J Diebold

Paris Diderot University, Lutetia Parisorum, Île-de-France, France

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Publications (417)707.83 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Large and systematic studies of non-Hodgkin lymphoma (NHL) in the Far East (FE) with good comparative data are scarce in the literature. In this study, five expert hematopathologists classified 730 consecutive cases of newly-diagnosed NHL from four sites in the FE (excluding Japan) using the World Health Organization classification. The results were compared to 399 cases from North America (NA). We found a significantly higher male to female ratio in the FE compared to NA (1.7 versus 1.1; p < 0.05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in the FE (58 and 51 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). The FE had a significantly lower relative frequency of B-NHL and a higher frequency of T-NHL (82 vs. 18 %) compared to NA (90.5 vs. 9.5 %). Among mature B cell lymphomas, the FE had a significantly higher relative frequency of HG B-NHL (54.8 %) and a lower frequency of LG B-NHL (27.2 %) than NA (34.3 and 56.1 %, respectively). Diffuse large B cell lymphoma was more common in the FE (49.4 %) compared to NA (29.3 %), whereas the relative frequency of follicular lymphoma was lower in the FE (9.4 %) compared to NA (33.6 %). Among T-NHL, nasal NK/T cell NHL was more frequent in the FE (5.2 %) compared to NA (0 %). Peripheral T cell lymphoma was also more common in the FE (9.1 %) than in NA (5.3 %). Further epidemiologic studies are needed to better understand the pathobiology of these differences.
    Annals of Hematology 11/2015; DOI:10.1007/s00277-015-2543-4 · 2.63 Impact Factor
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    ABSTRACT: Epidemiologic studies of non-Hodgkin lymphoma (NHL) in Eastern Europe are scarce in the literature. We report the experience of the “Ion Chiricuta” Institute of Oncology in Cluj-Napoca (IOCN), Romania, in the diagnosis and outcome of patients with NHL. We studied 184 consecutive NHL patients diagnosed in the Pathology Department of IOCN during the years 2004–2006. We also obtained epidemiological data from the Northwestern (NW) Cancer Registry. In the IOCN series, the most common lymphoma subtype was diffuse large B-cell lymphoma (43.5%), followed by the chronic lymphocytic leukaemia/small lymphocytic lymphoma (21.2%). T-cell lymphomas represented a small proportion (8.2%). The median age of the patients was 57 years, with a male-to-female ratio of 0.94. Patients with indolent B-cell lymphomas had the best overall survival, whereas those with mantle cell lymphoma had the worst survival. The NW Cancer Registry data showed that the occurrence of NHL in the NW region of Romania was higher in men [world age-standardized incidence rate/100 000 (ASR)—5.9; 95% CI 5.1–6.6] than in women (ASR—4.1; 95% CI 3.5–4.7) with age-standardized male-to-female ratio of 1.44 (p = 0.038). Chronic lymphocytic leukaemia/small lymphocytic lymphoma was the most common NHL in the NW region of Romania, accounting for 43% of all cases, followed by diffuse large B-cell lymphoma (36%). The 5-year, age-standardized cumulative relative survival for NHL in the County of Cluj in NW Romania, for the period of 2006–2010, was 51.4%, with 58.4% survival for men and 43.2% for women. Additional studies of NHL in Eastern Europe are needed. Copyright © 2015 John Wiley & Sons, Ltd.
    Hematological Oncology 10/2015; DOI:10.1002/hon.2266 · 3.08 Impact Factor
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    ABSTRACT: The distribution of non-Hodgkin lymphoma (NHL) subtypes varies around the world, but a systematic study of South-eastern Europe (SEEU) has never been done. Therefore, we evaluated the relative frequencies of NHL subtypes in three SEEU countries - Croatia, Romania and Macedonia. Five expert haematopathologists reviewed 632 consecutive cases of newly diagnosed NHL from the three SEEU countries using the World Health Organization classification. The results were compared to 399 cases from North America (NA) and 580 cases from Western Europe (WEU). The proportions of B- and T-cell NHL and the sex distribution in SEEU were similar to WEU and NA. However, the median ages of patients with low- and high-grade B-NHL in SEEU (60 and 59 years, respectively) were significantly lower than in NA (64 and 68 years, respectively; P < 0·05). SEEU had a significantly lower proportion of low-grade B-NHL (46·6%) and higher proportion of high-grade B-NHL (44·5%) compared to both WEU (54·5% and 36·4%, respectively) and NA (56·1% and 34·3%, respectively). There were no significant differences in the relative frequencies of T-NHL subtypes. This study provides new insights into differences in the relative frequencies of NHL subtypes in different geographic regions. Epidemiological studies are needed to better characterize and explain these differences. © 2015 John Wiley & Sons Ltd.
    British Journal of Haematology 07/2015; 171(3). DOI:10.1111/bjh.13586 · 4.71 Impact Factor
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    ABSTRACT: Le terme d’histiocytose désigne l’accumulation pathologique d’histiocytes dans un tissu ou un organe. La rate est l’un des organes où les histiocytoses sont fréquentes. Elles réalisent une splénomégalie. Le diagnostic repose sur l’étude des signes cliniques et biologiques. Les techniques d’imagerie montrent si le parenchyme est infiltré de façon diffuse ou s’il existe des masses. Souvent une splénectomie d’intérêt diagnostique est proposée. L’examen anatomo-pathologique apporte des éléments majeurs pour le diagnostic en particulier grâce à la morphologie et à l’immunophénotype (expression de CD68 et CD 163), pour le diagnostic de l’affection responsable et la prise en charge thérapeutique.
    Revue Francophone des Laboratoires 01/2015; 2015(468). DOI:10.1016/S1773-035X(15)72787-5
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    ABSTRACT: ABSTRACT The relative distribution of non-Hodgkin lymphoma (NHL) subtypes differs remarkably around the world. The aim of this study is to report this distribution in Algeria. A panel of four hematopathologists classified 197 consecutive cases according to the WHO classification, including 87.3% B-cell and 12.7% T- or NK-cell NHL. This series was compared to similar cohorts from Western Europe (WEU) and North America (NA). Algeria had a significantly higher frequency of diffuse large B-cell lymphoma (DLBCL: 52.8%) and a lower frequency of follicular lymphoma (FL: 13.2%) compared to WEU (DLBCL: 32.2%: FL: 20.0%,) and NA (DLBCL: 29.3%; FL: 33.6%). The frequency of mantle cell lymphoma was lower in Algeria (2.5%) compared to WEU (8.3%). Smaller differences were also found among the NK/T-cell lymphomas. In conclusion, we found important differences between Algeria and Western countries, and further epidemiologic studies are needed to explain these differences.
    Leukemia and Lymphoma 07/2014; 56(4):1-19. DOI:10.3109/10428194.2014.939967 · 2.89 Impact Factor
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    1st Macedonian Inter-Congress Meeting with International Participation, Skopje, Republic of Macedonia; 05/2013

  • Revue Francophone des Laboratoires 01/2013; 2013(448):83–84. DOI:10.1016/S1773-035X(13)71895-1
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    ABSTRACT: Myelolipoma is a lesion arising in the adrenal glands or in various extra-adrenal sites. Only one human case developing in the spleen has been published in the literature. We report two such exceptional cases discovered in two women aged 65 and 67 years, presenting with splenomegaly. Both spleens showed a round mass constituted by red pulp containing nests of extra-medullar haematopoiesis and adipose tissue resembling bone marrow tissue. In addition, Emh developed in the surrounding red pulp. Erythroblasts and granulocytic cells at different stages of normal maturation and a few megakaryocytes were observed, without blasts. We consider the relationship with extra-adrenal myelolipoma and the differential diagnosis with non neoplastic and neoplastic Emh.
    Revue Francophone des Laboratoires 01/2013; 2013(448):71–75. DOI:10.1016/S1773-035X(13)71892-6
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    ABSTRACT: The distribution of non-Hodgkin lymphoma (NHL) subtypes differs around the world but a systematic study of Latin America has not been done. Therefore, we evaluated the relative frequencies of NHL subtypes in Central and South America (CSA). Five expert hematopathologists classified consecutive cases of NHL from five CSA countries using the WHO classification and compared them to 400 cases from North America (NA). Among the 1028 CSA cases, the proportions of B- and T-cell NHL and the sex distribution were similar to NA. However, the median age of B-cell NHL in CSA (59 years) was significantly lower than in NA (66 years; p<0.0001). The distribution of high-grade (52.9%) and low-grade (47.1%) mature B-cell NHL in CSA was also significantly different from NA (37.5% and 62.5%; p<0.0001). Diffuse large B-cell lymphoma was more common in CSA (40%) than in NA (29.2%; p<0.0001), whereas the frequency of follicular lymphoma was similar in Argentina (34.1%) and NA (33.8%), and higher than the rest of CSA (17%; p<0.001). Extranodal NK/T-cell NHL was also more common in CSA (p<0.0001). Our study provides new objective evidence that the distribution of NHL subtypes varies significantly by geographic region and should prompt epidemiological studies to explain these differences.
    Blood 10/2012; 120(24). DOI:10.1182/blood-2012-07-440073 · 10.45 Impact Factor
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    ABSTRACT: The distribution of subtypes of non-Hodgkin lymphoma (NHL) in Latin America is not well known. This Chilean study included 207 consecutive cases of NHL diagnosed at five cancer centers in the capital, Santiago, and one center in Viña del Mar. All cases were reviewed and classified independently by five expert hematopathologists according to the 2001 World Health Organization classification of NHL. A consensus diagnosis of NHL was reached in 195 of the 207 cases (94%). B-cell lymphomas constituted 88% of NHL, and diffuse large B-cell lymphoma (DLBCL, 38.5%) and follicular lymphoma (25.1%) were the most common subtypes. There was a high frequency of marginal zone B-cell lymphoma (10.3%), as well as of extranodal natural killer (NK)/T-cell lymphoma, nasal type (2.6%) and adult T-cell leukemia/lymphoma (0.5%). Extranodal presentation was seen in 74 of the 195 cases (38%) and the most common extranodal presentation was in the stomach (37.6%). The most common gastric lymphoma was DLBCL (54.5%) followed by mucosa-associated lymphoid tissue (MALT) lymphoma (41%). Overall, the frequency of NHL subtypes in Chile is between that reported in Western and Eastern countries, which is probably a reflection of the admixture of ethnicities as well as the environment and socioeconomic status of its population.
    Leukemia & lymphoma 01/2012; 53(7):1311-7. DOI:10.3109/10428194.2012.654471 · 2.89 Impact Factor
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    ABSTRACT: Lymphomas may involve the breast either primary or secondary and in both conditions, the same types of lymphomas are observed. Unilateral localisation is the most frequent. The occurrence in males is exceptional. The majority of lymphomas are of B-cell type. NK/T cell lymphomas remain very rare in the western countries. The most frequent type is represented by diffuse large B-cell lymphoma, which present, when primary, a peculiar type of relapse in the central nervous system. Among small B-cell lymphomas, which occur less frequently, follicular lymphoma and marginal zone lymphoma, MALT type predominate. A very few number of the last type may be associated with amyloidosis. During the last decade, a peculiar type of primary breast lymphoma, presenting as a large anaplastic T-cell lymphoma, ALK negative, has been described, developing in direct contact with a silicon implant, surrounded by chronic inflammatory reaction and often accumulation of liquid called ‘seroma’. Only limited surgery should be done in all type of lymphomas. The treatment is based on chemotherapy and immunotherapy, with central nervous system prophylaxis in cases of primary diffuse large B-cell lymphoma.
    Revue Francophone des Laboratoires 01/2012; 2012(438):79–84. DOI:10.1016/S1773-035X(12)71257-1

  • Histopathology 11/2011; 59(5):1027-9. DOI:10.1111/j.1365-2559.2011.03982.x · 3.45 Impact Factor
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    ABSTRACT: The aim of this study is to report the relative frequencies of non-Hodgkin lymphoma (NHL) subtypes in Guatemala. A panel of five hematopathologists reviewed 226 consecutive biopsies and classified them according to the 2001 World Health Organization (WHO) classification. The 83 cases of diffuse large B-cell lymphoma (DLBCL) were further subclassified into germinal center B-cell-like (GCB) and non-GCB subtypes. Of the 226 cases, 194 (86%) were confirmed as NHL, including 169 (87%) B-cell and 25 (13%) T- or natural killer (NK)-cell NHL. The most common subtype was DLBCL (44.3%), and the most frequent subtype among T- and NK-cell NHL was extranodal NK/T-cell lymphoma, nasal type (7.8% of all NHL). A comparison of the frequencies of NHL subtypes between Guatemala and other parts of the world showed that Guatemala is most similar to the Middle East and Asia. However, there is no significant difference in the frequency of the DLBCL subtypes compared to North America and Europe.
    Leukemia & lymphoma 06/2011; 52(9):1681-8. DOI:10.3109/10428194.2011.584254 · 2.89 Impact Factor
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    ABSTRACT: Diffuse large B-cell Lymphoma (DLBCL) constitutes the most frequent type of adult lymphoma. However, this lymphoma is heterogeneous, clinically, morphologically, phenotypically and molecularly. Among this heterogeneity, few clinicopathological entities are recognized by the 2008 WHO Classification and should be recognized by the pathologist taking into account the whole clinical, biological and pathological parameters. Once these entities being eliminated, the pathologist is facing the group DLBCL “NOS” (Not Otherwise specified”). Inside this large group, also heterogeneous, the pathologist should recognize the immunohistochemical and even better the molecular subtype. Even if today, there is no direct clinical application, some targeted therapies are used in phase I, II trials toward some recognized molecular subgroups. Immunohistochemistry, FISH, quantitative PCR, DNA sequencing performed from paraffin embedded tissue will allow in the near future to better recognize these subgroups and the oncogenic pathways for each case.
    Revue Francophone des Laboratoires 01/2011; 2011(428):57-64. DOI:10.1016/S1773-035X(11)70862-0
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    ABSTRACT: The diagnosis of myelodysplastic syndromes (MDS) is mostly based on clinical information, cytology, biology (particularly cytogenetics). However, bone marrow biopsy (BMB) brings useful information for the diagnosis and for the assessment of prognosis, in various entities. For ex. BMB allows to recognize hypoplastic type of MDS and MDS with fibrosis. BMB is particularly useful in the appreciation of the presence of blast cells and their quantification, allowing the diagnosis of refractory anaemia with excess of blasts and the identification of transformation in acute myeloid leukaemia, particularly in MDS with hypoplasia and MDS with fibrosis. BMB plays also an important role in differential diagnosis with diverse benign or malignant hemopathies.
    Revue Francophone des Laboratoires 01/2011; 2011(428):65-72. DOI:10.1016/S1773-035X(11)70863-2
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    Revue Francophone des Laboratoires 01/2011; 2011(428):77–78. DOI:10.1016/S1773-035X(11)70865-6
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    ABSTRACT: Fifty-five consecutive cases of Hodgkin’s lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein–Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed–Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.
    06/2010; 3(1). DOI:10.1007/s12308-010-0059-3

  • Histopathology 03/2010; 56(4):548-51. DOI:10.1111/j.1365-2559.2010.03498.x · 3.45 Impact Factor
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    ABSTRACT: Lymphoid clonality detection using PCR is becoming crucial in rare cases of lymphoid lesions difficult to interprete at the histo- and immunohistopathogical level. European Concerted Action “BIOMED-2” developed highly efficient PCR protocols as well as standardized methods and reagents involving 47 european Laboratories. However, it is important that these test results are interpreted with the full knowledge of the limits of these techniques. Therefore, close cooperation between clinician, pathologist, haematologist and molecularist are important to optimize the diagnostic and to further adapt the treatment.
    Revue Francophone des Laboratoires 01/2010; 2010(418):47-50. DOI:10.1016/S1773-035X(10)70345-2
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    ABSTRACT: PCR has been shown previously to be the most sensitive technique to detect a clonal population in marrow aspirates (MAs), and the clinical standard for evaluation of bone marrow lymphoma involvement today is bone marrow trephine biopsy (BMTB). The goal of this study was to compare morphological evaluation of B cell neoplasm in BMTB (histology and immunohistochemistry) and PCR analysis in MA, with both specimens obtained at the same time, in patients with a known molecular marker of the disease. This was a retrospective evaluation of 98 consecutive BMTB specimens from 60 patients with a known B-cell neoplasm and a previous PCR marker of the disease (BCL2 and/or IGH). Considering the IGH PCR cases alone, a B cell clone was detected in 85% and 39% of the morphology (M) positive and negative groups, respectively. Five M(+), IGH(-) cases were found, including two cases of follicular lymphoma (FL), one case of diffuse large B cell lymphoma, and two cases of mantle cell lymphoma. The FLs had about 20% and 50% of BMTB involvement each. All other cases had minimal lymphoma localisation. The two FLs were also BCL2-MBR(+). Use of BCL2-MBR detected all M(+) cases and 66% of M(-) cases whenever it was an initial marker of disease. IGH PCR alone is not good enough for BMTB assessment, especially in FL. On the other hand, the PCR study for BCL2 is more sensitive than morphology, without any false negative results in this series, suggesting that BCL2-MBR PCR on MA can be used as an alternative and more sensitive examination for disease evaluation, providing that there is careful analysis of data, adequate knowledge of PCR pitfalls and absence of other haematological disorders.
    Journal of clinical pathology 05/2009; 62(4):357-60. DOI:10.1136/jcp.2008.061622 · 2.92 Impact Factor

Publication Stats

9k Citations
707.83 Total Impact Points


  • 2015
    • Paris Diderot University
      Lutetia Parisorum, Île-de-France, France
  • 2009-2013
    • Université René Descartes - Paris 5
      • Faculté de Médecine
      Lutetia Parisorum, Île-de-France, France
  • 1974-2013
    • Hôtel-Dieu de Paris – Hôpitaux universitaires Paris Centre
      Lutetia Parisorum, Île-de-France, France
  • 2010
    • Hotel Dieu Hospital
      Kingston, Ontario, Canada
  • 1999
    • University of Southern California
      • Division of Hematology
      Los Angeles, California, United States
  • 1995
    • University of Grenoble
      Grenoble, Rhône-Alpes, France
  • 1993
    • Hôpital Henri Mondor (Hôpitaux Universitaires Henri Mondor)
      • Département de Pathologie
      Créteil, Ile-de-France, France
  • 1991
    • Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
      Lutetia Parisorum, Île-de-France, France
  • 1989
    • Centre Hospitalier Universitaire d'Angers
      Angers, Pays de la Loire, France
    • University of Pécs
      Fuenfkirchen, Baranya county, Hungary