Jian Wang

Renji Hospital, Shanghai, Shanghai Shi, China

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Publications (317)609.4 Total impact

  • Long Zhu · Jian Wang ·

    Optics Letters 12/2015; 40(23):5463. DOI:10.1364/OL.40.005463 · 3.29 Impact Factor

  • Optics Letters 12/2015; 40(23):5475. DOI:10.1364/OL.40.005475 · 3.29 Impact Factor
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    ABSTRACT: The work in this paper aims to clarify the effect of angle on the lateral flame spread over inclined surfaces. PMMA slabs with width ranged from 2.5 cm to 12 cm were tested at the angles from 0° to 75°. Burning rate, flame spread rate, flame appearance and radiant heat flux were investigated experimentally and theoretically. The results suggest that in the cases of narrow PMMA slabs (less than 8 cm), the flame spread rate is in proportion to the square root of angle sine as . For wider slabs, the spread rate is higher than the theoretical result owing to enhanced radiant heat feedback. Pyrolysis length follows a power-law increase with the sample width, and the exponent approximates 0.48. Flame length is independent of the inclination angle, but also a power function of sample width.
    International Journal of Heat and Mass Transfer 12/2015; 91:68-76. DOI:10.1016/j.ijheatmasstransfer.2015.07.072 · 2.38 Impact Factor
  • Zhonglai Zhang · Xiao Hu · Jian Wang ·

    Scientific Reports 11/2015; 5:16072. DOI:10.1038/srep16072 · 5.58 Impact Factor
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    ABSTRACT: Leptin exerts many biological functions, such as in metabolism and reproduction, through binding to and activating the leptin receptor, LepRb, which is expressed in many regions of the brain. To better understand the roles of LepR downstream signaling pathways, Y123F mice, which expressed mutant leptin receptors with phenylalanine (F) substituted for three tyrosines (Y) (Tyr985, Tyr1077 and Tyr1138), were generated. The body weight and abdominal fat deposits of Y123F homozygous mice (HOM) were higher than those of wild-type mice (WT). HOM ovaries were atrophic and the follicles developed abnormally; however, the HOM ovaries did not exhibit polycystic phenotypes. Moreover, Y123F HOM adults had no estrous cycle and the blood estrogen concentration remained stable at a low level below detection limit of 5 pg/ml. LepR expression in HOM ovaries was higher than in WT ovaries. Using cDNA Microarrays, the mRNA expressions of 41 genes were increased, and 100 were decreased in HOM vs. WT ovaries, and many signaling pathways were evaluated to be involved significantly. The expressions of 19 genes were validated by real-time quantitative PCR, most of which were consistent with the microarray results. Thus, Y123F HOM mice were suggested as a new animal model of PCOS for research that mainly emphasizes metabolic disorders and anovulation, but not the polycystic phenotype. Meanwhile, using the model, we found that JAK-STAT and hormone biosynthesis pathways were involved in the follicular development and ovulation disorders caused by LepR deficiency in ovaries, although we could not exclude indirect actions from the brain.
    PLoS ONE 11/2015; 10(11):e0141800. DOI:10.1371/journal.pone.0141800 · 3.23 Impact Factor
  • Jiajie Yao · Jiahao Liu · Xiao Chen · Haihang Li · Yi Niu · Zhihui Zhou · Jian Wang ·
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    ABSTRACT: A series of experiments on n-heptane pool fires with water bath was conducted in an altitude chamber capable of reaching 26.4 kPa to investigate the performance of small scale pool fires under hypobaric conditions. The fuel pools chosen ranged from 3 cm to 8 cm in diameter which are in the conduction dominated range. The mass loss and flame envelopes were recorded during the experiments. Specific heat transfer mechanisms are discussed in this paper. Fuels in pool fires boil eventually due to the heat transferred back from the pool to the fuel. Water bath equipment used in this paper was applied to prevent the boiling stage. Experimental findings reveal that the length of the quasi-steady stage varied inversely to the pressure and the pool diameter. Meanwhile, the averaged mass loss rate in the steady burning stage increased with the increasing pressures and pool sizes. The flame with water bath turned to be stable at lower pressure and the flame height also decreased as the pressure decreased.
    International Journal of Heat and Mass Transfer 11/2015; 90:1153-1159. DOI:10.1016/j.ijheatmasstransfer.2015.07.058 · 2.38 Impact Factor
  • Yifan Zhao · Jian Wang ·
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    ABSTRACT: Polarization is a basic property of light. Different from well-known linear, circular, and elliptical polarizations, which are spatially homogeneous, a vector light beam with spatially variant polarization states has received increasing interest for its expanded functionalities. In this Letter, we present a visible-light communication link exploiting high-base vector beam encoding/decoding. Using a single phase-only spatial light modulator, we generate 16 states of vector beams representing hexadecimal numbers. In the visible-light communication link experiment, we transmit a random high-base number sequence with 10,000 hexadecimal numbers and a 64×64 pixel Lena gray image with 8192 hexadecimal numbers. The bit error rate is evaluated, and zero error among all received hexadecimal numbers is achieved, showing favorable link communication performance using the high-base vector beam encoding/decoding.
    Optics Letters 11/2015; 40(21):4843. DOI:10.1364/OL.40.004843 · 3.29 Impact Factor
  • Lin Yu · I Weng Lao · Jian Wang ·
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    ABSTRACT: We present our experience with seven cases of epithelioid rhabdomyosarcoma (RMS) to further characterise its clinicopathological features. There were five males and two females with ages ranging from 19 to 84 years (mean 56 years). Four tumours occurred in the somatic soft tissue, two in organs and one in the bone. The mean tumour size was 10.7 cm (range 3.5-15 cm). Histologically, six tumours were characterised by sheet-like growth of uniform epithelioid cells with large vesicular nuclei, prominent nucleoli, high mitotic activity and moderate to abundant amphophilic-to-eosinophilic cytoplasm. One tumour was composed of dyscohesive cells with rhabdoid appearance embedded in a myxoid matrix. Features suggestive of rhabdomyoblastic differentiation were absent. However, immunohistochemical study revealed skeletal muscle differentiation in all cases. Of note, focal expression of epithelial markers with co-expression of neuroendocrine markers was noted in five and three cases, respectively. Of six patients with follow-up, one experienced local recurrence and three developed metastases. To date, three patients have died of disease within 14 months. This study further demonstrates that epithelioid RMS represents a distinct variant of RMS with an aggressive behaviour. It may be misdiagnosed as poorly differentiated neuroendocrine carcinoma due to co-expression of epithelial and neuroendocrine markers.
    Pathology 10/2015; 47(7). DOI:10.1097/PAT.0000000000000321 · 2.19 Impact Factor
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    Shuhui Li · Jian Wang ·

    Scientific Reports 10/2015; 5:15406. DOI:10.1038/srep15406 · 5.58 Impact Factor
  • Long Zhu · Jian Wang ·
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    ABSTRACT: Based on the conventional iterative algorithm, we present a pattern search assisted iterative (PSI) algorithm to simultaneously generate multiple orbital angular momentum (OAM) modes using a single phase-only element. The PSI algorithm shows a favorable operation performance for generating 100 randomly spaced OAM modes and 50 evenly spaced OAM modes with high diffraction efficiency (>93%), low relative root-mean-square error (R-RMSE) and low standard deviation. Moreover, we can also manipulate the relative power distribution of the generated OAM modes simply by setting the initial weight coefficients in the PSI algorithm.
    Optics Express 10/2015; 23(20):26221-26233. DOI:10.1364/OE.23.026221 · 3.49 Impact Factor
  • Xiao Hu · Mengqi Zeng · Andong Wang · Long Zhu · Lei Fu · Jian Wang ·
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    ABSTRACT: We fabricate a nonlinear optical device based on a fiber pigtail cross-section coated with a single-layer graphene grown by chemical vapor deposition (CVD) method. Using such graphene-assisted nonlinear optical device, we experimentally demonstrate tunable wavelength conversion of a 10 Gbaud quadrature phase-shift keying (QPSK) signal by exploiting degenerate four-wave mixing (FWM) progress in graphene. We study the conversion efficiency as functions of the pump power and pump wavelength and evaluate the bit-error rate (BER) performance. The observed optical signal-to-noise ratio (OSNR) penalties for tunable QPSK wavelength conversion are less than 2.2 dB at a BER of 1 × 10<sup>-3</sup>.
    Optics Express 10/2015; 23(20):26158. DOI:10.1364/OE.23.026158 · 3.49 Impact Factor
  • Haihang Li · Zhihui Zhou · Yi Niu · Jiajie Yao · Dechuang Zhou · Jian Wang ·

    Chemistry and Technology of Fuels and Oils 09/2015; 51(4). DOI:10.1007/s10553-015-0616-7 · 0.13 Impact Factor
  • Hui Ye · Yaguo Li · Zhigang Yuan · Jian Wang · Wei Yang · Qiao Xu ·

    Applied Surface Science 09/2015; DOI:10.1016/j.apsusc.2015.09.065 · 2.71 Impact Factor
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    ABSTRACT: To explore the relationship between age at menarche and infertility. The cross-sectional study investigated 6906 couples from the communities in Sandu Shui Autonomous County of Guizhou Province, China. Face to face interviews were conducted to collect information on age at menarche and time to first pregnancy, as well as demographic characteristics and lifestyle factors. Infertility was defined as being unable to become pregnant after attempting for ≥12 months. Poisson regression was used to assess the relationship between age at menarche and infertility of first attempt. The prevalence rate of infertility for the first pregnancy attempt of the study population was 11.87%. There is an obvious monotonic, almost linear, trend of prevalence rate of infertility with increasing age at menarche (P for trend: <0.001). Compared with wives with age at menarche of 13 years, the prevalence ratios of infertility were 0.71 (95%CI: 0.42, 1.20), 1.33 (95%CI: 1.05, 1.68), 1.47 (95%CI: 1.17, 1.85), 1.57 (95%CI: 1.20, 2.04), 1.41 (95%CI: 1.00, 1.99) and 1.73 (95%CI: 1.18, 2.52) for wives with age at menarche of ≤12, 14, 15, 16, 17 and ≥18 years, respectively, after adjusting for wife's year at birth, age at marriage, ethnic group, education and occupation, and husband's smoking and drinking habits before marriage. The present community-based study indicated that increasing age at menarche was associated with an increased risk of infertility in the study population. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    European journal of obstetrics, gynecology, and reproductive biology 08/2015; 194:68-72. DOI:10.1016/j.ejogrb.2015.08.016 · 1.70 Impact Factor
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    ABSTRACT: MicroRNAs (miRNAs) are critical regulators of gene expression; they have emerged as new players in the pathophysiology of reproductive disorders such as preeclampsia and recurrent miscarriage (RM). In this study, miRNA expression profiles were determined by deep sequencing analysis in placental villi obtained from women with RM and with gestational age-matched normal pregnancy (NP). A total of 69 miRNAs were found to be aberrantly expressed in RM. Five of these human (Homo sapiens) miRNAs (hsa-miRNAs), including hsa-miR-3074-5p, -486-3p, -1269b, -6765-3p and -144-3p, were validated by qRT-PCR in 12 RM and 10 NP placental villi. Hsa-miR-3074-5p expression was significantly higher, while hsa-miR-486-3p expression was significantly lower, in RM compared to NP. Subsequently, the expression of mouse (Mus musculus) miR-486-3p (mmu-miR-486-3p) and mmu-miR-3074-5p, which are identical to hsa-miR-486-3p and hsa-miR-3074-5p, respectively, were examined by qRT-PCR in the uterus during early pregnancy. Mmu-miR-486-3p expression was significantly increased during the peri-implantation period, and the levels were significantly higher at implantation than at non-implantation sites. In contrast, the expression of mmu-miR-3074-5p was markedly decreased at implantation compared to non-implantation sites. These data suggest that miR-486-3p and miR-3074-5p may be involved in embryo implantation and that their aberrant expression is associated with RM. Larger studies are warranted to follow up this pilot study. © 2015 S. Karger AG, Basel.
    Gynecologic and Obstetric Investigation 08/2015; DOI:10.1159/000435879 · 1.70 Impact Factor
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    ABSTRACT: Hemangioblastoma is a benign cerebellar tumour which may occur as a sporadic entity or in association with von Hippel-Lindau (VHL) disease in approximately 25% of cases. Renal hemangioblastoma (RH) is an extremely rare and newly recognised tumour. Here, we describe five cases of RH, one discovered by CT in an accident and the other four detected during routine examinations. Five cases of renal hemangioblastoma retrieved from the Department of Pathology, Fudan University Shanghai Cancer Center were studied and the literatures were reviewed. Immunohistochemistry was used to differentiate and confirm this tumour. Pathological examination following tumour resection revealed RH in all cases, the first patient was also diagnosed with renal cell carcinoma (RCC), suggesting the possibility of VHL syndrome, but PCR sequencing analysis of the VHL gene confirmed no mutation in any of the three exons, implying sporadic disease .Histologically, the tumours were circumscribed, composed of sheets of oval or polygonal cells and a prominent vascular network. Tumour cells had pleomorphic nuclei, but mitotic figures were rare. The diagnosis of hemangioblastoma was confirmed by immunohistochemistry. RH is very rare and is challenging to differentially diagnose. Distinguishing RCC and RH is difficult and each has a different prognosis, so differentiating between them is essential for avoiding over-diagnosis and unnecessary treatment. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
    Journal of clinical pathology 07/2015; DOI:10.1136/jclinpath-2015-202900 · 2.92 Impact Factor
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    ABSTRACT: Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, and oocyte developmental competence is altered in patients with PCOS. In recent years microRNAs (miRNAs) have emerged as important regulators of gene expression, the aim of the study was to study miRNAs expression patterns of cumulus cells from PCOS patients. Methods: The study included 20 patients undergoing in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI): 10 diagnosed with PCOS and 10 matching controls. We used deep sequencing technology to identify the miRNAs differentially expressed in the cumulus cells of PCOS. Results: There were 17 differentially expressed miRNAs in PCOS cumulus cells, including 10 miRNAs increase and 7 miRNAs decrease. These miRNAs were predicted to target a large set of genes with different functions, including Wnt- and MAPK- signaling pathways, oocyte meiosis, progesterone-mediated oocyte maturation and cell cycle. Unsupervised hierarchical clustering analysis demonstrated that there was a specific miRNAs expression pattern in PCOS cumulus cells. Conclusion: We found that the miRNAs expression profile was different in cumulus cells isolated from PCOS patients compared with control. This study provided new evidence for understanding the pathogenesis of PCOS.
    Journal of Translational Medicine 07/2015; 13(1):238. DOI:10.1186/s12967-015-0605-y · 3.93 Impact Factor
  • Yun Long · Jian Wang ·
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    ABSTRACT: We propose and demonstrate an all-optical tuning mechanism to tune the response of a microwave photonic filter (MPF) based on a nonlinear silicon microring resonator (MRR). The tuning mechanism relies on the optical nonlinearities induced resonant wavelength shift in the silicon MRR, leading to the change of frequency difference between the optical carrier frequency and resonant frequency of the silicon MRR. A detailed theoretical model is established to describe the operation of the proposed all-optical tunable MPF. Two cases are studied in the experiment, i.e. the optical carrier frequency is located at the left or right side of the MRR resonant frequency. Both forward and backward pumping configurations in each case are demonstrated. Using the fabricated silicon MRR and exploiting light to control light, the central frequency of the notch MPF can be flexibly tuned by adjusting the pump light power. Moreover, the presented all-optical tuning mechanism might also facilitate interesting applications such as microwave switching and microwave modulation.
    Optics Express 07/2015; 23(14):17758-17771. DOI:10.1364/OE.23.017758 · 3.49 Impact Factor
  • Yun Long · Jian Wang ·
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    ABSTRACT: We propose a simple scheme to realize ultra-high peak rejection notch microwave photonic filter (MPF) based on a single silicon microring resonator (MRR). Using the combination of a conventional phase modulator (PM), a tunable bandpass filter (TBF), and a silicon MRR to manipulate the phase and amplitude of optical sidebands resulting in a signal cancellation at the RF notch filter frequency, we experimentally demonstrate a notch MPF with an ultra-high peak rejection beyond 60 dB. The frequency tunability of the proposed ultra-high peak rejection MPF is also demonstrated in the experiment.
    Optics Express 07/2015; 23(14):17739-17750. DOI:10.1364/OE.23.017739 · 3.49 Impact Factor
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    Chengcheng Gui · Jian Wang ·
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    ABSTRACT: We present a novel design of wedge hybrid plasmonic terahertz (THz) waveguide consisting of a silicon (Si) nanowire cylinder above a triangular gold wedge with surrounded high-density polyethylene as cladding. It features long propagation length and ultra-small deep-subwavelength mode confinement. The mode properties of wedge hybrid plasmonic THz waveguide are comprehensively characterized in terms of propagation length (L), normalized mode area (Aeff /A0), figure of merit (FoM), and chromatic dispersion (D). The designed wedge hybrid plasmonic THz waveguide enables an ultra-small deep-subwavelength mode area which is more than one-order of magnitude smaller compared to previous rectangular one. When choosing the diameter of Si nanowire cylinder, a smaller diameter (e.g. 10 μm) is preferred to achieve longer L and higher FoM, while a larger diameter (e.g. 60 μm) is favorable to obtain smaller Aeff /A0 and higher FoM. We further study the impacts of possible practical fabrication errors on the mode properties. The simulated results of propagation length and normalized mode area show that the proposed wedge hybrid plasmonic THz waveguide is tolerant to practical fabrication errors in geometry parameters such as misalignment in the horizontal direction, variation of wedge tip angle, and variation of wedge tip curvature radius.
    Scientific Reports 07/2015; 5:11457. DOI:10.1038/srep11457 · 5.58 Impact Factor

Publication Stats

2k Citations
609.40 Total Impact Points


  • 2015
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2009-2015
    • University of Science and Technology of China
      • State Key Laboratory of Fire Science
      Luchow, Anhui Sheng, China
  • 2008-2015
    • Third Military Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2002-2015
    • Fudan University
      • • Department of Oncology
      • • Department of Otolaryngology
      • • Department of Pathology
      • • Cancer Hospital
      Shanghai, Shanghai Shi, China
    • Shanghai Institute of Planned Parenthood Research
      Shanghai, Shanghai Shi, China
  • 2014
    • The Chinese University of Hong Kong
      • Department of Information Engineering
      Hong Kong, Hong Kong
  • 2012-2014
    • Huazhong University of Science and Technology
      • Wuhan National Laboratory for Optoelectronics
      Wu-han-shih, Hubei, China
    • Fuda Cancer Hospital
      Shengcheng, Guangdong, China
  • 2008-2014
    • Xinqiao Hospital
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2010-2012
    • University of California, Los Angeles
      • Department of Electrical Engineering
      Los Ángeles, California, United States
  • 2009-2012
    • University of Southern California
      • Department of Electrical Engineering
      Los Ángeles, California, United States
    • Yangzhou University
      • College of Physics Science and Technology
      Chiang-tu, Jiangsu Sheng, China
  • 2011
    • Monash University (Australia)
      Melbourne, Victoria, Australia
  • 2010-2011
    • Xiamen University
      • Department of Mechanical and Electrical Engineering
      Amoy, Fujian, China
  • 2003-2004
    • shihezi university
      Shikhedzy, Xinjiang Uygur Zizhiqu, China
  • 1999
    • Prince Henry's Institute
      Melbourne, Victoria, Australia