Jun Li

University of Bonn, Bonn, North Rhine-Westphalia, Germany

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Publications (361)1365.62 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The Al2O3 gate insulator was fabricated via atomic layer deposition technique.•The IZO-TFT with a dual-active-layer shows an excellent performance.•The DOS was calculated based on the experimentally obtained activation energy (EA).•The device can act as driving devices in the next generation flat panel displays.
    Superlattices and Microstructures 12/2014; 76. · 1.98 Impact Factor
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    ABSTRACT: High-performance bottom-gate indium zinc oxide thin-film transistor (TFT) with high-k aluminum oxide thin film as the gate insulator is developed in this paper. Good-quality aluminum oxide thin film deposited via an atomic layer deposition (ALD) technique shows a quite smooth surface (RMS roughness~0.46 nm). The device exhibits a field-effect mobility of 17.9 cm2/Vs, a threshold voltage of −0.46 V, an on/off ratio of 108, and a sub-threshold swing of 0.13 V/Dec. The instability of device under temperature stress has been investigated. The observed negative VTH shift with increasing temperature can be explained by the thermal activation process, the active energy EA can be obtained as a function of VGS from fitting of the temperature dependent log(IDS) and 1/kT. The density-of-states (DOS) was extracted based on the experimentally obtained differential of activation energy (EA) with respect to VGS.
    Materials Science in Semiconductor Processing 11/2014; 27:154–158. · 1.34 Impact Factor
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    ABSTRACT: Transformation induced plasticity effect was found in novel lean 19Cr DSSs.•Self-repairing behavior of diffusion layer occurred as the increase diffusion of Mn.•Ferrite diffusion layer became thicker with increase of oxidation time and Mn content.•Higher Mn content DSS showed compact and continuous Cr2O3 film at 1100 oC.
    Corrosion Science. 11/2014;
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    ABSTRACT: Objective Although there are different ways to treat bicondylar tibial plateau fractures, treatment remains as a challenge to most orthopaedic surgeons. The purpose of this study was to assess the outcomes of dual buttress plates fixation in treatment of bicondylar tibial plateau fractures and to determine risk factors for outcome. Methods Clinical data for 74 patients with bicondylar tibial plateau fracture were retrospectively reviewed. Dual buttress plates were placed through two incisions. All patients were evaluated both radiographically and clinically according to Rasmussen scores and Hospital for Special Surgery (HSS) scores during the follow-up period. The data were analyzed using univariate analysis and multivariate logistic regression analysis to identify independent risk factors for functional outcome (Rasmussen functional score). Results Rasmussen anatomic score was excellent in 34, good in 23, and fair in 17 patients. Sixty-nine patients were followed for a mean of 27 months. Functional results of excellent and good were obtained in 56(81.2%) patients by Rasmussen functional score and in 57 (82.6%) patients by HSS score. Univariate analysis showed Arbeitsgemeinschaft für Osteosynthesefragen (AO) fracture type and reduction quality were significantly related to functional results. Multivariate analysis showed that AO fracture type and reduction quality were independent risk factors for outcome Conclusion Dual buttress plates technique provided a favourable quality of fracture reduction and satisfactory clinical function. Appropriate selection for operation chance, limited soft tissue stripping and filling of osseous defects may lessen or prevent serious complications. Fracture reduction quality and AO fracture type were independent risk factors for clinical function.
    Injury 10/2014; · 2.46 Impact Factor
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    ABSTRACT: Background This provides the long-term patient/graft survival and outcome of BK-viremia and BK virus allograft nephropathy (BKVAN) in renal transplant recipients in the setting of intensive monitoring and preemptive of reduction of immunosuppression. Methods Quantitative BKV DNA PCR and urinary cytology surveillance were performed regularly after transplantation in 229 kidney recipients. Patients with BK-viremia and BKVAN were treated with 30% to 50% reduction in doses of Tacrolimus and/or Mycophenolate mofetil and were monitored for BKV every 3-6 months. All the patients were followed for 5 years. Results Overall 5-year patient and graft survival were 95.6% and 92.1% respectively and independent of presence of decoy cells, BK-viruria, viremia, or BKVAN. After reduction of immunosuppression, BK-viremia (n = 38) resolved in 100% of patients, without increased acute rejection. Recurrent BK-viremia was not observed in viremic patients without BKVAN (n = 30). All BKVAN patients (n = 7, 3.1%) cleared viremia with a mean time of 5.9 months (range 1–15 months) and manifested no decline in eGFR from 1 month to 5 years after transplantation. Conclusions Viral monitoring and preemptive reduction of immunosuppression resulted in the successful resolution of BK-viremia and BKVAN with excellent graft survival and renal function at 5-years.
    Diagnostic Microbiology and Infectious Disease. 10/2014;
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    ABSTRACT: Top-contact thin-film transistors (TFTs) are fabricated in this work by using radio frequency sputtering InZnO (IZO) as the channel layer so as to investigate the effect of working power densities (Pd) on the performance of IZO-TFTs. Good-quality Al2O3 thin films that are used as gate insulators are deposited via atomic layer deposition (ALD) technique. The results show that TFT with a Pd of 1 W/cm2 exhibits the best electrical performance; specifically, field-effect mobility of 17.9 cm2/V s, threshold voltage of −0.46 V, on/off ratio of 108 and sub-threshold swing of 0.13 V/dec. In order to understand the superior performance, the density-of-states (DOS) were investigated based on the temperature-dependent transfer curves. The investigation shows that the sputtering power density has significant effect on DOS of channel layer. The superior electric properties were attributed to the smaller DOS.
    Superlattices and Microstructures 10/2014; 74:11–18. · 1.98 Impact Factor
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    ABSTRACT: To the best of our knowledge, this is the first study to address the use of glucocorticoids in the comparatively special population of pure primary biliary cirrhosis (PBC) patients who have high levels of immunoglobulin G (IgG) and transaminases but do not have PBC-autoimmune hepatitis overlap syndrome. Ursodeoxycholic acid (UDCA) is now assumed to be the standard therapy for PBC patients. However, patients treated with UDCA still have a risk of progression to cirrhosis and end-stage liver disease. The most recent European Association for the Study of the Liver guidelines of 2009 declared that further studies on glucocorticoid therapy in this disease should be a priority. Therefore, we designed this 3-year longitudinal retrospective study, which might provide deep insight into the treatment for PBC.The aim of this study was to assess whether the combination of prednisolone, UDCA, and azathioprine was superior to UDCA alone in these PBC patients.Sixty patients were enrolled in this study. Thirty-one patients underwent UDCA monotherapy, and 29 patients were treated with prednisolone, UDCA, and azathioprine. We analyzed their biochemistries, immune parameters, liver synthetic function, and noninvasive assessments of liver fibrosis, as well as treatment efficacy and adverse effects at baseline and at 1, 3, 6, 12, 24, and 36 months.Alkaline phosphatase (ALP), γ-glutamyl transpeptidase, alanine aminotransferase, and aspartate aminotransferase levels and the aspartate aminotransferase-to-platelet ratio index (APRI) and S-index improved dramatically in both groups, whereas IgG levels only decreased in the combination group (all P < 0.05). Albumin (ALB) levels decreased in the UDCA group but increased with the combination treatment at 36 months. Significant differences between the 2 groups were observed at 36 months in ALP (P = 0.005), IgG (P = 0.002), ALB (P = 0.002), APRI (P = 0.015), and S-index (P = 0.020). Prednisolone combined with UDCA and azathioprine showed a higher efficacy based on our new criteria.The combination of prednisolone, UDCA, and azathioprine is superior to UDCA alone for the treatment of pure PBC patients with high levels of IgG and transaminases. Side effects were minimal or absent.
    Medicine. 10/2014; 93(20):e104.
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    ABSTRACT: Involvement of the renal parenchyma in the acute phase of brucellosis is very rare. Only two cases of renal brucelloma have been reported in the English language literature to date [Au?1]. We report a case of renal abscess caused by Brucella in the acute phase. A 45-year-old Chinese man presented with a high fever, urine occult blood, and a low density lesion in the right kidney. Ultrasound-guided aspiration was done. Brucella melitensis was isolated from both blood and puncture fluid culture. Minocycline combined with moxifloxacin was prescribed for 4 months. The infection relapsed at 6 months after discontinuation. Minocycline combined with rifampin was administered for another 2 months. The brucellosis had not relapsed at more than 20 months later. It is possible to cure renal brucelloma with antibiotics and ultrasound-guided aspiration. Treatment should not be discontinued until the abscess has disappeared and two consecutive blood cultures taken 1 month apart are negative [Au?1].
    International Journal of Infectious Diseases. 09/2014;
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    ABSTRACT: Objective: To report 9 cases of en bloc kidney transplantation from pediatric donors in China and share the clinical experience. Methods: From February 2010 to February 2014, 9 pediatric donors (aged 5 months to 6 years) were assigned to us by the modern donation and allocation system after cardiac death. The en bloc kidneys were recovered in all 9 patients. The inferior vena cava and aorta of the donors were anastomosed to the external vein and artery of the recipients (7 adults and 2 children). Alprostadil or enoxaparin sodium was used for anticoagulation. Results: The kidneys attained immediate perfusion after vascular anastomosis, except for one renal artery that developed thrombosis several minutes later, necessitating nephrectomy of the unilateral graft. The other eight en bloc grafts maintained normal function during the follow-up period of 1-50 months and all the patients survived. There were no rejections or other complications. Based on ultrasonography, the grafts increased in size during the follow-up period. Conclusions: These results indicate that en bloc renal transplantation from pediatric donors is an acceptable procedure, and more widespread use could increase the number of potential donors. Splitting of pediatric donor en bloc kidneys for transplantation into two recipients may also be feasible in well-matched cases. © 2014 S. Karger AG, Basel.
    Urologia Internationalis 08/2014; · 1.07 Impact Factor
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    ABSTRACT: We present a lightweight non-parametric method to generate wrinkles for 3D facial modeling and animation. The key lightweight feature of the method is that it can generate plausible wrinkles using a single low-cost Kinect camera and one high quality 3D face model with details as the example. Our method works in two stages: (1) Offline personalized wrinkled blendshape construction. User-specific expressions are recorded using the RGB-Depth camera, and the wrinkles are generated through example-based synthesis of geometric details. (2) Online 3D facial performance capturing. These reconstructed expressions are used as blendshapes to capture facial animations in real-time. Experiments on a variety of facial performance videos show that our method can produce plausible results, approximating the wrinkles in an accurate way, and is low-cost, convenient for common users.
    Computer-Aided Design 08/2014; · 1.26 Impact Factor
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    ABSTRACT: A high-performance InGaZnO (IGZO) thin-film transistor (TFT) with ZrO2–Al2O3 bilayer gate insulator is fabricated. Compared to IGZO-TFT with ZrO2 single gate insulator, its electrical characteristics are significantly improved, specifically, enhancement of Ion/Ioff ratios by one order of magnitude, increase of the field-effect mobility (from 9.8 to 14 cm2/Vs), reduction of the subthreshold swing from 0.46 to 0.33 V/dec, the maximum density of surface states at the channel-insulator interface decreased from 4.3 × 1012 to 2.5 × 1012 cm−2. The performance enhancements are attributed to the suppression of leakage current, smoother surface morphology, and suppression of charge trapping by using Al2O3 films to modify the high-k ZrO2 dielectric.
    Microelectronics Reliability 07/2014; · 1.14 Impact Factor
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    ABSTRACT: To construct and evaluate the functionality of a choanoid-fluidized bed bioreactor (CFBB) based on microencapsulated immortalized human hepatocytes.
    World journal of gastroenterology : WJG. 06/2014; 20(22):6869-77.
  • Article: Myxedema.
    The lancet. Diabetes & endocrinology. 06/2014;
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    ABSTRACT: The 3,000 rice genomes project The 3,000 rice genomes project 1,2,3* Abstract Background: Rice, Oryza sativa L., is the staple food for half the world's population. By 2030, the production of rice must increase by at least 25% in order to keep up with global population growth and demand. Accelerated genetic gains in rice improvement are needed to mitigate the effects of climate change and loss of arable land, as well as to ensure a stable global food supply. Findings: We resequenced a core collection of 3,000 rice accessions from 89 countries. All 3,000 genomes had an average sequencing depth of 14×, with average genome coverages and mapping rates of 94.0% and 92.5%, respectively. From our sequencing efforts, approximately 18.9 million single nucleotide polymorphisms (SNPs) in rice were discovered when aligned to the reference genome of the temperate japonica variety, Nipponbare. Phylogenetic analyses based on SNP data confirmed differentiation of the O. sativa gene pool into 5 varietal groups – indica, aus/boro, basmati/sadri, tropical japonica and temperate japonica. Conclusions: Here, we report an international resequencing effort of 3,000 rice genomes. This data serves as a foundation for large-scale discovery of novel alleles for important rice phenotypes using various bioinformatics and/or genetic approaches. It also serves to understand the genomic diversity within O. sativa at a higher level of detail. With the release of the sequencing data, the project calls for the global rice community to take advantage of this data as a foundation for establishing a global, public rice genetic/genomic database and information platform for advancing rice breeding technology for future rice improvement.
    GigaScience. 05/2014; 3(7).
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    ABSTRACT: Abstract Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by an abnormal copy number variation (CNV) with a trisomy of chromosome 17p12. The increase of the DNA-segment copy number is expected to alter the allele frequency of single nucleotide polymorphism (SNP) within the duplicated region. We tested whether SNP allele frequency determined by a Sequenom MassArray can be used to detect the CMT1A mutation. Our results revealed distinct patterns of SNP allele frequency distribution, which reliably differentiated CMT1A patients from controls. This finding suggests that this technique may serve as an alternative approach to identifying CNV in certain diseases, including CMT1A.
    Journal of neurogenetics 05/2014; · 0.73 Impact Factor
  • Tumor Biology 04/2014; · 2.52 Impact Factor
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    ABSTRACT: Development of intimal hyperplasia (IH) is the main pathology underlying graft failure following coronary artery bypass graft surgeries for ischaemic heart diseases, especially for great saphenous vein grafts which have a lower patency rate than internal mammary arteries. Neuropilin 1 (NRP1), which is a co-receptor for vascular endothelial growth factor found in vascular endothelial and smooth muscle cells, affects the development of IH. We examined the difference in NRP1 expression and distribution in human coronaries, aortas, mammary arteries and saphenous veins to detect a possible relation to their susceptibility to IH. Ninety-five human vascular segments obtained from 40 patients were used for the comparison of NRP1 expression between different groups of blood vessels by western blot and real-time PCR. Additionally, staining scores were generated by computerized analysis of the microscopic images obtained after immunofluorescence and immunohistochemical staining to compare NRP1 expression patterns in endothelium, smooth muscles and adventitia in each vessel type. NRP1 expression in the aorta (2.03 ± 1.44) was more than twice as high as mammary artery expression (0.85 ± 0.75; n = 16, P = 0.0004); NRP1 of the latter (0.99 ± 0.91) was more than 30% greater than that of the corresponding saphenous vein (0.73 ± 0.69; n = 20, P = 0.0085). In adventitia, NRP1 receptor staining of the saphenous vein was higher (22.96 ± 8.73) than in the mammary artery (15.83 ± 7.13; n = 7, P = 0.049). Variations in NRP1 protein levels were accompanied by parallel variations in its mRNA levels (n = 15, P = 0.34). Autologous saphenous vein grafts, unlike internal mammary artery grafts, have lower NRP1 expression and abundant adventitial distribution of NRP1 within their walls; this may correlate with higher susceptibility to IH development.
    European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 04/2014; · 2.40 Impact Factor
  • Jun Li, Juehua Jing
    Tumor Biology 03/2014; · 2.52 Impact Factor
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    ABSTRACT: Augmenter of liver regeneration (ALR) is an important polypeptide that participates in the process of liver regeneration. Two forms of ALR proteins are expressed in hepatocytes. Previous data have shown that ALR is essential for cell survival and has potential antimetastatic properties in hepatocellular carcinoma (HCC).
    OncoTargets and Therapy 01/2014; 7:887-93. · 2.07 Impact Factor

Publication Stats

6k Citations
1,365.62 Total Impact Points

Institutions

  • 2014
    • University of Bonn
      Bonn, North Rhine-Westphalia, Germany
  • 2009–2014
    • Shanghai University
      • • Institute of Materials Science
      • • School of Materials Science and Engineering
      Shanghai, Shanghai Shi, China
    • Wuhan University
      Wu-han-shih, Hubei, China
  • 2008–2014
    • Beijing Medical University
      • Department of Infectious Diseases
      Peping, Beijing, China
    • Beijing Normal University
      Peping, Beijing, China
    • Wuhan Union Hospital
      Wu-han-shih, Hubei, China
  • 2005–2014
    • Zhejiang University
      • School of Medicine
      Hang-hsien, Zhejiang Sheng, China
  • 2013
    • Chinese Academy of Sciences
      • Institute of Plasma Physics
      Peping, Beijing, China
    • Wuhan University of Science and Technology
      Wu-han-shih, Hubei, China
    • University of Oxford
      • Department of Zoology
      Oxford, ENG, United Kingdom
    • Harbin Medical University
      • Department of Urology
      Charbin, Heilongjiang Sheng, China
    • Zagazig University
      • Department of Cardiothoracic Surgery
      Ez Zaqāzīq, Eastern Province, Egypt
    • Anhui Medical University
      • Department of Orthopaedics
      Luchow, Anhui Sheng, China
  • 2010–2013
    • University of Technology Sydney 
      • Centre for Quantum Computation and Intelligent Systems (QCIS)
      Sydney, New South Wales, Australia
    • The University of Hong Kong
      • School of Biological Sciences
      Hong Kong, Hong Kong
    • Nantong University
      Tungchow, Jiangsu Sheng, China
  • 2008–2013
    • Sun Yat-Sen University
      • • Department of Biochemistry
      • • Department of Organ Transplantation
      • • Department of Microbiology
      • • Section of Histology and Embryology
      Guangzhou, Guangdong Sheng, China
  • 2012
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Shanghai Jiao Tong University
      • Department of Ophthalmology
      Shanghai, Shanghai Shi, China
  • 2011–2012
    • Nanfang Hospital
      Shengcheng, Guangdong, China
    • Vanderbilt University
      • Department of Neurology
      Nashville, MI, United States
    • Guilin University of Electronic Technology
      Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China
    • Shanghai Putuo District People's Hospital
      Shanghai, Shanghai Shi, China
    • Sun Yat-Sen University of Medical Sciences
      Shengcheng, Guangdong, China
  • 2010–2012
    • Sun Yat-Sen University Cancer Center
      Shengcheng, Guangdong, China
  • 2006–2012
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2007–2011
    • Huazhong University of Science and Technology
      • Department of Otorhinolaryngology, Head and Neck Surgery
      Wu-han-shih, Hubei, China
  • 2002–2011
    • Wayne State University
      • Department of Neurology
      Detroit, MI, United States
    • University of Utah
      • Department of Neurology
      Salt Lake City, UT, United States
  • 2009–2010
    • Chongqing University
      • Engineering Thermophysics Research Institute
      Chongqing, Chongqing Shi, China
  • 2008–2010
    • Nanyang Technological University
      • School of Mechanical and Aerospace Engineering (MAE)
      Singapore, Singapore
  • 2006–2009
    • Xi'an Jiaotong University
      • School of Energy and Power Engineering
      Xi’an, Shaanxi Sheng, China
  • 2005–2009
    • Southwest University in Chongqing
      Pehpei, Chongqing Shi, China
    • Beijing Genomics Institute
      Bao'an, Guangdong, China
  • 2002–2007
    • Peking University
      • Institute of Mental Health
      Beijing, Beijing Shi, China
  • 2005–2006
    • Northeast Institute of Geography and Agroecology
      • • Institute of Computing Technology
      • • Key Laboratory for Cellular and Molecular Evolution
      Beijing, Beijing Shi, China
    • Peking University People's Hospital
      Peping, Beijing, China