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ABSTRACT: To detect BRCA1 gene mutations in early-onset breast cancer. We use polymerase chain reaction and single strand conformation polymorphism analysis (PCR-SSCP) to examine the mutation at BRCA1 gene exon 2, 11 and 20 in 10 patients with early-onset breast cancer. Mutation was found in one cases (24 years old at diagnosis) at nucleotide 3 732, the substitution of a "G" to a "C" in codon 1 205 changed a Gly to a Arg. Our data suggest that BRCA1 may have effect on early-onset breast cancer.Zhonghua yi xue za zhi 03/2000; 80(2):111-3.