-
[show abstract]
[hide abstract]
ABSTRACT: To determine cellular viability of lung parenchyma and neoplastic cells in areas of ground-glass opacity (GGO) on computed tomography (CT) images immediately after pulmonary radiofrequency ablation (RFA) in rabbits.
A LeVeen RFA electrode was placed percutaneously into rabbit lungs with or without metastatic VX2 tumors. Five minutes later, seven isolated lungs were imaged by use of a multi-detector row CT scanner, and the images were compared with histological features. The cellular viability of the lung tissues was assessed by nicotinamide adenine dinucleotide hydrogen (NADH) staining in eight normal lungs and in three lungs with multiple metastatic tumors.
All lung lesions appeared as bilayered structures with a central, dense, attenuated area and an outer area of GGO on CT images, and as three-layered structures on macroscopic and microscopic images 5 min after RFA. The GGO areas approximately corresponded to the outer two layers in macroscopic images that were exudative and congestive on microscopic images. Staining for NADH was significantly reduced in the GGO and densely attenuated areas with or without tumor tissue staining compared with the non-ablated area.
Our results suggest that an area of GGO that appears on CT immediately after RFA can be effectively treated by RFA.
Japanese journal of radiology 02/2012; 30(4):323-30. · 0.65 Impact Factor
-
Shigeki Nagamachi,
Hideyuki Wakamatsu,
Shogo Kiyohara,
Ryuichi Nishii,
Youichi Mizutani,
Seigo Fujita,
Shigemi Futami,
Hideo Arita,
Masaomi Kuroki, Hiroshi Nakada,
Noriko Uchino,
Shozo Tamura,
Keiichi Kawai
[show abstract]
[hide abstract]
ABSTRACT: The first aim of this study was to compare the detectability of metastasis of postoperative differentiated thyroid cancer (DTC) among (131)I whole body scintigraphy (IWBS), fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), and diffusion-weighted magnetic resonance imaging (DWI). The second aim was to clarify the association between the image pattern and prognosis.
We evaluated 70 postoperative DTC patients on both a patient basis and an organ basis (lymph nodes, lung, bone), and we analyzed the correlation between the image pattern and the prognosis.
For the patient-basis analysis, the detectability by IWBS, PET/CT, and DWI was 67.1%, 84.2%, and 57.6%, respectively. IWBS provided complementary information to that provided by PET/CT in 11 of 70 (15.7%) cases. For the organ-basis analysis, IWBS was the best detector for lymph node metastasis (72.4%). PET/CT was superior to IWBS for detecting metastasis of bone (85.7% vs. 71.4%) and lung (94.1% vs. 62.7%). For the correlation analysis, PET and DWI positivity were the factors predicting a poor prognosis.
PET/CT was the best modality for detecting metastases in postoperative DTC patients, although IWBS provided complementary information. Because PET/CT and DWI gave similar information (e.g., positivity) suggesting poor prognoses, the combination of IWBS and DWI might be the method of choice for monitoring postoperative DTC.
Japanese journal of radiology 07/2011; 29(6):413-22. · 0.65 Impact Factor
-
Seigo Fujita,
Shigeki Nagamachi,
Ryuichi Nishii,
Shigemi Futami, Hiroshi Nakada,
Masaomi Kuroki,
Seiji Ono,
Shozo Tamura,
Yasunori Matsuzaki,
Toshio Onizuka,
Yujiro Asada,
Hiroaki Kataoka
[show abstract]
[hide abstract]
ABSTRACT: Predictivity of mediastinal lymph nodes metastasis of 201Tl SPECT were examined before operation in 113 patients with non-small cell lung cancer (69 adenocarcinoma, 31 squamous cell carcinoma, 10 large cell carcinoma, 2 bronchiolo-alveolar carcinoma, 1 neuroendocrine cell carcinoma). Patients were classified into two groups, with or without lymph nodes metastasis according to the pathological diagnosis. We calculated parameters of 201Tl SPECT early ratio, delayed ratio, retention index (RI) and maximal diameters. In addition, we calculated optimal cut-off value of RI to estimate the mediastinal lymph nodes metastasis. Mediastinal lymph nodes metastasis was confirmed pathologically in 62 patients. ER and DR did not show any statistical significance between two groups. Maximal diameters of primary tumor were also comparable between two groups. RI was significantly higher in mediastinal lymph node metastasis positive group compared to that in mediastinal lymph node metastasis negative group. The sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV) and accuracy (Acc) of 201Tl SPECT were 82.2%, 82.3%, 85.0%, 79.2% and 82.3%. These parameters were similar of higher than 72.6%, 82.4%, 83.3%, 71.2% and 77.0% of chest CT. The RI of 201Tl SPECT was useful tool for predicting lymph nodes metastasis in non-small cell lung cancer. The optimum cut-off value of RI in the prediction of mediastinal lymph nodes metastasis was 35%. We should take into account of upstaging in cases with higher RI (>35%).
Kaku igaku. The Japanese journal of nuclear medicine 02/2004; 41(1):1-7.
-
Seigo Fujita,
Shigeki Nagamachi,
Ryuichi Nishii,
Shigemi Futami, Hiroshi Nakada,
Masaomi Kuroki,
Seiji Ono,
Shozo Tamura,
Yasunori Matsuzaki,
Toshio Onizuka, [......],
Junichi Yamazaki,
Hiroshi Watabe,
Hidehiro Iida,
Keiichi Matsumoto,
Setsu Sakamoto,
Michio Senda,
Masayoshi Watanabe,
Naofumi Ishikawa,
Kunihiko Ito,
Koichi Ito
Annals of Nuclear Medicine 01/2004; 18(2):169-170. · 1.50 Impact Factor
