J Liu

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Publications (2)4.84 Total impact

  • Article: Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han population.
    W Tang, Y Shi, G Feng, L Yan, Y Xing, S Zhu, J Liu, X Zhao, R Tang, J Du, J Zhang, G He, P Liang, L He
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    ABSTRACT: A previous case-control study by Yang et al. indicated that the TCP1 gene in 6q25 was associated with schizophrenia in the Han population. To replicate this result, we selected eight SNPs (rs2273828, rs3818298, rs1547094, rs1547093, rs2295898, rs2295899, rs4832, rs15982) spanning the whole gene and performed a family-based study using 325 trios samples. Our transmission disequilibrium test showed neither allele nor haplotype association with schizophrenia, and suggests that the TCP1 locus is not associated with schizophrenia in the Chinese population. Since 6q25 has consistently been found to be a susceptible region for schizophrenia, we suggest that other genes within this region should be the focus of attention.
    Acta Neurovegetativa 11/2006; 113(10):1537-43. · 2.73 Impact Factor
  • Article: Interleukin-10 -1082 promoter polymorphism is associated with schizophrenia in a Han Chinese sib-pair study.
    G He, J Zhang, X W Li, W Y Chen, Y X Pan, F P Yang, N F Gu, G Y Feng, S L Yang, J Y He, B X Liu, Y W Peng, J Liu, L He
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    ABSTRACT: The interleukin-10 (IL-10) gene has been identified as a susceptibility gene for schizophrenia in Caucasians. A previous case-control study conducted by our group revealed a weak association between polymorphism, -592C/A, of the IL-10 gene promoter and schizophrenia. Our present study was aimed at confirming the association of the IL-10 promoter with schizophrenia using 197 Han Chinese sib-pair families. A family-based association test (FBAT) and haplotype analysis was undertaken using the FBAT v1.5.5. The global TDT was significant for a different polymorphism, -1082G/A (chi2=13.16, P=0.000285) and that the allele -1082G was preferentially transmitted to schizophrenia-affected children. Furthermore, haplotype TDT analysis showed that haplotype "GCC" was significantly associated with the disease (chi2=8.1, P=0.00443). Our results also indicate that the IL-10 gene may play a significant role in the etiology of schizophrenia among Han Chinese.
    Neuroscience Letters 03/2006; 394(1):1-4. · 2.11 Impact Factor
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