J Liu

Publications (3)4.22 Total impact

• Article: Controlled release of insulin from PLGA nanoparticles embedded within PVA hydrogels.

  J Liu, S M Zhang, P P Chen, L Cheng, W Zhou, W X Tang, Z W Chen, C M Ke
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  ABSTRACT: A simple and versatile delivery platform for peptide and protein based on physically cross-linked poly (vinyl alcohol) (PVA) hydrogels containing insulin-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles was successfully fabricated. The particle morphology and size were characterized by SEM and laser light scattering method, respectively. Results showed that these particles had a mean diameter of 615 nm with a narrow size distribution and homogeneous particle production. The protein encapsulation efficiency was 72.6%. When insulin-loaded PLGA nanoparticles were administered intraperitoneally as a single dose (20 U/kg) to streptozotocin-induced diabetic mouse, blood glucose levels of these mice decreased and it could be sustained at such levels over 24 h. In vitro release further indicated that entrapment of the nanoparticles into the PVA hydrogels causes a reduction in both the release rate and the total amount of insulin released, which suggesting that PLGA nanoparticles entrapped into the PVA hydrogels showed more suitable controlled release kinetics for protein delivery.
  Journal of Materials Science Materials in Medicine 12/2007; 18(11):2205-10. · 2.32 Impact Factor
• Article: Fabrication and characterization of fluorohydroxyapatite nanocrystals/poly(d,l-lactide) composite scaffolds

  L. Cheng, S.M. Zhang, P.P. Chen, S.L. Huang, L. Liu, W. Zhou, J. Liu, H. Gong, Q.M. Luo
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  ABSTRACT: Poly(d,l-lactide) (PDLLA)/fluorohydroxyapatite nanocrystals (nano-F-HA) porous scaffolds were successfully fabricated through a solvent-casting and particulate-leaching technique. Nano-HA/PDLLA scaffold and PDLLA scaffold were prepared by using the same process for comparison. The structure, phase and morphology of the nanocomposite scaffolds were observed by SEM. The results indicated that F-HA nanocrystals were homogeneously dispersed in the PDLLA matrix. The porosity of the scaffolds was up to 90%, and macropores and micropores coexisted and interconnected throughout the scaffolds. Cell culture experiments demonstrated that the nano-F-HA/PDLLA scaffold had the best adhesion tendency to chondrocytes among the scaffolds investigated.
  Current Applied Physics 7. · 1.90 Impact Factor
• Article: Interfacial fabrication and property of hydroxyapatite/polylactide resorbable bone fixation composites

  S.M. Zhang, J. Liu, W. Zhou, L. Cheng, X.D. Guo
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  ABSTRACT: Based on surface modification of hydroxyapatite with silane derivatives, interfacial fabrications of hydroxyapatite (HAP)/polylactide (PLA) resorbable bone fixation composites are realized. The results indicate that interfacial adhesion, swelling property, and ultimate mechanical properties of the HAP/PLA composites are significantly improved. As a result, the maximum bending strength enhances 27.8%. Scanning electron microscopy (SEM) observation suggests that the modified HA particles are homogeneously dispersed in the composites, their size ranges are about 2–15 μm. The modified HA/PLA composites are of toughened rupture. This conclusion is consistent with bending property of the composites. Finally, a possible mechanism for the interfacial adhesion is also discussed.
  Current Applied Physics.