Publications (2)2.48 Total impact
Article: [Hemorheologic change after strong blood flow disturbance caused by gunshot and its influence on the prognosis of the wounded animals].[show abstract] [hide abstract]
ABSTRACT: Three types of experimental models were used in this study: 1. Both thighs of dogs were wounded by 5.56 mm bullet. 2. Femoral artery and vein were tied at the time of wounding. 3. Shock caused by simply bleeding the dogs' femoral arteries. We observed the characteristics of change hemorheology and analyzed its effects on the wounded dogs. The results showed that strong blood flow disturbances always brought about hemorheologic changes such as rapidly increased blood viscosity and red cell's aggregation index and the simultaneous phenomenon of blood concentration. These may be related to extensive endothelium injury and destruction of a number of blood cells caused by disturbance wave. The above change may give rise to abnormality of microcirculation and disturbance of matter transmission; in that sense, it may provide the physiopathologic basis for the occurrence and development of the complication.Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 04/1998; 15(1):49-52.
Article: Injury to vascular endothelial cells and the change of plasma endothelin level in dogs with gunshot wounds.[show abstract] [hide abstract]
ABSTRACT: The purpose of this study was to evaluate the relationship between injury to endothelial cells and the plasma endothelin level after gunshot wounds. Forty dogs were divided into four groups. The dogs in group 1 served as a control. The dogs in groups 2,3, and 4, respectively, were shot in both hind legs, in the hypogastric part of the abdomen, or in the right chest by military bullets (5.56 mm or 7.62 mm). After wounding, blood samples were taken at different intervals and the number of circulating endothelial cells (CEC), an indicator of injury to vascular endothelial cells (VEC), and the level of plasma endothelin were measured. Results showed that the CEC number increased in all groups immediately after wounding and showed a peak value at 10 minutes and at 6 hours. The change in plasma endothelin level paralleled that of the change of CEC number, and a linear relationship was found between them. These results suggest that, in gunshot wounds, extensive injury to VEC may be the result of the temporary cavity and shock waves produced by high velocity missiles striking the body and causing secretions of endothelin. The mechanism of injury to VEC after a gunshot wound in discussed in this paper.The Journal of trauma 04/1996; 40(3 Suppl):S60-2. · 2.48 Impact Factor