J F O'Grady

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Publications (5)11.27 Total impact

  • N A Firth, J F O'Grady, P C Reade
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    ABSTRACT: Candidosis endocrinopathy syndrome is a rare condition characterized by mucocutaneous candidosis and multiple endocrinal abnormalities. This case reports a patient with the syndrome who also developed an oral mucosal squamous cell carcinoma at the age of 21.
    International Journal of Oral and Maxillofacial Surgery 03/1997; 26(1):42-4. · 1.52 Impact Factor
  • J F O'Grady, P C Reade
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    ABSTRACT: A model of candidosis in experimental rats was used to study the role of trauma in the aetiology of oral mucosal infections caused by Candida albicans. Standardised thermal trauma was delivered to the dorsum of the tongue of Sprague-Dawley rats and experimental candidosis was induced. Histologically, the site of trauma was invaded by hyphae earlier and more extensively than in control animals, leading to the conclusion that trauma facilitated the establishment of the C. albicans infections.
    Journal of Oral Pathology and Medicine 04/1993; 22(3):132-7. · 2.06 Impact Factor
  • John F. O'Grady, Peter C. Reade
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    ABSTRACT: A model of candidosis in experimental rats was used to study the role of trauma in the aetiology of oral mucosal infections caused by Candida albicans. Standardised thermal trauma was delivered to the dorsum of the tongue of Sprague-Dawley rats and experimental candidosis was induced. Histologically. the site of trauma was invaded by hyphae earlier and more extensively than in control animals, leading to the conclusion that trauma facilitated the establishment of the C. alhicana infections.
    Journal of Oral Pathology and Medicine 02/1993; 22(3):132 - 137. · 2.06 Impact Factor
  • J F O'Grady, P C Reade
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    ABSTRACT: A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the application of 4NQO to their palatal and tongue mucosa 3 times weekly for 4 weeks. The animals then received either application of a phorbol ester to act as a promoter, induction of experimental oral mucosal infection with C. albicans, or no further procedures. Animals were killed at 34 or 52 weeks and the tongues and palates sectioned for light-microscopic examination. Control groups with no treatment, mucosal infection only, phorbol ester application only, 4NQO with the tetracycline or vehicle application only were also used. The development of carcinoma in the experimental groups was similar to that in the positive control groups, indicating that the particular strain of Candida used had a similar ability to promote neoplastic changes as the known promoter phorbol-12,13-didecanoate and caused neoplastic changes to occur by week 34 with no additional lesions occurring by week 52. This indicated that the speculation that strains of C. albicans may participate in causing neoplastic transformation in humans was well founded.
    Carcinogenesis 06/1992; 13(5):783-6. · 5.64 Impact Factor
  • D N Crockett, J F O'Grady, P C Reade
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    ABSTRACT: A group of full-denture-wearing patients with erythematous candidiasis was matched by age and sex with a group of healthy, full-denture-wearing persons who served as controls. In the group with erythematous candidiasis, clinical symptoms and signs of the disease were recorded. Denture hygiene and tobacco use were noted in both groups. Epithelial smears and imprint cultures were obtained from both groups from specified sites. Cultures were grown and subjected to species identification and C. albicans strain differentiation by a morphotyping technique. Denture-wearing subjects who smoked tobacco had a significantly greater incidence of erythematous candidiasis than the controls. Five species of Candida were isolated from both groups, with C. albicans as the dominant species. Twenty different morphotypes of C. albicans as well as strains involved in erythematous candidiasis were also isolated from the oral cavities of healthy, full-denture-wearing control subjects.
    Oral Surgery Oral Medicine Oral Pathology 06/1992; 73(5):559-63.

Publication Stats

64 Citations
11.27 Total Impact Points

Institutions

  • 1997
    • Peter MacCallum Cancer Centre
      Melbourne, Victoria, Australia
  • 1992–1997
    • University of Melbourne
      • Faculty of Medicine, Dentistry and Health Sciences
      Melbourne, Victoria, Australia