-
[show abstract]
[hide abstract]
ABSTRACT: An 8-year-old girl was admitted for severe electrolyte imbalance and for hyponatremic seizure. In July 2005, at 3 years of age, she underwent isolated small-bowel transplantation of 100 cm ileum from her father. Her own bowel was only 50 cm of proximal jejunum which had been directly connected to the anus due to extended total aganglionosis. The graft was placed into the middle of her remaining bowel, using the splenic artery and vein as feeding vessels with saving of the spleen. Daclizumab induction and tacrolimus monotherapy were applied for immunosuppression. Two acute cellular rejection episodes, E on day 10 and 4 years after transplantation, were successfully treated with OKT-3 and recombinant antithymocyte globulin, respectively. However, because of intermittent bowel dysfunction, she was hospitalized several times for hydration and metabolic care. On admission, her abdomen was moderately distended, and a simple abdominal film showed a fixed dilated loop. Colonoscopy could not pass the narrowed lumen, with stiffness at the anastomosis between the graft and the distal bowel. Endoscopic biopsy at the entrance to the stricture showed a nonspecific inflammatory reaction with fibrosis. Similar findings on a gastrograffin enema suggested chronic rejection (CR). On laparotomy, an irregularly narrowed fibrotic loop was noticed at the distal part of the graft, proximal to the anastomosis. We performed a 20-cm segmental resection with an end-to-end anastomosis. Histopathologic findings showed CR with fibrosis and hyalinization of the entire bowel wall and vessel walls with mild cellular infiltrations. She recovered in 10 days. The graft may have been saved, but intermittent requirement of hydration over the following months suggested progressive graft dysfunction. A case of segmental involvement of CR with subsequent successful graft salvage by partial resection is rare in the literature.
Transplantation Proceedings 05/2012; 44(4):1180-2. · 1.00 Impact Factor
-
S I Kim,
C J Kim,
Y J Kim,
H Son,
Y E Kim,
M S Kim,
S Hwang, J I Kim,
Y K You,
D G Kim,
M W Kang
[show abstract]
[hide abstract]
ABSTRACT: Cytomegalovirus (CMV), the most significant viral infection in liver transplant recipients, is addressed by 2 methods: Preemptive therapy (PT) or universal prophylaxis (UP).
We analyzed medical records including at least 1 year follow-up of patients who underwent liver transplantation from 2006 to 2009 in 3 tertiary hospitals. PT was used in 2 hospitals (PT group), whereas UP with valganciclovir for 3 months was adopted in the other hospital (UP group). The 2 groups were matched using propensity scoring by perioperative variables. We performed a 1:1 comparison of the efficacy of UP and PT.
We analyzed 634 liver transplant patients, including 562 matched subjects. Baseline characteristics and underlying liver status were comparable. CMV immunoglobulin G of recipients was positive in 98.9% of the PT group and 99.3% of the UP group. CMV viremia episodes that required administration of an antiviral agent occurred in 26 (9.3%) PT and 37 (13.2%) UP subjects (P = .18). CMV-related mortalities were similar (0.7% vs 1.8%; P = .45), but all-cause mortality was higher in the PT group (18.5% vs 13.2%; P = .08).
The efficacy of PT was similar to UP to prevent CMV disease and related mortality among a group at moderate risk for CMV infection.
Transplantation Proceedings 04/2012; 44(3):787-90. · 1.00 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: This study evaluated the effect of the donor kidney to recipient body weight (Kw/Rw) ratio on long-term graft function and survival. We investigated retrospectively whether there was any association between Kw/Rw ratio and long-term graft survival and function after a follow-up of >10 years. We studied a consecutive series of 123 adult-to-adult living kidney transplants. According to the Kw/Rw ratio, patients were divided into 3 groups: "low" (Kw/Rw <2.85; n = 29), "medium" (2.85 ≤ Kw/Rw < 4.04; n = 63), and "high" (≥4.04; n = 31). Among the 3 groups, the mean serum creatinine levels at 1 and 6 months as well as 1 year after transplantation were significantly lower among patients with a high Kw/Rw ratio than in those with a medium or low ratio, but serum creatinine levels at 3 and 5 years did not differ significantly (P = .394 and 0.620, respectively). Graft survival rates at 5 and 10 years after transplantation were significantly lower in the "low" group. We observed a significant association between Kw/Rw ratio and graft survival (P = .018). The Kw/Rw ratio is an important factor for long-term graft survival and early graft function. However, it did not significantly affect subsequent renal function.
Transplantation Proceedings 01/2012; 44(1):276-80. · 1.00 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Kidneys with multiple renal arteries are increasingly procured for transplantation. To compare the outcomes of kidney transplantation using allografts with multiple arteries, we studied long-term graft function and survival according to their number of arterial anastomoses during an 18-year period from July 1, 1990, through December 31, 2008, in which only the recipient's external iliac artery or internal iliac artery was used for anastomosis (n = 1186). The recipients were divided into four groups: group I, single renal artery with single anastomosis (n = 890, 75.0%); group Il, multiple renal arteries, single anastomosis (n = 26, 2.2%); group Ill, multiple renal arteries, multiple anastomoses (n = 236, 19.9%); and group IV, polar artery ligation (n = 34, 2.9%). We compared the following variables patient and graft survivals; mean creatinine levels at 1 and 6 months, as well as 1-, 3-, and 5-years posttransplant; the number of acute rejection episodes, and the rates of vascular and urologic complications. The creatinine values and incidences of acute rejection episodes did not differ significantly (P = 0.399 and P = 0.990, respectively). There were no significant differences among the four groups in graft survival (P = 0.951), patient survival (P = 0.751), incidence of vascular (P = 0.999) or urologic complications (P = 0.371). The four groups were subdivided according to the recipient arterial anastomosis to the main graft renal artery. The subdivided groups showed no significant differences in graft or patient survival, or complications rates. The results indicated that multiplicity of renal arteries in kidney transplantation did not adversely affect allograft or patient survival compared with single renal artery transplantation. Moreover, the type of the arterial anastomosis (main renal artery end-to-end anastomosed to internal iliac artery or end-to-side anastomosed to external iliac artery appeared to not affect graft or patient survival or the incidence of vascular or urologic complications.
Transplantation Proceedings 12/2010; 42(10):4053-7. · 1.00 Impact Factor
-
Transplantation 01/2010; 90. · 4.00 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Usually, the transplanted kidney is placed into the right retroperitoneal iliac fossa through a right abdominal surgical skin incision. The skin incision may be oblique or inverted J-shaped known as the "hockey stick." The oblique or curvilinear incision, parallel to the inguinal ligament, known as the "pelvic Gibson incision," is also extended medially to the midline, just above the pubis. The most common incision for kidney transplantation in our center is a paramedian incision, which is parallel to rectus abdominis muscle and extends medially to the midline, just above the pubis symphysis ("hockey stick"). Nowadays, minimally invasive surgery is popular in various field of surgery; the number of patients who are concerned about cosmetic effects are increasing. We make the skin incision in the lower right abdomen from laterally below the anterior superior iliac spine to the midline just above the pubis in five young unmarried women whose body mass index was >25 and there were no anatomic variations. The lower transverse abdominal skin incision showed more favorable cosmetic results and there was no difference in postoperative factors, including renal function, compared with other routine renal transplant patients.
Transplantation Proceedings 10/2008; 40(7):2347-8. · 1.00 Impact Factor
-
Y J Kim,
J H Yoon,
S I Kim,
K W Hong, J I Kim,
J Y Choi,
S K Yoon,
Y K You,
M D Lee,
I S Moon,
D G Kim,
M W Kang
[show abstract]
[hide abstract]
ABSTRACT: Acinetobacter species have become increasingly important nosocomial pathogens worldwide and can result in a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis, among others. The aim of this study was to investigate clinical characteristics, mortality, and outcomes among liver transplant recipients with Acinetobacter species infections.
We retrospectively analyzed 451 subjects who had undergone living donor liver transplantations between January 2001 and May 2010. Pandrug-resistant (PDR) Acinetobacter species were defined as resistant to all commercially available antibiotics except colistin.
Infectious complications due to Acinetobacter species appeared in 26 patients (5.8%) with a total of 37 episodes. Of the species identified, 34 were Acinetobacter baumannii and 3 Acinetobacter Iwoffiii. The presumed sources of infection were the biliary tract (n = 21, 56.8%), lung (n = 7, 18.9%), intra-abdomen (n = 6, 16.2%), catheter (n = 2, 5.4%), and urinary tract (n = 1, 3.6%). Among the 37 Acinetobacter species, 75.7% (28/37) were PDR species. Age, duration of intensive care unit stay, Child-Pugh score, and Model for End-stage Liver Disease score were not significant risk factors for Acinetobacter species infection. However, the overall mortality among patients with Acinetobacter species infections was 50% (13/26), which was significantly higher than that among those free of infection (50% vs 11.5%, P < .05). Multivariate analysis using a Cox regression model showed that inappropriate antimicrobial treatment was a significant independent risk factor for mortality among patients with Acinetobacter species infections (hazard Ratio = 4.19, 95% confidence interval 1.1-18.7; P = .06).
Patients with Acinetobacter species infections after liver transplantation show a significantly worse prognosis. PDR Acinetobacter species have been a major problem in our center.
Transplantation Proceedings 43(6):2397-9. · 1.00 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Ipsilateral acute iliofemoral deep vein thrombosis (DVT) immediately after kidney transplantation is rare but highly morbid, resulting in allograft failure, rupture, or even death. Treatment modalities for iliofemoral DVT occurring just after transplantation are limited due to bleeding risk and impaired renal function. A 55-year-old woman with end-stage renal disease from hypertension underwent a living nonrelated donor procedure using a kidney from her husband. On postoperative day 1, the patient presented edema and pain in the right lower extremity associated with local heat and redness. The symptoms became aggravated with time. Duplex ultrasonography (US) revealed a DVT involving from the right femoral vein to the common iliac vein and an increased resistive index of 0.96 to 0.97. A venogram using carbon dioxide as the contrast medium showed also same findings as the duplex US. After inferior vena cava filter insertion, percutaneous transluminal thromboaspiration (PTA) was performed with complete removal of the thrombus. Early PTA with carbon dioxide as intravenous contrast material seemed to be an effective and safe procedure to treat this complication.
Transplantation Proceedings 43(6):2415-7. · 1.00 Impact Factor
