Jong Hyun Kim

KEPCO International Nuclear Graduate School, Urusan, Ulsan, South Korea

Are you Jong Hyun Kim?

Claim your profile

Publications (227)503.52 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Gamma knife radiosurgery (GKS) is efficacious for treating recurrent malignant gliomas as a salvage treatment. However, contrast enhancement alone on MR imaging remains difficult to determine the treatment response following GKS. The purpose of this study was to evaluate the radiosurgical effect for recurrent malignant gliomas and to clarify if relative cerebral blood volume (rCBV) derived from dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion MR imaging could represent the treatment response. Between March 2006 and December 2008, 38 patients underwent GKS for recurrent malignant gliomas. Before and after GKS, DSC perfusion MR imaging datasets were retrospectively reprocessed and regions of interest were drawn around the contrast-enhancing region targeted with GKS. DSC-perfusion MR scans were assessed at a regular interval of two months. Following GKS for the recurrent lesions, MR images showed response (stable disease or partial response) in 26 of 38 patients (68.4 %) at post-GKS 2 months and 18 of 38 patients (47.3 %) at post-GKS 4 months. Initial mean rCBV value was 2.552 (0.586-6.178) at the pre-GKS MRI. In the response group, mean rCBV value was significantly decreased (P < 0.05) at the follow up of 2 and 4 months. However, in the treatment-failure group, mean rCBV value had no significant change. We suggest that GKS is an alternative treatment choice for the recurrent glioma. DSC-perfusion MR images are helpful to predict the treatment response after GKS.
    Journal of Neuro-Oncology 12/2014; · 3.12 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In higher eukaryotes, one of the two arginyl-tRNA synthetases (ArgRSs) has evolved to have an extended N-terminal domain that plays a crucial role in protein synthesis and cell growth and in integration into the multisynthetase complex (MSC). Here, we report a crystal structure of the MSC subcomplex comprising ArgRS, glutaminyl-tRNA synthetase (GlnRS), and the auxiliary factor aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1)/p43. In this complex, the N-terminal domain of ArgRS forms a long coiled-coil structure with the N-terminal helix of AIMP1 and anchors the C-terminal core of GlnRS, thereby playing a central role in assembly of the three components. Mutation of AIMP1 destabilized the N-terminal helix of ArgRS and abrogated its catalytic activity. Mutation of the N-terminal helix of ArgRS liberated GlnRS, which is known to control cell death. This ternary complex was further anchored to AIMP2/p38 through interaction with AIMP1. These findings demonstrate the importance of interactions between the N-terminal domains of ArgRS and AIMP1 for the catalytic and noncatalytic activities of ArgRS and for the assembly of the higher-order MSC protein complex.
    Proceedings of the National Academy of Sciences 10/2014; · 9.81 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dielectric and piezoelectric properties of CuO-added KNbO3 (KN) ceramics were investigated. The CuO reacted with the Nb2O5, formed a CuO–Nb2O5-related liquid phase during the sintering, and assisted the densification of the KN ceramics at low temperatures. Moreover, some of the Cu2+ ions replaced the Nb5+ ions in the matrix and behaved as a hardener. The dielectric and piezoelectric properties of the KN ceramics were considerably influenced by the relative density. The 1.0 mol% CuO-added KN ceramic sintered at 960°C for 1.0 h, which showed a maximum relative density, exhibited a high phase angle of 86.9°, Pr of 14.8 μC/cm2, and Ec of 1.8 kV/mm. This specimen also exhibited good dielectric and piezoelectric properties: εT33/εo of 364, d33 of 122 pC/N, kp of 0.29, and Qm of 611.
    Journal of the American Ceramic Society 09/2014; · 2.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the regulation mechanism of transcription factors that control adipogenesis. In addition, the adipogenic roles of translational factors remain unclear. Here, we show that aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1), an auxiliary factor that is associated with a macromolecular tRNA synthetase complex, negatively regulates adipogenesis via a direct interaction with the DNA-binding domain of peroxisome proliferator-activated receptor γ (PPARγ). AIMP1 expression increased during adipocyte differentiation. Adipogenesis was augmented in AIMP1-deficient cells, as compared with control cells. AIMP1 exhibited high affinity for active PPARγ and interacted with the DNA-binding domain of PPARγ, thereby inhibiting its transcriptional activity. Thus, AIMP1 appears to function as a novel inhibitor of PPARγ that regulates adipocyte differentiation by preventing the transcriptional activation of PPARγ.
    Journal of cell science. 08/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Since automation was introduced in various industrial fields, the concept of the automation rate has been used to indicate the inclusion proportion of automation among all work processes or facilities. Expressions of the inclusion proportion of automation are predictable, as is the ability to express the degree of the enhancement of human performance. However, many researchers have found that a high automation rate does not guarantee high performance. Therefore, to reflect the effects of automation on human performance, this paper proposes a new estimation method of the automation rate that considers the effects of automation on human operators in nuclear power plants (NPPs). Automation in NPPs can be divided into two types: system automation and cognitive automation. Some general descriptions and characteristics of each type of automation are provided, and the advantages of automation are investigated. The advantages of each type of automation are used as measures of the estimation method of the automation rate. One advantage was found to be a reduction in the number of tasks, and another was a reduction in human cognitive task loads. The system and the cognitive automation rate were proposed as quantitative measures by taking advantage of the aforementioned benefits. To quantify the required human cognitive task loads and thus suggest the cognitive automation rate, Conant’s information-theory-based model was applied. The validity of the suggested method, especially as regards the cognitive automation rate, was proven by conducting experiments. The result showed that a decreased rate of the operator working time was significantly related to the cognitive automation rate and that the calculation of the cognitive task load was useful as a measure of the cognitive automation rate.
    Annals of Nuclear Energy 08/2014; 70:48–55. · 0.80 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: At present, gold-standard technique of cervical cord decompression is surgical decompression and fusion. But, many complications related cervical fusion have been reported. We adopted an extended anterior cervical foraminotomy (EACF) technique to decompress the anterolateral portion of cervical cord and report clinical results and effectiveness of this procedure.
    Journal of Korean Neurosurgical Society 08/2014; 56(2):114-20. · 0.52 Impact Factor
  • Neurosurgery Quarterly 07/2014; · 0.09 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The reported mortality rates range from 28% to 100% in burn patients who develop acute kidney injury (AKI) and from 50% to 100% among such patients treated with renal replacement therapy. Recently, the serum cystatin C and plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) levels have been introduced as early biomarkers for AKI; the levels of these biomarkers are known to increase 24 to 48 hours before the serum creatinine levels increase. In this study, we aimed to estimate the diagnostic utility of the cystatin C and plasma and urine NGAL levels in the early post-burn period as biomarkers for predicting AKI and mortality in patients with major burn injuries.
    Critical care (London, England) 07/2014; 18(4):R151. · 5.04 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To determine epidemiological trends among burns patients admitted to our burns center during 2003-2012, and the usefulness of the Abbreviated Burns Severity Index (ABSI) for predicting burns-related mortality.
    Burns: journal of the International Society for Burn Injuries 07/2014; · 1.95 Impact Factor
  • Jong Hyun Kim, Suk Sang Chang, Geunbae Lim
    Current Applied Physics 05/2014; · 2.03 Impact Factor
  • International journal of cardiology 04/2014; · 6.18 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Ganglioglioma is an infrequent tumor of the central nervous system (CNS); mostly supratentorial region. But, they can occur anywhere in the central nervous system such as brainstem, cerebellopontine angle (CPA), thalamus, optic nerve and spinal cord. Although it occurs rarely, ganglioglioma should be included in the differential diagnosis of a posterior fossa mass because early recognition is important for treatment and patient counseling.
    Journal of Korean Neurosurgical Society 03/2014; 55(3):164-6. · 0.52 Impact Factor
  • Source
    Jong Hyun Kim, Suk Sang Chang, Geunbae Lim
    [Show abstract] [Hide abstract]
    ABSTRACT: Conventional machining technologies such as a milling process have limitations in accuracy to fabricate microstructures. Deep X-ray lithography using the synchrotron radiation is a promising micromachining process with an excellent accuracy, whereas there are difficulties in the fabrication of multi-layered structures. Therefore, it is mainly used for fabricating simple mono-layered microstructures with a high aspect ratio. In this study, a novel technology for fabricating multi-layered microstructures is proposed by combining two processes. In advance, an X-ray resist material is cut and machined into various shapes and heights by the micro milling process. Subsequent X-ray irradiation process facilitates the fabrication of multi-layered microstructures. The proposed technology can overcome the limitation of the pattern accuracy in conventional milling process and the difficulty of the multi-layered machining in x-ray process. The usefulness of the proposed technology is demonstrated in this study by applying the technique in the realization of various multi-layered microstructures.
    Journal of the Korean Society for Precision Engineering. 01/2014; 31(3).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective To evaluate the effect of burn rehabilitation massage therapy on hypertrophic scar after burn. Method One hundred and forty-six burn patients with hypertrophic scar(s) were randomly divided into an experimental group and a control group. All patients received standard rehabilitation therapy for hypertrophic scars and 76 patients (massage group) additionally received burn scar rehabilitation massage therapy. Both before and after the treatment, we determined the scores of visual analog scale (VAS) and itching scale and assessed the scar characteristics of thickness, melanin, erythema, transepidermal water loss (TEWL), sebum, and elasticity by using ultrasonography, Mexameter®, Tewameter®, Sebumeter®, and Cutometer®, respectively. Results The scores of both VAS and itching scale decreased significantly in both groups, indicating a significant intragroup difference. With regard to the scar characteristics, the massage group showed a significant decrease after treatment in scar thickness, melanin, erythema, TEWL and a significant intergroup difference. In terms of scar elasticity, a significant intergroup difference was noted in immediate distension and gross skin elasticity, while the massage group significant improvement in skin distensibility, immediate distension, immediate retraction, and delayed distension. Conclusion Our results suggest that burn rehabilitation massage therapy is effective in improving pain, pruritus, and scar characteristics in hypertrophic scars after burn.
    Burns: journal of the International Society for Burn Injuries 01/2014; · 1.95 Impact Factor
  • Source
    Jong Hyun Kim, Dong Sik Jin, Soon Heung Chang
    [Show abstract] [Hide abstract]
    ABSTRACT: The new safety analysis methodology for the CANDU-6 nuclear power plant (NPP) moderator system failure has been developed by using the coupling technology with the thermalhydraulic code, CATHENA and reactor core physics code, RFSP-IST. This sophisticated methodology can replace the legacy methodology using the MODSTBOIL and SMOKIN-G2 in the field of the thermalhydraulics and reactor physics, respectively. The CATHENA thermalhydraulic model of the moderator system can simulate the thermalhydraulic behaviors of all the moderator systems such as the calandria tank, head tank, moderator circulating circuit and cover gas circulating circuit and can also predict the thermalhydraulic property of the moderator such as moderator density, temperature and water level in the calandria tank as the moderator system failures go on. And these calculated moderator thermalhydraulic properties are provided to the 3-dimensional neutron kinetics solution module – CERBRRS of RFSP-IST as inputs, which can predict the change of the reactor power and provide the calculated reactor power to the CATHENA. These coupling calculations are performed at every 2 s time steps, which are equivalent to the slow control of CANDU-6 reactor regulating systems (RRS).The safety analysis results using this coupling methodology reveal that the reactor operation enters into the self-shutdown mode without any engineering safety system and/or human interventions for the postulated moderator system failures of the loss of heat sink and moderator inventory, respectively.
    Nuclear Engineering and Design 10/2013; 263:241–254. · 0.97 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Aminoacyl-tRNA synthetases recognize cognate amino acids and tRNAs from their noncognate counterparts and catalyze the formation of aminoacyl-tRNAs. Halofuginone (HF), a coccidiostat used in veterinary medicine, exerts its effects by acting as a high-affinity inhibitor of the enzyme glutamyl-prolyl-tRNA synthetase (EPRS). In order to elucidate the precise molecular basis of this inhibition mechanism of human EPRS, the crystal structures of the prolyl-tRNA synthetase domain of human EPRS (hPRS) at 2.4 Å resolution (hPRS-apo), of hPRS complexed with ATP and the substrate proline at 2.3 Å resolution (hPRS-sub) and of hPRS complexed with HF at 2.62 Å resolution (hPRS-HF) are presented. These structures show plainly that motif 1 functions as a cap in hPRS, which is loosely opened in hPRS-apo, tightly closed in hPRS-sub and incorrectly closed in hPRS-HF. In addition, the structural analyses are consistent with more effective binding of hPRS to HF with ATP. Mutagenesis and biochemical analysis confirmed the key roles of two residues, Phe1097 and Arg1152, in the HF inhibition mechanism. These structures will lead to the development of more potent and selective hPRS inhibitors for promoting inflammatory resolution.
    Acta Crystallographica Section D Biological Crystallography 10/2013; 69(Pt 10):2136-2145. · 7.23 Impact Factor
  • Jong Hyun Kim, Jung Min Han, Sunghoon Kim
    [Show abstract] [Hide abstract]
    ABSTRACT: Protein-protein interaction occurs transiently or stably when two or more proteins bind together to mediate a wide range of cellular processes such as protein modification, signal transduction, protein trafficking, and structural folding. The macromolecules involved in protein biosynthesis such as aminoacyl-tRNA synthetase (ARS) have a number of protein-protein interactions. The mammalian multi-tRNA synthetase complex (MSC) consists of eight different enzymes: EPRS, IRS, LRS, QRS, MRS, KRS, RRS, and DRS, and three auxiliary proteins: AIMP1/p43, AIMP2/p38, and AIMP/p18. The distinct ARS proteins are also connected to diverse protein networks to carry out biological functions. In this chapter we first show the protein networks of the entire MSC and explain how MSC components interact with or can regulate other proteins. Finally, it is pointed out that the understanding of protein-protein interaction mechanism will provide insight to potential therapeutic application for diseases related to the MSC network.
    Topics in current chemistry 09/2013; · 4.61 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: The purpose of this study is to clarify the clinical significance of serum transthyretin (TTR) in massively burned patients in nutrition support and clinical severity. Methods: A retrospective study was performed with 204 patients admitted to Hangang Sacred Heart Hospital's Burn Center September 2010-September 2012 with burn wounds > 20% of total body surface area (TBSA) burned. Serum TTR, C-reactive protein (CRP), lactic acid, and an NST index (calculated by dividing real caloric intake by estimated caloric need for 7 days) were analyzed on a weekly basis for 5 weeks after admission. Results: When we classified patients with severity according to mortality, percentage of TBSA burned, serum lactic acid, and CRP, mean serum TTR level was significantly higher in the less severe patient group than in the severe patient group in each week for every severity index. And the serum TTR level did not show significant differences by NST index in both the severe patient group and the less severe patient group. In a multivariate logistic regression, percentage TBSA burned, TTR, and lactic acid had an independent association with mortality. Conclusion: Serum TTR did not show a significant difference by nutrition support in massively burned patients with >20% of TBSA burned. But serum TTR was significantly different by the severity of the patient and independently associated with mortality. Hence, serum TTR level can be 1 of the useful biomarkers for comprehending the severity of the illness in massively burned patients.
    Journal of Parenteral and Enteral Nutrition 08/2013; · 3.14 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to investage the effects of dietary bamboo charcoal on the carcass characteristics and meat quality of fattening pigs. Fifty four crossed pigs of kg body weight (BW) were grouped and housed in 6 animals (3 barrows and 3 gilts) per pen and 3 replications per treatment. The basal diet (C) was supplied with 0.3% bamboo charcoal as treatment 1 (T1) and 0.6 % as treatment 2 (T2). The pigs were fed that experimental diet for 42 days, thereafter 10 longissimus dorsi (LD) per treatment were randomly collected at the time the pigs reached an average weight of kg. The carcass weight, backfat thickness, and the carcass grade were better (p
    Hangug chugsan sigpum haghoeji = Korean journal for food science of animal resources 06/2013; 33(3). · 0.25 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by alteration of the adenosine triphosphatase 7B gene. It is rare to diagnose WD below the age of three years. Molecular genetic testing is one of the most important diagnostic methods and may confirm the diagnosis in equivocal cases. We report a case of a 9-mo old boy with WD who presented as chronic hepatitis. Genetic analysis showed compound heterozygotes of p.G1186S and c.4006delA.
    World journal of hepatology. 03/2013; 5(3):156-9.

Publication Stats

1k Citations
503.52 Total Impact Points

Institutions

  • 2014
    • KEPCO International Nuclear Graduate School
      Urusan, Ulsan, South Korea
  • 2013–2014
    • Seoul National University
      • • Department of Molecular Medicine and Biopharmaceutical Sciences (WCU)
      • • Medicinal Bioconvergence Research Center
      Sŏul, Seoul, South Korea
    • Gyeongnam National University of Science and Technology
      • Department of Animal Resources Technology (Graduate School)
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
    • National Institutes of Health
      • Laboratory of Molecular Biology
      Bethesda, MD, United States
    • National Fisheries Research and Development Institution
      Sŏul, Seoul, South Korea
    • Gwangju Institute of Science and Technology
      • School of Mechatronics
      Gwangju, Gwangju, South Korea
    • Sapporo Higashi Tokushukai Hospital
      Sapporo, Hokkaidō, Japan
  • 2003–2014
    • Korea University
      • • Department of Materials Science and Engineering
      • • Department of Neurosurgery
      • • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2002–2014
    • Pohang University of Science and Technology
      • • Department of Mechanical Engineering
      • • Division of Molecular and Life Sciences
      Geijitsu, North Gyeongsang, South Korea
    • Kumoh National Institute of Technology
      Sŏul, Seoul, South Korea
    • Seoul National University Hospital
      • Department of Ophthalmology
      Seoul, Seoul, South Korea
  • 2011–2013
    • Gyeongsang National University
      • • College of Veterinary Medicine
      • • Department of Neurosurgery
      Chinju, South Gyeongsang, South Korea
    • National Heart, Lung, and Blood Institute
      Maryland, United States
    • Sogang University
      • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2009–2013
    • Catholic University of Korea
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
    • Hallym University Medical Center
      • Department of Burn Surgery
      Sŏul, Seoul, South Korea
    • Chungnam National University
      • Department of Physics
      Seongnam, Gyeonggi, South Korea
  • 1993–2013
    • Korea Advanced Institute of Science and Technology
      • • Department of Nuclear and Quantum Engineering
      • • Department of Chemical and Biomolecular Engineering
      • • Department of Physics
      Sŏul, Seoul, South Korea
  • 2010–2012
    • Hannam University
      Daiden, Daejeon, South Korea
    • National Institute of Health, Korea
      • Division of Enteric and Hepatitis Viruses
      Cheongsong gun, North Gyeongsang, South Korea
    • Samsung Medical Center
      • Department of Neurosurgery
      Seoul, Seoul, South Korea
  • 2008–2012
    • Pohang Accelerator Laboratory
      Urusan, Ulsan, South Korea
    • Chonnam National University
      • Department of Internal Medicine
      Gwangju, Gwangju, South Korea
    • Korea Hydro and Nuclear Power - Central Research Institute
      Sŏul, Seoul, South Korea
    • National Cancer Center Korea
      Kōyō, Gyeonggi Province, South Korea
  • 2002–2012
    • Sungkyunkwan University
      • • Department of Neurosurgery
      • • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2009–2011
    • Chonnam National University Hospital
      Sŏul, Seoul, South Korea
    • Harvard Medical School
      • Department of Genetics
      Boston, MA, United States
  • 2008–2010
    • Hallym University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2007
    • Yonsei University
      • Department of Computer Science
      Seoul, Seoul, South Korea
    • University of Southern California
      • Department of Computer Science
      Los Angeles, CA, United States
  • 2005
    • Showa University
      • Institute of Molecular Oncology
      Shinagawa, Tōkyō, Japan
  • 1996
    • Pusan National University
      Tsau-liang-hai, Busan, South Korea
  • 1995
    • Dongseo University
      • Department of Bio-chemical Engineering
      Tsau-liang-hai, Busan, South Korea