J Farrell

Publications (29)48.58 Total impact

• Source

  Available from: Andrei Talalaevskii

  Article: The High Voltage Feedthroughs for the ATLAS Liquid Argon Calorimeters

  B. Botchev, G Finocchiaro, J Hoffman, R.L. Mccarthy, M Rijssenbeek, J. Steffens, A. Talalaevskii, M. Thioye, M Zdrazil, J Farrell, S. Kane
  [show abstract] [hide abstract]
  ABSTRACT: The purpose, design specifications, construction techniques, and testing methods are described for the high voltage feedthrough ports and filters of the ATLAS Liquid Argon calorimeters. These feedthroughs carry about 5000 high voltage wires from a room-temperature environment (300 K) through the cryostat walls to the calorimeters cells (89 K) while maintaining the electrical and cryogenic integrity of the system. The feedthrough wiring and filters operate at a maximum high voltage of 2.5 kV without danger of degradation by corona discharges or radiation at the Large Hadron Collider.
  Journal of Instrumentation 02/2013; 2:T10002. · 1.87 Impact Factor
• Article: ATLAS liquid argon calorimeter front end electronics

  N J Buchanan, L Chen, D M Gingrich, S Liu, H Chen, D Damazio, F Densing, S Duffin, J Farrell, S Kandasamy, [......], J Ye, P Zarzhitsky, K -J Grahn, P Hansson, B Lund-Jensen, M L Chu, S -C Lee, D S Su, P K Teng, H M Braun
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  ABSTRACT: The ATLAS detector has been designed for operation at CERN's Large Hadron Collider. ATLAS includes a complex system of liquid argon calorimeters. This paper describes the architecture and implementation of the system of custom front end electronics developed for the readout of the ATLAS liquid argon calorimeters.
  Journal of Instrumentation 09/2008; 3(09):P09003. · 1.87 Impact Factor
• Source

  Available from: Giuseppe Battistoni

  Article: Design and implementation of the Front End Board for the readout of the ATLAS liquid argon calorimeters

  N J Buchanan, L Chen, D M Gingrich, S Liu, H Chen, J Farrell, J Kierstead, F Lanni, D Lissauer, H Ma, [......], B Mansoulié, J Teiger, B Dinkespiler, T Liu, R Stroynowski, C -A Yang, J Ye, M L Chu, S -C Lee, P K Teng
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  ABSTRACT: The ATLAS detector has been designed for operation at CERN's Large Hadron Collider. ATLAS includes a complex system of liquid argon calorimeters. The electronics for amplifying, shaping, sampling, pipelining, and digitizing the calorimeter signals is implemented on the Front End Boards (FEBs). This paper describes the design, implementation and production of the FEBs and presents measurement results from testing performed at several stages during the production process.
  Journal of Instrumentation 03/2008; 3(03):P03004. · 1.87 Impact Factor
• Article: The HELLP syndrome, a prospective study.

  K A Abraham, G Connolly, J Farrell, J J Walshe
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  ABSTRACT: We undertook this study to evaluate the incidence and outcome of HELLP in Irish patients. In addition, duration and trends of the abnormal laboratory results were studied. This prospective observational study screened 12068 pregnant women between January 1995 and March 1997. Any pregnant woman with hypertension, proteinuria, thrombocytopenia or anemia was monitored for hemolysis and elevated liver transaminases, from the time of recruitment till six weeks postpartum or resolution. Thirteen of 12068 pregnant women (0.11%) developed HELLP. All had hypertension and 84.6% had proteinuria. Delivery was the only factor found to terminate the syndrome. Acute renal dysfunction was noted in 53.8% but none required dialysis. Laboratory parameters stabilized by the sixth postpartum day. Fetal mortality was 1 out of 14. There were no maternal deaths. HELLP syndrome is a rare but potentially serious complication of pregnancy. Correlation with laboratory data and early intervention are vital in achieving a favorable outcome for both mother and fetus.
  Renal Failure 10/2001; 23(5):705-13. · 0.82 Impact Factor
• Article: Selected abstracts.

  P Corkery, B Leek, B Caulfield, M Garrett, J Gormley, P O'Donnell, N Kennedy, K Sayers, E Stokes, B Bresnihan, [......], B Higglns, A Katkada, G Canny, P MacMathuna, M O'Donovan, A Schuur, K Murphy, A Foley, S Ten Bruggencate, L Ireland
  Irish Journal of Medical Science 10/2000; 169(4):272-368. · 0.58 Impact Factor
• Article: Renal thrombotic microangiopathy associated with interferon-alpha treatment of chronic myeloid leukemia.

  C C Magee, K Abraham, J Farrell, T Dorman, J J Walshe
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  ABSTRACT: Recent reports have documented the development of renal thrombotic microangiopathy in patients with chronic myeloid leukemia (CML) who have undergone treatment with interferon-alpha. The pathogenesis of the renal lesion in such cases remains unclear. We report the case of a patient with chronic myeloid leukemia who developed renal failure and nephrotic syndrome while being treated with hydroxyurea and interferon-alpha. The renal biopsy showed features of chronic thrombotic microangiopathy. The patient had serologic and functional evidence of anti-phospholipid antibody. Interferon-alpha is known to cause induction of multiple autoantibodies. We propose that in the context of CML, interferon-alpha treatment can induce pathogenic anti-phospholipid antibodies that result in renal thrombotic microangiopathy. This has important implications for patients with CML receiving immune-stimulating therapy because it suggests that prospective monitoring of such patients for anti-phospholipid antibody might identify those at risk of developing thrombotic microangiopathy. Furthermore, patients with established anti-phospholipid antibody syndrome in this context might benefit from intervention such as early anticoagulation.
  American Journal of Kidney Diseases 08/2000; 36(1):E5. · 5.43 Impact Factor
• Article: Serum beta 2-microglobulin levels in patients chronically dialyzed with CA-210 versus CT-190 dialysis membranes.

  P DeFranco, J Farrell, M Gellens, B Bastani
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  ABSTRACT: beta 2-Microglobulin (B2M) amyloidosis (dialysis-related amyloidosis), manifested primarily by carpal tunnel syndrome and destructive osteoarthropathy, is a major sequel of long-term dialysis. Previous investigators have shown that high-flux biocompatible synthetic membranes (e.g., polyacrylonitrile) lower beta 2M levels when compared to cellulosic membranes (e.g., cuprophane). To date, however, no study has compared beta 2M levels of patients dialyzed with the two more biocompatible cellulosic membranes CA-210 (cellulose acetate) and CT-190 (cellulose triacetate; high flux, more biocompatible). We retrospectively compared the serum beta 2M levels in two chronic hemodialysis populations: 22 patients on CT-190 and 21 patients on CA-210. There was no difference between the two groups with regard to age, sex, or duration of dialysis. The patients on the CA-210 membrane had significantly higher serum beta 2M levels (mean +/- SE; 53.6 +/- 4.7 vs. 36.8 +/- 2.6 mg/l, CA-210 vs. CT-190, respectively, p = 0.003). Subsequently we switched 13 patients dialyzed with a CA-210 membrane to a CT-190 membrane and followed serum beta 2M levels for 14 months. We found a significant decrease in serum beta 2M levels within 1 month which was maintained over 14 months of follow-up (47.4 +/- 4.4 vs. 62.8 +/- 6.7 mg/l, CT-190 at 14 months vs. CA-210 at baseline, respectively, p < 0.01).
  American Journal of Nephrology 01/1998; 18(1):16-20. · 2.54 Impact Factor
• Article: Complications associated with insertion of jugular venous catheters for hemodialysis: the value of postprocedural radiograph.

  J Farrell, J Walshe, M Gellens, K J Martin
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  ABSTRACT: It is routine in hemodialysis units to require a chest radiograph after the insertion of an internal jugular line for venous access before dialysis is commenced. There are two principal reasons for this: (1) to ensure that no procedural complications have occurred and (2) to verify correct catheter placement. Knowledge of the time delay involved may prompt nephrologists to opt for femoral access (with increased hemodialysis recirculation and need for repeated line placement). The benefit of the postprocedural chest radiograph has never been evaluated in the hemodialysis population. We retrospectively reviewed the data on internal jugular access placement from two large nephrology training centers. Over a 36-month period, 460 internal jugular dialysis catheters were placed in 312 patients. Wherever possible, 15-cm lines were used for the left internal jugular vein and 12-cm lines for the right internal jugular vein. Ultrasound guidance was used in 105 cases (22.8%). There were a total of 90 (19.6%) clinical complications in 62 patients (13.5%). These consisted of carotid artery puncture (n = 35, 7.6%) and hematoma (n = 55, 12%). All of these patients had a normal post-internal jugular chest radiograph. Carotid artery puncture did not occur if ultrasound guidance was used. There was no case of associated pneumothorax. Of the 370 line insertions in 250 patients in whom it was believed clinically that no complication had occurred, the chest radiograph only showed unsuspected line malposition in four cases (1.08%). Routine chest radiographs rarely contribute to the diagnosis of any procedural complications and are of little value after internal jugular access placement, especially if it is believed clinically that no complication occurred.
  American Journal of Kidney Diseases 12/1997; 30(5):690-2. · 5.43 Impact Factor
• Source

  Available from: oxfordjournals.org

  Article: Familial interstitial nephritis and retinitis pigmentosa.

  J Farrell, V Tormey, E Campbell, J J Walshe
  Nephrology Dialysis Transplantation 08/1997; 12(7):1468-70. · 3.40 Impact Factor
• Source

  Available from: oxfordjournals.org

  Article: Ultrasound-guided cannulation versus the landmark-guided technique for acute haemodialysis access.

  J Farrell, M Gellens
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  ABSTRACT: The correct placement of large-bore venous catheters plays an important role in the management of haemodialysis patients. Whilst the procedure for landmark-based placement of these catheters is well known, the technique is not without significant morbidity and mortality. Complications include arterial puncture, haematoma, and pneumothorax. The procedure may be further complicated in these patients by venous thrombosis and abnormal vein position from multiple previous attempts at venous access. Data on the use of ultrasound guidance versus anatomical landmarks for the placement of internal jugular vein (n = 69) and femoral vein (n = 30) dialysis access was retrospectively analysed over a 13-month period. Data collected included age, sex, duration on dialysis, number of vein cannulation sets required, number of attempts for successful cannulation, salvage of failed cannulation using landmark-based technique by ultrasound guidance, and the complication rate. Internal jugular vein cannulation using ultrasound was ultimately successful in 96.7% compared to 82% in the landmark group. The vein was entered on the first attempt in 83.3% of patients with ultrasound compared to 35.9% of the landmark group (P < 0.0001). Seven patients in whom the landmark technique was unsuccessful had access placed under ultrasound guidance. There were fewer carotid artery punctures in the ultrasound group (7.7 versus 0%, P = n.s.). In the femoral vein group, the vein was entered on the first attempt in 85.7% of patients with ultrasound compared to 56.25% of the landmark group (P = n.s.). The use of ultrasound guidance is associated with fewer complications and is more likely to lead to cannulation of the vein at the first attempt in haemodialysis patients.
  Nephrology Dialysis Transplantation 06/1997; 12(6):1234-7. · 3.40 Impact Factor
• Source

  Available from: oxfordjournals.org

  Article: The effect of dialysis membrane on serum beta 2-microglobulin (beta 2M) in chronic haemodialysis patients.

  J Farrell, B Bastani
  Nephrology Dialysis Transplantation 05/1997; 12(4):856. · 3.40 Impact Factor
• Source

  Available from: asnjournals.org

  Article: Beta 2-microglobulin amyloidosis in chronic dialysis patients: a case report and review of the literature.

  J Farrell, B Bastani
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  ABSTRACT: Dialysis-related amyloidosis secondary to beta-2-microglobulin (beta 2m) deposits is a common complication of long-term dialysis patients and is responsible for significant morbidity with potential mortality. Beta 2m amyloid has a propensity to deposit in the osteoarticular tissues, particularly in large bones close to the joint spaces, and in synovial membranes and carpal tunnel tissue. Older age at the onset of dialysis and the duration of dialysis are two important risk factors for development of this disease. The high-flux, more biocompatible membranes have been shown to remove and adsorb beta 2m more efficiently than the cellulosic membranes. This study presents the case of a chronic dialysis patient who developed recurrent arthritis of the left knee, followed by carpal tunnel syndrome; biopsy of the patient's knee showed very large aggregates of beta 2m amyloid deposits in the tendon sheets. A brief review of the literature on this subject is also presented.
  Journal of the American Society of Nephrology 04/1997; 8(3):509-14. · 9.66 Impact Factor
• Source

  Available from: Peter J Conlon

  Article: Long-term successful management of refractory congestive cardiac failure by intermittent ambulatory peritoneal ultrafiltration.

  V Tormey, P J Conlon, J Farrell, J Horgan, J J Walshe
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  ABSTRACT: Despite advances in the pharmacological management of cardiac failure, some patients remain refractory to this therapy. However, improved understanding of the physiology and technique of peritoneal dialysis has recently allowed ambulatory peritoneal ultrafiltration to be applied to the treatment of patients with intractable heart failure. We report the management of three such patients with New York Heart Association (NYHA) class IV cardiac failure, each with a left ventricular ejection fraction < 20%. They had become unresponsive to maximum pharmacological management with inotropes, diuretics and ACE inhibitors. All patients had biochemical evidence of pre-renal azotemia. Initially, patients received aggressive ultrafiltration by continuous veno-venous haemofiltration (CVVH) or one- to two-hourly peritoneal dialysis exchanges until they achieved an optimal dry body weight. Once stabilized, they were converted to an intermittent ambulatory peritoneal ultrafiltration (IAPU) regimen of one to three exchanges per 24 h according to their individual needs. During an 18 +/- 10-month follow-up, their duration of hospital confinement was reduced by 85% and all three patients improved from class IV to class II cardiac failure. IAPU may have a useful role in the long-term management of intractable heart failure in a selected group of patients.
  QJM: monthly journal of the Association of Physicians 09/1996; 89(9):681-3. · 2.33 Impact Factor
• Article: Renal failure associated with alternative medical therapies.

  J Farrell, E Campbell, J J Walshe
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  ABSTRACT: Because the kidney is the major excretory organ for drugs and toxins, it is especially susceptible to damage from such agents. While alternative medical therapies appear to be on an increase worldwide, there have been few case reports regarding their nephrotoxicity. However we have recently observed three patients who developed irreversible renal impairment, which we believe was due to such therapies.
  Renal Failure 12/1995; 17(6):759-64. · 0.82 Impact Factor
• Article: The beneficial effect of enalapril on erythrocytosis after renal transplantation.

  P J Conlon, J Farrell, J Donohoe, J J Walshe
  Transplantation 08/1993; 56(1):217-9. · 4.00 Impact Factor
• Article: The Foraminifer Record at ODP Site 847: Paleoceanographic Response to Late Pleistocene Climate Variability

  V S McKenna, J Farrell, D Murray, S C Clemens
  Ocean Drilling Program manuscript 138S-141. 01/1993;
• Article: Procedures for estimating the effects of design and operational characteristics of jet aircraft on ground noise

  J Farrell, G. Henry, R Lee, A Lowe
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  ABSTRACT: Estimation procedures for effect of design and flight characteristics of jets on ground noise
  07/1968;
• Source

  Available from: V. M. Aulchenko

  Article: Performance of the Atlas electromagnetic calorimeter barrel module 0

  B Aubert, J. Ballansat, A Bazan, B Beaugiraud, J Boniface, F Chollet, J Colas, P Delebecque, L Di Ciaccio, N. Dumont-Dayot, [......], J. Lundqvist, L Megner, M. Pearce, S. Rydstrom, J. Egdemir, R. Engelmann, J Hoffman, R McCarthy, M Rijssenbeek, J. Steffens
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  ABSTRACT: The construction and performance of the barrel pre-series module 0 of the future ATLAS electromagnetic calorimeter at the LHC is described. The signal reconstruction and performance of ATLAS-like electronics has been studied. The signal to noise ratio for muons has been found to be 7.11+-0.07. An energy resolution of better than 9.5% GeV^1/2/sqrt{E} (sampling term) has been obtained with electron beams of up to 245GeV. The uniformity of the response to electrons in an area of Delta_eta x Delta_phi = 1.2 x 0.075 has been measured to be better than 0.8%.
• Article: Long-term successful management of refractory congestive cardiac failure by intermittent ambulatory peritoneal ultrafiltration

  V Tormey, PJ Conlon, J Farrell, J Horgan, JJ Walshe
• Article: Performance of the ATLAS electromagnetic calorimeter barrel module 0

  B. Aubert, J. Ballansat, A. Bazan, B. Beaugiraud, J. Boniface, F. Chollet, J. Colas, P. Delebecque, L. Di Ciaccio, N. Dumont-Dayot, [......], J. Lundqvist, L. Megner, M. Pearce, S. Rydstrom, J. Egdemir, R. Engelmann, J. Hoffman, R. McCarthy, M. Rijssenbeek, J. Steffens
  [show abstract] [hide abstract]
  ABSTRACT: The construction and performance of the barrel pre-series module 0 of the future ATLAS electromagnetic calorimeter at the LHC is described. The signal reconstruction and performance of ATLAS-like electronics has been studied. The signal to noise ratio for muons has been found to be 7.11±0.07. An energy resolution of better than (sampling term) has been obtained with electron beams of up to . The uniformity of the response to electrons in an area of Δη×Δφ=1.2×0.075 has been measured to be better than 0.8%.
  Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.