J Li

Pennsylvania State University, University Park, Maryland, United States

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Publications (28)51.3 Total impact

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    ABSTRACT: To date, epidemiological studies have assessed the association between Toll-like receptor 2 (TLR2) gene polymorphisms and cancer risk. However, the results of these studies remain controversial. We aimed to examine the associations between three SNPs (Delta22, rs3804099 and rs3804100) of TLR2 gene and cancer risk by conducting a meta-analysis of case-control studies. A total of eight studies eligible for TLR2 Delta22 polymorphism (2,061 cancer cases and 3,490 controls), six studies for rs3804099 polymorphism (1,681 cases and 1,996 controls), and five studies for rs3804100 polymorphism (3,131 cases and 2,969 controls) were included in this meta-analysis. Our results suggested that Delta22 represented a risk factor on cancers (del-allele versus ins-allele, OR=1.35, 95% CI: 1.05-1.72; del/del versus ins/ins, OR=1.91, 95% CI: 1.03-3.56; del/del + del/ins versus ins/ins, OR=1.33, 95% CI: 1.02-1.73; del/del versus del/ins + ins/ins, OR=1.79, 95% CI: 1.02-3.13), especially in Caucasian population and among population-based studies. For TLR2 rs3804099 polymorphism, we found a decreased cancer risk associated with CC/CT genotype only in Asians compared with TT genotype. TLR2 rs3804100 polymorphism was significantly associated with an elevated cancer risk in overall analysis (CC versus CT, OR=1.70, 95% CI: 1.20-2.42; CC versus CT/TT, OR=1.61, 95% CI: 1.15-2.25). In a stratified analysis, a statistically significant correlation was also observed in non-Caucasian population and population-based studies. In conclusion, the Delta22 and rs3804100 polymorphisms in TLR2 are risk factors for cancer susceptibility while the TLR2 rs3804099 dominant genotype is a protective factor, especially in Asians. Further large and well-designed studies are needed to confirm these conclusions. Keywords: TLR2; Polymorphism; Cancer risk; Meta-analysis.
    Neoplasma 04/2013; · 1.57 Impact Factor
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    ABSTRACT: As the consequence of complex interactions between different parts of an organ, shape can be used as a predictor of structural-functional relationships implicated in changing environments. Despite such importance, however, it is no surprise that little is known about the genetic detail involved in shape variation, because no approach is currently available for mapping quantitative trait loci (QTLs) that control shape. Here, we address this problem by developing a statistical model that integrates the principle of shape analysis into a mixture-model-based likelihood formulated for QTL mapping. One state-of-the-art approach for shape analysis is to identify and analyze the polar coordinates of anatomical landmarks on a shape measured in terms of radii from the centroid to the contour at regular intervals. A procrustes analysis is used to align shapes to filter out position, scale and rotation effects on shape variation. To the end, the accurate and quantitative representation of a shape is produced with aligned radius-centroid-contour (RCC) curves, that is, a function of radial angle at the centroid. The high dimensionality of the RCC data, crucial for a comprehensive description of the geometric feature of a shape, is reduced by principal component (PC) analysis, and the resulting PC axes are treated as phenotypic traits, allowing specific QTLs for global and local shape variability to be mapped, respectively. The usefulness and utilization of the new model for shape mapping in practice are validated by analyzing a mapping data collected from a natural population of poplar, Populus szechuanica var tibetica, and identifying several QTLs for leaf shape in this species. The model provides a powerful tool to compute which genes determine biological shape in plants, animals and humans.Heredity advance online publication, 10 April 2013; doi:10.1038/hdy.2012.97.
    Heredity 04/2013; · 4.11 Impact Factor
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    ABSTRACT: An effective approach for grafting graphene oxide (GO) onto poly (phenylene benzobisoxazole) (PBO) fiber surface through ethanediamine as linkage using solvothermal method was proposed. Grafting GO onto the PBO fiber surface was an attempt to improve the interfacial properties between PBO fibers and epoxy matrix. Experimental results reveal that GO was grafted uniformly on the PBO fiber surface through chemical bonds. The polar functional groups and surface energy of PBO fiber were obviously increased after the grafting process. Results of the mechanical property tests show the interfacial shear strength increased obviously and single fiber tensile strength have not any discernable decrease after the grafting process. GO effectively enhanced the interfacial adhesion of PBO fiber-reinforced composite by increasing chemical bonding, improving wettability and mechanical interlocking.
    Applied Surface Science 02/2013; 266:306–312. · 2.11 Impact Factor
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    ABSTRACT: AIM:The aim of this paper was to investigate the predictive value of ankle-brachial index (ABI) and blood glucose to estimate mortality in Chinese type 2 diabetes patients. METHODS:Chinese type 2 diabetes patients (1706 subjects) were followed up for about 6 years, RESULTS: One thousand four hundred fourteen were included in the final statistical analysis during a median follow-up of 69 months. Overall, 398 patients died during follow-up and 254 deaths were attributable to cardiovascular disease (CVD). Relative risks of all-cause and CVD mortality of patients with ABI≤0.4 were increased by 2.073-fold (95% CI: 1.236-3.478) and 3.086-fold (95% CI: 1.702-5.595), compared with those of patients with ABI>1.0 and ≤1.4. Mortality was significantly increased with increasing plasma glucose and decreasing ABI. All-cause and CVD mortality was the highest (55.6% and 44.4%) with ABI≤0.4 and plasma glucose >10 mmol/L simultaneously. Relative risks of all-cause and CVD mortality in these patients were increased by 3.905-fold (95% CI: 1.334-11.431) and 3.771-fold (95% CI: 1.079-13.171), compared with patients with ABI>1.0 and ≤1.4, and plasma glucose ≤6 mmol/L simultaneously. Models to evaluate additional predictive value of ABI for mortality of type 2 diabetes patients suggested that addition of ABI significantly improved the prediction of the death rate compared with the model including conventional risk factors only. CONCLUSION: High plasma glucose and low ABI had synergistic effects on increasing mortality of type 2 diabetes patients. The addition of ABI can significantly improve the prediction of mortality compared to protocol using conventional risk factors only.
    International angiology: a journal of the International Union of Angiology 12/2012; 31(6):586-594. · 1.46 Impact Factor
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    ABSTRACT: Osteoarthritis (OA) has a profound impact on health-related quality of life. Increasing importance has been attached to utilization of disease-specific, self-reported outcome measures, such as the Hip Disability and Osteoarthritis Outcome Score (HOOS) instrument. China is the most populous country in the world with 1.3 billion people. Hence, we translated and adapted the HOOS into a Simplified Chinese version (SC-HOOS) and validated it in a cohort of native Chinese-speaking patients with hip OA, relative to the Short Form Health Survey (SF-36), a visual analog scale (VAS), and the Harris hip score (HHS) test. Psychometric testing for internal consistency, test-retest reliability, construct validity, and responsiveness was conducted. The SC-HOOS showed satisfactory internal consistency, test-retest reliability, construct validity, and responsiveness when evaluated in Chinese-speaking patients with hip OA.
    Osteoarthritis and Cartilage 08/2012; 20(12):1563-7. · 4.26 Impact Factor
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    ABSTRACT: The main objective of this study is to investigate the formation and evolution mechanism of the regional haze in megacity Beijing by analyzing the process of a severe haze that occurred 20-27 September 2011. Mass concentration and size distribution of aerosol particles as well as aerosol optical properties were concurrently measured at the Beijing urban atmospheric environment monitoring station. Gaseous pollutants (SO2, NO-NO2-NOx, O3, CO) and meteorological parameters (wind speed, wind direction, and relative humidity (RH)) were simultaneously monitored. Meanwhile, aerosol spatial distribution and the height of planetary boundary layer (PBL) were retrieved from the signal of satellite and LIDAR (light detection and ranging). Results showed that high intensity of local pollutants from Beijing urban source is the fundamental cause that led to the regional haze. Meteorological factors such as higher RH, weak surface wind speed, and decreasing height of PBL played an important role on the deterioration of air quality. New particle formation was considered to be the most important factor contributing the formation of haze. In order to improve the atmospheric visibility and reduce the occurrence of the haze, the mass concentration of PM2.5 at dry condition should be less than 60 µg m-3 in Beijing according to the empirical relationship of visibility, PM2.5 mass concentration and RH. This case study may provide valuable information for the public to recognize the formation mechanism of the regional haze event over the megacity, which is also useful for the government to adopt scientific approach to forecast and eliminate the occurrence of regional haze in China.
    Atmospheric Chemistry and Physics 07/2012; 12(7):16259-16292. · 4.88 Impact Factor
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    ABSTRACT: What is known and Objective:  Invasive fungal infections are a major threat to renal transplant recipients. Micafungin and voriconazole are two useful antifungal agents for treating such infections. Our objective is to evaluate the comparative efficacy and safety of micafungin and voriconazole in the initial treatment of such infections. Methods:  In this prospective, multicentre, open-labelled, randomized, controlled trial, renal transplant recipients with invasive fungal infections were assigned to receive either micafungin or voriconazole. The enrolled subjects received a kidney transplant between March 2008 and March 2010 at one of the two transplant centres in Henan Province, China. The efficacy and adverse effects of the two treatments were compared. Results and Discussion:  The clinical trial enrolled 65 patients, of whom 31 were treated with micafungin, and 34 with voriconazole. The rates of microbiological evidence of infection in the micafungin and voriconazole groups were 64·5% and 70·5%, respectively, whereas the rates of Candida as the major cultured fungus were 80·0% and 75·0%, respectively. Complicated bacterial infection rates in the two treatment groups were 38·7% and 32·4%, respectively, whereas complicated CMV viral infection occurred at a rate of 19·2% and 23·5%, respectively. Fungal infection within one to 3 months after transplant was 83·6% (26/31) and 85·3% (29/34) in the micafungin and voriconazole groups, respectively. There was no significant difference between the two groups in terms of efficacy, survival beyond 10 days and discontinuation of treatment because of lack of efficacy (P > 0·05). Mortality rates in the micafungin and voriconazole groups were 9·7% (3/31) and 12·1% (4/33), respectively. Rates of adverse effects in the two groups were 41·9% and 51·6% (P > 0·05), respectively. What is new and Conclusions:  This is the first comparison of micafungin and voriconazole in renal transplant patients. Our study shows that the effectiveness of micafungin was similar to that of voriconazole in such patients.
    Journal of Clinical Pharmacy and Therapeutics 06/2012; · 2.10 Impact Factor
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    ABSTRACT: Akt has been demonstrated as a survival kinase in brain after hypoxia-ischemia (HI). Previous studies have shown that glycogen synthase kinase-3β (GSK-3β)/collapsin response mediator protein 2 (CRMP-2) signaling pathway could be regulated by Akt for axonal-dendritic polarity. CRMP-2 is associated also with microtubule-mediated trafficking. However, whether Akt could regulate GSK-3β/CRMP-2 pathway and the possible effects of this regulation is unclear in developing brain after HI. In this study, we detected the expression of total and phosphorylated Akt, GSK-3β, and CRMP-2, as well as the axonal injury marker amyloid precursor protein (APP) by utilizing an HI model in postnatal 10-day rats. Axonal loss was determined by Bielschowsky silver impregnation, and histological injury was evaluated by hematoxylin and eosin (H&E) staining. We found that the phosphorylation of Akt was accompanied by phosphorylation of GSK-3β and dephosphorylation of CRMP-2 after HI. Furthermore, Akt inhibition significantly decreased the phosphorylation of GSK-3β and dephosphorylation of CRMP-2. Moreover, the down-regulation of dephosphorylated CRMP-2 was associated with increased axonal injury (increased APP expression and axonal loss). Our findings suggest that the Akt/GSK-3β/CRMP-2 pathway mediates axonal injury in neonatal rat brain after HI.
    Neuroscience 04/2012; 216:123-32. · 3.12 Impact Factor
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    ABSTRACT: An investigation on subcritical spheroidization anneal of the cold-rolled 50CrV4 steel at 720°C has been carried out. During spheroidization anneal, the lamellar cementite was gradually broken down and changed to spherical shape. With prolonging of soaking time, the amount of lamellar cementite decreases gradually, and that of the spheroidized cementite particle increases gradually. The relationship of the spheroidization ratio versus soaking time for the steel can be described by a typically sigmoid curve. Additionally, the cold rolling deformation accelerates the breakup of lamellar cementite and the formation of spheroidal cementite particles during spheroidization anneal of the steel. The more severe the deformation is, the more rapidly the spheroidization occurs. From the results of tensile and hardness test, the yield strength, ultimate tensile strength, and hardness decrease and the percentage elongation to failure increases rapidly during the first 2h of spheroidization. Between 2 and 8 h, the yield strength, ultimate tensile strength, hardness nearly keep a constant, which are independent of the soaking time, whereas the percentage elongation to failure firstly increases and then decreases with prolonging of soaking time. Keywords50CrV4 steel–mechanical property–microstructure–spheroidization–subcritical
    Journal of Materials Engineering and Performance 01/2012; · 0.92 Impact Factor
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    ABSTRACT: The study was designed to investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (IMT), and provide scientific basis for primary and secondary prevention of atherosclerotic diseases. Participants were recruited for this investigation from Inner Mongolia in China through cluster multistage and random sampling. ABI and carotid-IMT were measured for each subject. Periphery arterial disease (PAD) was defined as an ABI≤0.9 in either leg. ABI values were divided into eight groups at every 0.05, and three carotid-IMT measures were compared among groups separately using analysis of variance (ANOVA) and multivariate linear regression analyses. The results indicated that the prevalence of PAD among 1236 participants was 1.9%. The average common carotid IMT was 0.70±0.21 mm, internal carotid IMT 0.77±0.24 mm, and carotid artery bifurcation IMT 0.78±0.25 mm. A U-shaped relationship was observed that the values of common carotid, carotid artery bifurcation, and internal carotid arteries IMT were decreased at first then increased as ABI values increased. The U-shaped relationship between ABI and three carotid-IMT measures were remained after adjusting for covariates. The data suggests that carotid IMT values are correlated with ABI values in a U-shaped curve. Increased carotid IMT is correlated with the high prevalence of PAD in population of Inner Mongolia in China.
    International angiology: a journal of the International Union of Angiology 10/2011; 30(5):451-7. · 1.46 Impact Factor
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    ABSTRACT: Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal survival, proliferation, and synaptic remodeling and modulates the function of many other neurotransmitters. Additionally, it likely underlies neurodegenerative and psychiatric disorders, including alcohol dependence-related depression (AD-D). Here, we investigated the possible association between three single nucleotide polymorphisms (SNPs) of the BDNF gene (rs13306221, rs6265, rs16917204) and AD-D. Of 548 patients with alcohol dependence (AD), 166 had AD-D and 312 healthy controls. Response to 8-week sertraline treatment was also assessed. The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction). The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction). Additionally, carriers of the A allele of rs6265 responded better to sertraline treatment (p=0.001). Our results suggested a novel association between BDNF rs6265 and AD-D. These findings might lead to earlier detection of AD-D, perhaps providing better tools for clinical care of these patients in the future.
    Brain research 08/2011; 1415:119-26. · 2.46 Impact Factor
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    ABSTRACT: Lipopolysaccharides (LPS) activates several signaling pathways in macrophages including mitogen-activated protein kinases (MAPK). Previous studies have investigated effect of LPS on MAPK activation in macrophage of normal rats. In the current study, we investigated the effect of LPS exposure on activation of MAPK in alveolar macrophage (AM) of chronic bronchitis (CB) rats and researched the corresponding cyclooxygenase-2 (COX-2), prostaglandins-2 (PGE(2)) and transforming growth factor- β (TGF-β) production and their MAPK signal pathways. CB model was established by injection of Bacillus Calmette-Guerin (BCG) and LPS in rats. Special inhibitors of p38, extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinases (JNK) MAPK signal pathways were used to determine the effect of MAPK activation on COX-2, PGE(2), TGF-β production in AM of CB rats via RT-PCR, western blotting, radioimmunoassay and ELISA. Key Synthesis of PGE(2) from AM of CB rats was increased and suppressed by either PD98059 or SB203580. SB203580 and PD98059, (inhibitors of ERK and p38 MAPK), could significantly inhibit COX-2 mRNA and protein expression. Moreover, ERK and p38 MAPK had synergistic effect on COX-2 expression. Inhibitor of ERK MAPK signal transduction could inhibit TGF-β expression in AM. These results demonstrated COX-2, PGE(2) and TGF-β productions in AM of CB rats were significantly increased, which might be regulated by the different MAPK signaling pathway.
    Immunopharmacology and Immunotoxicology 03/2011; 33(4):645-51. · 1.36 Impact Factor
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    ABSTRACT: To investigate the relationship between brachial ankle pulse wave velocity (BaPWV), radial augmentation index (radial AI), ankle-brachial index (ABI), and carotid intima-media thickness (carotid-IMT), and to study the prevalence and characteristics of atherosclerosis and peripheral arterial disease in a Chinese population of Inner Mongolia. Participants were recruited from Inner Mongolia in China through cluster multistage and random sampling. BaPWV, radial AI, ABI, and carotid-IMT values were measured in each subject. A total of 1,236 participants from natural population of Inner Mongolia in China were included in this study. The average ABI value was 1.082 ± 0.093. The average values of common carotid, internal carotid, and carotid artery bifurcation IMT were 0.70 ± 0.21, 0.77 ± 0.24, and 0.78 ± 0.25 mm, respectively. The average value of BaPWV was 1450.5 ± 301.5 cm/s. The average value of radial AI was 78.9 ± 16.8 %. BaPWV, radial AI, and carotid-IMT values were positively correlated with ages significantly. BaPWV values were positively correlated with radial AI significantly. BaPWV values were positively correlated with values of common carotid, internal carotid, and carotid artery bifurcation IMT respectively. Radial AI values were positively correlated with the values of common carotid, internal carotid, and carotid artery bifurcation IMT respectively. A U-shaped relationship was observed that radial AI values were decreased at first and then increased as ABI values increased. The data suggests that BaPWV, radial AI, and carotid-IMT values are positively correlated with each other, and AI values are correlated with ABI values in a U-shaped curve in a Chinese population of Inner Mongolia.
    VASA.: Zeitschrift für Gefässkrankheiten. Journal for vascular diseases 02/2011; 40(1):49-56. · 1.01 Impact Factor
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    ABSTRACT: To investigate the prevalence of peripheral arterial disease (PAD) and correlating risk factors and comorbidities in a natural female population in China, and to study the characteristics of atherosclerotic disease in females. Natural population from communities in several cities and districts including Beijing, Shanghai, Changsha, Guangdong, Inner Mongolia, and Xinjiang in China were investigated as study subjects through cluster multistage and random sampling. Ankle-brachial index (ABI) was measured among participants in the communities by trained investigators and correlative information and clinical data were collected. PAD was defined as an ABI≤0.9 in either leg. 21,152 eligible participants were included in the survey. The prevalence in males and females was 2.52 % and 3.66 %, the standardized prevalence was 1.84% and 4.31% respectively, and the prevalence in females was higher than that in males (p<0.01). The prevalence in females obviously increased (p<0.01) with increasing age. More female participants with PAD were over 69 years old compared with those without PAD (18.8% vs. 10.0%, p=0.000) and more frequently have a smoking habit (11.1% vs. 2.5%, p=0.000), lipid disorders (34.8% vs. 29.2%, p=0.047), diabetes mellitus (14.8% vs. 8.6%, p=0.000), coronary heart disease (16.9% vs. 10.0%, p=0.000) and a history of stroke (6.8% vs. 2.3%, p=0.000). Using multiple logistic regression analysis, older age (>69 years old, OR: 1.60, 95% CI: 1.11-2.29), a smoking habit (OR: 5.98, 95% CI: 3.88-9.21), comorbidities of lipid disorders (OR: 1.45, 95% CI: 1.10-1.91), diabetes mellitus (OR: 1.46, 95% CI: 1.02-2.11), coronary heart disease (OR: 1.50, 95% CI: 1.02-2.19)and a history of stroke (OR: 1.71, 95% CI: 1.01-2.91) were correlated with the prevalence of PAD in females in China. Only 0.8% of female patients with PAD had been diagnosed previously. The data suggest that the prevalence of PAD in a female natural population in China is higher than that in males. Many conventional risk factors and comorbidities were correlated with the high prevalence of PAD in females. But only very few female patients with PAD were diagnosed. Thus, more measures should be taken to diagnose, prevent and control PAD in females in China.
    VASA.: Zeitschrift für Gefässkrankheiten. Journal for vascular diseases 11/2010; 39(4):305-11. · 1.01 Impact Factor
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    ABSTRACT: To evaluate the association between body mass index (BMI) and incident hypertension in a cohort of rural women in the Chinese population. A population-based sample of 11,468 rural Chinese women aged >or=35 years and free from hypertension at baseline were followed-up from 2004-2006 to 2008. We calculated BMI from measured weight and height. Incident hypertension was defined as systolic blood pressure (BP) >or=140 mm Hg, diastolic BP>or=90 mm Hg or current use of antihypertensive medications. During a median follow-up of 28 months, 2,666 participants developed hypertension. Higher baseline BMI, even within the 'normal' range, was consistently associated with an increased risk of hypertension. Compared with participants in the lowest BMI quintile (18.5-21.1 kg/m(2)), the multivariable-adjusted relative risks (95% confidence interval) of developing hypertension for women with a BMI of 21.2 to 22.4, 22.5 to 23.7, 23.8 to 25.4 and >or=25.4 kg/m(2) were 1.200 (1.058-1.361), 1.250 (1.100-1.419), 1.466 (1.291-1.666) and 1.785 (1.584-2.012), respectively (P for trend, <0.001). Further adjustment for baseline BP did not substantially alter these results. We found similar associations using other BMI categories and after excluding women with smoking history at baseline. The pattern of association also existed among old women (age >or=55 years). In this large cohort, we found a strong gradient association between higher BMI and increased risk of hypertension, even among older women within the normal BMI range. Clinicians should emphasize the importance of weight management for the primary prevention of hypertension in rural women in the Chinese population.
    European journal of clinical nutrition 08/2010; 64(8):769-75. · 3.07 Impact Factor
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    ABSTRACT: The effect of 2,2'-dipyridyl (DP) on cerebral vasospasm was investigated in a double-injection rabbit model of subarachnoid haemorrhage (SAH). Thirty-six animals were divided between four groups: control (sham-operated), SAH (model alone), SAH + DP (the SAH model in which DP dissolved in dimethyl sulphoxide [DMSO] was injected once daily for 5 days into the cisterna magna), and SAH + DMSO (the SAH model in which DMSO [vehicle] was injected daily for 5 days). There were significant differences in the basilar artery luminal area, wall thickness, neurological deficit score and vasospasm index between the SAH + DP and SAH groups. There was a significant negative correlation between arterial luminal area and arterial wall thickness, and also between the neurological deficit score and vasospasm index. Cells that were positive for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labelling (TUNEL) and p53 expression were significantly increased in the SAH + DMSO and SAH groups, but not in the SAH + DP group, versus controls. Thus, DP may attenuate cerebral vasospasm after SAH by suppressing p53-induced apoptosis in the cerebral vessels.
    The Journal of international medical research 04/2010; 38(2):583-92. · 0.96 Impact Factor
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    ABSTRACT: Cube-shaped Pt nanocrystals (with the size of about 160 nm) are prepared by a square-wave potential electrochemical pretreatment at the expense of Pt nanospheres. A cyclic voltammogram of Pt nanospheres in sulphuric acid shows two pairs of hydrogen adsorption/desorption peaks, which corresponds to the characteristics of a Pt polyoriented surface. However, a cyclic voltammogram of cubic Pt nanocrystals in sulphuric acid shows another pair of hydrogen adsorption/desorption peak at 0.22 V (vs. NHE), which corresponds to the characteristics of Pt (100) surface orientation. Cubic Pt nanocrystals show enhanced electrocatalytic activity over Pt nanospheres for methanol oxidation. The peak current density of cubic Pt nanocrystals is 1.39 mA cm–2Pt, which is 1.48 times that of Pt nanospheres. The poison resistant and oxygen reduction reaction (ORR) activity of cubic Pt nanocrystals are also enhanced compared with those of Pt nanospheres.
    Fuel Cells 02/2010; 10(3):384 - 389. · 2.36 Impact Factor
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    ABSTRACT: Loquats ( Eriobotrya japonica Lindl.) have formed different ecological types in various zones during the long course of their cultivation and acclimatization. The data of biological responses and ecological suitability was very important for loquat plantation in different eco-zones. In this study, we evaluated the growth and development characters, flowering and fruiting habits and fruit quality of loquat in three diverse ecotypes of Sichuan by field survey. The results showed that in mid-subtropical damp and heat ecotype, the loquat trees grew vigorously and young shoots sprouted four times annually. The flower buds were mainly originated from the Summer shoots and the flowering stage most centered from September to December. In addition, a rapid growth stage of fruits was observed from March to April and fruit quality was fine in May. In Southern subtropical dry and hot eco-zone, young shoots might be developed four or five times annually. Flowering and fruiting could occur several times a year as the development differences of Spring and Summer shoots with flower buds differentiation without trees treatments. In the valley of Southern temperate warm and dry ecotype, the phenophase of loquat were late about 20 to 30 days. The loquat fruits were mainly originated from Summer flowerings and mature at June with more than 15% soluble solids, super quality and nice appearance. These results obtained from comprehensive investigation would provide valuable information for techniques of cultivation in distinctive ecotypes and facilitated the economic plantation for loquats in the diverse eco-zones of the world.
    Journal of Agronomy. 01/2010;
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    X Li, Y Luo, Y Xu, J Li, D Hu
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    ABSTRACT: This study aimed to investigate the relationship of ankle-brachial index (ABI) with all-cause mortality and cardiovascular (CV) mortality in Chinese inpatients after 3 years of follow-up. All the participants were inpatients at high risk of atherosclerosis and enrolled from July to November 2004. A total of 3210 patients were followed up until an end point was reached or until February 2008. The mean follow-up time was 37.65+/-1.54 months. Patients with ABI <or=0.4 were significantly older than other ABI categories (P<0.001) at baseline. The all-cause and CV disease (CVD) mortality were highest (37.7 and 27.5%, respectively) after a 3-year follow-up in patients with ABI <or=0.4. There was a significant increasing tendency in mortality with decreasing ABI levels (P<0.001). The Kaplan-Meier curves of survival showed a decreasing survival rate with the ABI decreasing, not only for all-cause mortality but also for CVD mortality (P<0.001). Adjusted for other risk factors, patients with ABI <or=0.4 were 3.105 times (95% CI 1.936-4.979) as likely to die as those with ABI in the range of 1.00-1.4; patients with ABI <or=0.4 were about five times (95% CI 2.740-8.388) as likely to die of CVD as those with ABI in the range of 1.00-1.4. Even patients with ABI in the range of 0.41-0.90 were more than 1.5 times as likely to die (relative risk=1.534, 95% CI 1.199-1.962), or die of CVD (relative risk=2.031, 95% CI 1.479-2.789) as those with ABI in the range of 1.00-1.4. Low ABI is related to a higher all-cause and CV mortality compared with normal ABI. ABI as a marker of atherosclerosis should be routinely evaluated to assess the risk of CV mortality in Chinese patients.
    Journal of human hypertension 06/2009; 24(2):111-6. · 2.80 Impact Factor
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    ABSTRACT: The goal of this study was to investigate the possible therapy mechanism of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf (TAL) in alveolar macrophage (AM) of chronic bronchitis (CB) rats. CB model was established by injection of bacillus calmette guein (BCG) plus lipopolisacharide (LPS) in rats. TAL significantly inhibited the increased NO concentration, iNOS expression and phosphorylation of p38 MAPK in alveolar macrophages (AMs) of CB rats. Using in vivo test, we found that SB203580, a p38 MAPK inhibitor, (10 muM) significantly inhibited inducible nitric oxide synthase (iNOS) mRNA expression in AM. This data indicate that TAL highly decreases excessive iNOS expression and NO induction, and p38 MAPK signal transduction participates in iNOS expression and NO induction in AM of CB rats. The effect of TAL on iNOS expression in AM may be related to its inhibition of p38 MAPK signal transduction.
    The American Journal of Chinese Medicine 01/2009; 37(6):1099-111. · 2.28 Impact Factor

Publication Stats

57 Citations
51.30 Total Impact Points


  • 2013
    • Pennsylvania State University
      • Department of Statistics
      University Park, Maryland, United States
    • Harbin Institute of Technology
      • School of Chemical Engineering and Technology
      Charbin, Heilongjiang Sheng, China
  • 2012
    • China Iron and Steel Research Institute
      Peping, Beijing, China
    • Tongji Medical University
      • Department of Cardiology
      Shanghai, Shanghai Shi, China
  • 2011
    • Anhui Medical University
      Luchow, Anhui Sheng, China
  • 2008–2010
    • Tongji University
      Shanghai, Shanghai Shi, China