Hiromasa Yabe,
Hiroyasu Inoue,
Masae Matsumoto,
Satoshi Hamanoue,
Takashi Koike,
Hiroyuki Ishiguro,
Hideki Koike, Kazuo Suzuki,
Shunichi Kato,
Seiji Kojima,
Masahiro Tsuchida,
Tetsuya Mori,
Souichi Adachi,
Koichiro Tsuji,
Kenichi Koike,
Akira Morimoto,
Masahiro Sako,
Miharu Yabe
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ABSTRACT: A pilot study was undertaken using a fludarabine-based conditioning regimen to improve haematopoietic cell transplantation (HCT) from alternative donors in 27 Fanconi anaemia (FA) patients. Patients were conditioned with 150-180 mg/m2 of fludarabine, 40 mg/kg of cyclophosphamide, 5-10 mg/kg of antithymocyte globulin, and 300-450 cGy of thoracoabdominal/total body irradiation. One patient who received unrelated cord blood transplantation failed to engraft, another patient died of sepsis. The 1-year overall survival was 96.3% (95% CI, 89-100). This conditioning regimen exerted an immunosuppressive effect that enabled durable engraftment in alternative donor HCT without severe toxicity.
British Journal of Haematology 08/2006; 134(2):208-12. · 4.94 Impact Factor
