oncology 01/2002; 6(6):296-301. · 1.73 Impact Factor

Publication Stats

3k Citations
593.99 Total Impact Points

Institutions

  • 2009–2010
    • National Cancer Center
      • Center for Cancer Control and Information Services
      Tokyo, Tokyo-to, Japan
  • 1983–2009
    • Kyushu University
      • • Faculty of Medical Sciences
      • • Division of Pathobiology
      Fukuoka-shi, Fukuoka-ken, Japan
  • 2008
    • Shizuoka Cancer Center
      Sizuoka, Shizuoka, Japan
  • 2001–2004
    • Nagasaki University
      • Department of Parasitology
      Nagasaki-shi, Nagasaki-ken, Japan
  • 2002
    • Saitama Cancer Center
      Saitama, Saitama, Japan
  • 1993–2001
    • Himeji Institute of Technology
      • Faculty of Science
      Himezi, Hyōgo, Japan
    • Jichi Medical University
      • Division of Anatomy
      Totigi, Tochigi, Japan
  • 2000
    • Fujita Health University
      • Division of General Thoracic Surgery
      Nagoya, Aichi, Japan
    • Niigata Cancer Center Hospital
      Niahi-niigata, Niigata, Japan
    • Toyama Medical and Pharmaceutical University
      Тояма, Toyama, Japan
  • 1999
    • Kobe University
      Kōbe, Hyōgo, Japan
  • 1997
    • Kokura Memorial Hospital
      Kitakyūshū, Fukuoka, Japan
    • Tokyo Metropolitan Institute
      Edo, Tōkyō, Japan
  • 1991–1996
    • Noguchi Thyroid Clinic and Hospital Foundation
      Бэппу, Ōita, Japan
  • 1995
    • Toyohashi Municipal Hospital
      Toyohasi, Aichi, Japan
  • 1994–1995
    • Kohnan Hospital
      Sendai, Kagoshima, Japan
  • 1988–1992
    • National Institute for Basic Biology
      Okazaki, Aichi, Japan
  • 1985
    • Kyoto University
      • Department of Physics I
      Kyoto, Kyoto-fu, Japan