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ABSTRACT: To investigate modulation of cytokines on biological activities of scar-derived fibroblasts.
This study focused on the effects of interleukin-1 (IL-1) on collagen biosynthesis, nucleic acid, and cell organs of fibroblasts.
The results showed the IL-1 could reduce not only the collagen synthesis of fibroblasts, but also quantity of nucleic acid.
The authors confirm that IL-1 is a cytokine with down-regulation effect on scar formation, and suggest that IL-1 can play an important role in prevention and treatment of scar.
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns / [Chung-hua cheng hsing shao shang wai k'o tsa chih pien chi wei yüan hui pien chi] 12/1999; 15(6):434-6.