Publications (3)5.16 Total impact
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Article: Cytokeratin expression in pilonidal sinus.
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ABSTRACT: Pilonidal sinus (PS) is considered to belong in the category of follicular occlusion diseases (acne triad). The aim of our study was to elucidate the pathogenesis of PS by evaluating its cytokeratin (CK) expression. CK expression in nine cases of PS was studied immunohistochemically using six antikeratin antibodies. Infundibular-like epithelium contained CK1, 10 and 14 similar to normal infundibulum, but it did not contain CK17. In non-infundibular-like epithelium, CK14, 16 and 17 were detected similar to that in normal outer root sheath. CK expression in PS was similar to that in hidradenitis suppurativa, suggesting that sinus epithelium may be fragile, hyperproliferative and undifferentiated. PS can be classified in the same entity as follicular occlusion diseases based on CK expression.British Journal of Dermatology 04/2002; 146(3):409-13. · 3.67 Impact Factor -
Conference Proceeding: A new scheme of case-based decision support systems by using DEA and GA techniques
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ABSTRACT: We propose a new scheme for case-based decision support systems (DSS) using data envelopment analysis (DEA) and genetic algorithms (GA). The application field for our scheme is cases of multiple input-output activity in which the efficiency of the outputs is evaluated. The case-based DSS offer activity-policy which reflects any level, both of the efficiency and features in the activity, referring to many past cases in the same area. Our scheme is based on two procedures, an analysis procedure and an estimation procedure. In the analysis procedure, all the cases are recursively evaluated by solving the modified model of DEA, i.e., the generalized BCC model. The remaining cases, except for cases belonging to the efficiency frontier, are also evaluated by the generalized BCC model, and the processing is repeated. After the analysis procedure, it is possible to classify the cases into multiple hierarchies by level of efficiency, and also into the groups with common features between inputs and output, which cover multiple hierarchies. In the estimation procedure, according to past cases, features, frontier levels, and required conditions, any solution set of future activity plans is searched by a GA with a fitness function using these factors. After the estimation procedure, the user controls the variety of required conditions about past cases of activity, and finally chooses the future planSystems, Man, and Cybernetics, 1999. IEEE SMC '99 Conference Proceedings. 1999 IEEE International Conference on; 02/1999 -
Article: Pyodermia chronica glutealis complicated by acromegalic gigantism.
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ABSTRACT: We report a case of pyodermia chronica glutealis complicated by acromegalic gigantism associated with hyperprolactinemia. The serum prolactin, growth hormone, adrenocorticotropic hormone, and 11-deoxycortisol levels were elevated, but the estradiol and dehydroepiandrosterone-sulphate levels were within normal limits. However, the testosterone level was very low. Histopathologically, we found sinus tracts and scarring in a specimen from the buttocks. We could not immunohistochemically detect clear androgen, growth hormone, or prolactin receptors at any site. The patient was a man with a height of 197 cm and weight of 140 kg, he had clinical features of active acromegaly such as excessive sweating and increased thickness of soft tissue. He was also diagnosed with diabetes mellitus. Under such conditions, bacteria could easily grow and lesions might have been aggravated by the heavy pressure from his weight, a possible causes of his pyodermia chronica glutealis.The Journal of Dermatology 05/1998; 25(4):242-5. · 1.49 Impact Factor
