Jun Ma

Shanghai Institutes for Biological Sciences, Shanghai, Shanghai Shi, China

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Publications (76)76.78 Total impact

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    ABSTRACT: Three genome-wide association studies were previously done for nonalcoholic fatty liver disease (NAFLD) among individuals of western countries and identified several genetic variants associated with NAFLD. The study aimed to identify whether seven GWAS-identified common variants (GCKR rs780094, PDGFA rs343064, FDFT1 rs2645424, COL13A1 rs1227756, EHBP1L1 rs6591182, NCAN rs2228603, PNPLA3 rs738409) were associated with NAFLD in Chinese children. The case-control study recruited 1,027 Chinese children aged 7 to 18, including 162 children with NAFLD and 865 children without NAFLD. Anthropometric measurements, alanine transaminase (ALT) detection, liver ultrasound examination and genotyping of 7 variants were performed. The G-allele of PNPLA3 rs738409 was associated with NAFLD (OR = 1.55, 95%CI: 1.13-2.11, P = 0.006) and moderate to severe steatosis (OR = 3.77, 95%CI: 1.78-7.98, P = 0.001) adjusted for age, gender and BMI standard deviation score (BMI-SDS). Additionally we found each G-allele of rs738409 increased ALT level by 1.09 IU/L (P = 0.011). Subjects carrying 10 or more risk alleles of 7 variants had an odds ratio of 4.76 (P = 0.025) for NAFLD compared with subjects carrying 3 or fewer risk alleles. The PNPLA3 rs738409 G-allele was associated with NAFLD and ALT level in Chinese children. It had stronger association with moderate to severe steatosis. Children carrying 10 or more risk alleles of 7 variants were susceptible for NAFLD.
    Journal of pediatric gastroenterology and nutrition. 12/2014;
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    ABSTRACT: Childhood obesity has been a serious public health problem. An effective school-based physical activity (PA) intervention is still lacking in China. This study aimed to assess the effectiveness of a school-based physical activity intervention during 12 weeks on obesity and related health outcomes in school children. It was a non-randomized controlled trial. Altogether 921 children aged 7 to 15 years were recruited at baseline survey. Children in the intervention group (n = 388) participated in a multi-component physical activity intervention during 12 weeks that included improvement of physical education, extracurricular physical activities for overweight/obese students, physical activities at home, and health education lectures for students and parents. Children (n = 533) in the control group participated in usual practice. Participants had mean age of 10.4 years, mean body mass index (BMI) of 19.59 kg/m2, and 36.8 % of them were overweight or obese at baseline survey. The change in BMI in intervention group (-0.02 +/- 0.06 kg/m2) was significantly different from that in control group (0.41 +/- 0.08 kg/m2). The adjusted mean difference was -0.43 kg/m2 (95%CI: -0.63 to -0.23 kg/m2, P < 0.001). The effects on triceps, subscapular, abdominal skinfold thickness and fasting glucose were also significant in intervention group compared with control group (all P < 0.05). The change in duration of moderate to vigorous physical activity (MVPA) in intervention group (8.9 +/- 4.3 min/day) was significantly different from that in control group (-13.8 +/- 3.3 min/day). The adjusted mean difference was 22.7 min/day (95%CI: 12.2 to 33.2 min/day, P < 0.001). The school-based, multi-component physical activity intervention was effective to decreasing levels of BMI, skinfold thickness, fasting glucose and increasing duration of MVPA. These findings provided evidence for the development of effective and feasible school-based obesity interventions.Trial registration: Clinicaltrials.gov Identifier: NCT02074332 (2014-02-26).
    BMC Public Health 12/2014; 14(1):1282. · 2.32 Impact Factor
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    ABSTRACT: To estimate the shifts in age at menarche from 1985 to 2010, compare the differences of average age at menarche between urban and rural groups, and determine the association of menarche with body mass index (BMI).
    Journal of Pediatrics 09/2014; · 3.74 Impact Factor
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    ABSTRACT: The committed step of leucine biosynthesis, converting acetyl-CoA and α-ketoisovalerate into α-isopropylmalate, is catalyzed by α-isopropylmalate synthase (IPMS), an allosteric enzyme subjected to feedback inhibition by the end product L-leucine. We characterized the short form IPMS from Leptospira biflexa (LbIPMS2) which exhibits a catalytic activity comparable to that of the long form IPMS (LbIPMS1) and has a similar N-terminal domain followed by subdomain I and subdomain II but lacks the whole C-terminal regulatory domain. We found that partial deletion of the regulatory domain of LbIPMS1 lost about 50% of the catalytic activity; however, complete missing of the regulatory domain up to R385, almost equivalent to the intact LbIPMS2, maintained about 90% of the activity. Moreover, in either LbIPMS2 or LbIPMS1, further deletion of several residues from the C-terminus of subdomain II significantly impaired or completely abolished the catalytic activity. These results define a complete and independently functional catalytic module of IPMS consisting of both the N terminal domain and the two subdomains. Structural comparison of LbIPMS2 and the Mycobacterium tuberculosis IPMS reveals two different conformations of subdomain II, which likely represent two substrate-binding states related to cooperative catalysis. The biochemical and structural analyses together with the previously published hydrogen-deuterium exchange data lead us to propose a conformation transition mechanism for feedback inhibition mediated by subdomains I and II which might associate with alteration of the binding affinity towards acetyl-CoA.
    Journal of Biological Chemistry 08/2014; · 4.60 Impact Factor
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    ABSTRACT: The purpose of this study was to explore an objective measure to assess actual body shape of children and adolescents in China.
    Biomedical and environmental sciences : BES. 08/2014; 27(8):582-93.
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    ABSTRACT: Resting heart rate (RHR) is an accessible index of sympathetic activity. The objective of this study was to assess the associations between blood pressure (BP) and RHR in children with different waist circumferences (WCs). The data of the Chinese National Survey on Students' Constitution and Health in 2010 were used. A total of 91,762 participates aged 9 to 18 years with complete records were included. RHR was categorised into quintile groups and WC was stratified into small (<-1.035), medium (≥-1.035 and <1.035) and large (≥1.035) groups respectively, after they were converted into age- and sex-specific z-score. Multivariate linear regression revealed that the association between RHR z-score and BP was similar before and after WC was adjusted for. With 1 standard deviation variation in RHR, BP changed from 2.22 (95 % confidence interval (CI): 1.51, 2.93) to 3.58 mmHg (95 % CI: 2.54, 4.62) in small WC group and 1.83 (95 % CI: 1.10, 2.56) to 4.23 mmHg (95 % CI: 3.38, 5.09) in large WC group respectively. Conclusions: This study revealed that BP was positively associated with RHR among children with different WCs, which implied the positive association between sympathetic activity and BP in children regardless of the amount of abdominal fat.
    European Journal of Pediatrics 07/2014; · 1.98 Impact Factor
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    ABSTRACT: Abstract: Objectives: To analyze the characteristics of sleep duration in Chinese primary and middle school students. Methods The data was collected from 30 provinces (Autonomous regions, Municipalities) in 165 363 Han Primary school students above 4 grade, the junior and senior high school students who participated in 2010 National Physical Fitness and Health Surveillance by using stratified random cluster sampling method, and the questionnaire of sleep duration, insufficient sleep and commuting way from school was conducted at the same time. χ2 test and χ2linear-by-linear test were used to analyze the difference between the different groups, and logistic regression was used to analyze the factors of insufficient sleep. Results Nationwide in 2010, 39.09% (64 646/165 363) of students reported they had more than 8 hours sleep duration per day, the prevalence was lower among urban (37.06% (30 767/83 027)) than rural (41.15% (33 879/82 336)) students (χ2=290.525, P﹤0.01), and higher among boys (40.25% (33 193/82 446)) than girls (37.94% (31 453/82 897)) (χ2=92.508, P﹤0.01). The prevalence of having more than 8 hours sleep duration per day in 9~12 years group, 13~15 years group and 16~18 years group was 70.24% (43 934/62 549)、31.31% (16 166/51 652)and 8.89% (546/51 162), respectively, and decreased with the age increasing (χ2linear-by-linear =50 617.752, P﹤0.01). The prevalence of insufficient sleep was 93.64% (154 838/165 363) in total students, the prevalence was higher among urban (94.94% (78 829/83 027))than rural students(92.32% (76 009/82336)) (χ2 =479.135, P﹤0.01), and lower among boys (92.65% (76 408/82 466) than girls 94.61% (78 430/82 897) (χ2=265.785, P﹤0.01). The prevalence of insufficient sleep in 9~12 years group, 13~15 years group and 16~18 years group was 96.42% (60 310/62 549)、92.76% (47 912/51 562) and 91.11% (46 616/51 162) , respectively. A multivariate logistic regression analysis (OR(95%CI)) revealed that the insufficient sleep was significantly associated with being urban (1.58 (1.51-1.65)), being girls (1.39 (1.34-1.45)), being 9-12 years group (2.77 (2.62-2.93)), living in the middle (1.19 (1.13-1.25)) or western (1.08 (1.03-1.13)) of China, and commuting from school by bicycle (1.21 (1.14-1.28)), bus/car (1.09 (1.03-1.15)), or in a boarding school (1.17 (1.10-1.24)). Conclusion The sleep duration in Chinese school children is low, a sizeable proportion of school children sleep less than the recommended hours. The prevalence of insufficient sleep is high, and there are obvious different in different groups.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 07/2014; 48(7):596-601.
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    ABSTRACT: Background:Being overweight or obese is becoming increasingly common in low- and middle-income countries. The present study aimed to examine association of eight genetic variants with obesity and to estimate the cumulative effects of these variants in Chinese children.Methods:We conducted the case-control study in a total of 2030 subjects. Genotyping of 7 novel variants was performed with matrix assisted laser desorption ionization time of flight mass spectrometry, while rs9939609 was genotyped with tetra-primer amplification refractory mutation system analysis.Results:The association of two FTO SNPs (rs9939609 and rs62048402) with BMI or obesity reached nominal significance at P<0.05. We found a cumulative effect of 5 SNPs on the risk of overweight and obesity (OR= 1.197, 95% CI: 1.068-1.342, P=0.002). Subjects carrying 9 or more effect alleles had a 127% increased risk of overweight and obesity (OR=2.270, 95% CI: 1.403-3.671, P=0.001) compared with subjects that carry 6 or fewer effect alleles.Conclusion:We confirmed two FTO SNPs (rs62048402 and rs9939609) had nominal significant effects on BMI or obesity. We identified the cumulative effect of 5 SNPs on risk of overweight and obesity. The results provided evidences for identifying genetic factors related to childhood obesity.Pediatric Research (2014); doi:10.1038/pr.2014.88.
    Pediatric Research 06/2014; · 2.84 Impact Factor
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    ABSTRACT: To investigate the association between rs780094 polymorphism in glucokinase regulatory protein (GCKR) and plasma lipid levels in children and adolescents.
    06/2014; 35(6):626-629.
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    ABSTRACT: An increasing number of people are at risk for developing nonalcoholic fatty liver disease (NAFLD). Because obesity is a risk factor for NAFLD, the common variants of obesity-susceptible genes may be associated with NAFLD. Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD. The case-control study recruited 1027 Chinese children ages 7 to 18 years, including 162 children with NAFLD and 865 children without NAFLD. Anthropometric measurements, alanine transaminase (ALT) detection, liver ultrasound examination, and genotyping of 8 gene variants were performed. The A-allele of FTO rs9939609 was associated with increased NAFLD risk (P = 0.029, odds ratio 1.43), but was not significant after being adjusted for body mass index (BMI) (P = 0.268). We also found an association between the 2 variants (rs12970134 in MC4R and rs9308762 in INSIG2) and ALT level. For rs12970134, each additional A-allele increased ALT level by 1.87 IU/L (P = 0.032). For rs9308762, the homozygotes of the C-allele had a higher ALT level than the T-allele carriers (β = 3.19, P = 0.007). After adjustment for BMI, the former association did not exist, whereas the latter reminded significant (P = 0.003). The FTO rs9939609 A-allele increased risk of NAFLD and MC4R rs12970134 was associated with ALT level through an effect on BMI. The association between INSIG2 rs9308762 and ALT level was independent of BMI. The results provided evidence for identifying genetic factors of NAFLD and may be useful for risk assessment and personalized medicine of NAFLD.
    Journal of pediatric gastroenterology and nutrition 02/2014; 58(2):157-61. · 2.18 Impact Factor
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    ABSTRACT: Background. Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children. Methods. A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls. We genotyped 15 single nucleotide polymorphisms (SNPs) of five genes in INSIG-SCAP-SREBP pathway, including insulin induced gene 1 (INSIG1), insulin induced gene 2 (INSIG2), SREBP cleavage-activating protein gene (SCAP), sterol regulatory element binding protein gene 1 (SREBP1), and sterol regulatory element binding protein gene 2 (SREBP2). We used generalized multifactor dimensionality reduction (GMDR) and logistic regression to investigate gene-gene interactions. Results. Single polymorphism analyses showed that SCAP rs12487736 and rs12490383 were nominally associated with obesity. We identified a 3-locus interaction on obesity in GMDR analyses (P = 0.001), involving 3 genetic variants of INSIG2, SCAP, and SREBP2. The individuals in high-risk group of the 3-locus combinations had a 79.9% increased risk of obesity compared with those in low-risk group (OR = 1.799, 95% CI: 1.475-2.193, P = 6.61 × 10(-9)). Conclusion. We identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
    BioMed Research International 01/2014; 2014:538564. · 2.71 Impact Factor
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    ABSTRACT: Objective: To identify gender differences among Chinese school-aged children from 1995 to 2010, and to project the future BMI-for-age z-score distribution and prevalence of obesity. Design and methods: The data were from four cross-sectional surveys (1995, 2000, 2005, and 2010) of Chinese National Surveys on Students Constitution and Health (CNSSCH) with a national representative sample of Chinese children, involving more than 200,000 participants at each survey. BMI-for-age Z-score distributional shifts overall and in percentiles were compared by gender. Average shift was calculated for 4 survey periods and used for projecting future distributions and obesity prevalence. Results: BMI-for-age Z-score increased more in their upper percentile distribution, indicating that Chinese children have become heavier over the past 15 years. Gender disparity in BMI-for-age Z-score has become wider during the period. Over a 15-year period, BMI-for-age Z-score shift among girls has been stable, while boy's BMI-for-age Z-score shifts has increased linearly. By 2020, the obesity prevalence is predicted to be 10.18% and 4.99% for boys and girls, respectively. Conclusions: The wider gender disparity suggested a larger proportion of obesity in boys than in girls. Therefore, gender-specific preventive guidelines and public health policies for childhood obesity and cardiovascular diseases are urgently needed in China.
    Obesity 12/2013; · 4.39 Impact Factor
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    ABSTRACT: The dramatic rise of overweight and obesity among Chinese children has greatly affected the social economic development. However, no information on the cost-effectiveness of interventions in China is available. The objective of this study is to evaluate the cost and the cost-effectiveness of a comprehensive intervention program for childhood obesity. We hypothesized the integrated intervention which combined nutrition education and physical activity (PA) is more cost-effective than the same intensity of single intervention. And Findings: A multi-center randomized controlled trial conducted in six large cities during 2009-2010. A total of 8301 primary school students were categorized into five groups and followed one academic year. Nutrition intervention, PA intervention and their shared common control group were located in Beijing. The combined intervention and its' control group were located in other 5 cities. In nutrition education group, 'nutrition and health classes' were given 6 times for the students, 2 times for the parents and 4 times for the teachers and health workers. "Happy 10" was carried out twice per day in PA group. The comprehensive intervention was a combination of nutrition and PA interventions. BMI and BAZ increment was 0.65 kg/m(2) (SE 0.09) and 0.01 (SE 0.11) in the combined intervention, respectively, significantly lower than that in its' control group (0.82±0.09 for BMI, 0.10±0.11 for BAZ). No significant difference were found neither in BMI nor in BAZ change between the PA intervention and its' control, which is the same case in the nutrition intervention. The single intervention has a relative lower intervention costs compared with the combined intervention. Labor costs in Guangzhou, Shanghai and Jinan was higher compared to other cities. The cost-effectiveness ratio was $120.3 for BMI and $249.3 for BAZ in combined intervention, respectively. The school-based integrated obesity intervention program was cost-effectiveness for children in urban China. Chinese Clinical Trial Registry ChiCTR-PRC-09000402 URL:http://www.chictr.org/cn/
    PLoS ONE 10/2013; 8(10):e77971. · 3.53 Impact Factor
  • Jun Ma
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):680-683.
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    ABSTRACT: To analyze the association between abdominal obesity and blood pressure among 7-10 years old Chinese children. A total of 40 495 children aged 7-10 years with complete height, weight, waist circumference and blood pressure data were chosen from the data of 2010 Chinese National Survey on Students Constitution and Health. Based on the "Reference Norms for Screening Overweight and Obesity in Chinese Children and Adolescents" developed by Working Group Obesity in China (WGOC) and the waist to height ratio reference value for children (WHtR ≤ 0.46) , the children were divided into 4 body types (normal weight, simple abdominal obesity, combined obesity and other types). High blood pressure was defined as the systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) higher than the P 95 blood pressure value of 2010 national student of the same gender and age. The prevalence of simple abdominal obesity, combined obesity and high blood pressure were described. Three groups (with 2165 children in each) of children with normal weight, simple abdominal obesity, combined obesity respectively were selected from the chosen ones matched by gender, age (within ± 0.5 years old) and height (within ± 0.3 cm) at the ratio of 1: 1: 1. The value of blood pressure and prevalence of high blood pressure were described.χ(2) test, analysis of variance and multilevel models were used to analyze the relationship between obesity and blood pressure. A total of 40 475 children were selected from the database, including 20 175 boys and 20 320 girls. The prevalence of simple abdominal obesity was 6.36% (2576/40 495), the prevalence of boys and girls was 7.41% (1494/20 175) and 5.32% (1082/20 320) respectively. The prevalence of combined obesity was 16.33% (6611/40 495), the prevalence of boys and girls was 21.30% (4298/20 175) and 11.38% (2313/20 320) respectively. There were statistical differences in the body type distribution of both boys and girls (χ(2) = 869.01, P < 0.01). The prevalence of high blood pressure was 9.62% (3896/40 495), the prevalence of boys (10.05% (2028/20 175)) was higher than girls (9.19% (1868/20 320)) (χ(2) = 8.59, P < 0.01). The value of SBP and DBP among combined obesity group (boys: (103.8 ± 11.3), (64.7 ± 10.1) mm Hg (1 mm Hg = 0.133 kPa); girls: (102.9 ± 12.1), (64.5 ± 10.0) mm Hg) > simple abdominal obesity group (boys: (99.5 ± 11.2), (61.6 ± 9.9) mm Hg; girls: (99.6 ± 11.4), (62.6 ± 9.3) mm Hg)> normal weight group (boys: (97.4 ± 10.8), (60.5 ± 9.4) mm Hg; girls: (97.2 ± 10.8), (60.8 ± 9.4) mm Hg), and the differences were statistical significant (Fboys: 113.22, 62.05; Fgirls: 54.19, 32.31, P < 0.01). According to the results of multilevel model, among boys, compared with the normal weight group, the SBP of combined obesity group and simple abdominal obesity group was 6.0 and 1.8 mm Hg higher respectively (Wald χ(2): 17.55, 204.94, P < 0.01); the DBP was 4.0 and 0.9 mm Hg higher respectively (Wald χ(2): 6.37, 114.05, P < 0.05). Among girls, the SBP was 5.0 and 2.1 mm Hg higher respectively (Wald χ(2):16.47, 92.52, P < 0.01); the DBP was 3.5 and 1.6 mm Hg higher respectively (Wald χ(2): 12.29, 57.52, P < 0.01). Comparing with normal group, the risk of high SBP among boys with simple abdominal obesity was higher (OR = 1.48; 95%CI: 1.06-2.06), and both the boys (SBP: OR = 3.06; 95%CI: 2.28-4.11) ; DBP: OR = 2.72; 95%CI: 1.99-3.72) and girls (SBP: OR = 2.48; 95%CI: 1.75-3.53; DBP: OR = 2.64; 95%CI: 1.82-3.93) in combined obesity group had a higher risk of high SBP and high DBP. Simple abdominal obesity is associated with the increasing of blood pressure in children, and combined obesity has a closer ties than simple abdominal obesity.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):689-694.
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    ABSTRACT: To explore the association between early menarche with anthropometry measurements among adolescent girls in China. Research material was selected from the data of 2010 Chinese National Surveys on Students Constitution and Health. Probability unit regression method was used to calculate the age of 10th percentile (P 10) at menarche and menarche age before the P 10 was defined as early menarche(9.0-11.6 years old). A total of 1072 girls with early menarche were screened. Each girl with early menarche was frequency matched with two girls who hadn't achieved menarche and with the age difference less than 0.1 yr and from the same urban or rural locations. A total of 2144 girls without menarche were screened. Participants' data of height, weight, sitting height, chest circumference, body mass index(BMI) and height and sitting height index were analyzed. t test and wilcoxon test were used to analyze the anthropometry measurements differences between the two groups, Chi square test was used to analyze the differences of overweight and obesity between the two groups. Multilevel model was used to explore the association between early menarche with anthropometry measurements and overweight and obesity. A total of 1072 girls with early menarche and 2144 girls without menarche. Early menarche girls' height, sitting height, chest circumference, weight and BMI were (151.42 ± 7.46) cm, (80.86 ± 4.21) cm, (73.88 ± 7.72) cm, (44.32 ± 9.35) kg, and (19.18 ± 3.03) kg/m(2), while they were (144.86 ± 7.55) cm, (76.96 ± 4.05) cm, (67.25 ± 6.94) cm, (36.07 ± 7.88) kg and (16.64 ± 2.48) kg/m(2) in girls without menarche. The difference between two groups were significant(Z values were -22.20, -23.69, -24.38, -23.12, -20.17, -6.33 respectively with all P values < 0.01). Multilevel analysis results showed that in 9.0-11.6 years old girls early menarche was associated with anthropometry measurements(all P values < 0.05). Compared with girls without menarche, girls with early menarche had a relative higher height, sitting height, weight, chest circumference, with increments of 5.28 cm, 3.37 cm, 5.53 cm, 6.37 kg, 1.79 kg/m(2). Within subgroup analysis, there were parabolic trends with age in the height, weight and sitting height differences and "U" trend in chest circumference difference between girls with early menarche and girls without menarche.In 9.0-10.8 years old, 10.9-11.0 years old and 11.1-11.2 years old groups, the risk of overweight and obesity among girls with early menarche were 2.98 (95%CI:1.92-4.63) times, 6.76 (95%CI:2.79-16.39) times, 2.99 (95%CI:1.40-6.40) times of girls without menarche. The early onset of menarche is related with height, sitting height, weight and chest circumference, and it is closely associated with overweight and obesity among adolescent girls in China.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):712-717.
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    ABSTRACT: To explore the association between spermatorrhea and physical development during puberty for boys aged 11 to 15 years old in China. The height, weight, chest circumference, waist circumference, hip circumference and the station of spermatorrhea of boys aged 11-15 years old were selected from the data of 2010 National Survey on Students Constitution and Health. Body mass index (BMI) and waist to height ratio were calculated. After 1: 1 random matching in every 0.1 year of age, 6880 boys (3440 with spermatorrhea and 3440 without spermatorrhea) were included in our study. t-test was used to analyze differences in anthropometry measurements between boys with spermatorrhea and boys without spermatorrhea in each age group. Multilevel model was used to analyze the relationship between anthropometry measurements and spermatorrhea. A total of 6880 boys were put in this research. Heights of boys with spermatorrhea aged 11 to 15 years old were (150.96 ± 8.01), (159.46 ± 8.03), (163.76 ± 7.43), (167.03 ± 7.12) and (169.50 ± 6.64) cm, respectively, while heights of boys without spermatorrhea aged 11 to 15 were (147.38 ± 6.54), (153.55 ± 8.68), (160.35 ± 8.66), (164.44 ± 7.98) and (167.98 ± 7.80) cm, respectively. The differences were significant (t values were 3.70, 9.96, 10.76, 8.26, and 3.21 respectively with all P values < 0.01). of multilevel analysis showed that the differences of weight were the largest from 11 to 13 years old, boys with spermatorrhea having a 4.20, 7.23 and 3.93 kg (Waldχ(2) values were 13.11, 70.73 and 72.93 respectively, all P values < 0.01) larger weight than boys without spermatorrhea, respectively. Differences of height were the largest from 14 to 15 years old, boys with spermatorrhea having a 2.81 and 1.99 cm (Waldχ(2) values were 87.80 and 19.54, P < 0.01) larger height than boys without spermatorrhea. The trends of the differences between boys with spermatorrhea and boys without spermatorrhea (β value) with age were parabolic on weight, BMI, height, chest circumference, waist circumference, hip circumference and waist to height ratio. The β values reached maximum at 12 years old, which were 7.23 kg, 1.64 kg/m(2), 5.55 cm, 4.40 cm, 4.63 cm, 4.94 cm, and 0.015, respectively. The β values reached minimum at 15 years old, which were -0.39 kg, -0.56 kg/m(2), 1.99 cm, -0.57 cm, -1.59 cm, -0.42 cm and -0.015, respectively. There is an association between spermatorrhea and physical development among boys aged 11 to 15 years in China , which has a parabolic trend with age.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):695-699.
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    ABSTRACT: To explore the influencing factors on physical endurance among Chinese primary and middle school students aged 10-17. Data was used from "2010 National Physical Fitness and Health Surveillance", from which 68 458 primary and middle school students with complete information were selected. Good physical endurance was defined as endurance running time ≤ P 25 of same gender and age, poor physical endurance as ≥ P 75 of same gender and age. Difference of endurance running time in different physical endurance groups was compared; chi-square test, logistic regression and multiple level model were used to analyze influence of region, BMI, diet, exercise and exercise willingness on physical endurance. There were 34 293 (50.0%) students of good physical endurance and 34 219 (50.0%) ones of poor physical endurance in 68 458 subjects. Percentage of good physical endurance was 53.8% (18 285/33 996) in rural students, higher than urban ones (46.3% (15 954/34 462)) (χ(2) = 384.16, P < 0.01). Percentage of good physical endurance was 12.2% (448/3660) in obese students, lower than normal (55.2% (28 183/51 028)), overweight (29.3% (2012/6874)) and emaciated ones (52.1% (3596/6896)) (χ(2) = 3840.08, P < 0.01). Percentage of good physical endurance was 52.5% (25 534/48 679) in students having breakfast everyday, higher than ones never having breakfast or 1-2 times per week (41.3% (3209/7768))(χ(2) = 438.31, P < 0.01). Percentage of good physical endurance was 51.7% (11 580/22 379) in students having milk everyday, slightly higher than ones never or sometimes having milk (49.2% (22 659/46 079)) (χ(2) = 39.84, P < 0.01). Percentage of good physical endurance was 55.3% (18 961/34 314) in students with adequate physical education class, higher than ones with inadequate class (44.7% (15 278/34 144)) (χ(2) = 756.41, P < 0.01). Percentage of good physical endurance was 58.6% (9484/16 195) in students with one hour exercise or more per day, higher than ones with less than one hour exercise (47.4% (24 755/52 263)) (χ(2) = 619.82, P < 0.01). Percentage of good physical endurance was 60.1% (19 287/32 118) in students who were "very willing" to take part in endurance running, higher than "generally willing" ones (45.4% (10 569/23 272)) and "not willing" ones (33.5% (4383/13 068)) (χ(2) = 2909.61, P < 0.01). Multiple level analysis revealed that risk of poor physical endurance was lower in rural students (OR = 0.80, 95%CI: 0.77-0.82) than urban ones. Risk in emaciated students (OR = 1.11, 95%CI: 1.05-1.17), overweight students (OR = 2.69, 95%CI: 2.55-2.85) and obese students (OR = 7.71, 95%CI: 6.97-8.52) was higher than normal ones. Concerning diet, risk of poor physical endurance in students never having breakfast or once to twice per week was highest (OR = 1.20, 95%CI: 1.13-1.26), followed by students having breakfast three to five times per week (OR = 1.13, 95%CI: 1.08-1.18); risk in students having one bag of milk per day was higher (OR = 1.09, 95%CI: 1.02-1.17) than ones having two bags. Concerning exercise, risk of poor physical endurance in students with inadequate physical education class (OR = 1.20, 95%CI: 1.13-1.26) and less than one hour exercise per day (OR = 1.34, 95%CI: 1.29-1.40) was higher than ones with adequate physical education class and one hour exercise or more respectively. Risk of poor physical endurance in students who were "generally willing" (OR = 1.67, 95%CI: 1.61-1.73) and "not willing" (OR = 2.72, 95%CI: 2.60-2.85) to take part in endurance running was higher than "very willing" ones. Urban and rural residence, BMI, breakfast, milk, physical education class, exercise time and exercise willingness were related to primary and middle school students'physical endurance.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):700-706.
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    ABSTRACT: To explore the association between sleep duration and the level of puberty blood pressure of students aged 9 to 17 years in China. The data were from physical fitness and health research of chinese school students in 2010. A total of 123 919 boys aged 11 to 17 years and girls aged 9 to 17 years were included in our study, whose record of height, weight, blood pressure, sleep duration and first spermatorrhea/menarche were performed. Students were grouped as relative enough sleep duration group and short sleep duration group by their sleep duration reported. The level of blood pressure, as well as the prevalence of high blood pressure (HBP), was compared between different sleep duration groups, and multilevel model was used and analyzed the relationship between sleep duration and blood pressure. 123 919 students were surveyed in this study, including 52 549 boys and 71 370 girls. The mean blood pressure of boys was 109.41/67.05 mm Hg (1 mm Hg = 0.133 kPa), 30 830 boys (58.7%) experienced first spermatorrhea, and 18 692 boys (35.6%) were defined as relative enough sleep duration. The mean level blood pressure of girls surveyed was 103.65/65.12 mm Hg, 46 031 girls (64.5%) experienced menarche, and 23 143 girls (32.4%) were defined as relative enough sleep duration. Among the boys without first spermatorrhea, 7481 boys (34.4%) were defined as relative enough sleep duration, whose mean blood pressure was 105.25/65.01 mm Hg and prevalence of HBP was 4.3% (325/7481), and 14 238 boys (65.6%) were defined as short sleep duration, whose mean blood pressure was 105.9/65.27 mm Hg and prevalence of HBP was 5.6% (802/14 238), boys with relative enough sleep duration showed a significant lower blood pressure level and the prevalence of HBP compared with boys with short sleep duration (F = 15.38, P < 0.01;χ(2) = 16.55, P < 0.01). Among girls without menarche, 9311 girls (36.7%) were defined as relative enough sleep duration, whose mean blood pressure was 100.47/63.25 mm Hg and prevalence of HBP was 2.9% (271/9311), 16 028 girls (63.3%) were defined as short sleep duration, whose mean blood pressure was 101.06/63.57 mm Hg and prevalence of HBP was 3.3% (536/16 028), girls with relative enough sleep duration showed a lower level of blood pressure compared with girls with short sleep duration (F = 17.44 and 7.11, respectively, all P values < 0.01). Among girls experienced menarche, 13 832 girls (30.0%) were defined as relative enough sleep duration, whose mean blood pressure was 105.27/66.19 mm Hg and prevalence of HBP was 6.25% (864/13 832), and 32 199(70.0%) girls were defined as short sleep duration, whose mean blood pressure was 105.12/66.19 mm Hg and prevalence of HBP was 6.0% (1924/32 199), girls with relative enough sleep duration showed significant higher level of blood pressure than girls with short sleep duration (F = 5.98, P = 0.015). After adjustment of region, BMI, height, age and urban/rural area by multilevel model, the level of systolic pressure decreased 0.18 mm Hg with 1 h increase of sleep duration among boys without first spermatorrhea (Wald χ(2) = 7.27, P = 0.007), the level of diastolic pressure decreased 0.13 mm Hg with 1 h increase of sleep duration among girls without menstruation (Wald χ(2) = 5.52, P = 0.019), and the systolic pressure and diastolic pressure increased 0.19 mm Hg and 0.14 mm Hg with 1 h increase of sleep duration among girls with menstruation, respectively (Wald χ(2) = 13.47 and 9.94, respectively, all P values < 0.01). Short sleep duration may be one of the influential factors of HBP during puberty.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):718-725.
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    ABSTRACT: To investigate the association between early age at menarche and blood pressure in Chinese girls aged 7 to 17 years. A total of 76 869 girls aged 7 to 17 years old were selected from the national physical fitness and health research in 2010, and probit analyses were used to calculate the average age of menarche for each province. Girls whose age were lower than the P 10 of age at menarche were judged as early age at menarche, and matched with two selected participant without menarche based on the age and the same urban or rural areas. High blood pressure was defined as whose systolic pressure and/or diastolic pressure was higher than P 95 of systolic pressure or diastolic pressure at the same age group. The difference of the rate of high blood pressure in girls with and without menarche by Chi-square test, and multilevel model was used to analyze the relationship between early age at menarche and blood pressure. In 76 869 grils, the values of hight and BMI were separately (152.2 ± 10.4) cm and (18.7 ± 3.1) kg/m(2), while the systolic pressure and diastolic pressure were (103.4 ± 11.0) mm Hg (1 mm Hg = 0.133 kPa) and (65.0 ± 9.1) mm Hg respectively. In 47 942 girls (62.4%) had occurred menstruation while 28 927 girls (37.6%) without menstruation. The girls began to report menstruation at the age of 9, and 81.5% (7123/8736) girls had already reported menstruation at the age of 13. The rate of high blood pressure in menstruation group from 11 to 13 years were separately 6.71% (100/1490), 5.99% (265/4423) and 5.38% (383/7123), which was significant higher than 3.78% (265/7005), 3.33% (144/4328) and 4.09% (66/1613) in the same age group of non-menstruation (the values of Chi-square were separately 25.62, 32.36, 4.46, and all P values < 0.05) . The mean age of early age at menarche was 9 to 11 years old, and the rate of high blood pressure, high systolic pressure, and high diastolic pressure at 11 years group was separately 6.08% (49/806), 4.84% (39/806) and 3.35% (27/806), which was significant higher than that in non-menstruation group (separately 3.11% (50/1607), 2.30% (37/1607) and 1.43% (23/1607), and the values of Chi-square were separately 12.02, 11.32 and 9.74, while all P values <0.01). After adjusted by region and age, early age at menarche were separately associated with the rate of high blood pressure (OR = 2.188; 95%CI: 1.254-3.818), high systolic pressure (OR = 1.925; 95%CI:1.097-3.379) and high diastolic pressure (OR = 2.088; 95%CI: 1.072-4.065). Early age at menarche may be one of the influence factors of high blood pressure, which may contribute to early age of high blood pressure in Chinese children and adolescents.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 08/2013; 47(8):726-730.

Publication Stats

226 Citations
76.78 Total Impact Points

Institutions

  • 2014
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
  • 2009–2014
    • Peking University
      • • School of Public Health
      • • Institute of Child and Adolescent Health
      Peping, Beijing, China
    • Peking University Health Science Center
      Peping, Beijing, China
    • Chinese Academy of Sciences
      • Key Laboratory of Zoological Systematics and Evolution
      Peping, Beijing, China
  • 2010–2013
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
    • Beijing Medical University
      • Institute of Child and Adolescent Health
      Peping, Beijing, China