K. Mukai

National Institute of Radiological Sciences, Tiba, Chiba, Japan

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Publications (6)7.19 Total impact

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    ABSTRACT: Experimentally measured cross sections are presented for the Cu-nat(alpha, xn)Ga-66,Ga-67,Ga-68 and Zn-68(p, xn)Ga-67,Ga-68 nuclear processes up to 36 and 20 MeV, respectively. Based on these results and the reliable cross section data available in the literature, the possible thick target yields were also calculated. Two different Ga-68 production routes (Cu+alpha and Zn+p) are discussed in detail, especially with regard to the Ga-66 and Ga-67 contamination levels as a function of the target enrichment level and the incident bombarding energies. Both processes can be used for in-house Ga-68 production with low (<1%) Ga-66 and/or Ga-67 EOB contamination using enriched Zn-68 (>80%) or Cu-65 (>95%) target. The maximum available yield on 100% enriched Zn-68 and Cu-65 (irradiation time: 2.25 h; bombarding energy: E-p = 20 MeV and E-alpha = 18 MeV) is 352.45 mCi/mu A (13.04 GBq/mu A) and 14.28 mCi/mu A (528.36 MBq/mu A), respectively.
    Radiochimica Acta 01/2012; 100:5-10. DOI:10.1524/ract.2011.1896 · 1.41 Impact Factor
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    ABSTRACT: The production possibility of four medically important copper radioisotopes via Zn + p reactions was studied up to 80 MeV. Based on experimentally evaluated excitation function curves of the 64Zn(p,x)61Cu, natZn(p,x)62Zn → 62Cu, 66Zn(p,2pn)64Cu, 68Zn(p,x)64Cu and 68Zn(p,2p)67Cu reactions, production energy windows are recommended for the 61Cu, 62Cu, 64Cu and 67Cu isotopes. The available yields for these radioisotopes as well as the predicted yields of the major radiocontaminants are also presented.
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    ABSTRACT: The goal of this study was to develop an improved (62)Zn/(62)Cu generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use. A natural Cu target was irradiated with proton beam in the energy range of 30-->19 MeV at a beam current of 10 muA for 1 h to obtain around 1.7 GBq of (62)Zn. The (62)Zn was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The (62)Zn/(62)Cu generator was prepared by loading the (62)Zn(2+) on a Sep-Pak plus CM cartridge. The generator showed high elution efficiency ( approximately 96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of (62)Zn (<0.1%). This (62)Zn/(62)Cu generator has been proven to be highly useful as a source of (62)Cu for the synthesis of (62)Cu-labeled compounds. The clinical application of [(62)Cu]Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences.
    Nuclear Medicine and Biology 09/2006; 33(6):821-7. DOI:10.1016/j.nucmedbio.2006.05.003 · 2.41 Impact Factor
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    ABSTRACT: Cross-sections of the 66Zn(p,2pn)64Cu and 68Zn(p,x)64Cu nuclear processes were measured on highly enriched zinc targets using the stacked-foil activation technique up to 100 MeV. The new cross-sections were compared to literature data. The optimum energy range for production of 64Cu was found to be 70 → 35 MeV on 66Zn and 37 → 20 MeV on 68Zn. The thick-target yields were determined as 777 MBq/μAh (21.0 mCi/μAh) and 185 MBq/μAh (5.0 mCi/μAh), respectively. The yields of the longer-lived contaminant copper radioisotopes (i.e. 61Cu when using 66Zn as target material and both 61Cu and 67Cu in the case of 68Zn target material) were also calculated. The results obtained from the present study indicate that both reactions are suited for the production of 64Cu at a medium energy cyclotron. The optimum energy ranges are also complementary therefore the potential to utilize tandem targetry exists.
    Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 11/2005; 240(3):625-637. DOI:10.1016/j.nimb.2005.05.057 · 1.12 Impact Factor
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    ABSTRACT: Excitation functions were measured for the 66Zn(p,n)66Ga, 68Zn(p,3n)66Ga, natZn(p,x)66Ga, 68Zn(p,2n)67Ga and natZn(p,x)67Ga nuclear processes up to 100 MeV. These results were compared to the available cross-section values from previous studies. A detailed compilation of the earlier works was also performed.
    Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 07/2005; 234(4):375-386. DOI:10.1016/j.nimb.2005.02.011 · 1.12 Impact Factor
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    ABSTRACT: Excitation functions for 60Cu and 61Cu radioactive nuclei produced in 3He bombardment of 59Co up to 70 MeV has been measured using the stacked-foil activation technique. The experimental cross-sections of the 59Co(3He,2n)60Cu and 59Co(3He,n)61Cu nuclear reactions were compared with published literature data. Our yield calculations with respect to the application of the above reactions for practical production of 60Cu showed that around 3.1 mCi/μA 60Cu yield is available at EOB in the energy range 26→10 MeV (supposing one half-life of 60Cu activation time). Unfortunately, the level of 61Cu impurity increases continuously after EOB (1.4% at EOB), but remains around 4% even at the end of a PET study (supposing one half-live cooling (processing) time and around 20 min counting time with PET). On the bases of the present work the Co+3He route seems to be a good candidate for routine production of 60Cu even with a low energy multiparticle cyclotron.
    Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 08/2004; 222(3):364-370. DOI:10.1016/j.nimb.2004.03.013 · 1.12 Impact Factor