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Publications (1)0 Total impact

  • H Douglas Morris, James P Sumner
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    ABSTRACT: MRI has proven to be an excellent tool for cell tracking via magnetic nano- or micro-particles. In particular single cell tracking is possible via magnetic particles of 1 micrometer or greater size via high resolution MR microscopy. These techniques rely on the magnetic field distortion of the particle to produce a local artifact in the image many times larger that the particle itself.[1] This technique can be used to track cells in tissue in 3D and in vivo. Recently, cell labeling techniques enable the use of in vivo labeling in the rat brain.[2] Global magnetic field distortions prevent the use of high-SNR efficiency techniques such as steady-state free precession (SSFP) in such labeled tissue.[3] These field banding artifacts can be suppressed to good effect by use of a linear combination of SSFP images (LCSSP).[4] We describe the application of the LCSSFP technique as a method for rapidly obtaining MR images of the rat brain labeled with micron-sized magnetic particles.
    01/2009; 50:400.