Jong Hyun Kim

KEPCO International Nuclear Graduate School, Urusan, Ulsan, South Korea

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Publications (267)584.83 Total impact

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    ABSTRACT: Objective: Optimal treatment decision and estimation of the prognosis in traumatic brain injury (TBI) is currently based on demographic and clinical predictors. But sometimes, there are limitations in these factors. In this study, we analyzed three central nervous system biomarkers in TBI patients, will discuss the roles and clinical applications of biomarkers in TBI. Methods: From July on 2013 to August on 2014, a total of 45 patients were included. The serum was obtained at the time of hospital admission, and biomarkers were extracted with centrifugal process. It was analyzed for the level of S-100 beta (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1). Results: This study included 33 males and 12 females with a mean age of 58.5 (19-84) years. TBI patients were classified into two groups. Group A was severe TBI with Glasgow Coma Scale (GCS) score 3-5 and Group B was mild TBI with GCS score 13-15. The median serum concentration of S100B, GFAP, and UCH-L1 in severe TBI were raised 5.1 fold, 5.5 fold, and 439.1 fold compared to mild injury, respectively. The serum levels of these markers correlated significantly with the injury severity and clinical outcome (p<0.001). Increased level of markers was strongly predicted poor outcomes. Conclusion: S100B, GFAP, and UCH-L1 serum level of were significantly increased in TBI according to severity and associated clinical outcomes. Biomarkers have potential utility as diagnostic, prognostic, and therapeutic adjuncts in the setting of TBI.
    Journal of Korean Neurosurgical Society 09/2015; 58(2):93-100. DOI:10.3340/jkns.2015.58.2.93 · 0.64 Impact Factor
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    ABSTRACT: This study aims to investigate the clinical features, angiographic findings, and outcomes of younger Korean ST-segment elevation myocardial infarction (STEMI) patients. We analyzed major adverse cardiac events (MACE) in the Korea Acute Myocardial Infarction Registry from November 2005 to October 2010. The registered patients were divided into two groups; young age group (<65 years) and old age group (≥65 years). The young age group included 5281 patients (age, 53±7.8 years), and the old age group included 4896 patients (age, 74.3±6.5 years). Male gender, smoking, family history, dyslipidemia, and metabolic syndrome were more frequently observed in the young age group than in the old age group (89.5% vs. 59.3%, p<0.001; 77.3% vs. 47.2%, p<0.001; 11% vs. 4.6%, p<0.001; 11.2% vs. 7.7%, p<0.001; 67.6% vs. 62.9%, p<0.001). Most of the young Korean adults with STEMI complained of typical chest pain (89.8%), and they had a shorter symptom-to-door time (12±53.2 hours vs. 17.3±132 hours, p=0.010). The young age group showed a favorable prognosis, which was represented by the MACE, compared with the old age group at one month (1.8% vs. 2.8%, p=0.028), six months (6.8% vs. 8.2%, p<0.001), and twelve months (10.1% vs. 11.9%, p=0.025). However, there was no significant difference in the adjusted MACE rate at one month {hazard ratio (HR) 0.95, 95% confidence interval (CI) 0.60-1.51, p=0.828} and twelve months (HR 0.86, 95% CI 0.68-1.10, p=0.233). Younger Korean adults with STEMI have clinical outcomes similar to old aged patients, and therefore, they should be treated intensively like the elderly patients.
    Korean Circulation Journal 07/2015; 45(4):275-84. DOI:10.4070/kcj.2015.45.4.275 · 0.75 Impact Factor
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    ABSTRACT: The crystal structure and piezoelectric properties of (1−x)Pb(Zr1−yTiy)O3-xPb(Zn0.4Ni0.6)1/3Nb2/3O3 [(1−x)PZ1−yTy-xPZNN] ceramics were investigated. The 0.665PZ0.45T0.55-0.335PZNN ceramic has the triple point composition, where the rhombohedral, pseudocubic, and tetragonal structures coexist. Maximum d33 and kp values of 770 pC/N and 0.69, respectively, were observed from this specimen; it also exhibited a large εT33/εo value of 3250. Although the maximum d33 value was obtained from the triple point composition specimen, its g33 and d33 × g33 values were relatively small because of its large εT33/εo value. However, the 0.665PZ0.46T0.54-0.335PZNN ceramic, which has a rhombohedral structure, exhibited a large g33 value of 43 × 10−3 Vm/N and a d33 × g33 value of 27 000 × 10−15 m2/N. Therefore, this ceramic is a good candidate for multilayer actuators and piezoelectric energy harvesters.
    Journal of the American Ceramic Society 06/2015; DOI:10.1111/jace.13687 · 2.61 Impact Factor
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    ABSTRACT: With the introduction of automation in various industries including the nuclear field, its side effect, referred to as the Out-of-the-Loop (OOTL) problem, has emerged as a critical issue that needs to be addressed. Many studies have been attempted to analyze and solve the OOTL problem, but this issue still needs a clear solution to provide criteria for introducing automation. Therefore, a quantitative estimation method for identifying negative effects of automation is proposed in this paper. The representative aspect of the OOTL problem in nuclear power plants (NPPs) is that human operators in automated operations are given less information than human operators in manual operations. In other words, human operators have less opportunity to obtain needed information as automation is introduced. From this point of view, the degree of difficulty in obtaining information from automated systems is defined as the Level of Ostracism (LOO). Using the LOO and information theory, we propose the ostracism rate, which is a new estimation method that expresses how much automation interrupts human operators’ situation awareness. We applied production rules to describe the human operators’ thinking processes, Bayesian inference to describe the production rules mathematically, and information theory to calculate the amount of information that human operators receive through observations. The validity of the suggested method was proven by conducting an experiment. The results show that the ostracism rate was significantly related to the accuracy of human operators’ situation awareness, and that the calculation of the amount of information that human operators receive is useful as a measure of the ostracism rate.
    Annals of Nuclear Energy 05/2015; 79. DOI:10.1016/j.anucene.2015.01.021 · 0.96 Impact Factor
  • Jong‐Hyun Kim · Chang‐Hun Kim · Jung Lee
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    ABSTRACT: We propose a hybrid signed distance field (SDF) method for reconstructing the detailed surface of a model as it changes from a solid state to a liquid state. Previous particle-based fluid simulations suffer from a noisy surface problem when the particles are distributed irregularly. If a smoothing scheme is applied to reduce the problem, sharp and detailed features can be lost by over-smoothing artifacts. Our method constructs a hybrid SDF by combining level-set values from the solid and liquid parts of the object. This makes it possible to represent the detailed features and smooth surfaces of an object when both solid and liquid parts are mixed in that object. In addition, the concept of a guiding shape is proposed, which uses a coordinate-warping technique to query the level-set values quickly. The guiding shape is constructed from the object before the simulation begins and some parts of it become liquid. To track the details of the initial solid shape and preserve it, the transformation of the guiding shape is accumulated while the phase-shift is in progress. By warping the coordinates of this accumulated transformation of the guiding shape, the level-set values of the solid part can be acquired very quickly. Copyright © 2015 John Wiley & Sons, Ltd.
    Computer Animation and Virtual Worlds 04/2015; DOI:10.1002/cav.1663 · 0.46 Impact Factor
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    ABSTRACT: Although the thalamus is an important module in 'pain networks', there are few studies of the effect of experimental pain upon thalamic oscillations. We have now examined the hypothesis that during a series of painful cutaneous laser stimuli thalamic signals will show stimulus-related gamma band spectral activity, which is modulated by attention to versus distraction from the painful stimulus. When the series of laser stimuli was presented, attention was focused by counting the laser stimuli (count laser task) while distraction was produced by counting backward (count back plus laser task). We have studied the effect of a cutaneous laser upon thalamic local field potentials (LFPs) and EEG activity during awake procedures (DBS implants) for the treatment of essential tremor. At different delays after the stimulus, three low gamma (30-50 Hz) and two high gamma band (70-90 Hz) activations were observed during the two tasks. Greater high gamma activation was found during the count laser task for the earlier Window, while greater high gamma activation was found during the count back plus laser task for the later Window. Thalamic signals were coherent with EEG signals in the beta band, which indicated significant synchrony. Thalamic cross frequency coupling analysis indicated that the phase of the lower frequency activity (theta to beta) modulated the amplitude of the higher frequency activity (low and high gamma) more strongly during the count laser task than during the count back plus laser task. This modulation might result in multiplexed signals each encoding a different aspect of pain. Copyright © 2014, Journal of Neurophysiology.
    Journal of Neurophysiology 12/2014; 113(5):jn.00778.2014. DOI:10.1152/jn.00778.2014 · 2.89 Impact Factor
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    ABSTRACT: Gamma knife radiosurgery (GKS) is efficacious for treating recurrent malignant gliomas as a salvage treatment. However, contrast enhancement alone on MR imaging remains difficult to determine the treatment response following GKS. The purpose of this study was to evaluate the radiosurgical effect for recurrent malignant gliomas and to clarify if relative cerebral blood volume (rCBV) derived from dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion MR imaging could represent the treatment response. Between March 2006 and December 2008, 38 patients underwent GKS for recurrent malignant gliomas. Before and after GKS, DSC perfusion MR imaging datasets were retrospectively reprocessed and regions of interest were drawn around the contrast-enhancing region targeted with GKS. DSC-perfusion MR scans were assessed at a regular interval of two months. Following GKS for the recurrent lesions, MR images showed response (stable disease or partial response) in 26 of 38 patients (68.4 %) at post-GKS 2 months and 18 of 38 patients (47.3 %) at post-GKS 4 months. Initial mean rCBV value was 2.552 (0.586-6.178) at the pre-GKS MRI. In the response group, mean rCBV value was significantly decreased (P < 0.05) at the follow up of 2 and 4 months. However, in the treatment-failure group, mean rCBV value had no significant change. We suggest that GKS is an alternative treatment choice for the recurrent glioma. DSC-perfusion MR images are helpful to predict the treatment response after GKS.
    Journal of Neuro-Oncology 12/2014; 121(2). DOI:10.1007/s11060-014-1634-8 · 3.07 Impact Factor
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    ABSTRACT: Objective To evaluate the effect of burn rehabilitation massage therapy on hypertrophic scar after burn. Method One hundred and forty-six burn patients with hypertrophic scar(s) were randomly divided into an experimental group and a control group. All patients received standard rehabilitation therapy for hypertrophic scars and 76 patients (massage group) additionally received burn scar rehabilitation massage therapy. Both before and after the treatment, we determined the scores of visual analog scale (VAS) and itching scale and assessed the scar characteristics of thickness, melanin, erythema, transepidermal water loss (TEWL), sebum, and elasticity by using ultrasonography, Mexameter®, Tewameter®, Sebumeter®, and Cutometer®, respectively. Results The scores of both VAS and itching scale decreased significantly in both groups, indicating a significant intragroup difference. With regard to the scar characteristics, the massage group showed a significant decrease after treatment in scar thickness, melanin, erythema, TEWL and a significant intergroup difference. In terms of scar elasticity, a significant intergroup difference was noted in immediate distension and gross skin elasticity, while the massage group significant improvement in skin distensibility, immediate distension, immediate retraction, and delayed distension. Conclusion Our results suggest that burn rehabilitation massage therapy is effective in improving pain, pruritus, and scar characteristics in hypertrophic scars after burn.
    Burns: journal of the International Society for Burn Injuries 12/2014; 40(8). DOI:10.1016/j.burns.2014.02.005 · 1.88 Impact Factor
  • Jong Hyun Kim · Suk Sang Chang · Geunbae Lim
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    ABSTRACT: We present a novel method of fabricating ultra-precise patterns using multiple x-ray irradiations and precision stage movement. As the typical deep x-ray mask by ultraviolet (UV) lithography can have a minimum several-microns-scale pattern, fabrication of smaller patterns using general deep x-ray lithography with such a UV-process-based x-ray mask has limitations. In the present study, a substrate was loaded onto a precision stage allowing independent motion in the horizontal and vertical directions. The vertical stage, during x-ray irradiation, moves only up and down; after the initial x-ray irradiation, the horizontal stage moves the substrate in the horizontal direction in preparation for the next x-ray irradiation, which subsequently is carried out. The horizontal movement distance, crucially, can be adjusted to control the fabricated pattern size. By these combinations of precision stage movements and multiple x-ray irradiations, a pattern smaller than the original can be fabricated. The experimental results show in fact that this simple technique can be easily utilized for sub-micron-scale pattern fabrication using the typical UV-based x-ray mask
    International Journal of Precision Engineering and Manufacturing 11/2014; 15(11):2385-2390. DOI:10.1007/s12541-014-0604-6 · 1.50 Impact Factor
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    ABSTRACT: In higher eukaryotes, one of the two arginyl-tRNA synthetases (ArgRSs) has evolved to have an extended N-terminal domain that plays a crucial role in protein synthesis and cell growth and in integration into the multisynthetase complex (MSC). Here, we report a crystal structure of the MSC subcomplex comprising ArgRS, glutaminyl-tRNA synthetase (GlnRS), and the auxiliary factor aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1)/p43. In this complex, the N-terminal domain of ArgRS forms a long coiled-coil structure with the N-terminal helix of AIMP1 and anchors the C-terminal core of GlnRS, thereby playing a central role in assembly of the three components. Mutation of AIMP1 destabilized the N-terminal helix of ArgRS and abrogated its catalytic activity. Mutation of the N-terminal helix of ArgRS liberated GlnRS, which is known to control cell death. This ternary complex was further anchored to AIMP2/p38 through interaction with AIMP1. These findings demonstrate the importance of interactions between the N-terminal domains of ArgRS and AIMP1 for the catalytic and noncatalytic activities of ArgRS and for the assembly of the higher-order MSC protein complex.
    Proceedings of the National Academy of Sciences 10/2014; 111(42). DOI:10.1073/pnas.1408836111 · 9.67 Impact Factor
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    ABSTRACT: Dielectric and piezoelectric properties of CuO-added KNbO3 (KN) ceramics were investigated. The CuO reacted with the Nb2O5, formed a CuO–Nb2O5-related liquid phase during the sintering, and assisted the densification of the KN ceramics at low temperatures. Moreover, some of the Cu2+ ions replaced the Nb5+ ions in the matrix and behaved as a hardener. The dielectric and piezoelectric properties of the KN ceramics were considerably influenced by the relative density. The 1.0 mol% CuO-added KN ceramic sintered at 960°C for 1.0 h, which showed a maximum relative density, exhibited a high phase angle of 86.9°, Pr of 14.8 μC/cm2, and Ec of 1.8 kV/mm. This specimen also exhibited good dielectric and piezoelectric properties: εT33/εo of 364, d33 of 122 pC/N, kp of 0.29, and Qm of 611.
    Journal of the American Ceramic Society 09/2014; 97(12). DOI:10.1111/jace.13225 · 2.61 Impact Factor
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    ABSTRACT: Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the regulation mechanism of transcription factors that control adipogenesis. In addition, the adipogenic roles of translational factors remain unclear. Here, we show that aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1), an auxiliary factor that is associated with a macromolecular tRNA synthetase complex, negatively regulates adipogenesis via a direct interaction with the DNA-binding domain of peroxisome proliferator-activated receptor γ (PPARγ). AIMP1 expression increased during adipocyte differentiation. Adipogenesis was augmented in AIMP1-deficient cells, as compared with control cells. AIMP1 exhibited high affinity for active PPARγ and interacted with the DNA-binding domain of PPARγ, thereby inhibiting its transcriptional activity. Thus, AIMP1 appears to function as a novel inhibitor of PPARγ that regulates adipocyte differentiation by preventing the transcriptional activation of PPARγ.
  • Seung Min Lee · Jong Hyun Kim · Poong Hyun Seong
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    ABSTRACT: Since automation was introduced in various industrial fields, the concept of the automation rate has been used to indicate the inclusion proportion of automation among all work processes or facilities. Expressions of the inclusion proportion of automation are predictable, as is the ability to express the degree of the enhancement of human performance. However, many researchers have found that a high automation rate does not guarantee high performance. Therefore, to reflect the effects of automation on human performance, this paper proposes a new estimation method of the automation rate that considers the effects of automation on human operators in nuclear power plants (NPPs). Automation in NPPs can be divided into two types: system automation and cognitive automation. Some general descriptions and characteristics of each type of automation are provided, and the advantages of automation are investigated. The advantages of each type of automation are used as measures of the estimation method of the automation rate. One advantage was found to be a reduction in the number of tasks, and another was a reduction in human cognitive task loads. The system and the cognitive automation rate were proposed as quantitative measures by taking advantage of the aforementioned benefits. To quantify the required human cognitive task loads and thus suggest the cognitive automation rate, Conant’s information-theory-based model was applied. The validity of the suggested method, especially as regards the cognitive automation rate, was proven by conducting experiments. The result showed that a decreased rate of the operator working time was significantly related to the cognitive automation rate and that the calculation of the cognitive task load was useful as a measure of the cognitive automation rate.
    Annals of Nuclear Energy 08/2014; 70:48–55. DOI:10.1016/j.anucene.2014.03.003 · 0.96 Impact Factor
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    ABSTRACT: Objective At present, gold-standard technique of cervical cord decompression is surgical decompression and fusion. But, many complications related cervical fusion have been reported. We adopted an extended anterior cervical foraminotomy (EACF) technique to decompress the anterolateral portion of cervical cord and report clinical results and effectiveness of this procedure. Methods Fifty-three patients were operated consecutively using EACF from 2008 to 2013. All of them were operated by a single surgeon via the unilateral approach. Twenty-two patients who exhibited radicular and/or myelopathic symptoms were enrolled in this study. All of them showed cervical cord compression in their preoperative magnetic resonance scan images. Results In surgical outcomes, 14 patients (64%) were classified as excellent and six (27%), as good. The mean difference of cervical cord anterior-posterior diameter after surgery was 0.92 mm (p<0.01) and transverse area was 9.77 mm2 (p<0.01). The dynamic radiological study showed that the average post-operative translation (retrolisthesis) was 0.36 mm and the disc height loss at the operated level was 0.81 mm. The change in the Cobb angle decreased to 3.46, and showed slight kyphosis. The average vertebral body resection rate was 11.47%. No procedure-related complications occurred. Only one patient who had two-level decompression needed anterior fusion at one level as a secondary surgery due to postoperative instability. Conclusions Cervical cord decompression was successfully performed using EACF technique. This procedure will be an alternative surgical option for treating cord compressing lesions. Long-term follow-up and a further study in larger series will be needed.
    Journal of Korean Neurosurgical Society 08/2014; 56(2):114-20. DOI:10.3340/jkns.2014.56.2.114 · 0.64 Impact Factor
  • Neurosurgery Quarterly 07/2014; · 0.09 Impact Factor
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    ABSTRACT: Introduction The reported mortality rates range from 28% to 100% in burn patients who develop acute kidney injury (AKI) and from 50% to 100% among such patients treated with renal replacement therapy. Recently, the serum cystatin C and plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) levels have been introduced as early biomarkers for AKI; the levels of these biomarkers are known to increase 24 to 48 hours before the serum creatinine levels increase. In this study, we aimed to estimate the diagnostic utility of the cystatin C and plasma and urine NGAL levels in the early post-burn period as biomarkers for predicting AKI and mortality in patients with major burn injuries. Methods From May 2011 to July 2012, 90 consecutive patients with a burn wound area comprising ≥ 20% of the total body surface area (TBSA) were enrolled in this study. Whole blood and urine samples were obtained for measuring the serum creatinine, serum cystatin C, and urine and plasma NGAL levels at 0, 3, 6, 12, 24, and 48 hours after admission. Receiver operating characteristic curve, area under the curve, and multivariate logistic regression analyses were performed to assess the predictive values of these biomarkers for AKI and mortality. Results In the multivariate logistic regression analysis, all variables, including age, percentage TBSA burned, sex, inhalation injury, and serum creatinine levels, serum cystatin C levels, and plasma and urine NGAL levels were independently associated with AKI development. Moreover, age, sex, percentage TBSA burned, and plasma and urine NGAL levels were independently associated with mortality. However, inhalation injury and the serum creatinine and cystatin C levels were not independently associated with mortality. Conclusions Massively burned patients who maintained high plasma and urine NGAL levels until 12 hours after admission were at the risk of developing early AKI and early mortality with burn shock. However, the plasma and urine NGAL levels in the early post-burn period failed to predict late AKI and non-burn shock mortality in this study. Nevertheless, the plasma and urine NGAL levels were independently associated with AKI development and mortality within 48 hours after admission.
    Critical care (London, England) 07/2014; 18(4):R151. DOI:10.1186/cc13989 · 4.48 Impact Factor
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    ABSTRACT: Purpose: To determine epidemiological trends among burns patients admitted to our burns center during 2003-2012, and the usefulness of the Abbreviated Burns Severity Index (ABSI) for predicting burns-related mortality. Methods: We retrospectively reviewed the data of 4481 burns patients. We analyzed the epidemiological trends and ABSI scores using Student t-test and one-way analysis of variance (continuous variables), chi-square test (categorical variables) and stepwise logistic-regression analysis (predictors of mortality). Results: The mean age and male-to-female ratio were 39.9±19.7 years and 2.88, respectively. ABSI scores decreased from 7.7±3.0 in 2003 to 6.9±3.0 in 2012. Mortality rate improved from 24.5% in 2003 to 15.8% in 2012. Burns were caused by flames (67.3%), scalding (22.0%) and electrical (7.5%), chemical (1.6%) and contact (1.5%) injuries. Scalding and flames were the most common causes in patients aged ≤20 years and ≥21 years, respectively. Female sex, inhalation injury, full-thickness burns, large total body surface area (TBSA) burned and old age predicted mortality. ABSI scores <4 and >14 were associated with 0.7% and >90% mortality, respectively. Conclusions: The mortality of major burns has decreased but remains high. ABSI scores predict burns-related mortality.
    Burns: journal of the International Society for Burn Injuries 07/2014; 41(1). DOI:10.1016/j.burns.2014.05.004 · 1.88 Impact Factor
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    ABSTRACT: Pituitary metastasis (PM) secondary to systemic malignancies has been reported in the literature. Variety of clinical and neuroimaging presentation has been reported; however the diagnosis of PM is challenging. We report a case of a 44-year-old male with PM from non-small cell lung cancer (stage IV). He presented with sudden onset polyuria, polydypsia, and visual disturbance. Laboratory evaluation revealed pan-hypopituitarism and visual field test showed bitemporal lower quadrantanopsia. Brain magnetic resonance imaging demonstrated a suprasellar mass with focal hemorrhage and thickening of infundibular stalk. Surgical resection of the tumor followed by chemoradiotherapy was employed. Histopathologic examination of the tumor specimen revealed metastatic adenocarcinoma and immunostaning demonstrated findings consistent with lung carcinoma. Visual disturbances improved postoperatively and the patient is tumor free with no clinical or radiologic evidence of recurrence at 19 months of follow-up. The review of literature is included with the goal of elucidating the clinical presentation, imaging diagnosis, histogenesis, and the treatment strategies associated with the PM.
    Neurosurgery Quarterly 07/2014; DOI:10.1097/WNQ.0000000000000050 · 0.09 Impact Factor
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    ABSTRACT: The non-phase locked EEG response to painful stimuli has usually been characterized as decreased oscillatory activity (event-related desynchronization, ERD) in the alpha band. Increased activity (event-related synchronization, ERS) in the gamma band has been reported more recently. We have now tested the hypothesis that the non-phase locked responses to non-painful electro-cutaneous stimuli are different from those to painful cutaneous laser stimuli when the baseline salience of the two stimuli is the same and the salience during the protocol is modulated by attention and distraction tasks. Both of these stimuli were presented in random order in a single train at intensities which produced the same baseline salience in the same somatic location. The response to the laser stimulus was characterized by five windows in the Time-frequency domain: early (200-400 ms) and late (600-1400 ms) delta/theta ERS, 500-900 ms alpha ERD, 1200-1600 ms beta ERS (rebound), and 800-1200 ms gamma ERS. Similar ERS/ERD windows of activity were found for the electric stimulus. Individual participants largely had activity in windows consistent with the overall analysis. Linear regression of ERS/ERD for parietal channels was most commonly found for sensory- (pain or unpleasantness) or attention- (salience) related measures. Overall, the main effect for modality was the result of activity in Windows I and V, and the modality with task interaction was found for all five windows. There was no significant interaction term which did not include modality. Therefore, the modality was the most common factor explaining of our results, which is consistent with our hypothesis.
    Journal of Neurophysiology 05/2014; 112(4). DOI:10.1152/jn.00209.2014 · 2.89 Impact Factor
  • Jong Hyun Kim · Suk Sang Chang · Geunbae Lim
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    ABSTRACT: Synchrotron hard X-ray irradiation can be utilized in lithography processes to manufacture precise structures. Due to the difficulty of precise X-ray mask fabrication in hard X-ray lithography, this X-ray process has been used mainly to fabricate precise microstructures. In this study, a technology is proposed for fabricating novel multi-scale patterns that include submicron-scale structures using hard X-rays. The required X-ray masks for submicron-sized patterning are fabricated by a simple UV lithography process and sidewall metal deposition. Above all, thanks to the high penetration capability of hard X-rays with sub-nanometer wavelengths, it is possible to employ multiple masks to fabricate a variety of patterns. By combining each sub-micron X-ray mask with typical micro-sized X-ray masks, a unique X-ray lithography is performed, and various multi-scale structures are fabricated. The usefulness of the proposed technology is demonstrated by the realization of these structures. (C) 2014 Published by Elsevier B.V.
    Current Applied Physics 05/2014; 14(5). DOI:10.1016/j.cap.2014.03.013 · 2.21 Impact Factor

Publication Stats

2k Citations
584.83 Total Impact Points


  • 2013–2015
    • KEPCO International Nuclear Graduate School
      Urusan, Ulsan, South Korea
    • University of Colorado at Boulder
      • Department of Chemistry and Biochemistry
      Boulder, Colorado, United States
    • Gyeongnam National University of Science and Technology
      Sŏul, Seoul, South Korea
  • 2003–2015
    • Korea University
      • • Department of Biotechnology
      • • Department of Neurosurgery
      • • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2014
    • Konyang University
      Ronsan, Chungcheongnam-do, South Korea
  • 2013–2014
    • Seoul National University
      • • Department of Molecular Medicine and Biopharmaceutical Sciences (WCU)
      • • Medicinal Bioconvergence Research Center
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
    • Hannam University
      Daiden, Daejeon, South Korea
    • National Fisheries Research and Development Institution
      Sŏul, Seoul, South Korea
    • Gwangju Institute of Science and Technology
      • School of Mechatronics
      Gwangju, Gwangju, South Korea
  • 2011–2014
    • Hallym University Medical Center
      • Department of Burn Surgery
      Sŏul, Seoul, South Korea
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
    • Sogang University
      • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2008–2014
    • Pohang Accelerator Laboratory
      Urusan, Ulsan, South Korea
    • Busan Veterans Hospital
      Busan, Busan, South Korea
    • Korea Hydro and Nuclear Power - Central Research Institute
      Sŏul, Seoul, South Korea
  • 2003–2014
    • Hallym University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2002–2014
    • Pohang University of Science and Technology
      • • Department of Mechanical Engineering
      • • Division of Molecular and Life Sciences
      • • Department of Life Sciences
      Geijitsu, North Gyeongsang, South Korea
    • Kumoh National Institute of Technology
      Sŏul, Seoul, South Korea
    • Seoul National University Hospital
      • Department of Ophthalmology
      Sŏul, Seoul, South Korea
  • 2007–2013
    • Catholic University of Korea
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
    • Yonsei University
      • Department of Computer Science
      Sŏul, Seoul, South Korea
    • Hanyang University
      • Division of Materials Science and Engineering (MSE)
      Sŏul, Seoul, South Korea
  • 2000–2013
    • Korea Advanced Institute of Science and Technology
      • • Department of Nuclear and Quantum Engineering
      • • Department of Chemical and Biomolecular Engineering
      Sŏul, Seoul, South Korea
    • Pusan National University
      • • Department of Nanomechatronics Engineering
      • • Division of Computer Science and Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2001–2012
    • Sungkyunkwan University
      • Department of Neurosurgery
      Sŏul, Seoul, South Korea
  • 2010–2011
    • National Heart, Lung, and Blood Institute
      Maryland, United States
    • Chonbuk National University
      Tsiuentcheou, Jeollabuk-do, South Korea
    • National Institute of Health, Korea
      Seishō-gun, Gyeongsangbuk-do, South Korea
    • Changwon Polytechnic College
      Shōgen, Gyeongsangnam-do, South Korea
    • Electronics and Telecommunications Research Institute
      Sŏul, Seoul, South Korea
  • 2008–2011
    • National Cancer Center Korea
      Kōyō, Gyeonggi Province, South Korea
    • Chonnam National University
      • Department of Internal Medicine
      Gwangju, Gwangju, South Korea
  • 2008–2010
    • Chonnam National University Hospital
      Sŏul, Seoul, South Korea
  • 2002–2010
    • Samsung Medical Center
      • Department of Neurosurgery
      Seoul, Seoul, South Korea
  • 2009
    • Yeungnam University
      • School of Materials Science and Engineering
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2008–2009
    • Chungnam National University
      • Department of Physics
      Seongnam, Gyeonggi, South Korea
  • 2005–2009
    • Harvard University
      Cambridge, Massachusetts, United States
    • Showa University
      • Institute of Molecular Oncology
      Shinagawa, Tōkyō, Japan
  • 2006
    • Konkuk University
      • Artificial Muscle Research Center
      Sŏul, Seoul, South Korea
  • 2005–2006
    • Korea Electrotechnology Research Institute-KERI
      Tsau-liang-hai, Busan, South Korea
  • 2004
    • University of Southern California
      Los Angeles, California, United States