Hong Li

Guangzhou University of Traditional Chinese Medicine, Shengcheng, Guangdong, China

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Publications (2)0 Total impact

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    ABSTRACT: To explore the changes of protein expression of IKK-alpha as well as the effects of Kuijieling Decoction (KD) on colonic mucosa of ulcerative colitis (UC) model rats. UC model rats were induced by TNBS. The rats were randomly divided into six groups: normal control (NC) group, model control (MC) group, Kuijieling low dose (KLD), middle dose (KMD) group, high dose (KHD) group and SASP group. After 10-days' treatment the rats were killed to get their colonic tissues. The positive rate of IKK-alpha expression was detected by immunohistochemical (IHC). The positive rate of IKK-alpha in MC group was significantly higher than that in NC group (P < 0.01). The positive rate of IKK-alpha in KMD group was significantly lower than that in MC group (P < 0.05). The positive rate of IKK-alpha in KHD and SASP group were significantly lower than that in MC group (P < 0.01). IKK-alpha may be involved in the pathogenesis of UC, and KD can inhibit positive rate of IKK-alpha in colonic mucosa of UC model rats induced by TNBS. The inhibitory effects of KD on UC may be associated with this.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 07/2008; 31(7):1016-8.
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    ABSTRACT: To investigate the effect of Kuijieling Decoction (KD) on gene expression of Toll-like receptor (TLR) 2,4 in colonic mucosa of ulcerative colitis( UC) rats. 48 rats were divided into six groups as follows: normal control (NC) group, model control (MC) group, Kuijieling low dose (KLD) group, Kuijieling medium dose (KMD) group, Kuijieling high dose (KHD) group and SASP group. TLR2/4 gene expression in colonic mucosa was measured by reverse-transcription polymerase chain reaction (RT-PCR). Relative gene expression of TLR2/4 in MC group were significantly higher than that in NC group (P < 0.01). Relative gene expression of TLR2 in KMD and KHD group was significantly lower than that in MC group (P < 0.05). Relative gene expression of TLR4 in KHD group was significantly lower than that in MC group (P < 0.05). Up-regulation of TLR2 and TLR4 gene expression can be seen in colonic mucosa of UC rats. KD can inhibit the gene expression of TLR2 and TLR4. The inhibitory effects of KD on UC may be associated with the inhibition of TLR2 and TLR4 gene expression.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 02/2007; 30(1):56-9.

Institutions

  • 2007
    • Guangzhou University of Traditional Chinese Medicine
      Shengcheng, Guangdong, China