Jin Wook Kim

Hoseo University, Onyang, South Chungcheong, South Korea

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Publications (180)273.84 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Angiographic findings suggest that central neurocytoma (CN) might originate from neuronal cells of the subventricular zone (SVZ) around the foramen of Monro rather than from the septum pellucidum. The majority of CN cells have neuroblast characteristics. Most importantly, CN-derived tumor spheres have a phenotype of transit-amplifying type C cells, implying that these cells might arise from transformed transit-amplifying type C cells that reside in the SVZ. These CN-derived tumor spheres are also reminiscent of radial glial cells. Immunohistochemical and electrophysiologic studies show that these cells exhibit bipotential neuroglial differentiation in vitro. Copyright © 2015 Elsevier Inc. All rights reserved.
    Neurosurgery clinics of North America. 01/2015; 26(1):31-36.
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    ABSTRACT: Retreatment after initial treatment failure for Helicobacter pylori is very challenging. The purpose of this study was to evaluate the efficacies of moxifloxacin-containing triple and bismuth-containing quadruple therapy.
    Gut and liver. 11/2014; 8(6):605-11.
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    ABSTRACT: BCP and TPBi were used as an ETL material with a QTW structure in OLEDs.•The inter-layer of TCTA and mCP was used to reduce the roll-off effect.•The thickness of inter-layer affects efficiency of devices and roll-off properties.•It had a 23% of roll-off improvement.•The difference of the highest and the lowest efficiency is 64% and 52%.
    Optical Materials. 11/2014; 37.
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    ABSTRACT: Objective While several prognostic models have been presented in NSCLC patients with brain metastasis, none of these models have included molecular markers as an index. The aim of our study was to evaluate the prognostic value of EGFR mutations and to integrate these EGFR mutations into the prognostic index in NSCLC patients with brain metastasis. Materials and Methods We analyzed retrospectively 292 lung adenocarcinoma patients with brain metastasis. Clinico-pathological features and overall survival (OS) were compared between patients with EGFR mutations and patients with EGFR wild type. EGFR mutation status was integrated with lung specific Graded Prognostic Assessment (GPA) score. Results Among 292 patients, EGFR mutation status was tested in 183 patients. One hundred and five patients (57.4%) had EGFR activating mutations, 14 (7.7%) had EGFR non-activating mutations and 64 (35.0%) had EGFR wild type. OS was significantly longer in patients with EGFR activating mutations than in those with EGFR wild type patients (20.4 vs. 10.1 months, p = 0.002). However, patients with EGFR non-activating mutations did not show superior OS compared with EGFR wild type patients (14.6 vs. 10.1 months, p = 0.83). Multivariate analysis revealed that the presence of EGFR activating mutation is an independent positive prognostic factor for OS (adjusted hazard ratio 0.56, p = 0.002). Conclusions EGFR activating mutations have a prognostic role in lung adenocarcinoma patients with brain metastasis that is independent of other known prognostic factors. The frequency of EGFR mutation was higher than expected. The presence of EGFR activating mutations should be included as an index in the prognostic models for lung adenocarcinoma patients with brain metastasis.
    Lung Cancer. 10/2014;
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    ABSTRACT: This study aimed to confirm the utility of the European Organization for Research and Treatment of Cancer (EORTC) and the Spanish Urological Club for Oncological Treatment (CUETO) scoring systems and to determine which model is preferred as a prognostic model in Korean patients with non-muscle-invasive bladder cancer.
    Korean journal of urology. 10/2014; 55(10):643-9.
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    ABSTRACT: Complications after prostate biopsy have increased and various causes have been reported. Growing evidence of increasing quinolone resistance is of particular concern. In the current retrospective study, we evaluated the incidence of infectious complications after prostate biopsy and identified the risk factors.
    Korean journal of urology. 10/2014; 55(10):660-4.
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    ABSTRACT: We investigated the effect of propofol and fentanyl on microelectrode recording (MER) and its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. We analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS with MER. Their left sides were done under awake and then their right sides were done with a continuous infusion of propofol and fentanyl under local anesthesia. The electrode position was evaluated by preoperative MRI and postoperative CT. The clinical outcomes were assessed at six months after surgery. We isolated single unit activities from the left and the right side MERs. There was no significant difference in the mean firing rate between the left side MERs (38.7±16.8 spikes/sec, n=78) and the right side MERs (35.5±17.2 spikes/sec, n=66). The bursting pattern of spikes was more frequently observed in the right STN than in the left STN. All the electrode positions were within the STNs on both sides and the off-time Unified Parkinson's Disease Rating Scale part III scores at six months after surgery decreased by 67% of the preoperative level. In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients.
    Journal of Korean Medical Science 09/2014; 29(9):1278-86. · 1.25 Impact Factor
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    ABSTRACT: In order to characterize physical properties and sediment structure (micro- and macro structures) for gassy sediments from the southeastern inner shelf of Korea, physical property measurements and sediment structure analysis for two sediment cores were carried out. One core (SG12-PC4) was collected from gassy sediments, and the other core (SG12-PC10) was obtained from gas-free sediments. The micro- and macro-structures for the gassy core were investigated using X-ray computed tomography (CT) scanning and soft X-radiography. In addition, scanning electron microscope (SEM) photomicrographs were used for understanding the clay fabric in the gassy sediments. Wet bulk density and porosity for both gassy sediments and gas-free sediments are characterized by a general trend caused by compaction with burial depth. On the other hand, the velocity shows different patterns in both burial depth and the correlation between velocity and other physical properties. Thus, the gas plays an important role in the control of velocity in the gassy sediments. This is clearly seen in the relationship between characteristic CT images and low velocity in the depth intervals characterized by gas and/or degassing cracks. In addition, shear strength measurements for gassy sediments have lower values than gas-free sediments, due to the weak bond between clay particles caused by gas and/or degassing. This suggests that original clay microstructure could be rearranged due to forces that gas exerts on clay particles. From CT images of both cross section and top-views, we may estimate possible conduits of gas migration within the gas-charged interval. Using SEM photomicrographs, the various traces (e.g., displacement of clay particles, oval-shape depressions) created by the escape of gas bubbles were identified on the images. Therefore, the presence of gas in marine sediments may control not only the variation of physical properties (e.g., velocity, shear strength) but also the arrangement of clay particles.
    Quaternary International 09/2014; · 2.13 Impact Factor
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    ABSTRACT: This study was performed to investigate the discomfort reported by patients taking phosphodiesterase type 5 inhibitors (PDE5Is) in clinical practice.
    The world journal of men's health. 08/2014; 32(2):69-75.
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    ABSTRACT: Introduction: Fibrotic scar formation is a main cause of recurrent urethral stricture after initial management with direct vision internal urethrotomy (DVIU). In the present study, we devised a new technique of combined the transurethral resection of fibrotic scar tissue and temporary urethral stenting, using a thermo-expandable urethral stent (Memokath(TM) 044TW) in patients with anterior urethral stricture. Materials and Methods: As a first step, multiple incisions were made around stricture site with cold-utting knife and Collins knife electrode to release a stricture band. Fibrotic tissue was then resected with a 13Fr pediatric resectoscope before deployment of a MemokathTM 044TW stent (40 - 60mm) on a pre-mounted sheath using 0° cystoscopy. Stents were removed within12 months after initial placement.
    International braz j urol: official journal of the Brazilian Society of Urology 07/2014; 40(4):576-577.
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    ABSTRACT: Blue phosphorescence organic light-emitting diodes (PHOLEDs) with interfacial mixed layer (IML) were fabricated to observe their electrical characteristics. The IML was composed of mCP as host material in the emissive layer (EML) and 3TPYMB as material for the electron transport layer (ETL) with the blue phosphorescent dopant FIrpic. PHOLEDs with IML were improved by 41% of current density and 35% of luminous efficiency compared to PHOLEDs without IML. The electron and energy transition mechanisms between EML and ETL in the presence of IML were confirmed through I–V–L characteristics and blue color coordinates.
    Physica Status Solidi (A) Applications and Materials 07/2014; · 1.53 Impact Factor
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    ABSTRACT: Blue PHOLEDs with interfacial mixed layer (IML) were fabricated to observe their electrical characteristics. IML was composed of mCP as host material in EML and 3TPYMB as electron transport material with phosphorescent blue dopant of FIrpic. PHOLED with IML were improved 41% of current density and 35% of luminous efficiency comparing to PHOLED without IML.
    SID Symposium Digest of Technical Papers. 06/2014; 45(1).
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    ABSTRACT: We fabricated white phosphorescent organic light-emitting diodes (PHOLEDs) with the primary color(Red, Green and Blue) in single emissive layer using NPB, TCTA and TAPC as hole transporting layer (HTL) having different triplet energy level to observe triplet exciton's behavior. White PHOLED with TAPC having higher triplet energy level shows 51cd/A of luminous efficiency, and CIEXY color coordinate of (0.35, 0.40) at 10V.
    SID Symposium Digest of Technical Papers. 06/2014; 45(1).
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    ABSTRACT: Temozolomide resistance is associated with multiple DNA repair pathways. We investigated homeobox (HOX) genes for their role in temozolomide resistance, focusing on the homologous recombination (HR) pathway, and we tested their therapeutic implications in conjunction with O(6)-methylguanine DNA methyltransferase (MGMT) status. Two glioblastoma cell lines with different MGMT statuses were used to test the augmented anticancer effect of temozolomide with HOXA10 inhibition. In vitro experiments, including gene expression studies with RNA interference, were performed to verify the related pathway dynamics. HOXA10 inhibition reinforced temozolomide sensitivity independent of MGMT status and was related to the impaired double-strand DNA breakage repair process resulting from the downregulation of Rad51 paralogs. Early growth response 1 (EGR1) and phosphatase and tensin homolog (PTEN) were the regulatory mediators between HOXA10 and the HR pathway. Moreover, HOXA10 inhibition selectively affected the nuclear function of PTEN without interfering with its cytoplasmic function of suppressing the phosphoinositide 3-kinase/Akt pathway. The mechanism of HR pathway regulation by HOXA10 harbors another target mechanism for overcoming temozolomide resistance in glioblastoma patients.
    Genes & cancer. 05/2014; 5(5-6):165-74.
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    ABSTRACT: Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying it to human LC originating from lung cancer, the most common cause of CNS metastasis. Cerebrospinal fluid from LC (n = 26) and normal groups (n = 41) were obtained, and the diagnosis was established with clinical signs, cytology, MRI and biochemical tests. The cytology on the CSF, the current gold standard, exhibited 69% sensitivity (~ 100% specificity) from the first round of CSF tapping. In comparison, the NMR spectra on the CSF showed a clear difference in the metabolic profile between the LC and normal groups. Multivariate analysis and cross-validation yielded the diagnostic sensitivity of 92%, the specificity of 96%, and the AUC of 0.991. Further spectral and statistical analysis identified myo-inositol (p < 5 x 10-14), creatine (p < 7 x 10-8), lactate (p < 9 x 10-4), alanine (p < 7.9 x 10-3), and citrate (p < 3 x 10-4) as the most contributory metabolites, whose combination exhibited an ROC diagnostic AUC of 0.996. In addition, the metabolic profile could be correlated with the grading of radiological leptomeningeal enhancement (R2 = 0.3881 and p = 6.66 x 10-4), suggesting its potential utility in grading LC. Overall, we propose that the metabolomic approach might augment current diagnostic modalities for LC, the accurate diagnosis of which remains a challenge. © 2014 Wiley Periodicals, Inc.
    International Journal of Cancer 05/2014; · 6.20 Impact Factor
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    ABSTRACT: Problems related to string inclusion and non-inclusion have been vigorously studied in diverse fields such as data compression, molecular biology and computer security. Given a finite set of positive strings and a finite set of negative strings , a string α is a consistent superstring if every positive string is a substring of α and no negative string is a substring of α. The shortest (resp. longest) consistent superstring problem is to find a string α that is the shortest (resp. longest) among all the consistent superstrings for the given sets of strings. In this paper, we first propose a new graph model for consistent superstrings for given and . In our graph model, the set of strings represented by paths satisfying some conditions is the same as the set of consistent superstrings for and . We also present algorithms for the shortest and the longest consistent superstring problems. Our algorithms solve the consistent superstring problems for all cases, including cases that are not considered in previous work. Moreover, our algorithms solve in polynomial time the consistent superstring problems for more cases than the previous algorithms. For the polynomially solvable cases, our algorithms are more efficient than the previous ones.
    Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences 04/2014; 372(2016):20130134. · 2.89 Impact Factor
  • The American surgeon 04/2014; 80(4):114-115. · 0.92 Impact Factor
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    ABSTRACT: Sudden cardiac death (SCD), which is primarily caused by lethal heart disorders resulting in structural and arrhythmogenic abnormalities, is one of the prevalent modes of death in most developed countries. Myocardial ischemia, mainly due to coronary artery disease, is the most common type of heart disease leading to SCD. However, postmortem diagnosis of SCD is frequently complicated by obscure histological evidence. Here, we show that certain mRNA species, namely those encoding hemoglobin A1/2 and B (Hba1/2 and Hbb, respectively) as well as pyruvate dehydrogenase kinase 4 (Pdk4), exhibit distinct postmortem expression patterns in the left ventricular free wall of SCD subjects when compared with their expression patterns in the corresponding tissues from control subjects with non-cardiac causes of death. Hba1/2 and Hbb mRNA expression levels were higher in ischemic SCD cases with acute myocardial infarction or ischemic heart disease without recent infarction, and even in cardiac death subjects without apparent pathological signs of heart injuries, than control subjects. By contrast, Pdk4 mRNA was expressed at lower levels in SCD subjects. In conclusion, we found that altered myocardial Hba1/2, Hbb, and Pdk4 mRNA expression patterns can be employed as molecular signatures of fatal cardiac dysfunction to forensically implicate SCD as the primary cause of death.
    Molecules and Cells 03/2014; · 2.21 Impact Factor
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    ABSTRACT: We performed this retrospective study to analyze the outcome of patients with cavernous sinus hemangioma (CSH) after stereotactic radiosurgery (SRS). We analyzed 19 patients with CSHs who were treated with SRS between 1998 and 2011. The median age of the patients was 50 years (range, 35-73 years), and 16 (84.2 %) of the patients were female. SRS was performed as a primary treatment for 18 patients and to treat a residual lesion after surgical resection in one patient. Nine (47.4 %) patients had cranial neuropathies in 14 cranial nerves before SRS, whereas five (26.3 %) patients were initially asymptomatic. The mean volume of the CSHs was 6.1 ± 7.2 cm(3) (range, 0.3-32.3 cm(3)), and the median marginal dose at the 50 % isodose line was 14.5 Gy (range, 11.5-16.0 Gy). The mean follow-up period was 37 months (range, 12-85 months). At the last follow-up, the lesion volume had decreased in all patients. The average tumor volume had decreased to 26 % (range, 0-70 %) of the initial volume at the last follow-up MRI. The first follow-up MRI, performed 6.1 ± 1.0 months after the SRS, showed that the tumor volume had decreased to 41 % (range, 0-88 %) of the initial volume. All 14 of the cranial neuropathies observed before SRS had improved, with complete remission in 12 (85.7 %) cranial nerves and partial remission in two (14.3 %). There were no radiation-induced neuropathies or complications during the follow-up period. SRS appears to be an effective and safe treatment modality for the management of CSHs.
    Journal of Neuro-Oncology 03/2014; · 3.12 Impact Factor
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    ABSTRACT: Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study. Results Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels (<3.5 ng/mL) increased after the 12-week desmopressin treatment (2.85 ± 0.58 to 3.97 ± 1.44 ng/mL; P = .001). Mean scores had decreased from 17.7 to 13.9 (IPSS), 3.8 to 3.2 (IPSS-Quality of Life), and 33.7 to 31.1 (Aging Male's Symptom). On the frequency volume chart, nocturnal urine volume, nocturnal polyuria index, actual number of nocturia events, nocturia index, and nocturnal bladder capacity index were significantly decreased. Conclusion Desmopressin improved nocturia and other urinary symptoms. Moreover, serum testosterone levels increased significantly in men with low testosterone levels after 12-week desmopressin treatment.
    Urology 01/2014; 83(4):837–842. · 2.42 Impact Factor

Publication Stats

573 Citations
273.84 Total Impact Points

Institutions

  • 2014
    • Hoseo University
      Onyang, South Chungcheong, South Korea
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
    • Ulsan National Institute of Science and Technology
      Urusan, Ulsan, South Korea
  • 2013–2014
    • Gyeongsang National University
      Shinshū, South Gyeongsang, South Korea
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
    • Chonbuk National University
      • Graduate School of Flexible Pinted Electronics
      Tsiuentcheou, North Jeolla, South Korea
    • Chungbuk National University
      • College of Veterinary Medicine
      Chinsen, North Chungcheong, South Korea
  • 2011–2014
    • Korea University
      • • College of Medicine
      • • Department of Urology
      Sŏul, Seoul, South Korea
  • 2007–2014
    • Seoul National University Bundang Hospital
      • Department of Neurosurgery
      Sŏul, Seoul, South Korea
    • Inha University
      • Department of Neurosurgery
      Seoul, Seoul, South Korea
  • 2006–2014
    • Seoul National University Hospital
      • • Department of Neurosurgery
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2005–2014
    • Yonsei University
      • Department of Earth System Sciences
      Sŏul, Seoul, South Korea
  • 2010–2013
    • Sogang University
      Sŏul, Seoul, South Korea
  • 2012
    • Korea Electrotechnology Research Institute-KERI
      Tsau-liang-hai, Busan, South Korea
  • 1999–2010
    • Kyungpook National University
      • Computer System Engineering
      Daikyū, Daegu, South Korea
  • 1998–2010
    • Seoul National University
      • • Department of Neurosurgery
      • • Department of Computer Science and Engineering
      • • School of Computer Science and Engineering
      • • Department of Electrical and Computer Engineering
      • • School of Mechanical and Aerospace Engineering
      Seoul, Seoul, South Korea
  • 2009
    • Pohang University of Science and Technology
      • Department of Electrical and Computer Engineering
      Andong, North Gyeongsang, South Korea
  • 1999–2000
    • Korea Advanced Institute of Science and Technology
      • Department of Electrical Engineering
      Seoul, Seoul, South Korea