Jian Wang

Publications (3)2.47 Total impact

• Article: [Pharmaceutical therapy for the severe hemodynamic depression with carotid artery stenting].

  Min Yang, Li Song, Jian Wang, Xiao-qiang Tong, Ying-hua Zou
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  ABSTRACT: To evaluate the efficacy of pharmaceutical therapy for the severe hemodynamic depression with carotid artery stenting(CAS). Clinical data were retrospectively analyzed on CAS over the last 5 years. Severe hemodynamic depression was defined as periprocedural hypotension (blood pressure <90/60 mmHg) or bradycardia (heart rate <50 beats/min) persisting for at least 1 hour. 13 patients were included in the research. Dopamine was pumped intravenously in all the 13 patients .The dose was from 2 microg/min/kg to 10 microg/min/kg, the duration was from 4 to 48 hours. Dobutamine was used in 2 patients and dose from 5 microg/min/kg to 7 microg/min/kg, duration was from 24 to 36 hours. None of the patients developed any permanent neurological complications. One acute coronary syndrome occured during the postprocedure period. Severe hemodynamic depression can be controlled with vasopressors (dopamine or dobutamine) and the associated complications can be prevented.
  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 06/2009; 41(3):373-5.
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  Available from: wjgnet.com

  Article: Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo.

  Jian Wang, Satoru Murata, Tatsuo Kumazaki
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  ABSTRACT: To observe the dynamic changes of liver microcirculation in vivo after arterial embolization with degradable starch microspheres (DSM). DSM were injected into the proper hepatic artery through a silastic tube inserted retrogradely in gastroduodenal artery (GDA) of SD rats. Fluorescent microscopy was used to evaluate the dynamic changes of blood flow through the terminal portal venules (TPVs), sinusoids and terminal hepatic venules (THVs). The movements of DSM debris were also recorded. Six hours after injection of DSM, percentages of THVs with completely stagnant blood flow were recorded. Two phases of blood flow change were recorded. In phase one: after intra-arterial injection of DSM, slow or stagnant blood flow was immediately recorded in TPVs, sinusoids and THVs. This change was reversible, and blood flow resumed completely. In phase two: after phase one, blood flow in TPVs changed again and three patterns of blood flow were recorded. Six hours after DSM injection, 36.9% +/- 9.2% of THVs were found with completely stagnant blood flow. DSM can stop the microcirculatory blood flow in some areas of liver parenchyma. Liver parenchyma supplied by arteries with larger A-P shunt is considered at a higher risk of total microcirculatory blood stagnation after injection of DSM through hepatic artery.
  World Journal of Gastroenterology 08/2006; 12(26):4214-8. · 2.47 Impact Factor
• Article: [In vivo fluorescent microscopy of the liver microcirculation after embolization with a newly developed trans-proper hepatic arterial infusion animal model].

  Jian Wang, Ying-hua Zou, Xiao-qiang Tong, Yong-xing Lv, Xue-xiang Jiang
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  ABSTRACT: To evaluate the value of the in vivo fluorescent microscopy in studying the changes of liver microcirculation after embolization with a newly developed animal model for tans-proper hepatic arterial infusion, and to summarize the method of making this animal model. Ten Sprague-Dawley rats were used in this study. After a midline abdominal incision, microcatheter was placed into the gastroduodenal artery (GDA). The tip of the catheter was placed facing the orifice of proper hepatic artery. After infusions of 0.02%, 0.1%, 0.5%, 1% fluorescent sodium, fluorescent microscopy was used to evaluate the liver microcirculation. The image quality was then accessed. Embolization was obtained by injections of Lipiodol and Degradable Starch Microspheres (DSM) from the microcatheter. Corresponding changes of the liver microcirculation was evaluated by fluorescent microscopy. From the 10 rats, 8 animal models were successfully established. The microcirculation of the liver could be clearly visualized by the fluorescent microscopy. The optimal concentration of fluorescent sodium was 0.1%. The direct and indirect phenomena caused by embolic material could be evaluated by fluorescent microscopy. Fluorescent microscopy with the corresponding Trans-hepatic arterial infusion animal model is a valuable method to evaluate the microcirculation of the liver and can be used for the evaluation of changes of liver microcirculation caused by embolization material.
  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 07/2006; 38(3):314-7.