[show abstract][hide abstract] ABSTRACT: Damage in structures may render risk of catastrophic failure. Identifying damages and their locations is termed as damage detection. In this paper, use of digital video imaging is proposed for detecting damage in structures. The theory of measuring structural vibration using high-resolution images is presented first, based on sub-pixel edge identification. Then a concept of mode shape difference function is developed for structural damage detection. A laboratory test program was carried out to implement these concepts using a high-speed digital video camera. The images were analyzed to obtain displacement time series at sub-pixel resolution. Mode shapes were obtained from the time series to find the mode shape difference functions between the damaged and the reference states. They were subjected to wavelet transformation for determining the damage locations. Results show that the proposed approach is able to identify the introduced damage cases and their locations.
[show abstract][hide abstract] ABSTRACT: In vivo all-trans-retinoic acid (ATRA), a differentiation inducer, is capable of causing clinical remission in about 90% of patients with acute promyelocytic leukemia (APL). The molecular basis for the differentiation of APL cells after treatment with ATRA remains obscure and may involve genes other than the known retinoid nuclear transcription factors. We report here the ATRA-induced gene expression in a cell line (NB4) derived from a patient with APL. By differential display-PCR, we isolated and characterized a novel gene (RIG-E) whose expression is up-regulated by ATRA. The gene is 4.0 kb long, consisting of four exons and three introns, and is localized on human chromosome region 8q24. The deduced amino acid sequence predicts a cell surface protein containing 20 amino acids at the N-terminal end corresponding to a signal peptide and an extracellular sequence containing 111 amino acids. The RIG-E coded protein shares some homology with CD59 and with a number of growth factor receptors. It shares high sequence homology with the murine LY-6 multigene family, whose members are small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and appear to function in signal transduction. It seems that so far RIG-E is the closest human homolog of the LY-6 family. Expression of RIG-E is not restricted to myeloid differentiation, because it is also present in thymocytes and in a number of other tissues at different levels.
Proceedings of the National Academy of Sciences 07/1996; 93(12):5910-4. · 9.74 Impact Factor