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ABSTRACT: Terminalia macroptera Guill. and Perr. (Combretaceae) is a West African species used on traditional medicine to treat infectious diseases. Hereby we present the results of an antimicrobial activity screening performed by the twofold serial microdilution assay against seven reference bacterial strains and against Candida albicans, with a leaf hydroethanol extract (Tml) and liquid-liquid partition fractions Tml-1 (hexane), Tml-2 (diethyl ether), Tml-3 (ethyl acetate), Tml-4 (Tml water filtered fraction) and Tml-5 (Tml water precipitate fraction). In the range of tested concentrations (3200 to 50µg/ml), the extract was active against all tested microorganisms. The best results were obtained against Shigella dysenteriae and Vibrio cholerae and the most active fraction was identified as the ethyl acetate one (Tml-3). Chemical profile of this fraction includes polyphenols as main compounds.
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Planta Medica 08/2010; 76:1310. · 2.34 Impact Factor