K. Javidnia

Shiraz University of Medical Sciences, Chimaz, Fārs, Iran

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Publications (26)25.81 Total impact

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    ABSTRACT: Ohmic and microwave assisted hydrodistillation (OAHD and MAHD, respectively) are advanced hydrodistillation (HD) techniques utilizing ohmic and microwave heating processes for extraction of essential oils. OAHD and MAHD of essential oils from the aerial parts of peppermint were studied and the results were compared with those of the traditional HD. The results showed that OAHD and MAHD methods require less than half an hour for extraction process while HD require about one hour. Scanning electron microscopy of mint leaves undergone OAHD and MAHD provided evidences as to a sudden rupture of essential oil glands. GC-MS analysis did not indicate any noticeable changes in the compounds of the essential oils obtained by novel studied methods in comparison with HD. The results introduced OAHD as the greenest technique in terms of energy consumption. MAHD was superior in terms of rate of essential oils accumulation and also extraction duration parameter.
    Food and Bioproducts Processing 01/2015; 94. · 1.86 Impact Factor
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    ABSTRACT: Apple leather is made by dehydration of cooked fruit into leathery sheets. Mould growth and patulin production can occur in damaged apples or when fallen fruit is collected for apple leather processing. A survey was conducted to determine levels and dietary intake of patulin from apple leather marketed in Iran. Patulin was detected in all samples at concentrations ranging from <10 to 2559 µg/kg. Mean patulin concentration was 620 µg/kg and 91.4% of the samples had levels higher than 50 µg/kg. Estimated daily intake (EDI) of patulin for adults and children considering the mean concentration of patulin obtained in this study (620 µg/kg) were higher than the provisional maximum tolerable daily intake (PMTDI) of 0.4 µg/kg bw/day for patulin that has been established by the Joint FAO/WHO Expert Committee on Food Additives. This indicated the need for stricter control and improvement in processing techniques to reduce the incidence of patulin in apple leather.
    Food Additives and Contaminants: Part B Surveillance 06/2014; 7(2):106-109.
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    ABSTRACT: In the extraction process of essential oils (EOs), one of the major problems of traditional methods is long extraction times. Ohmic-assisted hydrodistillation (OAHD) is a specific hydrodistillation (HD) technique utilizing ohmic heating to generate heat faster and in a different form from traditional methods. OAHD was applied as a novel technology for the isolation of EO from the aerial parts of Myrtus communis L. (myrtle) and the results were compared with those of the conventional HD. The results showed that OAHD method had an extraction time of 26.11 minutes while this value was more than 1 hour for HD for approximately the same amount of EO recovery (0.7% v/w). Gas chromatography–mass spectrometry (GC–MS) analysis did not indicate any noticeable changes in the constitutes of the EO obtained by OAHD in comparison with HD and the major compound of EOs was 1,8-cineol. The proposed method required considerably less energy per mL of EO extraction and the results of this study revealed the innovative OAHD as an environmentally friendly technology.
    Journal of Essential Oil Research 08/2013; 25(4):257-266. · 0.82 Impact Factor
  • Annals of Biological Research. 01/2013; 4(8):85-89.
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    ABSTRACT: Ohmic-assisted hydrodistillation (OAHD) is an advanced hydrodistillation (HD) technique utilizing ohmic heating process and could be considered as a novel method for the extraction of essential oils. One of the major problems with traditional methods is long extraction time. OAHD of essential oils from the aerial parts of Thymus vulgaris L. (common thyme) was studied and the results were compared with those of the conventional HD. The results showed that OAHD method had the extraction time of 24.75 min while this value was about 1 h for HD. Scanning electron micrographs of thyme leaves showed a sudden eruption of essential oil glands and their surrounding area for OAHD samples. GC–MS analysis did not indicate any noticeable changes in the compounds of the essential oils obtained by OAHD in comparison with HD. Results of this study introduced OAHD as a green technology because of less energy required per ml of essential oil extraction.Industrial relevanceThe quality and quantity of essential oils extracted from herbs and other raw materials are affected by the extraction method. In this research ohmic-assisted hydrodistillation (OAHD) was used as an advanced and novel hydrodistillation (HD) technique and compared with traditional hydrodistillation in extraction of essential oils from the aerial parts of Thymus vulgaris L. (common thyme). OAHD method was quicker, more economical and environmentally friendly than hydrodistillation method. The results of this study introduced OAHD as a green technology.
    Innovative Food Science & Emerging Technologies 04/2012; 14:85-91. · 2.25 Impact Factor
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    ABSTRACT: Ohmic-assisted hydrodistillation (OAHD) is a combination of ohmic heating and distillation, and could be considered as a novel method for the extraction of essential oils. Major problems with traditional methods are long extraction time and lower purity of the extract. In this study, OAHD was applied as an economic and green technology for the extraction of essential oils from Zataria multiflora Boiss. (Shirazi thyme) aerial parts and the results were compared to those obtained from hydrodistillation (HD) as a conventional method. The results showed that OAHD method had the extraction time of 32.21 ± 2.59 min while this value was about 57.21 ± 2.33 min for hydrodistillation (HD). Scanning electron micrographs of thyme leaves showed a sudden eruption of essential oil glands and their surrounding area for OAHD samples. GC–MS analysis indicated that both methods of OAHD and HD can extract the same compounds.
    International Journal of Food Science & Technology 12/2011; 46(12). · 1.35 Impact Factor
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    ABSTRACT: Cited By (since 1996):1, Export Date: 18 October 2014
    Advances in Environmental Biology 01/2011; 5(8):2326-2331.
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    ABSTRACT: Hyperhomocysteinemia is a hypothesis for the association of homocysteine with cerebrovascular diseases, neurodegenerative diseases and depression of mood. Thus, we examined whether oral betaine can act as a preventive agent in ethanol-induced hyperhomocysteinemia on the monoaminergic system. A total of 32 New Zealand White rabbits were divided into four groups (n=8) among which is the control group (C). The ethanol group (E) was administered ethanol at a dosage of 4 g/kg daily. The betaine group (B) received betaine at a dosage 1.5% (w/w) of the diet daily, and the betaine and ethanol group (B and E) was administered with the betaine group diet; after one hour the rabbits received ethanol at a dosage of 4 g/kg daily. Blood samples were taken in the morning of the day before beginning treatment (0.0 day) and on the 30th, 60th and 90th day of the treatment. Serum folate and vitamin B12 levels were determined using a radioimmunoassay, total plasma homocysteine (tHcy) level was determined by homocysteine EIA kit, and 5-hydroxyindoleacetic acid (5-HIAA) of plasma was measured with HPLC-ECD. There was a significant negative correlation between 5-HIAA and tHcy in the E group (r=-0.473, P=0.02), and compared to the E group the concentrations of 5-HIAA in the B and E group increased considerably (p<0.05). In contrast to the E group, significantly high concentrations of 5-HIAA were observed in the B and C groups. While the serum concentrations of vitamin B12 showed no significant difference in the B and E group on the 90th day compared to the control group, the serum concentrations of folate on the 90th day differed significantly (p<0.05). However, no significant difference was observed between tHcy and gender. Overall, oral pretreatment with betaine significantly prevented ethanol-induced hyperhomocysteinemia, subsequently increasing 5-HIAA in the plasma as well as vitamin B12 and folate in the serum. Thus, betaine may be recommended as a pretreatment method for depressive patients with alcoholism.
    African Journal of Biochemistry Research. 12/2010; 4:246-254.
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    ABSTRACT: Essential oil composition of Otostegia persica Boiss. (Lamiaceae) from Iran was obtained by hydrodistallation and analyzed by GC and GC/MS techniques. Forty-four components representing 89.3% of the total oil were identified. The main components of the oil were dillapiole (43.1%), trans-verbenol (9.6%) and hexadecanoic acid (5.7%).
    Journal of Essential Oil Research 11/2010; 22(6):609-610. · 0.82 Impact Factor
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    ABSTRACT: Betaine has been shown to protect the body by increasing S-adenosyl methionine levels in experimental animals. Therefore, we investigated the preventive effect of betaine on ethanol-induced hyperhomocysteinemia in a rabbit animal model. A total of 32 New Zealand white rabbits were divided into four equal groups (control, ethanol, betaine, and betaine and ethanol) with different dietary regimens and were followed up for 3months. The day before the beginning, the 30th, 60th, and 90th days of the treatment, blood samples were collected from the marginal ear vein. Plasma total homocysteine was determined by an Axis® Homocysteine EIA kit, and a SimulTRAC-SNB Radioassay kit ([57Co]/folate [125I]) was used to determine folate and vitamin B12 in the serum. Ethanol-induced hyperhomocysteinemia was manifested by a decrease in the levels of vitamin B12 and folate with a concomitant increase in the level of total homocysteine (tHcy) for the ethanol group only. While vitamin B12 showed no significant difference in the betaine and ethanol group on the 90th day compared to the control group, the concentration of folate differed significantly (p < 0.05). There was a significant difference only on the 90th day between the ethanol and the other groups for tHcy (p < 0.05); however, no significant difference was observed between tHcy and gender. Taken together, the present study indicates that the protective effect of betaine is related to the ability to promote the betaine homocysteine methyl transferase pathway by providing the methyl group and subsequently increase B12 and folate. Therefore, this investigation recommends the use of the beneficial properties of betaine as a pretreatment method for alcoholics. KeywordsBetaine-Hyperhomocysteinemia-Ethanol-Vitamin B12 -Folate-Rabbit
    Comparative Clinical Pathology 08/2010;
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    ABSTRACT: The essential oils of Phlomis aucheri and Phlomis elliptica have been investigated by GC and GC/MS. Thirty-nine compounds of Ph. aucheri and fifty-eight of Ph. elliptica representing 91.2% and 90.1% of the oil samples were identified, respectively. Caryophyllene-type compounds comprised 63.8% of the oil of Ph. aucheri and the main constituents of this oil were caryophyllene oxide (33.5%), β-caryophyllene (27.0%) and β-selinene (10.2%), while for Ph. elliptica, the dominant structures were aliphatic hydrocarbons with hexadecanoic acid (19.1%), linoleic acid (10.2%) and β-selinene (9.9%) as the predominant compounds.
    Journal of Essential Oil Research 07/2010; 22(4):314-317. · 0.82 Impact Factor
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    ABSTRACT: The essential oil of Tanacetum macrophyllum growing wild in Turkey was obtained by hydrodistillation, and antimicrobial activity of the essential oil was tested against six bacteria and two yeasts including Candida albicans and Aspergillus niger by disc diffusion method. Further the oil of this plant was analyzed by GC and GC/MS technique. Best effect of the oil was against pseudomonas earuginosa. Twenty-eight components, representing 95.6% of the total oil, were identified. The main component of the oil was β-eudesmol (89.5%). The antioxidant activity of the essential oil was measured by the ferric reducing antioxidant power (FRAP) assay.
    Journal of Essential Oil Research 03/2010; 22(2):186-188. · 0.82 Impact Factor
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    V Rowshan, M Khosh Khoi, K Javidnia
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    ABSTRACT: The essential oil of Salvia macrosiphon Boiss use as a folk medicine. The effect of Exogenous application of salicylic acid (0 , 200 , 4oo mgL -1) in early flowering stage on components of essential oils of Salvia was evaluated. Its essential oil was analyzed by GC and GC/MS .The SA application increased Linalool from 20.02% (0 mgL -1) to 41.37% (400 mgL -1) , Hexyl isobutanat from 3.17%(0 mgL -1) to 5.6% (400 mgL -1) and decrease δ -cadinen from 5.63% (0 mgL -1) to 3.86% (400 mgL -1) . Some compounds such as Franesol, δ –Amorphene, Caryophyllene oxide, Hexyl octanoate, Beta Eudesmol and α-Bisabolol only detected in control treatment. α – Pinene and 1,8-Cineol only detected in plants treated with SA.The yield of essential oil was 0.23% in (0 mgL-1) and 0.48% (400 mgL-1). The results suggest that SA application manipulated essential oil.
    J. BIOL. ENVIRON. SCI. 01/2010; 4:77-82.
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    ABSTRACT: The essential oil of Otostegia michauxii Briq. growing wild in the Fars province of Iran was obtained by hydrodistallation and analyzed by GC and GC/MS techniques. Forty-five components representing 97.9% of the total oil were identified. The main components of the oil were dillapiole (23.9%), 2-methylbenzofuran (12.9%) and α-pinene (8.1%).
    Journal of Essential Oil Research 01/2010; 22(1):1-2. · 0.82 Impact Factor
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    ABSTRACT: Two data sets of natural antiviral agents including 107 anti-HIV1 and 18 anti-polio molecules were collected and subjected to quantitative structure-activity relationship (QSAR) analyses. A wide variety of molecular descriptors belonging to various structural properties were calculated for each molecule. Multiple linear regression (MLR) based on stepwise variable selection was employed to find the most convenient quantitative models. For each antiviral data set different QSAR models were established in two steps. Firstly, for each type of molecular descriptors separate QSAR analysis was performed, and then a new QSAR model was calculated using the selected descriptors in the first phase. For both types of antiviral data sets significant QSAR models were obtained. The atom-centered fragment descriptors represented the highest impact on the anti-HIV1 activity whereas for anti-polio agents, radial distribution function and three-dimensional MoRSE descriptors showed the most significant influences. Cross-validation and a separate prediction set were used to evaluate the stability and prediction ability of the models. It was found the discovered QSAR models for anti-HIV1 and anti-polio agents could reproduce about 80% and 90% of variances in the antiviral activity data with root mean square error of prediction of 0.421 and 0.171, respectively.
    Journal of the Iranian Chemical Society 06/2009; 6(2). · 1.41 Impact Factor
  • Chemistry of Natural Compounds 10/2008; 44(6):802-803. · 0.50 Impact Factor
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    ABSTRACT: A total extract of Linum persicum Kotschy ex Boiss. was investigated for biological activity. The extract was not active against Gram-negative and Gram-positive bacteria. The extract exhibited significant activity against brine shrimp (Artemia salina). Cytotoxic activity of the extract was evaluated by the MTT assay on five different cell lines. The total extract showed the highest cytotoxicity against human chronic myeloid leukemia (K-562), T-cell lines (Jurkat), and lung carcinoma (A5). Three aryltetralin lignans, podophyllotoxin, 5-methoxypodophyllotoxin, and 5-methoxy podophyllotoxin acetate, were isolated from the methanol extract of the aerial parts of L. persicum, and the structures were confirmed by spectroscopic methods.
    Pharmaceutical Biology 10/2008; 43(6):547-550. · 1.34 Impact Factor
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    ABSTRACT: The essential oil of Zosimia absinthifolia (Vent.) Link. growing wild in Iran was obtained by hydrodistallation and analyzed by GC and GC/MS. Sixty-one components representing 91.3% of the total oil were identified. The main components of the oil were octyl butyrate (19.2%), β-caryophyllene (13.9%), octanol (9.6%), geranyl valerate (9.6%) and caryophyllene oxide (5.7%).
    Journal of Essential Oil Research 03/2008; 20(2):114-116. · 0.82 Impact Factor
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    ABSTRACT: The essential oil of Marrubium astracanicum Jacq. growing wild in Iran was obtained by hydrodistallation and analyzed by GC and GC/MS. Seventy-two components representing 86.5% of the total oil were identified. The main components of the oil were β-caryophyllene (21.2%) and valeranone (5.4%).
    Journal of Essential Oil Research 11/2007; 19(6):559-561. · 0.82 Impact Factor
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    ABSTRACT: The essential oil of Dicyclophora persica Boiss. growing wild in Iran was obtained by hydrodistallation and analyzed by GC and GC/MS technique. Fifty-four components representing 89.0% of the total oil were identified. The main components of the oil were ρ-cymene (13.6%), α-pinene (13.4%), α—phellandrene (9.4%) and (Z)-falcarinol (5.0%).
    Journal of Essential Oil Research 11/2007; 19(6):543-544. · 0.82 Impact Factor

Publication Stats

94 Citations
25.81 Total Impact Points

Institutions

  • 2002–2014
    • Shiraz University of Medical Sciences
      • • Department of Pharmaceutics
      • • Medicinal and Natural Products Chemistry Research Center
      • • Department of Medicinal Chemistry
      Chimaz, Fārs, Iran
  • 2010
    • Shiraz University
      Chimaz, Fārs, Iran