Jian Wang

Renji Hospital, Shanghai, Shanghai Shi, China

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Publications (305)580.04 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The work in this paper aims to clarify the effect of angle on the lateral flame spread over inclined surfaces. PMMA slabs with width ranged from 2.5 cm to 12 cm were tested at the angles from 0° to 75°. Burning rate, flame spread rate, flame appearance and radiant heat flux were investigated experimentally and theoretically. The results suggest that in the cases of narrow PMMA slabs (less than 8 cm), the flame spread rate is in proportion to the square root of angle sine as . For wider slabs, the spread rate is higher than the theoretical result owing to enhanced radiant heat feedback. Pyrolysis length follows a power-law increase with the sample width, and the exponent approximates 0.48. Flame length is independent of the inclination angle, but also a power function of sample width.
    International Journal of Heat and Mass Transfer 12/2015; 91:68-76. DOI:10.1016/j.ijheatmasstransfer.2015.07.072 · 2.38 Impact Factor
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    ABSTRACT: A series of experiments on n-heptane pool fires with water bath was conducted in an altitude chamber capable of reaching 26.4 kPa to investigate the performance of small scale pool fires under hypobaric conditions. The fuel pools chosen ranged from 3 cm to 8 cm in diameter which are in the conduction dominated range. The mass loss and flame envelopes were recorded during the experiments. Specific heat transfer mechanisms are discussed in this paper. Fuels in pool fires boil eventually due to the heat transferred back from the pool to the fuel. Water bath equipment used in this paper was applied to prevent the boiling stage. Experimental findings reveal that the length of the quasi-steady stage varied inversely to the pressure and the pool diameter. Meanwhile, the averaged mass loss rate in the steady burning stage increased with the increasing pressures and pool sizes. The flame with water bath turned to be stable at lower pressure and the flame height also decreased as the pressure decreased.
    International Journal of Heat and Mass Transfer 11/2015; 90:1153-1159. DOI:10.1016/j.ijheatmasstransfer.2015.07.058 · 2.38 Impact Factor
  • Xiao Hu · Mengqi Zeng · Andong Wang · Long Zhu · Lei Fu · Jian Wang
    Optics Express 10/2015; 23(20):26158. DOI:10.1364/OE.23.026158 · 3.49 Impact Factor
  • Chemistry and Technology of Fuels and Oils 09/2015; 51(4). DOI:10.1007/s10553-015-0616-7 · 0.13 Impact Factor
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    ABSTRACT: To explore the relationship between age at menarche and infertility. The cross-sectional study investigated 6906 couples from the communities in Sandu Shui Autonomous County of Guizhou Province, China. Face to face interviews were conducted to collect information on age at menarche and time to first pregnancy, as well as demographic characteristics and lifestyle factors. Infertility was defined as being unable to become pregnant after attempting for ≥12 months. Poisson regression was used to assess the relationship between age at menarche and infertility of first attempt. The prevalence rate of infertility for the first pregnancy attempt of the study population was 11.87%. There is an obvious monotonic, almost linear, trend of prevalence rate of infertility with increasing age at menarche (P for trend: <0.001). Compared with wives with age at menarche of 13 years, the prevalence ratios of infertility were 0.71 (95%CI: 0.42, 1.20), 1.33 (95%CI: 1.05, 1.68), 1.47 (95%CI: 1.17, 1.85), 1.57 (95%CI: 1.20, 2.04), 1.41 (95%CI: 1.00, 1.99) and 1.73 (95%CI: 1.18, 2.52) for wives with age at menarche of ≤12, 14, 15, 16, 17 and ≥18 years, respectively, after adjusting for wife's year at birth, age at marriage, ethnic group, education and occupation, and husband's smoking and drinking habits before marriage. The present community-based study indicated that increasing age at menarche was associated with an increased risk of infertility in the study population. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    European journal of obstetrics, gynecology, and reproductive biology 08/2015; 194:68-72. DOI:10.1016/j.ejogrb.2015.08.016 · 1.70 Impact Factor
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    ABSTRACT: MicroRNAs (miRNAs) are critical regulators of gene expression; they have emerged as new players in the pathophysiology of reproductive disorders such as preeclampsia and recurrent miscarriage (RM). In this study, miRNA expression profiles were determined by deep sequencing analysis in placental villi obtained from women with RM and with gestational age-matched normal pregnancy (NP). A total of 69 miRNAs were found to be aberrantly expressed in RM. Five of these human (Homo sapiens) miRNAs (hsa-miRNAs), including hsa-miR-3074-5p, -486-3p, -1269b, -6765-3p and -144-3p, were validated by qRT-PCR in 12 RM and 10 NP placental villi. Hsa-miR-3074-5p expression was significantly higher, while hsa-miR-486-3p expression was significantly lower, in RM compared to NP. Subsequently, the expression of mouse (Mus musculus) miR-486-3p (mmu-miR-486-3p) and mmu-miR-3074-5p, which are identical to hsa-miR-486-3p and hsa-miR-3074-5p, respectively, were examined by qRT-PCR in the uterus during early pregnancy. Mmu-miR-486-3p expression was significantly increased during the peri-implantation period, and the levels were significantly higher at implantation than at non-implantation sites. In contrast, the expression of mmu-miR-3074-5p was markedly decreased at implantation compared to non-implantation sites. These data suggest that miR-486-3p and miR-3074-5p may be involved in embryo implantation and that their aberrant expression is associated with RM. Larger studies are warranted to follow up this pilot study. © 2015 S. Karger AG, Basel.
    Gynecologic and Obstetric Investigation 08/2015; DOI:10.1159/000435879 · 1.70 Impact Factor
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    ABSTRACT: Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, and oocyte developmental competence is altered in patients with PCOS. In recent years microRNAs (miRNAs) have emerged as important regulators of gene expression, the aim of the study was to study miRNAs expression patterns of cumulus cells from PCOS patients. Methods: The study included 20 patients undergoing in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI): 10 diagnosed with PCOS and 10 matching controls. We used deep sequencing technology to identify the miRNAs differentially expressed in the cumulus cells of PCOS. Results: There were 17 differentially expressed miRNAs in PCOS cumulus cells, including 10 miRNAs increase and 7 miRNAs decrease. These miRNAs were predicted to target a large set of genes with different functions, including Wnt- and MAPK- signaling pathways, oocyte meiosis, progesterone-mediated oocyte maturation and cell cycle. Unsupervised hierarchical clustering analysis demonstrated that there was a specific miRNAs expression pattern in PCOS cumulus cells. Conclusion: We found that the miRNAs expression profile was different in cumulus cells isolated from PCOS patients compared with control. This study provided new evidence for understanding the pathogenesis of PCOS.
    Journal of Translational Medicine 07/2015; 13(1):238. DOI:10.1186/s12967-015-0605-y · 3.93 Impact Factor
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    Chengcheng Gui · Jian Wang
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    ABSTRACT: We present a novel design of wedge hybrid plasmonic terahertz (THz) waveguide consisting of a silicon (Si) nanowire cylinder above a triangular gold wedge with surrounded high-density polyethylene as cladding. It features long propagation length and ultra-small deep-subwavelength mode confinement. The mode properties of wedge hybrid plasmonic THz waveguide are comprehensively characterized in terms of propagation length (L), normalized mode area (Aeff /A0), figure of merit (FoM), and chromatic dispersion (D). The designed wedge hybrid plasmonic THz waveguide enables an ultra-small deep-subwavelength mode area which is more than one-order of magnitude smaller compared to previous rectangular one. When choosing the diameter of Si nanowire cylinder, a smaller diameter (e.g. 10 μm) is preferred to achieve longer L and higher FoM, while a larger diameter (e.g. 60 μm) is favorable to obtain smaller Aeff /A0 and higher FoM. We further study the impacts of possible practical fabrication errors on the mode properties. The simulated results of propagation length and normalized mode area show that the proposed wedge hybrid plasmonic THz waveguide is tolerant to practical fabrication errors in geometry parameters such as misalignment in the horizontal direction, variation of wedge tip angle, and variation of wedge tip curvature radius.
    Scientific Reports 07/2015; 5:11457. DOI:10.1038/srep11457 · 5.58 Impact Factor
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    Jun Liu · Jian Wang
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    ABSTRACT: We present a simple configuration incorporating a single polarization-sensitive phase-only liquid crystal spatial light modulator (LC-SLM) to facilitate polarization-insensitive spatial light modulation. The polarization-insensitive configuration is formed by a polarization beam splitter (PBS), a polarization-sensitive phase-only LC-SLM, a half-wave plate (HWP), and a mirror in a loop structure. We experimentally demonstrate polarization-insensitive spatial light modulations for incident linearly polarized beams with different polarization states and polarization-multiplexed beams. Polarization-insensitive spatial light modulations generating orbital angular momentum (OAM) beams are demonstrated in the experiment. The designed polarization-insensitive configuration may find promising applications in spatial light modulations accommodating diverse incident polarizations.
    Scientific Reports 07/2015; 5:9959. DOI:10.1038/srep09959 · 5.58 Impact Factor
  • Dong Wang · Lei Song · Keqing Zhou · Xiaojuan Yu · Yuan Hu · Jian Wang
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    ABSTRACT: Polymer/graphene-analogous nanosheet composites have great potential for improving their physical and mechanical properties during the past few years. Herein, ultrathin molybdenum disulfide (MoS2) nanosheets were simultaneously exfoliated and non-covalently modified by ultrasonication in an aqueous solution of chitosan. The chitosan-modified MoS2 (CS-MoS2) nanosheets were then transferred from the aqueous solution to tetrahydrofuran by a simple solvent-exchange method for the fabrication of epoxy (EP) nanocomposites. Transmission electron microscopy and scanning electron microscopy were performed to display the homogeneous dispersion of CS-MoS2 in an EP matrix. On incorporating 2 wt% CS-MoS2 into an EP matrix, EP nanocomposites exhibited reductions of up to 43.3% and 14.6% in peak heat-release rate and total heat release derived from cone calorimeters compared to those of neat EP, respectively. Moreover, toxic volatiles, such as hydrocarbons, aromatic compounds and CO, that escaped from the flaming EP nanocomposites were decreased compared to that of neat EP, demonstrating the higher smoke safety. Combined with the analyses of char residues and thermal stability of EP nanocomposites, the reduced fire hazards of EP nanocomposites could be attributed to the nano-barrier effects of MoS2, which could effectively inhibit the release of combustible gas to support burning and restrain the effusion of volatile toxic substances that cause the majority of deaths in fires.
    06/2015; 3(27). DOI:10.1039/C5TA01720C
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    ABSTRACT: In applications of lithium ion batteries, it is a requisite to precisely appraise their fire and explosion hazards. In the current study, a fire calorimeter is utilized to test the combustion performance of two commercial 18650 lithium ion batteries (LiCoO2 and LiFePO4) at different state of charge (SOC). Characteristics on thermal hazards of lithium ion batteries including surface temperature, time to ejection, mass loss, and heat release rate (HRR) are measured and evaluated. In case of thermal runaway, all the lithium ion batteries will rupture the can and catch fire even explode automatically. The solid electrolyte interface layer decomposition and the polymer separator shrinking are direct causes of the lithium ion battery fire. The experimental results show that the HRR and total heat generally rise as the SOC increases, whereas the time to first ejection and the time gap between first and second ejection decrease. LiCoO2 18650 battery shows higher explosion risk than LiFePO4 18650, as the former has released much more oxygen. The experimental combustion heats calculated and modified in the oxygen consumption method reveal that the internally generated oxygen have significant effect on the estimate of the heat, where the largest modified rate is 29.9 for 100 % SOC LiCoO2 18650 battery. The results can provide scientific basis for fire protection during the storage and distribution of lithium ion batteries.
    Journal of Thermal Analysis and Calorimetry 06/2015; DOI:10.1007/s10973-015-4751-5 · 2.04 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate the usefulness of real-time contrast-enhanced sonography and microvascular imaging for differential diagnosis of neoplastic and non-neoplastic polypoid lesions of the gallbladder. Real-time contrast-enhanced sonography and microvascular imaging were performed in 128 patients with polypoid lesions of the gallbladder larger than 6 mm in diameter. The enhancement patterns, microvascular imaging types, and kinetic parameters were analyzed on contrast-enhanced sonography. The maximum diameters of the lesions measured by conventional and contrast-enhanced sonography were also recorded and subjected to a comparative analysis. Among the 128 patients, histologic diagnoses were obtained in 83 (27 neoplastic lesions and 56 non-neoplastic lesions), which constituted the study group. On contrast-enhanced sonography, mild enhancement and absence of contrast were more easily found in non-neoplastic lesions (12 [21.4%]), whereas all neoplastic lesions showed marked enhancement (27 [100%]; P = .006). Of the 27 neoplastic lesions, 6 malignant tumors showed a perfusion defect on contrast-enhanced sonography, whereas none of the non-neoplastic lesions showed a perfusion defect (P = .003). The microvascular architecture of the lesions was categorized into 4 types: spotty, linear, branched, and spinous, and there were significant differences between the groups (P< .001). In a kinetic evaluation, none of the parameters reached statistical significance (all P> .05). There was a discrepancy in maximum diameters between conventional and contrast-enhanced sonography in both groups but the discrepancy was significantly greater in the non-neoplastic group (P = .026). Contrast-enhanced sonography is a useful imaging technique and an adjunct to conventional sonography for differential diagnosis of neoplastic and non-neoplastic polypoid lesions of the gallbladder. © 2015 by the American Institute of Ultrasound in Medicine.
    Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine 06/2015; 34(6):1061-9. DOI:10.7863/ultra.34.6.1061 · 1.54 Impact Factor
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    ABSTRACT: We design and fabricate a silicon photonic crystal L3 resonator for chip-scale analog signal transmission. The lattice constant (a) is 420 nm, and the radius of holes (r) is 126 nm. The three holes adjacent to the cavity are laterally shifted by 0.175a, 0.025a and 0.175a, respectively. We experimentally evaluate the performance of silicon photonic crystal L3 resonator for chip-scale analog signal transmission. The spurious free dynamic ranges (SFDRs) of the second-order harmonic distortion (SHD) and the third-order harmonic distortion (THD), which are important factors to assess the analog link performance, are measured for the chip-scale analog signal transmission through the fabricated silicon photonic crystal L3 resonator. The SHD SFDR and THD SFDR are measured to be ~34.6 dB and ~52.2 dB even with the input optical carrier sitting at the dip resonance wavelength of the fabricated silicon photonic crystal L3 resonator. The influences of the optical carrier wavelength and input optical power on the SHD SFDR and THD SFDR are studied in the experiment. The impacts of geometric parameters of the cavity structure (lattice constant, radius of holes, shift of the hole) on the analog signal transmission are also analyzed, showing favorable analog link performance with relatively large fabrication tolerance to design parameters.
    Optics Express 06/2015; 23(11):13916. DOI:10.1364/OE.23.013916 · 3.49 Impact Factor
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    I Weng Lao · Lin Yu · Jian Wang
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    ABSTRACT: We describe a case of malignant perivascular epithelial cell tumor (PEComa) arising primarily in the distal left femur of a 47-year-old male. The patient presented with pain accompanied by progressive swelling of his left thigh. Computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed an osteolytic lesion. Curettage of the lesion was reported as a clear cell tumor with recommendation for exclusion of a metastatic clear cell carcinoma. However, thorough examinations did not find any primary site elsewhere, apart from the presence of bilateral pulmonary metastases. Evaluation of the submitted H & E slides identified a malignant PEComa which was further confirmed by subsequent immunohistochemical study. The occurrence of PEComa as a primary bone lesion is extremely rare. We present here a malignant PEComa of the distal left femur, and summarize the clinicopathological characteristics of this rare entity with literature review. The virtual slide (s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5729035221600545 .
    Diagnostic Pathology 05/2015; 10(1). DOI:10.1186/s13000-015-0292-2 · 2.60 Impact Factor
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    ABSTRACT: Background N-myc down-regulated gene 2 (NDRG2) is a tumor suppressor involved in cell proliferation and differentiation. The aim of this study was to determine the uterine expression pattern of this gene during early pregnancy in mice. Methods Uterine NDRG2 mRNA and protein expression levels were determined by RT-PCR and Western blot analyses, respectively, during the peri-implantation period in mice. Immunohistochemical (IHC) analysis was performed to examine the spatial localization of NDRG2 expression in mouse uterine tissues. The in vitro decidualization model of mouse endometrial stromal cells (ESCs) was used to evaluate decidualization of ESCs following NDRG2 knock down by small interfering RNA (siRNA). Statistical significance was analyzed by one-way ANOVA using SPSS 19.0 software. Results Uterine NDRG2 gene expression was significantly up-regulated and was predominantly localized to the secondary decidual zone on days 5 and 8 of pregnancy in mice. Its increased expression was associated with artificial decidualization as well as the activation of delayed implantation. Furthermore, uterine NDRG2 expression was induced by estrogen and progesterone treatments. The in vitro decidualization of mouse ESCs was accompanied by up-regulation of NDRG2 expression, and knock down of its expression in these cells by siRNA inhibited the decidualization process. Conclusions These results suggest that NDRG2 might play an important role in the process of decidualization during early pregnancy.
    Reproductive Biology and Endocrinology 05/2015; 13(1). DOI:10.1186/s12958-015-0047-7 · 2.23 Impact Factor
  • Bi Wu · Yan Shi · Xia Gong · Lin Yu · Qiuju Chen · Jian Wang · Zhaogui Sun
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    ABSTRACT: To evaluate multiple follicular development synchronization after estrogen stimulation in prepubertal mice, follicular responsiveness to gonadotropin superovulation, the prospective reproductive potential and ovarian polycystic ovary syndrome (PCOS)-like symptoms at adulthood, prepubertal mice were intraperitoneally injected with estrogen to establish an animal model with solvent as control. When synchronized tertiary follicles in ovaries, in vitro oocyte maturation and fertilization rates, blastocyst formation rate, developmental potential into offspring by embryo transfer, adult fertility and PCOS-like symptoms, and involved molecular mechanisms were focused, it was found that estrogen stimulation (10μg/gBW) leads to follicular development synchronization at the early tertiary stage in prepubertal mice; reproduction from oocytes to offspring could be realized by means of the artificial reproductive technology though the model mice lost their natural fertility when they were reared to adulthood; and typical symptoms of PCOS, except changes in inflammatory pathways, were not remained up to adulthood. So in conclusion, estrogen can lead to synchronization in follicular development in prepubertal mice, but does not affect reproductive outcome of oocytes, and no typical symptoms of PCOS remained at adulthood despite changes related to inflammation.
    PLoS ONE 05/2015; 10(5):e0127595. DOI:10.1371/journal.pone.0127595 · 3.23 Impact Factor
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    Shuhui Li · Jian Wang
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    ABSTRACT: We report feedback-assisted adaptive multicasting from a single Gaussian mode to multiple orbital angular momentum (OAM) modes using a single phase-only spatial light modulator loaded with a complex phase pattern. By designing and optimizing the complex phase pattern through the adaptive correction of feedback coefficients, the power of each multicast OAM channel can be arbitrarily controlled. We experimentally demonstrate power-controllable multicasting from a single Gaussian mode to two and six OAM modes with different target power distributions. Equalized power multicasting, "up-down" power multicasting and "ladder" power multicasting are realized in the experiment. The difference between measured power distributions and target power distributions is assessed to be less than 1 dB. Moreover, we demonstrate data-carrying OAM multicasting by employing orthogonal frequency-division multiplexing 64-ary quadrature amplitude modulation (OFDM 64-QAM) signal. The measured bit-error rate curves and observed optical signal-to-noise ratio penalties show favorable operation performance of the proposed adaptive power-controllable OAM multicasting.
    Scientific Reports 05/2015; 5:9677. DOI:10.1038/srep09677 · 5.58 Impact Factor
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    ABSTRACT: Lymph node metastasis of rabbit VX2 pyriform sinus carcinoma can be enhanced by MR scanning after injecting ultra-small superparamagnetic iron oxide (USPIO) into the submucosa beside the tumor. The metastasis lymph node which fit in with the diagnostic criteria will be placed into the alternating magnetic field after MR scanning. Then, magnetic particles can be heated to the effective therapeutic temperature. And it evaluates the possibility of diagnosis together with therapy in cervical metastasis of pyriform sinus carcinoma. Twenty rabbits bearing VX2 tumor in pyriform sinuses were randomly divided into hyperthermia group and control group after USPIO MR scanning; each group contained 10 rabbits. The hyperthermia for the experimental group was conducted by the alternating magnetic field. After hyperthermia, the detection of apoptosis for the two groups was tested by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL), transmission electron microscopy (TEM), and the expression of Bcl-2 and Bax evaluated by immunohistochemical analysis. The apoptosis rate detected by TUNEL in hyperthermia group was 100 %, while the control group was only 20 % (p < 0.05). TEM observation showed that cell chromatin condensation and clumping, condensed cytoplasm, endoplasmic reticulum membrane fusion with loose change, and the formation of a bubble could be seen in the hyperthermia group. However, the control group showed a more complete cytoplasm and nucleus. Bcl-2 protein expression in the hyperthermia group was lower than the control group, and Bax protein expression in hyperthermia group was higher (p < 0.05). USPIO indirect lymphography could localize the metastatic lymph nodes for hyperthermia. And it could make the metastatic cervical lymph nodes apoptosis when placed into the alternating magnetic field.
    Tumor Biology 05/2015; DOI:10.1007/s13277-015-3538-4 · 3.61 Impact Factor
  • Shuhui Li · Zhidan Xu · Jun Liu · Nan Zhou · Yifan Zhao · Long Zhu · Fei Xia · Jian Wang
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    ABSTRACT: We present a novel free-space communication link using orbital angular momentum (OAM) array encoding/decoding.
    CLEO: Science and Innovations, San Jose, CA, USA; 05/2015
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    Jing Du · Jian Wang
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    ABSTRACT: We design a V-shaped antenna array to realize on-chip multicasting from a single Gaussian beam to four orbital angular momentum (OAM) beams. A pattern search assisted iterative (PSI) algorithm is used to design an optimized continuous phase pattern which is further discretized to generate collinearly superimposed multiple OAM beams. Replacing the designed discrete phase pattern with corresponding V-shaped antennas, on-chip N-fold OAM multicasting is achieved. The designed on-chip 4-fold OAM multicasting exploiting V-shaped antenna array shows favorable operation performance with low crosstalk less than -15 dB.
    Scientific Reports 05/2015; 5:9662. DOI:10.1038/srep09662 · 5.58 Impact Factor

Publication Stats

1k Citations
580.04 Total Impact Points


  • 2015
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2012–2015
    • Huazhong University of Science and Technology
      • Wuhan National Laboratory for Optoelectronics
      Wu-han-shih, Hubei, China
  • 2009–2015
    • University of Science and Technology of China
      • State Key Laboratory of Fire Science
      Luchow, Anhui Sheng, China
  • 2008–2015
    • Third Military Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2002–2015
    • Fudan University
      • • Department of Oncology
      • • Department of Otolaryngology
      • • Department of Pathology
      • • Cancer Hospital
      Shanghai, Shanghai Shi, China
    • Shanghai Institute of Planned Parenthood Research
      Shanghai, Shanghai Shi, China
  • 2008–2014
    • Xinqiao Hospital
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2010–2012
    • University of California, Los Angeles
      • Department of Electrical Engineering
      Los Ángeles, California, United States
  • 2009–2012
    • University of Southern California
      • Department of Electrical Engineering
      Los Angeles, CA, United States
    • Yangzhou University
      • College of Physics Science and Technology
      Chiang-tu, Jiangsu Sheng, China
  • 2011
    • Monash University (Australia)
      Melbourne, Victoria, Australia
  • 2010–2011
    • Xiamen University
      • Department of Mechanical and Electrical Engineering
      Amoy, Fujian, China
  • 2003–2004
    • shihezi university
      Shikhedzy, Xinjiang Uygur Zizhiqu, China
  • 1999
    • Prince Henry's Institute
      Melbourne, Victoria, Australia