Ji Young Kim

The Children's Hospital of Philadelphia, Filadelfia, Pennsylvania, United States

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Publications (529)1398.17 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The effects of relative humidity (RH) on the antioxidant properties of ascorbic acid (10, 20, 42, and 84 ppm) were investigated in stripped corn oils stored at 60 °C. The degree of oxidation in oils was determined by analysing headspace oxygen content and conjugated dienoic acids. The oxidative stability of bulk oils without addition of ascorbic acid was significantly different depending on the RH. As the concentration of ascorbic acid increased from 10 to 84 ppm, oxidative stability increased significantly irrespective of RH (p < 0.05). Generally, oils containing ascorbic acid at low RH had higher oxidative stability after storage at 60 °C than those at high RH. The antioxidant properties of ascorbic acid were greatly influenced by both the moisture content in the oil and the ascorbic acid concentration.
    Food Chemistry 06/2015; 176. DOI:10.1016/j.foodchem.2014.12.079 · 3.26 Impact Factor
  • Mi Gyung Jeon, Ji Young Kim, Yung Chul Park
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    ABSTRACT: We sequenced and characterized a complete mitogenome (KP671850) of the Chinese Apodemus peninsulae and compared it with a previously published mitogenome of the Korean A. peninsulae (NC016060). The total length of the Chinese A. peninsulae mitogenome is 16,457 bp. The mitogenome consists of 13 protein-coding genes (PCGs), two rRNA (12S rRNA and 16S rRNA) genes, 22 tRNA genes, and one D-loop region. The most common start codon was ATG, used in the nine PCGs for initiation. The mitogenomes of Chinese and Korean A. peninsulae showed 98.9% sequence similarity. The intra-/interspecific phylogeny of the Chinese A. peninsulae revealed that the Chinese A. peninsulae was well grouped with the Korean A. peninsulae. The clade of A. peninsulae was sister to that of Apodemus agrarius, Apodemus chejuensis, and Apodemus chevrieri.
    Mitochondrial DNA 05/2015; DOI:10.3109/19401736.2015.1030618 · 1.70 Impact Factor
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    ABSTRACT: Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has become the main treatment modality in malignant gliomas. However unlike glioblastomas, there are inconsistent result about fluorescence status in WHO grade III gliomas. Here, we show that mutational status of IDH1 is linked to 5-ALA fluorescence. Using genetically engineered malignant glioma cells harboring wild type (U87MG-IDH1WT) or mutant (U87MG-IDH1R132H) IDH1, we demonstrated a lag in 5-ALA metabolism and accumulation of protoporphyrin IX (PpIX) in U87MG-IDH1R132Hcells. Next, we used liquid chromatography-mass spectrometry (LC-MS) to screen for tricarboxylic acid (TCA) cycle-related metabolite changes caused by 5-ALA exposure. We observed low baseline levels of NADPH, an essential cofactor for the rate-limiting step of heme degradation, in U87MG-IDH1R132H cells. High levels of NADPH are required to metabolize excessive 5-ALA, giving a plausible reason for the temporarily enhanced 5-ALA fluorescence in mutant IDH1 cells. This hypothesis was supported by the results of metabolic screening in human malignant glioma samples. In conclusion, we have discovered a relationship between enhanced 5-ALA fluorescence and IDH1 mutations in WHO grade III gliomas. Low levels of NADPH in tumors with mutated IDH1 is responsible for the enhanced fluorescence.
    Oncotarget 05/2015; · 6.63 Impact Factor
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    ABSTRACT: Chronic kidney disease is strongly linked to neurocognitive deficits in adults and children, but the pathophysiologic processes leading to these deficits remain poorly understood. The NiCK study (Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease) seeks to address critical gaps in our understanding of the biological basis for neurologic abnormalities in chronic kidney disease. In this report, we describe the objectives, design, and methods of the NiCK study. The NiCK Study is a cross-sectional cohort study in which neurocognitive and neuroimaging phenotyping is performed in children and young adults, aged 8 to 25 years, with chronic kidney disease compared to healthy controls. Assessments include (1) comprehensive neurocognitive testing (using traditional and computerized methods); (2) detailed clinical phenotyping; and (3) multimodal magnetic resonance imaging (MRI) to assess brain structure (using T1-weighted MRI, T2-weighted MRI, and diffusion tensor imaging), functional connectivity (using functional MRI), and blood flow (using arterial spin labeled MRI). Primary analyses will examine group differences in neurocognitive testing and neuroimaging between subjects with chronic kidney disease and healthy controls. Mechanisms responsible for neurocognitive dysfunction resulting from kidney disease will be explored by examining associations between neurocognitive testing and regional changes in brain structure, functional connectivity, or blood flow. In addition, the neurologic impact of kidney disease comorbidities such as anemia and hypertension will be explored. We highlight aspects of our analytical approach that illustrate the challenges and opportunities posed by data of this scope. The NiCK study provides a unique opportunity to address key questions about the biological basis of neurocognitive deficits in chronic kidney disease. Understanding these mechanisms could have great public health impact by guiding screening strategies, delivery of health information, and targeted treatment strategies for chronic kidney disease and its related comorbidities.
    BMC Nephrology 04/2015; 16(1):66. DOI:10.1186/s12882-015-0061-1 · 1.52 Impact Factor
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    ABSTRACT: This study assessed the reliability and validity of the Korean version of the Dimensions of Tobacco Dependence Scale (DTDS) for adolescents in Korea. The DTDS, Modified Fagerström Tolerance Questionnaire (M-FTQ), and urine nicotine test were administered to 360 Korean adolescents. The collected data were analyzed using SPSS 21.0 and AMOS 21.0. The construct validity, criterion validity, test-retest reliability, internal consistency reliability, and the area under the curve (AUC) of the Korean version of the DTDS were evaluated. The 4-subscale model of the DTDS (with social, emotional, physical, and sensory subscales) was validated using confirmatory factor analysis, and criterion validity was demonstrated with the M-FTQ. Furthermore, the AUC of the DTDS was 83.1. The Cronbach's α coefficient for internal consistency was .96, demonstrating sufficient test-retest reliability. The Korean version of the DTDS is a reliable and valid measure of tobacco dependence among Korean adolescents. © 2015 APJPH.
    Asia-Pacific Journal of Public Health 04/2015; DOI:10.1177/1010539515583504 · 1.11 Impact Factor
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    ABSTRACT: The effects of phosphatidylcholine on the antioxidant properties of α-tocopherol (84 ppm) were determined in stripped corn oil with various moisture contents at 60 °C. The degree of oxidation in the oils was determined by analysing headspace oxygen content and conjugated dienoic acids (CDA). Generally, phosphatidylcholine acted as an antioxidant in stripped corn oils, whereas it accelerated the rate of lipid oxidation in nonstripped corn oils. As the relative humidity and moisture content increased, the antioxidant properties of phosphatidylcholine increased significantly (P < 0.05). Strong synergistic antioxidant effects were observed in samples containing both phosphatidylcholine and α-tocopherol compared to samples with only phosphatidylcholine or α-tocopherol. Oils containing phosphatidylcholine or α-tocopherol under different moisture contents had different oxidative stabilities.
    International Journal of Food Science & Technology 04/2015; 50(6). DOI:10.1111/ijfs.12793 · 1.35 Impact Factor
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    Seung-Mok Youm, Ji Young Kim, Jeong Rim Lee
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    ABSTRACT: A 21-year-old female with a history of bulimia nervosa came to the emergency room due to severe abdominal pain after excessive eating five hours previously. On arrival at the emergency room, extreme abdominal distension was detected and the patient's legs changed color. Computed tomography suggested severe gastric dilatation, so abdominal compartment syndrome was suspected and an emergent laparotomy was supposed to be conducted. Though anesthesia was induced without event, abrupt hemodynamic collapse developed just after the operation started. In spite of active resuscitation for 29 min, the patient did not recover and expired. As the incidence of eating disorders is increasing, anesthesiologists should keep in mind the possibility of abdominal compartment syndrome in patients with a recent history of binge eating, and prepare optimal anesthetic and resuscitation remedies against sudden deteriorations of a patient's condition.
    Korean journal of anesthesiology 04/2015; 68(2):188-92. DOI:10.4097/kjae.2015.68.2.188
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    ABSTRACT: Activation of nuclear factor kappa-B (NF-κB) is implicated in drug resistant of lung cancer cells. Our previous data showed that thiacremonone inhibited activation of NF-κB. In the present study, we investigated whether thiacremonone enhanced susceptibility of lung cancer cells to a common anti-cancer drug paclitaxel by further inhibition of NF-κB. Thus, we used the threefold lower doses of IC50 values (50 μg/ml thiacremonone and 2.5 nM paclitaxel). We found that combination treatment with thiacremonone and paclitaxel was more susceptible (combination index; 0.40 in NCI-H460 cells and 0.46 in A549 cells) in cell growth inhibition of two types of lung cancer cell lines compared to a single agent treatment. Consistent with the combination effect on cancer cell growth inhibition, the combination treatment further induced apoptotic cell death and arrested the cancer cells in G2/M phase accompanied with a much lower expression of cdc2 and cyclin B1, and inhibited colony formation. Much more inactivation of NF-κB and greater expression of NF-κB target apoptosis regulated genes such as caspase-8 and PARPs were found by the combination treatment. Molecular model and pull down assay as well as MALDI-TOF analysis demonstrated that thiacremonone directly binds to p50. These data indicated that thiacremonone leads to increased apoptotic cell death in lung cancer cell lines through greater inhibition of NF-κB by the combination treatment with paclitaxel.
    Archives of Pharmacal Research 03/2015; DOI:10.1007/s12272-015-0589-4 · 1.75 Impact Factor
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    ABSTRACT: The association between progressive motor deficits (PMD) in acute pontine infarction and basilar stenosis is unclear. High resolution MRI (HRMRI) is an emerging tool for basilar artery evaluation and might provide more accurate information. We aimed to analyze the association between basilar plaque assessed by HRMRI and PMD after acute pontine infarction. We identified consecutive patients with unilateral pontine infarction within 24 h of stroke onset. All the patients underwent diffusion weighted MRI, MR angiography and HRMRI within 24 h of admission. PMD was defined as an increase in National Institutes of Health Stroke Scale score by ≥ 1 during hospitalization. Factors potentially associated with PMD were validated by multivariate analyses. Of a total of 87 patients, 63 (72%) had paramedian pontine infarction (PPI) and PMD was observed in 28 (32%) patients. Apparent basilar plaque assessed by HRMRI was more frequent in those with PMD than in those without PMD (52% versus 33%, p < 0.001). In contrast, the frequency of basilar stenosis (>30%) assessed by MR angiography was similar regardless of PMD. In the patients with PPI, PMD was associated with hypertension and apparent plaque on HRMRI. After adjusting covariates, PMD was independently associated with apparent plaque on HRMRI (OR, 9.1; 95% CI 1.4-58.9). Our results suggest that basilar plaque assessed by HRMRI is associated with PMD in patients with acute unilateral pontine infarction. Since basilar stenosis may be underestimated by MR angiography, HRMRI may provide additional information for predicting PMD and evaluating basilar artery stenosis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Atherosclerosis 03/2015; 240(1):278-283. DOI:10.1016/j.atherosclerosis.2015.03.029 · 3.97 Impact Factor
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    ABSTRACT: Background Persistent infection of the Japanese Encephalitis Virus (JEV) has been reported in clinical cases, experimental animals, and various cell culture systems. We previously reported the establishment of spontaneous JEV persistent infection, assisted by defective interfering particle accumulation and/or attenuated helper viruses, in BHK-21 cells devoid of virus-induced apoptosis, cBS6-2 and cBS6-3. However, cell-specific factors may play important roles in controlling JEV replication and have never been assessed for this specific phenomenon. Recent evidence suggests that viruses have evolved various mechanisms to cope with endoplasmic reticulum stress signaling pathways for their efficient amplification and transmission, including the unfolded protein response (UPR). Results To identify the host cell factors that affect JEV persistence, we investigated the expression of essential UPR factors in cBS6-2 and cBS6-3 cells. Of the selected UPR factors tested, the most noticeable deviations from those of the normal BHK-21 cells with JEV acute infection were as follows: the suppression of C/EBP homologous binding protein (CHOP) and the constant up-regulation of immunoglobulin binding protein (BiP) expression in cBS6-2 and cBS6-3 cells. In JEV acute infection on normal BHK-21 cells, silencing CHOP expression through specific siRNA blocked cell death almost completely. Meanwhile, depletion of BiP by specific siRNA unlocked CHOP expression in cBS6-2 and cBS6-3 cells, resulting in massive cell death. Fulminant apoptotic cell death for both cell clones on tunicamycin treatment revealed that the JEV persistently infected cells still contained functional arms for cell fate decisions. Conclusions BHK-21 cells with JEV persistent infection strive against virus-induced apoptosis through constant up-regulation of BiP expression, resulting in the complete depletion of CHOP even with apparent virus amplification in the cells. Accordingly, the attenuation of virus replication as well as the modifications to cell metabolism could be additional factors contributing to the development of JEV persistent infection in mammalian cells. Electronic supplementary material The online version of this article (doi:10.1186/s12985-015-0269-5) contains supplementary material, which is available to authorized users.
    Virology Journal 02/2015; 12(1). DOI:10.1186/s12985-015-0269-5 · 2.09 Impact Factor
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    ABSTRACT: Pazopanib is a potent multitargeted tyrosine kinase inhibitor that has been shown to have good efficacy in patients with renal cell carcinoma. A previous phase II trial demonstrated that short-term pazopanib administration was generally well tolerated and showed antitumor activity in patients with early-stage non-small cell lung cancer. Herein, we report on the case of a 66-year-old man with simultaneous metastatic squamous cell carcinoma of the lung and renal cell carcinoma who was treated with pazopanib. The patient showed an unexpected partial response and experienced a 10-month progression-free survival without significant toxicity. To the best of the authors' knowledge, this is the first report of pazopanib treatment in a non-small cell lung cancer patient in Korea. The results in this patient suggest that pazopanib may be a valid treatment option for advanced non-small cell lung cancer.
    Cancer Research and Treatment 02/2015; DOI:10.4143/crt.2014.209 · 2.98 Impact Factor
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    ABSTRACT: The impact of cancer on quality of life and depression is an important issue. The purpose of this study was to identify the impact of physical fitness on quality of life and depression in stage II-III colorectal cancer survivors. Participants in the current study included 122 stage II-III colorectal cancer survivors (57 females; 56.67 ± 9.16 years of age and 55 males; 54.69 ± 9.78 years of age). Fitness was assessed using the 6-min walk test, chair stand test, and push-up test. Quality of life and depression were measured using the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale and a 9-item patient health questionnaire interview, respectively. There was a significant association between physical fitness and quality of life and depression in colorectal cancer survivors. The 6-min walk test results were associated with FACT-C total (r = 0.298, p < 0.05), physical well-being (r = 0.230, p < 0.05), functional well-being (r = 0.234, p < 0.05), colorectal cancer concern (r = 0.229, p < 0.05), and depression (r = -0.228, p < 0.05), and the chair stand test results were associated with functional well-being (r = 0.231, p < 0.05), colorectal cancer concern (r = 0.242, p < 0.05), and depression (r = -0.227, p < 0.05) even after controlling for all potentially confounding variables. A multiple regression analysis indicated that the 6-min walk was a significant predictor of health-related quality of life, and participants in the lowest tertile of the 6-min walk test results had lower quality of life and greater depression than those in the highest tertile. Improving and maintaining physical fitness are important for quality of life and depression in stage II-III colorectal cancer survivors.
    Supportive Care Cancer 02/2015; DOI:10.1007/s00520-015-2615-y · 2.50 Impact Factor
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    ABSTRACT: The objectives of this study were to explore the feasibility of applying sequential dilute acid and alkali pretreatment into the hydrolysis of corn stover and to elucidate the effects of structural changes in the biomass on its enzymatic digestibility. H2SO4 used in the first step selectively hydrolyzed 74.6-77.3% of xylan and NaOH used in the second step removed 85.9-89.4% of lignin, from the raw corn stover. Compared to single dilute acid pretreatment, the proposed combined pretreatment minimized the generation of byproducts such as acetic acid, furfural and hydroxymethylfurfural in the hydrolysates, and enhanced the enzymatic hydrolysis of the solid residue. The changes in the structural features (porosity, morphology, and crystallinity) of the solid residue were strongly correlated with the enhancement of enzymatic digestibility. The overall glucose and xylose yields finally obtained after enzymatic hydrolysis reached 89.1-97.9% and 71.0-75.9%, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Bioresource Technology 02/2015; 182C:296-301. DOI:10.1016/j.biortech.2015.01.116 · 5.04 Impact Factor
  • 02/2015; 7(1):36-39. DOI:10.7763/IJET.2015.V7.762
  • Ji Young Kim, Spiro Kiousis, Zheng Xiang
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    ABSTRACT: Grounded in an agenda-building and agenda-setting framework, the current study explored the transfer of salience relationships among public relations materials, news media coverage and online public communications in a business communication context. A total of 2,576 communication messages were analyzed in terms of the dominant business corporation (object), corporate attributes (substantive attributes) and the tone of attributes (affective attributes). Our results showed that the transfer of salience relationships were strongly supported at the second-level among corporate public relations messages, media coverage and consumers’ messages online. The salience of corporate attributes has a stronger correlation than the salience of the corporate names among communication messages. The theoretical and practical implications are discussed.
    Corporate Reputation Review 02/2015; 18(1). DOI:10.1057/crr.2014.18
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    ABSTRACT: This study aimed to compare perioperative and postoperative morbidity of older and younger women undergoing sacrocolpopexy (SCP). A retrospective study included 271 patients who underwent laparotomic SCP for symptomatic pelvic organ prolapse from November 2008 to June 2013 at our institution. By the review of medical records, perioperative and postoperative data including the length of the surgery, estimated blood loss, blood transfusion, the length of hospital stay, wound complications and febrile morbidity were collected. In addition, cardiovascular, pulmonary, gastrointestinal, genitourinary, or neurological adverse events were retrieved. The need for an indwelling urinary catheter or performance of clean intermittent self-catheterization, mesh erosion rate and the number of days required for each were included in the postoperative outcomes. For the outcome variable analyzed in this study, the patients was dichomotized into women aged 65 and older and those younger than 65. One hundred and thirty-five (49.8%) patients were younger than 65 and 136 (50.2%) were aged 65 and older. Older women had higher body mass index, vaginal parity and prior surgery for hysterectomy than younger women (P<0.05). And older women had higher baseline comorbidities, such as hypertension, diabetes, cardiac disease (P<0.05), and their American society of Anesthesiologist class was higher (P<0.001). In the perioperative and postoperative complication, older group showed no differences in most of the operation-related complication rates, but gastrointestinal complication rate. Also, mesh erosion rate was not found to be significantly different between the two groups at the last visit. Older women undergoing laparotomic SCP have similar perioperative and postoperative morbidities as younger women, suggesting surgeons can counsel older and younger women similarly in terms of operative risks.
    01/2015; 58(1):59-64. DOI:10.5468/ogs.2015.58.1.59
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    ABSTRACT: The effects of relative humidity (RH) on the antioxidant properties of α-tocopherol (10, 20, 42, and 84ppm) were determined in stripped corn oil oxidised at 60°C. The degree of oxidation in oils was determined by analysing headspace oxygen content and conjugated dienoic acids (CDAs). Changes in moisture and α-tocopherol content were also monitored. The oxidative stability of stripped corn oil and stability of α-tocopherol differed significantly depending on the RH. As the concentration of α-tocopherol increased from 10 to 84ppm, oxidative stability decreased significantly irrespective of RH. The remaining α-tocopherol content decreased as RH increased, suggesting an important role for moisture content in the stability of α-tocopherol. Antioxidant properties of α-tocopherol were greatly influenced by both moisture content in oil and α-tocopherol concentration.
    Food Chemistry 01/2015; 167C:191-196. DOI:10.1016/j.foodchem.2014.06.108 · 3.26 Impact Factor
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    ABSTRACT: PRDX6 is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities. Even though several pathophysiological functions have been studied, the definitive role of PRDX6 on tumor growth has been not clear. Here, we compared carcinogen-induced tumor growth in PRDX6 transgenic (Tg) mice and non Tg mice to evaluate roles of PRDX6 in lung tumor development. Urethane (1g/kg)-induced tumor incidence in PRDX6 Tg mice was significant higher compared to non Tg mice. In the tumors of PRDX6 Tg mice, the activation of JAK2/STAT3 and STAT3 DNA binding were also increased, which is accompanied with increased GPx and iPLA2 activities. PRDX6 was colocalized with JAK2 in tumor tissues and lung cancer cells, and also showed physical interaction with JAK2. We found that the increasing level of Prdx6 increases the activation of the JAK2/STAT3 pathway. Furthermore, PRDX6 Tg mice showed altered cytokine levels in the tumors, especially leading to increased CCL5 level. We validated that the activation of JAK2 was also decreased in lung tumors of CCR5(-/-) mice, and CCL5 increased the JAK2/STAT3 pathway in the lung cancer cells. Thus, our findings suggest that PRDX6 promotes lung tumor development via its mediated and CCL5 associated activation of the JAK2/STAT3 pathways. Copyright © 2015. Published by Elsevier Inc.
    Free Radical Biology and Medicine 01/2015; 80. DOI:10.1016/j.freeradbiomed.2014.12.022 · 5.71 Impact Factor

Publication Stats

6k Citations
1,398.17 Total Impact Points

Institutions

  • 2014–2015
    • The Children's Hospital of Philadelphia
      Filadelfia, Pennsylvania, United States
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
    • Korea Institute of Radiological & Medical Sciences
      Sŏul, Seoul, South Korea
    • Seoul National University Bundang Hospital
      • Department of Radiology
      Sŏul, Seoul, South Korea
    • The Ohio State University
      Columbus, Ohio, United States
    • Hong Kong Baptist University
      • Department of Physics
      Chiu-lung, Kowloon City, Hong Kong
    • The Seoul Institute
      Sŏul, Seoul, South Korea
    • Washington University in St. Louis
      • Department of Biology
      San Luis, Missouri, United States
    • Konkuk University Medical Center
      • Department of Laboratory Medicine
      Changnyeong, South Gyeongsang, South Korea
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
  • 2013–2015
    • Catholic University of Daegu
      • Department of Physical Therapy
      Kayō, Gyeongsangbuk-do, South Korea
    • Daewoo Engineering and Construction
      Sŏul, Seoul, South Korea
    • University of Michigan
      • Department of Materials Science and Engineering
      Ann Arbor, Michigan, United States
    • Konkuk University
      Sŏul, Seoul, South Korea
    • Korea Maritime and Ocean University
      Tsau-liang-hai, Busan, South Korea
  • 2012–2015
    • Bradley University
      Peoria, Illinois, United States
    • Dankook University
      • Department of Food Science and Nutrition
      Eidō, Chungcheongbuk-do, South Korea
    • Fayetteville State University
      Fayetteville, New York, United States
    • Chungnam National University
      • Department of Biochemistry
      Sŏngnam, Gyeonggi Province, South Korea
  • 2011–2015
    • Chungbuk National University
      • College of Pharmacy
      Chinsen, Chungcheongbuk-do, South Korea
    • Cheil General Hospital
      Sŏul, Seoul, South Korea
    • University of Rochester
      • Division of General Medicine
      Rochester, New York, United States
    • Gyeongsang National University
      • Institute of Agriculture and Life Science
      Shinshū, South Gyeongsang, South Korea
    • Samsung Medical Center
      • Department of Nuclear Medicine
      Sŏul, Seoul, South Korea
    • Korea Food Research Institute
      Sŏul, Seoul, South Korea
  • 2009–2015
    • Kyung Hee University
      • • Research Institute for Basic Science
      • • College of Oriental Medicine
      • • Institute for Medical Science
      Sŏul, Seoul, South Korea
    • Kyungsung University
      • Graduate School of Digital Design
      Tsau-liang-hai, Busan, South Korea
    • Eunice Kennedy Shriver National Institute of Child Health and Human Development
      Maryland, United States
    • Korea Institute of Toxicology
      Sŏul, Seoul, South Korea
    • National Institutes of Health
      • Laboratory of Cellular Oncology
      Bethesda, MD, United States
    • Catholic Kwandong University
      • College of Medicine
      Gangneung, Gangwon-do, South Korea
    • Sookmyung Women's University
      • Department of Biological Science
      Sŏul, Seoul, South Korea
  • 2008–2015
    • Hanyang University
      • • Major in Nuclear Medicine
      • • College of Medicine
      • • Division of Materials Science and Engineering (MSE)
      Sŏul, Seoul, South Korea
    • Pohang University of Science and Technology
      • Department of Chemical Engineering
      Geijitsu, Gyeongsangbuk-do, South Korea
    • Gachon University
      Sŏngnam, Gyeonggi-do, South Korea
    • Union Corporation, South Korea
      Sŏul, Seoul, South Korea
    • Syracuse University
      Syracuse, New York, United States
  • 2006–2015
    • Jeju National University
      Tse-tsiu, Jeju-do, South Korea
  • 2004–2015
    • Chonbuk National University
      • • College of Nursing
      • • Department of Chemical Engineering
      Tsiuentcheou, Jeollabuk-do, South Korea
    • Northern Inyo Hospital
      BIH, California, United States
  • 2002–2015
    • Sungkyunkwan University
      • • Department of Food Science and Biotechnology
      • • Graduate School of Clinical Nursing
      Sŏul, Seoul, South Korea
  • 2000–2015
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 1997–2015
    • Seoul National University Hospital
      • • Department of Obstetrics and Gynecology
      • • Department of Neurosurgery
      • • Department of Internal Medicine
      • • Department of Ophthalmology
      Sŏul, Seoul, South Korea
  • 2013–2014
    • Sanford-Burnham Medical Research Institute
      La Jolla, California, United States
  • 2012–2014
    • Woosong University
      Onyang, Chungcheongnam-do, South Korea
    • Korea Research Institute of Bioscience and Biotechnology KRIBB
      • Infection Control Material Research Center
      Anzan, Gyeonggi Province, South Korea
  • 2011–2014
    • Kangwon National University
      • • College of Forest and Environmental Science
      • • Department of Forest Environment Protection
      Shunsen, Gangwon-do, South Korea
  • 2009–2014
    • Chonnam National University
      • • School of Biological Sciences and Technology
      • • College of Pharmacy
      Gwangju, Gwangju, South Korea
    • CHA University
      • Department of Pathology
      Sŏul, Seoul, South Korea
    • Korea Institute of Construction Technology
      Kōyō, Gyeonggi-do, South Korea
  • 2008–2014
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2002–2014
    • Pusan National University
      • • Department of Cogno-Mechatronics Engineering
      • • School of Dentistry
      • • Division of Pharmacy
      • • Department of Internal Medicine
      • • College of Pharmacy
      • • Department of Polymer Science and Engineering
      Tsau-liang-hai, Busan, South Korea
  • 1996–2014
    • Yonsei University
      • • Department of Orthodontics
      • • Anesthesia and Pain Research Institute
      • • Department of Food and Nutrition
      • • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 1994–2014
    • Seoul National University
      • • Department of Obstetrics and Gynecology
      • • Department of Pediatrics
      • • Research Institute of Pharmaceutical Sciences
      • • Division of Chemistry and Molecular Engineering
      • • Department of Ophthalmology
      Sŏul, Seoul, South Korea
  • 2010–2013
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
    • Inje University
      Kŭmhae, Gyeongsangnam-do, South Korea
    • Thai Red Cross College of Nursing
      Krung Thep, Bangkok, Thailand
    • International Potato Center
      Λίμα, Provincia de Lima, Peru
    • University of Cincinnati
      • Department of Cancer and Cell Biology
      Cincinnati, Ohio, United States
  • 2006–2013
    • Korea Research Institute of Chemical Technology
      • Division of Drug Discovery Research
      Daiden, Daejeon, South Korea
  • 2003–2013
    • Yeungnam University
      • • Department of Rehabillitation Medicine
      • • College of Pharmacy
      Daikyū, Daegu, South Korea
  • 2011–2012
    • Dong-A University
      • College of Medicine
      Tsau-liang-hai, Busan, South Korea
  • 2010–2012
    • Ewha Womans University
      • • College of Pharmacy
      • • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2008–2012
    • University of Ulsan
      Urusan, Ulsan, South Korea
    • Korea Advanced Institute of Science and Technology
      • • Department of Chemistry
      • • Department of Computer Science
      Sŏul, Seoul, South Korea
  • 2005–2012
    • Medical University of Ohio at Toledo
      • Department of Biochemistry and Cancer Biology
      Toledo, Ohio, United States
  • 2009–2011
    • University of Florida
      • College of Journalism and Communications
      Gainesville, Florida, United States
  • 2008–2011
    • Purdue University
      • • Department of Industrial and Physical Pharmacy (IPPH)
      • • Weldon School of Biomedical Engineering
      West Lafayette, Indiana, United States
    • Catholic University of Korea
      • Department of Radiology
      Sŏul, Seoul, South Korea
    • National Institute of Child Health and Human Development
      Maryland, United States
  • 2003–2011
    • Kumoh National Institute of Technology
      Sŏul, Seoul, South Korea
  • 1999–2011
    • Kyungpook National University
      • • School of Dentistry
      • • College of Natural Sciences
      Daikyū, Daegu, South Korea
  • 2006–2010
    • Chung-Ang University
      • • College of Medicine
      • • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2000–2010
    • University of Seoul
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2006–2009
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
  • 2001–2009
    • Chosun University
      • Department of Pharmacy
      Gwangju, Gwangju, South Korea
    • Cheongju University
      Sŏul, Seoul, South Korea
    • Sogang University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2007–2008
    • University of Toledo
      Toledo, Ohio, United States
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
    • Korea Food and Drug Administration
      Seishō-gun, Gyeongsangbuk-do, South Korea
    • Baylor College of Medicine
      • Department of Medicine
      Houston, Texas, United States
  • 2004–2007
    • Pukyong National University
      • Faculty of Food Science and Biotechnology
      Tsau-liang-hai, Busan, South Korea
  • 2003–2004
    • Wonkwang University
      • College of Pharmacy
      Riri, North Jeolla, South Korea
  • 2001–2003
    • Korea University
      • • Department of Life Sciences
      • • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 1995
    • Ajou University
      • Department of Medicine
      Sŏul, Seoul, South Korea