Jing Chen

Hohai University, Nan-ching, Jiangsu Sheng, China

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Publications (353)858.8 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Solid pseudopapillary tumor (SPT) of the pancreas is an epithelial tumor with low-grade malignant potential and present more common in females. At present, the gold standard for accurate diagnosis of pancreatic tumor was mostly depending on the pathological and/or cytological evaluation. In this work, TPEF microscopy was applied to obtain the images of human normal pancreas and SPT of the pancreas without hematoxylin and eosin (H&E) staining, for the purpose of identifying the organization structural, cell morphological, and cytoplasm changing, which were then compared to their corresponding H&E stained histopathological results. Our results showed that high-resolution TPEF imaging of the pancreatic SPT can clearly distinguish the pathological features from normal pancreas in unstained histological sections, and the results are consistent with the histological results. Moreover, we measured the nuclear-cytoplasmic ratios of the pancreatic SPT and normal pancreas to characterize their difference in the cytomorphological feature. It indicated that this technique can achieve the consistent information of pathological diagnosis, and has the potential to substantially improve the optical diagnosis and treatment of the pancreatic SPT without H&E staining in the future. SCANNING 9999:1-6, 2015. © 2015 Wiley Periodicals, Inc. © Wiley Periodicals, Inc.
    Scanning 09/2015; DOI:10.1002/sca.21267 · 1.89 Impact Factor
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    ABSTRACT: We report the draft genome sequence of Jiangella alkaliphila KCTC 19222(T), isolated from cave soil in Jeju, Republic of Korea. This genome sequence, together with the previously sequenced J. gansuensis strain DSM 44835(T), identified from a desert environmental source, will give us a better understanding of the school of "evolutionary taxonomy." Copyright © 2015 Jiao et al.
    Genome Announcements 08/2015; 3(4). DOI:10.1128/genomeA.00721-15
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    ABSTRACT: As human population increase, human-wildlife conflicts have reached unprecedented levels, often resulting in negative attitudes toward regional conservation initiatives, and thus are of concern for conservation communities. From April to May 2011, we carried out a survey to quantify carnivore-induced livestock losses perceived by local pastoralists in the Qinghai Lake region on the pastoral Qinghai—Tibetan Plateau and examined the ecological and socio-economic dimensions in the conflict. We finished 286 in-person interviews using a semi-structured questionnaire with mixed closed- and open-ended questions. Our results showed that 93.7% of the respondents reported livestock depredations by carnivores from March 2010 to March 2011. The perceived losses represented 3.7% of total standing value of livestock in the region. The losses were positively correlated with livestock number in each household and showed significant seasonal and diurnal difference. Adult sheep and goats were the mostly killed (54.9%), followed by lambs (21.0%), adult yaks and cattle (19.1%), calves (4.9%) and horses (0.1%). More than 80% of the respondents reported that they could not tolerate the contemporaneous depredations and nearly two thirds expected compensations for their losses. Wolf Canis lupus was blamed for most of the killings (76.0%) and was perceived most negative followed by brown bear Ursus arctos, Tibetan fox Vulpes ferrilata, red fox Vulpes vulpes and raptors. Attitudes toward the problem carnivores were positively correlated with livestock size but negatively with magnitudes of the depredations. The attitudes also varied among the three survey sites, which may be attributed to the different extent of openness and livelihood dependence on animal husbandry. In the light of our results, we suggested possible measures to mitigate the conflict and maintain coexistence between human and wild carnivores on the Qinghai—Tibetan Plateau.
    Wildlife Biology 08/2015; 21(4). DOI:10.2981/wlb.00083 · 0.88 Impact Factor
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    ABSTRACT: Polyoxymethylene dimethyl ethers (DMMn), which are ideal additives for diesel fuel, are mainly synthesized from the condensation of methanol (MeOH) or dimethoxymethane (DMM) with 1,3,5-trioxane (TOX) or paraformaldehyde (PF) promoted by different acid catalysts. However, up to date, few studies have been reported to examine the formation mechanism of DMMn which is essential in understanding the reaction and valuable in designing improved catalysts. In this work, using the density functional theory (DFT) calculations combined with experiment studies, we evaluate the formation mechanism of DMMn which is promoted by sulfonic acid-functionalized ionic liquids (SO3H-FILs). Our calculated results indicate TOX and PF should dissociate into formaldehyde monomers firstly and then to react with MeOH or DMM. However, their decomposition process is different where the dissociation of TOX proceeds along a two-step mechanism while it follows a one-step mechanism for PF dissociation. As for the formation of DMMn, the reaction proceeds along a hemiacetal-carbocation pathway when MeOH is selected as the capping group provider, while the reaction follows a carbocation pathway when DMM is chosen. The origination for the product distribution pattern has also been discussed in detail. The cations and anions of ionic liquids are found synergistically promote the condensation reaction by proton transfer and simultaneously stabilizing the formed intermediated and transition states. Moreover, all the processes related to the decomposition of TOX and PF and the condensation reaction are reversible.
    Journal of Molecular Catalysis A Chemical 07/2015; 408:228-236. DOI:10.1016/j.molcata.2015.07.028 · 3.62 Impact Factor
  • Jing Chen · Ping Xie · Juan Lin · Jun He · Cheng Zeng · Jun Chen
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    ABSTRACT: To reveal the toxicological effects of the hepatotoxic microcystin-leucine arginine (MC-LR) on gut microbial community composition in different gut regions, we conducted a subchronic exposure of BALB/c mice to MC-LR via intragastric administration. Denaturing gradient gel electrophoresis (DGGE) was employed to profile the shifts of microbes after MC-LR treatment in the jejuno-ileum, caecum and colon. DGGE profiles analysis showed that MC-LR increased the microbial species richness (number of microbial bands) in the caecum and colon as well as microbial diversity (Shannon-Wiener index) in the caecum. The cluster analysis of DGGE profiles indicated that the microbial structures in the caecum and colon shifted significantly after MC-LR treatment, while that in the jejuno-ileum did not. All the relatively decreased gut microbes belonged to Clostridia in the Firmicutes phylum, and most of them were Lachnospiraceae. The increased ones derived from a variety of microbes including species from Porphyromonadaceae and Prevotellaceae in the Bacteroidetes phylum, as well as Lachnospiraceae and Ruminococcaceae in the Firmicutes phylum, and among which, the increase of Barnesiella in Porphyromonadaceae was most remarkable. In conclusion, subchronic exposure to MC-LR could disturb the balance of gut microbes in mice, and its toxicological effects varied between the jejuno-ileum and the other two gut regions.
    The Journal of Toxicological Sciences 07/2015; 40(4):485-94. DOI:10.2131/jts.40.485 · 1.29 Impact Factor
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    ABSTRACT: Oncogenic transcription factors are known to mediate the conversion of somatic cells to tumour or induced pluripotent stem cells (iPSCs). Here we report c-Jun as a barrier for iPSC formation. c-Jun is expressed by and required for the proliferation of mouse embryonic fibroblasts (MEFs), but not mouse embryonic stem cells (mESCs). Consistently, c-Jun is induced during mESC differentiation, drives mESCs towards the endoderm lineage and completely blocks the generation of iPSCs from MEFs. Mechanistically, c-Jun activates mesenchymal-related genes, broadly suppresses the pluripotent ones, and derails the obligatory mesenchymal to epithelial transition during reprogramming. Furthermore, inhibition of c-Jun by shRNA, dominant-negative c-Jun or Jdp2 enhances reprogramming and replaces Oct4 among the Yamanaka factors. Finally, Jdp2 anchors 5 non-Yamanaka factors (Id1, Jhdm1b, Lrh1, Sall4 and Glis1) to reprogram MEFs into iPSCs. Our studies reveal c-Jun as a guardian of somatic cell fate and its suppression opens the gate to pluripotency.
    Nature Cell Biology 06/2015; 17(7):856-867. DOI:10.1038/ncb3193 · 19.68 Impact Factor
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    ABSTRACT: Copper-silica nanocomposite catalysts with uniform Cu dispersion prepared by precipitation-gel method have been disclosed to be highly efficient in the heterogeneous catalysis of hydrogenation of CO2-derived cyclic carbonates, providing an indirect but practical approach for the transformation of CO2 to methanol with the co-production of diols under relatively mild conditions. The catalysts possessed remarkable stability in both batch and fixed-bed continuous flow reactors especially after promotion with B2O3. The reaction was found to depend sensitively on the Cu particle sizes, the surface acid-basicity and Cu valence of the catalysts. The synergetic effect between balanced Cu0 and Cu+ sites was considered to play a critical role for attaining high yields of methanol and diols.
    Green Chemistry 06/2015; 17(8). DOI:10.1039/C5GC00810G · 8.02 Impact Factor
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    Junhua Hu · Zhigang Jiang · Jing Chen · Huijie Qiao
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    ABSTRACT: Ecological niche divergence and adaptation to new environments are thought to play important roles in driving speciation. Whether recently evolved species show evidence for niche divergence or conservation is vital towards understanding the role of ecology in the process of speciation. The genus Procapra is an ancient, monophyletic lineage endemic to Asia that contains three extant species (P. gutturosa, P. przewalskii and P. picticaudata). These species mainly inhabit the Qinghai-Tibetan and Mongolian Plateaus, and today have primarily allopatric distributions. We applied a series of geographic information system-based analyses to test for environmental variation and niche divergence among these three species. We found substantial evidence for niche divergence in species' bioclimatic preferences, which supports the hypothesis that niche divergence accelerates diversification in Procapra. Our results provide important insight into the evolutionary history of ungulates in Asia and help to elucidate how environmental changes accelerate lineage diversification.
    Scientific Reports 05/2015; 5:10069. DOI:10.1038/srep10069 · 5.58 Impact Factor
  • IEEE NEMS 2015; 04/2015
  • IEEE NEMS2015; 04/2015
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    ABSTRACT: A large body of evidence indicates that microRNAs play a critical role in tumor initiation and progression by negatively regulating oncogenes or tumor suppressor genes. Here, we report that the expression of miR-200a was notably downregulated in 45 renal cell carcinoma (RCC) samples. Restoration of miR-200a suppressed cell proliferation, migration, and invasion in two RCC cell lines. Furthermore, we used an epithelial-to-mesenchymal transition PCR array to explore the putative target genes of miR-200a. By performing quantitative real-time PCR, ELISA, and luciferase reporter assays, transforming growth factor beta2 (TGFB2) was validated as a direct target gene of miR-200a. Moreover, siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression. These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2, indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC.
    Tumor Biology 03/2015; DOI:10.1007/s13277-015-3355-9 · 3.61 Impact Factor
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    ABSTRACT: Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3'UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. Copyright © 2015. Published by Elsevier Inc.
    Biochemical and Biophysical Research Communications 03/2015; 460(3). DOI:10.1016/j.bbrc.2015.03.088 · 2.30 Impact Factor
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    ABSTRACT: Background: Multifunctional gold nanospheres (MGNs)-loaded with docetaxel (MGN@DTX) were prepared and evaluated for therapeutic efficacy in nude mice bearing human prostate cancer xenografts. Methods: MGNs were prepared from PEGylated hollow gold nanospheres (HGNs) coated with folic acid and DTPTT chelate. Then, the effect of radiolabelled MGNs ((99m)Tc-MGNs) on PC-3 cell apoptosis was assessed by flow cytometry, while their binding affinity to these cells was evaluated by cell binding assays. Next, biodistribution of (99m)Tc-MGNs in xenograft bearing mice was measured by SPECT imaging. Also, DTX loading and release rates were estimated in MGN@DTX. Finally, in vitro stability in human serum and cytotoxicity of MGN@DTX were assessed, as well as their antitumor effect in xenograft bearing mice. Results: (99m)Tc-MGNs (97.69% purity) showed good binding affinity to PC-3 cells, a specific recognition blocked by excess folic acid. Interestingly, MGN@DTX remained stable in human serum for 24 h, and exhibited higher mean cytotoxicity after NIR laser irradiation than free DTX. By day 28, tumor inhibition rates were higher in the MGN@DTX + NIR laser irradiation group compared with the DTX and MGNs + NIR laser irradiation groups. Conclusions: Loading chemotherapeutic drugs into MGNs can increase antitumor potency, reduce normal cell damage and decrease drug resistance, thus representing a promising approach for advanced prostate cancer treatment.
    Journal of Drug Targeting 03/2015; 23(6):1-9. DOI:10.3109/1061186X.2015.1018910 · 2.74 Impact Factor
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    ABSTRACT: Horns of Saiga antelope (Saiga tatarica) have always been an ingredient of “Lingyangjiao”, a traditional Chinese medicine (TCM). Persistent hunting for Saiga antelope has already threatened the survival of critical endangered populations in wild. To control the growing pressure, CITES and Chinese government have legislated for monitoring the trade of Saiga horns. However, similar ungulate horns are difficult to identify by their morphological characteristics, which has impeded the law enforcement. Besides Saiga antelope, other seven ungulate species which have similar horns are also sold and marked as “Lingyangjiao” in TCM markets to offset shortage of Saiga antelope horns. Such species are Gazella subgutturosa, Pantholops hodgsonii, Procapra picticaudata, Procapra gutturosa, Procapra przewalskii, Capra hircus, and Ovis aries. Our study aimed at implementing DNA barcoding technology to diagnose Saiga horns and the substitutes. We successfully extracted genomic DNA from horn samples. We recovered COI sequences of 644 bp with specific primers and 349 bp with nested PCR primers designed for degraded horn samples. The mean interspecific genetic distance of data set of the 644-bp full barcodes and the 349-bp mini-barcodes was 14.96% and 15.38%, respectively, and the mean intraspecific distance was 0.24% and 0.20%, respectively. Each species formed independent clades in neighbor-joining (NJ) phylogenetic tree of the two data sets with >99% supporting values, except P. gutturosa and P. przewalskii. The deep genetic distances gap and clear species clades in NJ tree of either full barcodes or mini-barcodes suggest that barcoding technology is an effective tool to diagnose Saiga horns and their substitutes. Barcoding diagnosis protocol developed here will simplify diagnosis of “Lingyangjiao” species and will facilitate conservation of endangered ungulates involved in TCM “Lingyangjiao” markets, especially the Saiga antelope.
    Ecology and Evolution 03/2015; 5(9). DOI:10.1002/ece3.1457 · 2.32 Impact Factor
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    ABSTRACT: The physiological role of cystic fibrosis transmembrane conductance regulator (CFTR) in keratinocytes and skin wound healing is completely unknown. The present study shows that CFTR is expressed in the multiple layers of keratinocytes in mouse epidermis and exhibits a dynamic expression pattern in a dorsal skin wound healing model, with diminishing levels observed from Day 3 to Day 5 and re-appearing from Day 7 to Day 10 after wounding. Knockdown of CFTR in cultured human keratinocytes promotes cell migration but inhibits differentiation, while overexpression of CFTR suppresses migration but enhances differentiation, indicating an important role of CFTR in regulating keratinocyte behavior. In addition, we have demonstrated a direct association of CFTR with epithelial junction formation as knockdown of CFTR downregulates the expression of adhesion molecules, such as E-cadherin, ZO-1 and β-catenin, and disrupts the formation of cell junction, while overexpression of CFTR enhances cell junction formation. More importantly, we have shown that ΔF508cftr-/- mice with defective CFTR exhibit delayed wound healing as compared to wild type mice, indicating that normal function of CFTR is critical for wound repair. Taken together, the present study has revealed a previously undefined role of CFTR in regulating skin wound healing processes, which may have implications in injury repair of other epithelial tissues. This article is protected by copyright. All rights reserved
    Journal of Cellular Physiology 01/2015; 230(9). DOI:10.1002/jcp.24931 · 3.84 Impact Factor
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    ABSTRACT: The short-term exposure to microcystin-LR (MC-LR, one of the most common and toxic variants generated by toxigenic cyanobacteria) induced gut dysfunction such as generation of reactive oxygen species, cell erosion and deficient intestinal absorption of nutrients. However, till now, little is known about its impact on gut microbial community, which has been considered as necessary metabolic assistant and stresses resistant entities for the host. This study was designed to reveal the shift of microbial functional genes in the gut of rat orally gavaged with MC-LR. GeoChip detected a high diversity of bacterial and fungal genes involved in basic metabolic processes and stress resistance. The results showed that the composition of functional genes was significantly changed in rat gut after one week of exposure to MC-LR, and we found some relatively enriched genes that are involved in carbon degradation including chitin, starch and limonene metabolism, and these genes were mainly derived from fungal and bacterial pathogens. In addition, we found large amounts of significantly enriched genes relevant to degradation of the specific carbon compounds, aromatics. The dysbiosis of bacterial and fungal flora gave an implication of pathogens invasion. The enriched gene functions could be linked to acute gastroenteritis induced by MC-LR. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Toxicon 01/2015; 96C(1):50-56. DOI:10.1016/j.toxicon.2015.01.011 · 2.49 Impact Factor
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    ABSTRACT: Simultaneous measurements of dissolved iron (Fe), phosphorus (P), and arsenic (As) were made using the diffusive gradients in thin films technique equipped with a mixed binding gel impregnated with zirconium oxide and Chelex-100 (ZrO–Chelex DGT). The ZrO–Chelex binding gel exhibited rapid binding dynamics to Fe(II), P(PO43−), and As(III)/As(V) in mixed solutions of the three elements. The bound Fe, P, and As could be quantitatively recovered using an established four-step elution procedure. Simultaneous measurements of the three elements with ZrO–Chelex DGT were validated through time-series experiments, and there was no influence of pH (4.1 to 7.1) and ionic strength (0.01 to 800 mM). The DGT capacities for As(III) and As(V) were 69.0 μg and 186 μg per device, respectively, which were much greater than those of the widely used ferrihydrite DGT. Applications in synthesized freshwaters and in sediments further confirmed its feasibility in simultaneous measurements in the environment. The present study offered that the ZrO–Chelex DGT will be a useful tool in in situ monitoring of Fe–P–As and assessment of their interactions in the biogeochemical processes.
    Environmental Sciences: Processes and Impacts 01/2015; 17(3). DOI:10.1039/C4EM00629A · 2.17 Impact Factor
  • Junpeng Wang · Jianhua Liu · Heyuan Song · Jing Chen
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    ABSTRACT: Methyl methoxyacetate (MMAc), a precursor to ethylene glycol (EG), was synthesized successfully via the liquid-phase carbonylation of dimethoxymethane (DMM) catalyzed by heteropolyacids (HPAs). The experiment results showed that H3PW12O40 (PW12) exhibited the best catalytic performance for the carbonylation of DMM, and its high catalytic activity was attributed to the synergistic effect between its superior acidic strength and the high polarity of the solvent.
    Chemistry Letters 01/2015; 44(6):806-808. DOI:10.1246/cl.150131 · 1.23 Impact Factor
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    ABSTRACT: Lead (Pb) is a priority pollutant, and the demand is growing for its cost-effective removal from water. A nanomaterial with Mn(II)-bearing Fe3O4 (Mn–Fe) as magnetic core and MnO2 as shell was synthesized, giving a specific surface area of 113.3 m2/g, particle size of 90–130 nm, cubic spinel magnetic phase, and saturation magnetization of 35.1 emu/g. It exhibited a strong propensity for adsorbing Pb(II), with a maximal adsorption capacity of 261.1 mg/g at pH 5.0. The process was rapid and pH dependent, but only slightly affected by ionic strength and coexisting cations, indicating the formation of the inner-sphere complexes. Used nanomaterial could be easily separated from solution by a magnet and readily regenerated with HCl. Its Pb(II) adsorption efficiency remained at about 80% of the original after the fourth regeneration. Thus, it has the potential for use as an effective adsorbent to remove Pb(II) from water.
    Industrial & Engineering Chemistry Research 12/2014; 53(48):18481-18488. DOI:10.1021/ie502967a · 2.59 Impact Factor
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    ABSTRACT: Rabbits are often preferred to be experimental animals during the skin research. The visualizing and understanding the full-thickness structure of rabbit skin has significance in biology, medicine, and animal husbandry. In this study, multiphoton microscopy (MPM) was employed to examine the rabbit skin on the back, which was based on second harmonic generation and two-photon excited fluorescence. High-resolution images were achieved from the fresh, unfixed, and unstained tissues, showing detailed microstructure of the skin without the administration of exogenous contrast agents. The morphology and distribution of the main components of epidermis and dermis, such as keratin, collagen fibers, elastic fibers, and hair follicles, can be distinctly identified in MPM images. Since the changes in these components are tightly related to skin diseases and wound healing, the noninvasive nature of MPM enables it become a valuable tool in skin research for detecting and monitoring. SCANNING 9999:XX–XX, 2014. © 2014 Wiley Periodicals, Inc.
    Scanning 12/2014; 37(2). DOI:10.1002/sca.21184 · 1.89 Impact Factor

Publication Stats

3k Citations
858.80 Total Impact Points


  • 2014–2015
    • Hohai University
      • Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education
      Nan-ching, Jiangsu Sheng, China
    • Fujian Normal University
      • College of Life Sciences
      Fujiang, Heilongjiang Sheng, China
  • 2013–2015
    • Beijing Genomics Institute
      Bao'an, Guangdong, China
    • Department of Nuclear Medicine
      Nyitra, Nitriansky, Slovakia
    • Peking University People's Hospital
      Peping, Beijing, China
  • 2011–2015
    • The Chinese University of Hong Kong
      • School of Biomedical Sciences
      Hong Kong, Hong Kong
    • Chang Gung University
      Hsin-chu-hsien, Taiwan, Taiwan
    • University of Nebraska at Lincoln
      • Department of Psychology
      Lincoln, Nebraska, United States
  • 2001–2015
    • Chinese Academy of Sciences
      • • Graduate School
      • • State Key Laboratory of Drug Research
      • • South China Institute for Stem Cell Biology and Regenerative Medicine
      • • Institute of Process Engineering
      • • Institute of Chemistry
      Peping, Beijing, China
  • 2011–2014
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2009–2014
    • Fourth Military Medical University
      • • Department of Neurology
      • • Department of Human Anatomy and Histoembryology
      Xi’an, Liaoning, China
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2007–2014
    • Peking University
      • • Institute of Microelectron
      • • State Key Laboratory for Structural Chemistry of Unstable and Stable Species
      Peping, Beijing, China
    • Shanghai Jiao Tong University
      • School of Medicine
      Shanghai, Shanghai Shi, China
    • Northeast Normal University
      Hsin-ching, Jilin Sheng, China
  • 2006–2014
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 2011–2013
    • 302 Military Hospital of China
      • Centre for Liver Failure Treatment and Research
      Peping, Beijing, China
  • 2005–2013
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
  • 2012
    • Sichuan University
      Hua-yang, Sichuan, China
    • Third Military Medical University
      • Institute of Burn Research
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2011–2012
    • North China University of Water Conservancy and Electric Power
      Cheng, Henan Sheng, China
  • 2009–2012
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
  • 2002–2012
    • Shanghai's Children's Medical Center
      Shanghai, Shanghai Shi, China
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
  • 2010
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
    • Chang'an University
      Xi’an, Guangdong, China
  • 2005–2008
    • Yunnan University
      Yün-nan, Yunnan, China