J Fujita

Publications (19)111.21 Total impact

• Article: Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy.

  K Hoshino, D Shibata, T Miyagi, Y Yamamoto, S Arakaki, T Maeshiro, A Hokama, F Kinjo, K Takahashi, J Fujita
  Endoscopy 01/2011; 43 Suppl 2 UCTN:E277-8. · 5.21 Impact Factor
• Article: An unusual cause of haematochezia.

  A Hokama, K Kishimoto, K Azama, H Chinen, F Kinjo, S Kato, J Fujita
  Gut 06/2010; 59(6):728, 793. · 10.11 Impact Factor
• Article: Epigastric pain in a woman with previous Behcet's disease.

  A Hokama, H Samura, J Arakaki, R Murabayashi, K Shimoji, H Chinen, K Kishimoto, F Kinjo, T Nishimaki, J Fujita
  Gut 08/2009; 58(7):896, 948. · 10.11 Impact Factor
• Article: All that's elevated is not a polyp.

  A Hokama, J Shiroma, K Kishimoto, K Azama, H Chinen, F Kinjo, J Fujita
  Gut 06/2009; 58(5):619, 702. · 10.11 Impact Factor
• Article: The Mount Fuji sign of the pneumoperitoneum.

  A Hokama, S Yara, J Fujita, S Nakamura, M Nakaema, Y Kuniyoshi
  Emergency Medicine Journal 05/2009; 26(4):300. · 1.44 Impact Factor
• Source

  Available from: Kenji Hibiya

  Article: Inhibition of intracellular hepatitis C virus replication by nelfinavir and synergistic effect with interferon-alpha.

  S Toma, T Yamashiro, S Arakaki, J Shiroma, T Maeshiro, K Hibiya, N Sakamoto, F Kinjo, M Tateyama, J Fujita
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  ABSTRACT: Liver diseases associated with hepatitis C virus (HCV) infection have become the major cause of mortality in patients with human immunodeficiency virus (HIV) infection since the introduction of highly active anti-retroviral therapy. HCV-related liver disease is more severe in HIV-infected patients than in non-HIV-infected patients, but the standard therapies used to treat chronic hepatitis C in HCV/HIV coinfected patients are the same as those for patients infected with HCV alone. HIV protease inhibitors might have potential to down-regulate HCV load of HCV/HIV coinfected patients. In this study, we evaluated the effects of nelfinavir on intracellular HCV replication using the HCV replicon system. We constructed an HCV replicon expressing a neomycin-selectable chimeric firefly luciferase reporter protein. Cytotoxicity and apoptosis induced by nelfinavir were assessed and synergism between nelfinavir and interferon (IFN) was calculated using CalcuSyn analysis. Nelfinavir dose-dependently repressed HCV replication at low concentrations (IC(50), 9.88 micromol/L). Nelfinavir failed to induce cytotoxicity or apoptosis at concentrations that inhibited HCV replication. Clinical concentrations of nelfinavir (5 micromol/L) combined with IFN showed synergistic inhibition of HCV replication in our replicon model. Our results suggest that the direct effects of nelfinavir on the HCV subgenome and its synergism with IFN could improve clinical responses to IFN therapy in HCV/HIV coinfected patients.
  Journal of Viral Hepatitis 04/2009; 16(7):506-12. · 4.09 Impact Factor
• Article: Education and imaging. Gastrointestinal: Signs of pneumoperitoneum.

  A Hokama, M Nakamura, C Kobashigawa, H Chinen, K Kishimoto, M Nakamoto, T Hirata, N Kinjo, F Kinjo, H Samura, T Nishimaki, J Fujita
  Journal of Gastroenterology and Hepatology 04/2009; 24(3):497. · 2.87 Impact Factor
• Article: Telescope sign of intussusception in Peutz-Jeghers syndrome.

  A Hokama, M Inamine, K Kishimoto, F Kinjo, Y Aoki, J Fujita
  Digestive and Liver Disease 02/2009; 42(2):153. · 3.05 Impact Factor
• Article: An uncommon cause of haematochezia in an adult with skin rash.

  A Hokama, K Shimoji, M Nakamura, H Chinen, K Kishimoto, T Hirata, F Kinjo, J Fujita
  Gut 11/2008; 57(10):1430, 1447. · 10.11 Impact Factor
• Article: Notched sign and bamboo-joint-like appearance in duodenal Crohn's disease.

  A Hokama, M Nakamura, Y Ihama, H Chinen, K Kishimoto, F Kinjo, J Fujita
  Endoscopy 09/2008; 40 Suppl 2:E151. · 5.21 Impact Factor
• Article: An unusual cause of abdominal fullness in a patient with Raynaud's phenomenon. Mixed connective tissue disease.

  A Hokama, K Kishimoto, M Nakamoto, N Kinjo, F Kinjo, J Fujita
  Gut 07/2008; 57(6):733, 820. · 10.11 Impact Factor
• Article: Education and imaging. Gastrointestinal: the shell sign of Crohn's disease.

  A Hokama, Y Ihama, K Kishimoto, F Kinjo, J Fujita
  Journal of Gastroenterology and Hepatology 02/2008; 23(1):163. · 2.87 Impact Factor
• Article: An unusual cause of bubbly urine.

  A Hokama, H Shokita, T Isa, F Kinjo, J Fujita
  Digestive and Liver Disease 12/2007; 39(11):1030. · 3.05 Impact Factor
• Article: Esophagitis dissecans superficialis associated with bisphosphonates.

  A Hokama, Y Ihama, M Nakamoto, N Kinjo, F Kinjo, J Fujita
  Endoscopy 03/2007; 39 Suppl 1:E91. · 5.21 Impact Factor
• Article: Chronic diarrhoea with thickening of the colonic wall.

  K Kishimoto, A Hokama, S Irei, H Aoyama, R Tomiyama, T Hirata, F Kinjo, J Fujita, M Sakiyama
  Gut 02/2007; 56(1):94, 114. · 10.11 Impact Factor
• Article: An unusual cause of polyposis.

  A Hokama, K Kishimoto, R Tomiyama, T Hirata, F Kinjo, J Fujita, M Masuda
  Gut 12/2006; 55(11):1574, 1591. · 10.11 Impact Factor
• Article: Detection of legionella species in clinical samples: Comparison of polymerase chain reaction and urinary antigen detection kits.

  M Koide, F Higa, M Tateyama, I Nakasone, N Yamane, J Fujita
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  ABSTRACT: Recently, two excellent methods have been used for the diagnosis of Legionnaires' disease: urinary antigen detection and PCR. The purpose of the present study is to analyze and evaluate the sensitivity and specificity of three different urinary antigen detection kits as well as PCR. A total of 148 samples were collected from 33 patients between 1993 and 2004. These consisted of 73 urine samples obtained from 33 patients, 57 serum samples provided by 29 patients, and 18 respiratory tract specimens from 13 patients. Three commercially available kits were used to detect urinary antigen. For the 5S PCR reaction, primers L5SL2 and L5SR84 were used. Positive results were shown in all patients' urine (representing 79.5% of total samples) using the Binax EIA kit, in 93.9% patients (representing 75.3% samples) using the Binax NOW immunochromatographic kit, and in 90.9% (representing 72.6% samples) using the Biotest EIA kit. Urine samples from 12.1% patients (representing 6.8% of total samples), serum samples from 41.4% patients (representing 35.1% of total samples), and respiratory samples from 84.6% patients (representing 88.9% of total samples) showed positive results with PCR. In testing urine of legionellosis patients, it was suggested that three kits were all valuable tools for diagnosis of legionellosis. Since over one-third of patients' serum samples and most respiratory specimens showed positive results with PCR, the addition of PCR for testing of these samples might be useful, particularly in cases of culture negative and serum antibody negative patients.
  Infection 11/2006; 34(5):264-8. · 2.66 Impact Factor
• Article: HRCT shows variations in appearance in disseminated tuberculosis in adults.

  J Fujita, S Bandoh, A Kubo, T Ishii, N Kanaji, H Nakamura, F Higa, M Tateyama, T Ishida
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  ABSTRACT: To examine patterns of high resolution computed tomography (HRCT) of lungs of adults with disseminated tuberculosis (TB). Disseminated TB was defined as radiological involvement of all lung lobes. The case series illustrated wide variation in HRCT of disseminated TB. Patterns identified on HRCT included (1) miliary TB (haematogenous dissemination), (2) miliary TB with exudative reaction, (3) bronchogenic spread, (4) miliary TB mixed with bronchogenic spread, and (5) bronchogenic spread with multiple cavity formation. The HRCT patterns described allow classification of disseminated TB according to the mechanism of spread (haematogenous and/or bronchogenic) and the degree of local lung involvement (reaction or cavitation).
  The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 03/2006; 10(2):222-6. · 2.73 Impact Factor
• Article: Colonoscopic Findings and Pathologic Characteristics of Strongyloides Colitis: A Case Series

  H. Minematsu, A. Hokama, T. Makishi, K. Arakaki, F. Kinjo, J. Fujita
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  ABSTRACT: Background/Aims: Strongyloidiasis, which is caused by Strongyloides stercoralis, is one of the prevalent infections in the tropical and subtropical regions worldwide. The larvae mainly infect the small intestine and cause serious disseminated strongyloidiasis. Although upper gastrointestinal features in strongyloidiasis are well known, colonoscopic evaluation has not been established yet. The aim of this study is to clarify the characteristic findings on colonic lesions in strongyloidiasis. Method: From January 2005 to December 2009, 10 cases with strongyloidiasis underwent colonoscopy at a single center on an endemic island of Japan. The clinical and colonoscopic findings were analyzed retrospectively. Results: Six (60%) cases had an immunocompromised condition, including human T lymphotropic virus type 1 infection, corticosteroids, and chemotherapy. Hyperinfection or disseminated strongyloidiasis was not presented. Endoscopic features included yellowish-white nodules, erythema, and loss of vascular pattern, which were mainly observed in the right colon. Pathological examination revealed the filariform Strongyloides larvae and the eosinophilic infiltration of the lamina propria. Conclusion: This study demonstrates that colonoscopic observation and biopsies are very useful to diagnose strongyloidiasis. Asymptomatic cases with strongyloidiasis can have colonic involvement. Yellowish-white nodules may be a characteristic finding of colonic lesions in strongyloidiasis and can be a cautious marker to prevent fatal disseminated strongyloidiasis in endemic regions.
  Digestion 08/1970; 83(3):210-214. · 2.05 Impact Factor