Jing Chen

Beihang University(BUAA), Peping, Beijing, China

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Publications (365)914.41 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Measurement-based electrical characterization of through silicon via (TSV) and redistribution layer (RDL) is of great importance for both fabrication process and system design of 3D integration. This paper presents the electrical measurements and analysis of TSV and double-sided RDL test structures, from DC to high frequency up to 40 GHz. TSV shows great dependence of DC resistance and leakage current on fabrication process. An inverse V-shaped C-V curve is presented between adjacent TSVs in N-type silicon substrate, from - 10 V to 10 V. In the high frequency characterization, two methods are proposed and applied to extract resistance and inductance of a single grounded TSV. Individual transmission loss of TSV, RDLs on top and bottom surface of silicon substrate are calculated, and corresponding circuit parameters thereof are extracted to characterize their electrical properties precisely.
    Microelectronic Engineering 01/2016; 149:145-152. DOI:10.1016/j.mee.2015.10.010 · 1.20 Impact Factor
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    ABSTRACT: This article has no Abstract.
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 11/2015; 23(9):704-706.
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    ABSTRACT: The mechanism underlying pulmonary inflammation in thermal inhalation injury remains elusive. Cystic fibrosis, also hallmarked with pulmonary inflammation, is caused by mutations in CFTR, the expression of which is temperature-sensitive. We investigated whether CFTR is involved in heat-induced pulmonary inflammation. We applied heat-treatment in 16HBE14o- cells with CFTR knockdown or overexpression and heat-inhalation in rats in vivo. Heat-treatment caused significant reduction in CFTR and, reciprocally, increase in COX-2 at early stages both in vitro and in vivo. Activation of ERK/JNK, NF-κ B and COX-2/PGE 2 were detected in heat-treated cells, which were mimicked by knockdown, and reversed by overexpression of CFTR or VX-809, a reported CFTR mutation corrector. JNK/ERK inhibition reversed heat-/CFTR-knockdown-induced NF-κ B activation, whereas NF-κ B inhibitor showed no effect on JNK/ERK. IL-8 was augmented by heat-treatment or CFTR-knockdown, which was abolished by inhibition of NF-κ B, JNK/ERK or COX-2. Moreover, in vitro or in vivo treatment with curcumin, a natural phenolic compound, significantly enhanced CFTR expression and reversed the heat-induced increases in COX-2/PGE 2 /IL-8, neutrophil infiltration and tissue damage in the airway. These results have revealed a CFTR-regulated MAPK/NF-κ B pathway leading to COX-2/PGE 2 /IL-8 activation in thermal inhalation injury, and demonstrated therapeutic potential of curcumin for alleviating heat-induced pulmonary inflammation.
    Scientific Reports 10/2015; 5:15946. DOI:10.1038/srep15946 · 5.58 Impact Factor
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    ABSTRACT: Copper is a transition metal that plays critical roles in many life processes. Controlling the cellular concentration and trafficking of copper offers a route to disrupt these processes. Here we report small molecules that inhibit the human copper trafficking proteins Atox1 and CCS, providing an approach to selectively disrupting cellular copper transport. The knockdown of Atox1 and CCS or their inhibition leads to significantly reduced proliferation of cancer cells but not normal cells, as well as attenuated tumor growth in mouse models. We show that blocking copper trafficking induces cellular oxidative stress and reduces levels of cellular ATP. The reduced level of ATP results in activation of the AMP-activated protein kinase that leads to reduced lipogenesis. Both effects contribute to inhibition of the cancer cell proliferation. Our results establish copper chaperones as new targets for future developments in anticancer therapies.
    Nature Chemistry 09/2015; 7(12). DOI:10.1038/nchem.2381 · 25.33 Impact Factor
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    ABSTRACT: Solid pseudopapillary tumor (SPT) of the pancreas is an epithelial tumor with low-grade malignant potential and present more common in females. At present, the gold standard for accurate diagnosis of pancreatic tumor was mostly depending on the pathological and/or cytological evaluation. In this work, TPEF microscopy was applied to obtain the images of human normal pancreas and SPT of the pancreas without hematoxylin and eosin (H&E) staining, for the purpose of identifying the organization structural, cell morphological, and cytoplasm changing, which were then compared to their corresponding H&E stained histopathological results. Our results showed that high-resolution TPEF imaging of the pancreatic SPT can clearly distinguish the pathological features from normal pancreas in unstained histological sections, and the results are consistent with the histological results. Moreover, we measured the nuclear-cytoplasmic ratios of the pancreatic SPT and normal pancreas to characterize their difference in the cytomorphological feature. It indicated that this technique can achieve the consistent information of pathological diagnosis, and has the potential to substantially improve the optical diagnosis and treatment of the pancreatic SPT without H&E staining in the future. SCANNING 9999:1-6, 2015. © 2015 Wiley Periodicals, Inc. © Wiley Periodicals, Inc.
    Scanning 09/2015; DOI:10.1002/sca.21267 · 1.89 Impact Factor
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    ABSTRACT: We report the draft genome sequence of Jiangella alkaliphila KCTC 19222(T), isolated from cave soil in Jeju, Republic of Korea. This genome sequence, together with the previously sequenced J. gansuensis strain DSM 44835(T), identified from a desert environmental source, will give us a better understanding of the school of "evolutionary taxonomy." Copyright © 2015 Jiao et al.
    Genome Announcements 08/2015; 3(4). DOI:10.1128/genomeA.00721-15
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    ABSTRACT: As human population increase, human-wildlife conflicts have reached unprecedented levels, often resulting in negative attitudes toward regional conservation initiatives, and thus are of concern for conservation communities. From April to May 2011, we carried out a survey to quantify carnivore-induced livestock losses perceived by local pastoralists in the Qinghai Lake region on the pastoral Qinghai—Tibetan Plateau and examined the ecological and socio-economic dimensions in the conflict. We finished 286 in-person interviews using a semi-structured questionnaire with mixed closed- and open-ended questions. Our results showed that 93.7% of the respondents reported livestock depredations by carnivores from March 2010 to March 2011. The perceived losses represented 3.7% of total standing value of livestock in the region. The losses were positively correlated with livestock number in each household and showed significant seasonal and diurnal difference. Adult sheep and goats were the mostly killed (54.9%), followed by lambs (21.0%), adult yaks and cattle (19.1%), calves (4.9%) and horses (0.1%). More than 80% of the respondents reported that they could not tolerate the contemporaneous depredations and nearly two thirds expected compensations for their losses. Wolf Canis lupus was blamed for most of the killings (76.0%) and was perceived most negative followed by brown bear Ursus arctos, Tibetan fox Vulpes ferrilata, red fox Vulpes vulpes and raptors. Attitudes toward the problem carnivores were positively correlated with livestock size but negatively with magnitudes of the depredations. The attitudes also varied among the three survey sites, which may be attributed to the different extent of openness and livelihood dependence on animal husbandry. In the light of our results, we suggested possible measures to mitigate the conflict and maintain coexistence between human and wild carnivores on the Qinghai—Tibetan Plateau.
    Wildlife Biology 08/2015; 21(4). DOI:10.2981/wlb.00083 · 0.88 Impact Factor
  • Fang Wang · Gangli Zhu · Zhen Li · Feng Zhao · Chungu Xia∗ · Jing Chen ·
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    ABSTRACT: Polyoxymethylene dimethyl ethers (DMMn), which are ideal additives for diesel fuel, are mainly synthesized from the condensation of methanol (MeOH) or dimethoxymethane (DMM) with 1,3,5-trioxane (TOX) or paraformaldehyde (PF) promoted by different acid catalysts. However, up to date, few studies have been reported to examine the formation mechanism of DMMn which is essential in understanding the reaction and valuable in designing improved catalysts. In this work, using the density functional theory (DFT) calculations combined with experiment studies, we evaluate the formation mechanism of DMMn which is promoted by sulfonic acid-functionalized ionic liquids (SO3H-FILs). Our calculated results indicate TOX and PF should dissociate into formaldehyde monomers firstly and then to react with MeOH or DMM. However, their decomposition process is different where the dissociation of TOX proceeds along a two-step mechanism while it follows a one-step mechanism for PF dissociation. As for the formation of DMMn, the reaction proceeds along a hemiacetal-carbocation pathway when MeOH is selected as the capping group provider, while the reaction follows a carbocation pathway when DMM is chosen. The origination for the product distribution pattern has also been discussed in detail. The cations and anions of ionic liquids are found synergistically promote the condensation reaction by proton transfer and simultaneously stabilizing the formed intermediated and transition states. Moreover, all the processes related to the decomposition of TOX and PF and the condensation reaction are reversible.
    Journal of Molecular Catalysis A Chemical 07/2015; 408:228-236. DOI:10.1016/j.molcata.2015.07.028 · 3.62 Impact Factor
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    Jing Chen · Ping Xie · Juan Lin · Jun He · Cheng Zeng · Jun Chen ·
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    ABSTRACT: To reveal the toxicological effects of the hepatotoxic microcystin-leucine arginine (MC-LR) on gut microbial community composition in different gut regions, we conducted a subchronic exposure of BALB/c mice to MC-LR via intragastric administration. Denaturing gradient gel electrophoresis (DGGE) was employed to profile the shifts of microbes after MC-LR treatment in the jejuno-ileum, caecum and colon. DGGE profiles analysis showed that MC-LR increased the microbial species richness (number of microbial bands) in the caecum and colon as well as microbial diversity (Shannon-Wiener index) in the caecum. The cluster analysis of DGGE profiles indicated that the microbial structures in the caecum and colon shifted significantly after MC-LR treatment, while that in the jejuno-ileum did not. All the relatively decreased gut microbes belonged to Clostridia in the Firmicutes phylum, and most of them were Lachnospiraceae. The increased ones derived from a variety of microbes including species from Porphyromonadaceae and Prevotellaceae in the Bacteroidetes phylum, as well as Lachnospiraceae and Ruminococcaceae in the Firmicutes phylum, and among which, the increase of Barnesiella in Porphyromonadaceae was most remarkable. In conclusion, subchronic exposure to MC-LR could disturb the balance of gut microbes in mice, and its toxicological effects varied between the jejuno-ileum and the other two gut regions.
    The Journal of Toxicological Sciences 07/2015; 40(4):485-94. DOI:10.2131/jts.40.485 · 1.29 Impact Factor
  • Jing Chen · Songmei Li · Juan Du · Jianhua Liu · Mei Yu · Shiming Meng · Bo Wang ·
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    ABSTRACT: In an attempt to enhance the electrocatalytic activity and CO tolerance of ceria modified Pt/C electrodes, a novel structured ceria material has been developed. Left-handed helical CeO2 nano-spindles with mesoporous structures were successfully synthesized through a template-free based precursor method on a large scale. By a microwave-assisted polyol synthesis process, the ceria modified Pt/C electrocatalysts were synthesized. The helical CeO2 nanospindle based electrode Pt@Heli-CeO2/C exhibits superior electrochemically active surface areas, and significantly enhanced methanol oxidation catalytic activity and CO antipoisoning activity, compared to Pt/C and a nano-octahedral CeO2 modified electrode Pt@Octa-CeO2/C. The experimental results show that Pt@Heli-CeO2/C possesses 8.2 times and 3.2 times higher activity for methanol electrooxidation than Pt/C and Pt@Octa-CeO2/C, respectively. This remarkable enhancement could be attributed to the reasons as follows: compared to octahedral CeO2, the unique helical CeO2 is more conductive with better electron transfer and can provide more active surface sites to strengthen the support–metal interactions based on an electronic transfer mechanism from CeO2 to Pt, thus helical CeO2 can promote better dispersion of the Pt(0) nanocrystallites and a high concentration of metallic Pt(0) in the composition.
    RSC Advances 07/2015; 5(79). DOI:10.1039/C5RA09047D · 3.84 Impact Factor
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    ABSTRACT: Oncogenic transcription factors are known to mediate the conversion of somatic cells to tumour or induced pluripotent stem cells (iPSCs). Here we report c-Jun as a barrier for iPSC formation. c-Jun is expressed by and required for the proliferation of mouse embryonic fibroblasts (MEFs), but not mouse embryonic stem cells (mESCs). Consistently, c-Jun is induced during mESC differentiation, drives mESCs towards the endoderm lineage and completely blocks the generation of iPSCs from MEFs. Mechanistically, c-Jun activates mesenchymal-related genes, broadly suppresses the pluripotent ones, and derails the obligatory mesenchymal to epithelial transition during reprogramming. Furthermore, inhibition of c-Jun by shRNA, dominant-negative c-Jun or Jdp2 enhances reprogramming and replaces Oct4 among the Yamanaka factors. Finally, Jdp2 anchors 5 non-Yamanaka factors (Id1, Jhdm1b, Lrh1, Sall4 and Glis1) to reprogram MEFs into iPSCs. Our studies reveal c-Jun as a guardian of somatic cell fate and its suppression opens the gate to pluripotency.
    Nature Cell Biology 06/2015; 17(7):856-867. DOI:10.1038/ncb3193 · 19.68 Impact Factor
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    ABSTRACT: Copper-silica nanocomposite catalysts with uniform Cu dispersion prepared by precipitation-gel method have been disclosed to be highly efficient in the heterogeneous catalysis of hydrogenation of CO2-derived cyclic carbonates, providing an indirect but practical approach for the transformation of CO2 to methanol with the co-production of diols under relatively mild conditions. The catalysts possessed remarkable stability in both batch and fixed-bed continuous flow reactors especially after promotion with B2O3. The reaction was found to depend sensitively on the Cu particle sizes, the surface acid-basicity and Cu valence of the catalysts. The synergetic effect between balanced Cu0 and Cu+ sites was considered to play a critical role for attaining high yields of methanol and diols.
    Green Chemistry 06/2015; 17(8). DOI:10.1039/C5GC00810G · 8.02 Impact Factor
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    Junhua Hu · Zhigang Jiang · Jing Chen · Huijie Qiao ·
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    ABSTRACT: Ecological niche divergence and adaptation to new environments are thought to play important roles in driving speciation. Whether recently evolved species show evidence for niche divergence or conservation is vital towards understanding the role of ecology in the process of speciation. The genus Procapra is an ancient, monophyletic lineage endemic to Asia that contains three extant species (P. gutturosa, P. przewalskii and P. picticaudata). These species mainly inhabit the Qinghai-Tibetan and Mongolian Plateaus, and today have primarily allopatric distributions. We applied a series of geographic information system-based analyses to test for environmental variation and niche divergence among these three species. We found substantial evidence for niche divergence in species' bioclimatic preferences, which supports the hypothesis that niche divergence accelerates diversification in Procapra. Our results provide important insight into the evolutionary history of ungulates in Asia and help to elucidate how environmental changes accelerate lineage diversification.
    Scientific Reports 05/2015; 5:10069. DOI:10.1038/srep10069 · 5.58 Impact Factor
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    ABSTRACT: This paper demonstrates a five layers wafer level packaging. This technology has been specially developed for chip scale atomic clock system package. It includes a sealed vapor cell and two supports for vertical-cavity surface-emitting lasers and photodetector. The sealed cavity is achieved by Glass-Silicon-Glass (G-S-G) anodic bonding with high hermeticity, high reliability and low bonding temperature (400°C). The triple structure is supported by two silicon wafers. It is realized by photosensitive BCB adhesive bonding with good uniformity, relatively high mechanical strength (8Mpa) and low bonding temperature (250°C). The results show that over 60% of wafer is bonded with no void on the joint area and well aligned. At last, the stacked wafer is diced into individual chips.
    IEEE NEMS 2015; 04/2015

  • IEEE NEMS2015; 04/2015
  • jinhua hu · Long Chen · Haozhen Yang · Fei Pang · Jing Chen ·

    Gastroenterology 04/2015; 148(4):S-1020. DOI:10.1016/S0016-5085(15)33489-2 · 16.72 Impact Factor
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    ABSTRACT: A large body of evidence indicates that microRNAs play a critical role in tumor initiation and progression by negatively regulating oncogenes or tumor suppressor genes. Here, we report that the expression of miR-200a was notably downregulated in 45 renal cell carcinoma (RCC) samples. Restoration of miR-200a suppressed cell proliferation, migration, and invasion in two RCC cell lines. Furthermore, we used an epithelial-to-mesenchymal transition PCR array to explore the putative target genes of miR-200a. By performing quantitative real-time PCR, ELISA, and luciferase reporter assays, transforming growth factor beta2 (TGFB2) was validated as a direct target gene of miR-200a. Moreover, siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression. These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2, indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC.
    Tumor Biology 03/2015; 36(9). DOI:10.1007/s13277-015-3355-9 · 3.61 Impact Factor
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    ABSTRACT: Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3'UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. Copyright © 2015. Published by Elsevier Inc.
    Biochemical and Biophysical Research Communications 03/2015; 460(3). DOI:10.1016/j.bbrc.2015.03.088 · 2.30 Impact Factor
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    ABSTRACT: Background: Multifunctional gold nanospheres (MGNs)-loaded with docetaxel (MGN@DTX) were prepared and evaluated for therapeutic efficacy in nude mice bearing human prostate cancer xenografts. Methods: MGNs were prepared from PEGylated hollow gold nanospheres (HGNs) coated with folic acid and DTPTT chelate. Then, the effect of radiolabelled MGNs ((99m)Tc-MGNs) on PC-3 cell apoptosis was assessed by flow cytometry, while their binding affinity to these cells was evaluated by cell binding assays. Next, biodistribution of (99m)Tc-MGNs in xenograft bearing mice was measured by SPECT imaging. Also, DTX loading and release rates were estimated in MGN@DTX. Finally, in vitro stability in human serum and cytotoxicity of MGN@DTX were assessed, as well as their antitumor effect in xenograft bearing mice. Results: (99m)Tc-MGNs (97.69% purity) showed good binding affinity to PC-3 cells, a specific recognition blocked by excess folic acid. Interestingly, MGN@DTX remained stable in human serum for 24 h, and exhibited higher mean cytotoxicity after NIR laser irradiation than free DTX. By day 28, tumor inhibition rates were higher in the MGN@DTX + NIR laser irradiation group compared with the DTX and MGNs + NIR laser irradiation groups. Conclusions: Loading chemotherapeutic drugs into MGNs can increase antitumor potency, reduce normal cell damage and decrease drug resistance, thus representing a promising approach for advanced prostate cancer treatment.
    Journal of Drug Targeting 03/2015; 23(6):1-9. DOI:10.3109/1061186X.2015.1018910 · 2.74 Impact Factor
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    ABSTRACT: Horns of Saiga antelope (Saiga tatarica) have always been an ingredient of “Lingyangjiao”, a traditional Chinese medicine (TCM). Persistent hunting for Saiga antelope has already threatened the survival of critical endangered populations in wild. To control the growing pressure, CITES and Chinese government have legislated for monitoring the trade of Saiga horns. However, similar ungulate horns are difficult to identify by their morphological characteristics, which has impeded the law enforcement. Besides Saiga antelope, other seven ungulate species which have similar horns are also sold and marked as “Lingyangjiao” in TCM markets to offset shortage of Saiga antelope horns. Such species are Gazella subgutturosa, Pantholops hodgsonii, Procapra picticaudata, Procapra gutturosa, Procapra przewalskii, Capra hircus, and Ovis aries. Our study aimed at implementing DNA barcoding technology to diagnose Saiga horns and the substitutes. We successfully extracted genomic DNA from horn samples. We recovered COI sequences of 644 bp with specific primers and 349 bp with nested PCR primers designed for degraded horn samples. The mean interspecific genetic distance of data set of the 644-bp full barcodes and the 349-bp mini-barcodes was 14.96% and 15.38%, respectively, and the mean intraspecific distance was 0.24% and 0.20%, respectively. Each species formed independent clades in neighbor-joining (NJ) phylogenetic tree of the two data sets with >99% supporting values, except P. gutturosa and P. przewalskii. The deep genetic distances gap and clear species clades in NJ tree of either full barcodes or mini-barcodes suggest that barcoding technology is an effective tool to diagnose Saiga horns and their substitutes. Barcoding diagnosis protocol developed here will simplify diagnosis of “Lingyangjiao” species and will facilitate conservation of endangered ungulates involved in TCM “Lingyangjiao” markets, especially the Saiga antelope.
    Ecology and Evolution 03/2015; 5(9). DOI:10.1002/ece3.1457 · 2.32 Impact Factor

Publication Stats

3k Citations
914.41 Total Impact Points


  • 2015
    • Beihang University(BUAA)
      • School of Material Science and Engineering
      Peping, Beijing, China
    • China Academy of Chinese Medical Sciences
      Peping, Beijing, China
  • 2014-2015
    • Hohai University
      • Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education
      Nan-ching, Jiangsu Sheng, China
    • Fujian Normal University
      • College of Life Sciences
      Fujiang, Heilongjiang Sheng, China
  • 2013-2015
    • Beijing Genomics Institute
      Bao'an, Guangdong, China
    • Department of Nuclear Medicine
      Nyitra, Nitriansky, Slovakia
    • Peking University People's Hospital
      Peping, Beijing, China
  • 2011-2015
    • The Chinese University of Hong Kong
      • School of Biomedical Sciences
      Hong Kong, Hong Kong
    • Chang Gung University
      Hsin-chu-hsien, Taiwan, Taiwan
    • University of Nebraska at Lincoln
      • Department of Psychology
      Lincoln, Nebraska, United States
    • Shanghai Children's Hospital
      Shanghai, Shanghai Shi, China
  • 2001-2015
    • Chinese Academy of Sciences
      • • Graduate School
      • • State Key Laboratory of Drug Research
      • • South China Institute for Stem Cell Biology and Regenerative Medicine
      • • Institute of Process Engineering
      • • Institute of Chemistry
      Peping, Beijing, China
  • 2011-2014
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2009-2014
    • Fourth Military Medical University
      • • Department of Neurology
      • • Department of Human Anatomy and Histoembryology
      Xi’an, Liaoning, China
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2007-2014
    • Shanghai Jiao Tong University
      • School of Medicine
      Shanghai, Shanghai Shi, China
    • Peking University
      • • Institute of Microelectron
      • • State Key Laboratory for Structural Chemistry of Unstable and Stable Species
      Peping, Beijing, China
    • Northeast Normal University
      Hsin-ching, Jilin Sheng, China
  • 2006-2014
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Nankai University
      • State Key Laboratory of Elemento-Organic Chemistry
      T’ien-ching-shih, Tianjin Shi, China
  • 2011-2013
    • 302 Military Hospital of China
      • Centre for Liver Failure Treatment and Research
      Peping, Beijing, China
  • 2005-2013
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
  • 2012
    • Third Military Medical University
      • Institute of Burn Research
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Sichuan University
      Hua-yang, Sichuan, China
  • 2010-2012
    • North China University of Water Conservancy and Electric Power
      Cheng, Henan Sheng, China
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
    • Chang'an University
      Xi’an, Guangdong, China
  • 2009-2012
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
  • 2002-2012
    • Shanghai's Children's Medical Center
      Shanghai, Shanghai Shi, China
  • 2005-2008
    • Yunnan University
      Yün-nan, Yunnan, China