J Fang

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada

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Publications (3)9.66 Total impact

  • X Q Wang · J Fang · AA Nunez · L G Clemens ·
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    ABSTRACT: Polychlorinated biphenyls (PCBs) are persistent environmental contaminants that have the potential to disrupt reproduction through a variety of different pathways. In the present study, we investigated the effects of fetal and lactational PCB exposure on reproductive behavior in male and female laboratory rats. These pregnant rats were injected daily with either 2,4,2',4'-tetrachlorobiphenyl (PCB 47) at the dosage of 1 or 20 mg/kg body weight or 3,4,3',4'-tetrachlorobiphenyl (PCB 77) at the dosage of 0.25 or 1 mg/kg body weight or sesame oil (control group) from gestational days 7 to 18. Offspring were then tested for sexual behavior as adults. Exposure to both PCB 77 and PCB 47 reduced the level of sexual receptivity in the female offspring, but had no detectable effects on the sexual behavior of the male offspring. In addition to changes in adult sexual behavior in the females, both PCBs produced a significant increase in the females' anogenital distance, suggesting a modification of androgen responsiveness in females resulting from PCB exposure during development. Similar effects were not seen with the males.
    Physiology & Behavior 05/2002; 75(5):689-96. DOI:10.1016/S0031-9384(02)00673-X · 2.98 Impact Factor
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    Chemosphere 11/2001; 45(4):701-701. DOI:10.1016/S0045-6535(01)00167-9 · 3.34 Impact Factor
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    A.A. Nunez · K Kannan · J.P. Giesy · J Fang · L.G. Clemens ·
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    ABSTRACT: Some environmental contaminants have the potential to affect humans or animals by mimicking the effects of hormones. Bisphenol A (BPA) is a weak estrogen agonist when tested using in vitro or in vivo bioassays. In addition to the well documented effects of estrogens on reproductive functions, ovarian hormones also have salient effects on mammalian energy balance and feeding behavior. In this study, we investigated the effects of BPA on body weight and food intake of ovariectomized adult female rats. Treatment with doses of 4 or 5 mg/day for 15 days resulted in a significant reduction of body weight gain with no reduction in food intake. A dose of 1 mg/day did not affect feeding or weight gain. BPA was detected in the blood, brain and adipose tissues of the BPA-treated animals but not in the vehicle control group. There was a preferential concentration of BPA in brown adipose tissue. These results indicate that BPA can affect energy balance and that brown adipose tissue may be a primary tissue into which BPA accumulates in mammals.
    Chemosphere 04/2001; 42(8):917-22. DOI:10.1016/S0045-6535(00)00196-X · 3.34 Impact Factor

Publication Stats

94 Citations
9.66 Total Impact Points

Top Journals


  • 2002
    • Institute for Clinical Evaluative Sciences
      Toronto, Ontario, Canada
  • 2001
    • Michigan State University
      • Department of Zoology
      Ист-Лансинг, Michigan, United States