Hye Jin Kim

University of North Carolina at Chapel Hill, North Carolina, United States

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Publications (254)572.18 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Vibrio cholerae can cause severe diarrhea and dehydration leading to high mortality and morbidity. Current cholera vaccines are formulated with KVC. Although the innate immune responses following vaccination deeply influence the induction of adaptive immunity, the initial recognition of cholera vaccines by the host innate immune system is not well characterized. In this study, the ability of KVC to induce innate immune responses was investigated. Unlike typical Gram-negative bacteria stimulating TLR2 and TLR4, KVC activated TLR2 but hardly TLR4. However, purified V. cholerae LPS preferentially stimulated TLR4, although not as potently as LPS of other Gram-negative bacteria, implying that LPS is not a major immunostimulatory component of KVC. Instead, MPFs were similar to KVC in the capacity to activate TLR2, transcription factors, and cytokine expression. Furthermore, OmpU is an abundant membrane protein of V. cholerae and could interact with TLR2 for inducing cytokine expression. Notably, cholera vaccine-induced immune responses are impaired in TLR2(-/-) mice. Conclusively, TLR2 is essential for the immune responses to cholera vaccination, and OmpU is the major immunostimulatory component of cholera vaccines. © Society for Leukocyte Biology.
    Journal of leukocyte biology 06/2015; DOI:10.1189/jlb.4A1014-498R · 4.99 Impact Factor
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    ABSTRACT: Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision is considered the standard of care for patients with locally advanced adenocarcinoma of the middle/low rectum. The present study evaluated the feasibility of using modified FOLFOX6 regimen as an adjuvant treatment for high-risk patients with locally advanced rectal cancer (LARC) treated with neoadjuvant CRT. Forty patients with LARC (ypT3-4 or N+) treated with neoadjuvant CRT were enrolled at Kyungpook National University Medical Center (Daegu, Korea) between December 2011 and December 2012. All the patients underwent rectal surgery with curative intent 8 weeks after the end of the neoadjuvant treatment. Adjuvant chemotherapy using modified FOLFOX6 regimen was then delivered for 3 months. The treatments were generally well tolerated. Dose reduction was recorded in 11 of the 40 patients (27.5 %). The incidence of febrile neutropenia was 5 %, the incidence of grade 3 or 4 asthenia was 10 %, and the incidence of grade 3 gastrointestinal adverse events was 5 % during treatment. Treatment discontinuation caused by toxic effects or any other reasons was observed in six patients (15 %). The reasons for discontinuation were asthenia (n = 2, 5 %), diarrhea (n = 2, 5 %), acute renal failure (n = 1, 2.5 %), and relapse during chemotherapy (n = 1, 2.5 %). With a median follow-up duration of 18 months, six patients (15 %) relapsed and one patient (2.5 %) died of disease progression. The estimated 3-year disease-free survival and overall survival rates were 84.2 and 97.3 %, respectively. Postoperative adjuvant modified FOLFOX6 regimen was found to be feasible for patients with LARC treated with neoadjuvant CRT.
    Cancer Chemotherapy and Pharmacology 05/2015; DOI:10.1007/s00280-015-2764-1 · 2.57 Impact Factor
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    ABSTRACT: In the seventh TNM classification, stage IIIA includes tumors with early stage of bowel wall invasion and regional lymph node metastasis. We investigated the validity of the current TNM classification of patients with stage IIIA colorectal cancer and identified prognostic factors of them for ameliorating treatment strategies for them. This study included the participation of four tertiary hospitals. A total of 4,236 patients with Stages I-IIIB colorectal cancer were analyzed. The primary end point was the 5-year relapse-free survival. The 5-year relapse-free survival of patients with stage IIIA disease was similar to that of patients with stage IIA. The 5-year relapse-free survival was 88.9% in the chemotherapy group (n = 152) and 82.3% in the no-chemotherapy group (n = 36, P = 0.111). Tumor differentiation (moderate or poor) and venous invasion were independent prognostic factors of relapse-free survival. The relapse-free survival of patients with stage IIIA tumors was similar to that of patients with stage IIA tumors, and the prognosis of stage IIIA tumors varied significantly by the tumor factors identified. These factors can be used to predict the risk of disease recurrence and to optimize the use of adjuvant chemotherapy. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Journal of Surgical Oncology 04/2015; 111(7). DOI:10.1002/jso.23892 · 2.84 Impact Factor
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    ABSTRACT: Noninvasive imaging has become the standard for hepatocellular carcinoma (HCC) diagnosis in cirrhotic livers. In this review paper, we go over the basics of MR imaging in cirrhotic livers and describe the imaging appearance of a spectrum of hepatic nodules marking the progression from regenerative nodules to low- and high-grade dysplastic nodules, and ultimately to HCCs. We detail and illustrate the typical imaging appearances of different types of HCC including focal, multi-focal, massive, diffuse/infiltrative, and intra-hepatic metastases; with emphasis on the diagnostic value of MR in imaging these lesions. We also shed some light on liver imaging reporting and data system, and the role of different magnetic resonance imaging (MRI) contrast agents and future MRI techniques including the use of advanced MR pulse sequences and utilization of hepatocyte-specific MRI contrast agents, and how they might contribute to improving the diagnostic performance of MRI in early stage HCC diagnosis.
    03/2015; 7(3):468-87. DOI:10.4254/wjh.v7.i3.468
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    ABSTRACT: This study was aimed at assessing left ventricular torsion (LVtor) mechanics using speckle tracking echocardiography (STE), establishing normal reference values of principal LVtor parameters, and analyzing the age-related changes in normal children. Eighty children (aged 3 months to 15 years) with normal cardiac function and rhythm were recruited. LVtor parameters including rotations, twist and untwist, torsion, and their rate indices were measured using STE. Age and heart rate related changes of the parameters were analyzed. Speckle tracking echocardiography analyses for LVtor parameters had excellent reliability in 64 of 80 subjects (80%) (intraclass correlation coefficients; 0.93-0.97). Early systolic twist (EST) motions (-8.4--0.1°) were observed in all subjects during an early 20±7% of systolic time intervals. The peak systolic twist and torsion were 17.0±6.5° and 2.9±1.3°/cm, respectively. The peak twist velocity was recorded at 51±13% of systolic time and the peak untwist velocity at 13.8±11.5% of diastolic time intervals. Multivariate analysis showed that heart rate change was an independent predictor of changes in torsion parameters; significantly decreasing LV length-normalized apical and basal rotation, torsion, and twist and untwist rate with increasing age. Isovolumetric recoil rate was independent of change in age and heart rate. Left ventricle showed unique torsion mechanics in children with EST, torsion, and untwists. Heart rate was an independent predictor of the change in torsion parameters with aging.
    Korean Circulation Journal 03/2015; 45(2):131-40. DOI:10.4070/kcj.2015.45.2.131
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    ABSTRACT: The sweet potato is an important industrial crop and a source of food that contains useful dietary fiber and vitamins. Recently, orange- and purple-fleshed varieties have come under the spotlight due to their healthful components, carotenoids and anthocyanins, respectively. In this study, an HPLC-DAD method was applied to determine the carotenoid composition and content in nine Korean cultural varieties of sweet potato. Changes in carotenoid contents and composition were also observed during home-processing of an orange-fleshed cultivar with high carotenoid content (530 ± 60 μg/g of dry weight, DW as all-trans-β-carotene). A loss of the carotenoids was observed for all of the home-processing methods examined; the baked or boiled or steamed sweet potatoes had higher amounts of all-trans-β-carotene (246 ± 34, 253 ± 29 and 240 ± 21 μg/g DW, respectively) than pressure-cooked, sautéed and fried ones (194 ± 21, 201 ± 28 and 111 ± 19 μg/g DW, respectively). Interestingly, cis-isomer of the all-trans-β-carotene, 13Z-β-carotene was found in elevated amounts in all of the processed samples, particularly in baked, pressure-cooked and steamed sweet potatoes compared to control. Variations in anthocyanin content in the nine cultural varieties and home-processed sweet potatoes were also determined by an HPLC-DAD method.
    Journal of Food Composition and Analysis 02/2015; 41. DOI:10.1016/j.jfca.2015.01.012 · 2.26 Impact Factor
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    ABSTRACT: Objectives: The clinical significance of aquaporin-1 (AQP1), aquaporin-3 (AQP3), and aquaporin-5 (AQP5) expression was analyzed in a large number of patients with colon cancer. Methods: AQP1, AQP3, and AQP5 expression was investigated based on the immunohistochemistry of tissue microarray specimens from 486 colon cancer patients who underwent curative surgery. Scores were given to the staining intensity and percentage of positive cells, and the staining score was defined as the sum of these scores then used to categorize the AQP expression as negative, weakly AQP-positive, or strongly AQP-positive. Results: A total of 298 (61.3%) patients were identified as strongly AQP1-positive (staining score ≥6), while 38 (7.8%) were strongly AQP3-positive and 145 (29.8%) were strongly AQP5-positive. The overexpression of AQP1, AQP3, and AQP5 was significantly correlated with lymph node metastasis in a multivariate logistic analysis (AQP1, p = 0.026; AQP3, p = 0.023; AQP5, p = 0.003). While the multivariate survival analysis, which included age, histology, TNM stage, and CEA level showed that the expression of AQP1, AQP3, and AQP5 had no effect on the overall survival and disease-free survival. Conclusions: The current study found a significant correlation between AQP1, AQP3, and AQP5 expression and lymph node metastasis in patients with surgically resected colon cancer. © 2015 S. Karger AG, Basel.
    Oncology 02/2015; 88(6). DOI:10.1159/000369073 · 2.61 Impact Factor
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    ABSTRACT: Rapid and efficient identification of the geographical origin of Angelica gigas roots (dang-gui) was performed using DART–TOF–MS (direct analysis in real time–time of flight–mass spectrometry) based metabolomics. As an ambient desorption/ionization technique, DART–TOF–MS can provide soft ionization and rapid analysis of samples with little sample preparation so it has been advantageously applied to high-throughput metabolomics analysis. In order to develop an efficient tool for discriminating, particularly geographical origin of raw herbal medicine, we employed DART–TOF–MS fingerprinting on dang-gui from Korean and Chinese markets. Principal component analysis of DART–TOF–MS fingerprints gave distinctive clustering information among two species of A. gigas and A. sinensis so that we used only A. gigas species for the sequential experiment. Orthogonal projections to latent structures-discriminant analysis of A. gigas samples revealed the separation between samples cultivated in two countries. Major discriminating components were elucidated as decursin/decursinol angelate, unidentified molecular ion of m/z 247 (protonated ions of molecular formula of C14H14O4) and another molecular ion of m/z 432. DART–TOF–MS based chemical fingerprinting with the multivariate analysis of dang-gui was shown to be efficient and accurate way to identify its geographical origin, between Korea and China.
    Metabolomics 02/2015; 11(1). DOI:10.1007/s11306-014-0671-9 · 3.97 Impact Factor
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    ABSTRACT: Opioid-based intravenous patient-controlled analgesia (IV-PCA) is a popular method of postoperative analgesia, but many patients suffer from PCA-related complications. We hypothesized that PCA was not essential in patients undergoing major abdominal surgery by minimal invasive approach. Between February 2013 and August 2013, 297 patients undergoing laparoscopic surgery for colorectal cancer were included in this retrospective comparative study. The PCA group received conventional opioid-based PCA postoperatively, and the non-PCA group received intravenous anti-inflammatory drugs (Tramadol) as necessary. Patients reported their postoperative pain using a subjective visual analogue scale (VAS). The PCA-related adverse effects and frequency of rescue analgesia were evaluated, and the recovery rates were measured. Patients in the PCA group experienced less postoperative pain on days 4 and 5 after surgery than those in the non-PCA group (mean [SD] VAS: day 4, 6.2 [0.3] vs. 7.0 [0.3], P = 0.010; and day 5, 5.1 [0.2] vs. 5.5 [0.2], P = 0.030, respectively). Fewer patients in the non-PCA group required additional parenteral analgesia (41 of 93 patients vs. 53 of 75 patients, respectively), and none in the non-PCA group required rescue PCA postoperatively. The incidence of postoperative nausea and vomiting was significantly higher in the non-PCA group than in the PCA group (P < 0.001). The mean (range) length of hospital stay was shorter in the non-PCA group (7.9 [6-10] days vs. 8.7 [7-16] days, respectively, P = 0.03). Our Results suggest that IV-PCA may not be necessary in selected patients those who underwent minimal invasive surgery for colorectal cancer.
    02/2015; 88(2):86-91. DOI:10.4174/astr.2015.88.2.86
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    ABSTRACT: Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Epithelial-mesenchymal transition is related to self-renewal capacity and circulating tumor cell (CTC) characteristics for tumor metastasis. Although tumor metastasis as a life-threatening complicated process occurs through circulation of tumor cells, mechanistic aspects of self-renewal and circulating capacities have been largely unknown. Hepatic TM4SF5 promotes EMT for malignant growth and migration, so that it was rationalized TM4SF5 as a hepatocellular carcinoma (HCC) biomarker might be important for metastatic potentials throughout metastasis. Here, self-renewal capacity by TM4SF5 was mechanistically explored using hepatocarcinoma cells with or without TM4SF5 expression, and explored whether they became CTCs using mouse liver-orthotopic model systems. We found that TM4SF5-dependent sphere growth correlated with CD24-, ALDH activity, and a physical association between CD44 and TM4SF5. The interaction between TM4SF5 and CD44 was through their extracellular domains with N-glycosylation modifications. The TM4SF5/CD44 interaction activated c-Src/STAT3/Twist1/Bmi1 signaling for spheroid formation, while disturbing the interaction, expression, or activity of any component in this signaling pathway inhibited the spheroid formation. In serial xenografts using 200 ∼ 5000 cells per injection, TM4SF5-positive tumors exhibited subpopulations with locally-increased CD44 expressions, supporting for tumor cell differentiation. TM4SF5-positive, but not TM4SF5- or CD44-knocked-down, cells were identified circulating in blood 4 to 6 weeks after orthotopic liver-injection using an in vivo laser scanning endomicroscopy. Anti-TM4SF5 reagent blocked their metastasis to distal intestinal organs. Conclusion: Altogether, our results evidence that TM4SF5 promotes self-renewal and CTC properties supported by TM4SF5+/CD44+(TM4SF5-bound)/ALDH+/CD24- markers, during HCC metastasis. This article is protected by copyright. All rights reserved.
    Hepatology 01/2015; 61(6):1978–1997. · 11.19 Impact Factor
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    Gyu Jin Heo, Hye Jin Kim, Jeong Im Hong
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    ABSTRACT: In the present study, we aimed to compare the results from nutritional risk screening based on nursing records with those using the Catholic Medical Center Nutritional Risk Screening (CMCNRS) tool. A cross-sectional study was performed involving 91 patients aged ≥ 18 years from an intensive care unit. We collected general characteristics of the patients and nutrition screening was conducted for each patient by using computerized hospital program for the nursing records as well as the CMCNRS conducted by clinical dietitians. The subjects were aged 64.0 ± 17.5 years, and 52 (57.1%) patients had a NPO (nothing by mouth) status. Neurological disease was the most common diagnosis (25.3%). Compared with the CMCNRS results from the clinical dietitians, the results for the nursing records had a sensitivity of 40.5% (95% CI 32.0-40.5) and a specificity of 100.0% (95% CI 92.8-100.0). The agreement was fair between the CMCNRS results obtained by clinical dietitians and the nursing records (k = 0.423). Analysis of the errors from the screening using the nursing records revealed significant differences for all subjective indicators (p < 0.001), compared with the CMCNRS by the clinical dietitians. Thus, after assessing the methods used for nutrition screening and the differences in the search results regarding malnourished status, we noted that the nursing records had a lower sensitivity than the screening by the CMCNRS.
    01/2015; 4(1):56. DOI:10.7762/cnr.2015.4.1.56
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    ABSTRACT: Angiogenesis, the process of new blood vessel formation, has been a major target for cancer therapy. Antiangiogenic herbal medicines are useful in the treatment of cancer. In this study, we found that a water extract of Cinnamomum cassia (CCWE) was a potent inhibitor of angiogenesis. In cultured human umbilical vein endothelial cells, CCWE suppressed vascular endothelial growth factor (VEGF)-induced proliferation, migration, invasion, tube formation, and intracellular signaling events such as phosphorylation of ERK, p38 and VEGFR2, and activation of matrix metalloproteinase. Furthermore, CCWE inhibited VEGF-induced vessel sprouting of rat aorta ex vivo. These findings might be of particular interest for drug development because VEGF signaling is a potential target for treatment of angiogenesis-associated diseases.
    Bioscience Biotechnology and Biochemistry 01/2015; 79(4):1-8. DOI:10.1080/09168451.2014.993917 · 1.21 Impact Factor
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    ABSTRACT: There is a fair amount of evidence indicating that increased risk of obesity and insulin resistance is associated with postmenopausal state, but can be modulated by diet and exercise. In this study, we explored whether a Pueraria lobata root-based supplement containing Rehmannia glutinosa (PR) and/or aerobic treadmill exercise can modify the metabolic changes associated with estrogen deficiency.
    01/2015; 48(2):133. DOI:10.4163/jnh.2015.48.2.133
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    ABSTRACT: Nerve-preserving surgery has been provided for patients with rectal cancer; however, sexual dysfunction remains a common complication of rectal cancer surgery. This study explored the efficacy of udenafil to treat erectile dysfunction in male patients who underwent total mesorectal excision (TME) for rectal cancer. We conducted a randomized, double-blind, placebo-controlled clinical trial involving 80 male patients who had decreased International Index of Erectile Function-5 (IIEF-5) scores after TME for rectal cancer. Patients received placebo (50 mg) or udenafil (50 mg) for 12 weeks. The primary outcome variable was the change in IIEF-5 scores. The secondary outcome variables were Sexual Encounter Profile (SEP) questions 2 (Q2) and 3 (Q3), and the Global Assessment Question (GAQ). Baseline IIEF-5 scores, SEP Q2 and Q3 responses, and spontaneous erection rates were consistent in both groups. At the end of treatment, the change in IIEF-5 scores from the baseline was significantly higher in the udenafil group than it was in the placebo group (mean IIEF-5 score, 4.8 ± 4.0 vs 2.0 ± 1.7; P < .05). Responses to SEP Q2, SEP Q3, and GAQ were significantly higher in the udenafil group than they were in the placebo group (SEP Q2, P = .025; SEP Q3, P = .044; GAQ, P < .001). Treatment-related adverse events (n = 4) were all mild in severity. Oral udenafil was deemed safe and effective for the treatment of erectile dysfunction in patients who underwent TME for rectal cancer. Copyright © 2015 Elsevier Inc. All rights reserved.
    Surgery 01/2015; 157(1):64-71. DOI:10.1016/j.surg.2014.07.007 · 3.11 Impact Factor
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    ABSTRACT: Cardiovascular complications are the leading cause of morbidity and mortality in childhood cancer survivors. Hematopoietic stem cell transplantation (HSCT) is a curable therapy for pediatric cancer. However, changes in cardiac function in children after HSCT are not well known. We assessed left ventricular (LV) function in children after HSCT using speckle tracking echocardiography (STE). Forty consecutive patients with median age of 11.9 years (range, 1.5-16 years) who received HSCT for acute leukemia and had comprehensive echocardiography before and after (median 9.2 month) HSCT were included in this study. The LV function parameters including conventional tissue Doppler imaging (TDI) and STE data were collected from pre- and post-HSCT echocardiography. These data were compared to those of 39 age-matched normal controls. Compared to normal controls, post HSCT patients had similar (p=0.06) LV ejection fraction. However, the following three LV function parameters were significantly decreased in post HSCT patients: rate-corrected velocity of circumferential fiber shortening (p=0.04), mitral inflow E velocity (p<0.001), and mitral septal annular E' velocity (p=0.03). The following four STE parameters were also significantly decreased in post HSCT patients: LV global circumferential systolic strain (p<0.01), strain rate (SR, p=0.01), circumferential diastolic SR (p<0.01), and longitudinal diastolic SR (p<0.001). There was no significant change in TDI or STE parameters after HSCT compared to pre-HSCT. Patients with anthracycline cumulative dose >400 mg/m(2) showed significantly (p<0.05) lower circumferential systolic strain and circumferential diastolic SR. Subclinical cardiac dysfunction is evident in children after HSCT. It might be associated with pre-HSCT anthracycline exposure with little effect of conditioning regimens. Serial monitoring of cardiac function is mandatory for all children following HSCT.
    Korean Circulation Journal 01/2015; 45(1):51-8. DOI:10.4070/kcj.2015.45.1.51
  • 12/2014; 20(4):209-220. DOI:10.15616/BSL.2014.20.4.209
  • 12/2014; 24(12):1345-1355. DOI:10.5352/JLS.2014.24.12.1345
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    ABSTRACT: Charcot–Marie–Tooth disease (CMT) is a group of clinically and genetically heterogeneous peripheral neuropathies. We identified two axonal CMT type 2F (CMT2F) families presented with distally predominant weakness in upper and lower extremities with sensory involvement. This study identified a c.404C>T (p.Ser135Phe) mutation in HSPB1 gene as the underlying cause of the both families by applying of whole exome sequencing. The p.Ser135Phe mutation was completely cosegregated with the affected members in the both families, and it was not found in 300 healthy controls. This mutation has been previously reported as the causes of CMT2F or hereditary motor neuropathy 2B (dHMN2B). The mutation was located in the highly conserved alpha-crystallin domain, and several in silico analyses also predicted that the mutation is likely to be pathogenic. HSPB1 encodes heat shock protein 27 (HSP27) which belongs to the superfamily of small stress induced proteins. These results suggest that the HSPB1 mutation is underlying cause of CMT2F phenotype shown in the present families. We believe that this study will be useful for the molecular diagnosis of peripheral neuropathies.
    Genes & genomics 12/2014; 37(3). DOI:10.1007/s13258-014-0259-9 · 0.57 Impact Factor
  • 11/2014; 24(11):1180-1186. DOI:10.5352/JLS.2014.24.11.1180
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    ABSTRACT: The objective of current study is to assess the relationship between characteristics of patients with acute ischemic stroke and clinical recurrences to identify predictors for the prognosis by modeling and simulation. Primary endpoint was clinical recurrence of ischemic stroke, and secondary endpoint was occurrence of any of the following clinical recurrence of ischemic stroke, transient ischemic attack, acute coronary syndrome, or vascular deaths. Time to event models were developed by NONMEM® using prospectively collected clinical data from 270 patients over 5 years, where 7.0% and 9.3% of them experienced lesion recurrence on MRI at 1 month (LR1M) and clinical recurrence, respectively. Exponential models best described the data. LR1M and diabetes mellitus history were significant predictors for primary endpoint. Times to recurrence for patients with LRIM(+) and diabetes mellitus (+) were predicted to be 0.095 and 0.317 of those for patients with LRIM (−) and diabetes mellitus (−), respectively. LR1M was only predictor for secondary endpoint with predicted time to recurrence in patients with LR1M(+) compared to 0.141 of LR1M(−). Quantitative prediction of clinical recurrence using MRI could improve personalized therapy by identifying patients at risk of recurrence, and could enable efficient clinical trials by stratifying the patients.
    The Journal of Clinical Pharmacology 11/2014; 55(4). DOI:10.1002/jcph.427 · 2.47 Impact Factor

Publication Stats

2k Citations
572.18 Total Impact Points

Institutions

  • 2015
    • University of North Carolina at Chapel Hill
      North Carolina, United States
  • 2011–2015
    • Gyeongsang National University
      • • Division of Applied Life Science
      • • Institute of Agriculture and Life Science
      Shinshū, Gyeongsangnam-do, South Korea
    • National Cancer Center Korea
      • Division of Cancer Biology
      Kōyō, Gyeonggi Province, South Korea
  • 2010–2015
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
  • 2009–2015
    • Kyung Hee University
      • • College of Pharmacy
      • • Oriental Pharmaceutical Science Division
      Sŏul, Seoul, South Korea
  • 2008–2015
    • Catholic University of Korea
      • • Department of Pediatrics
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • CHA University
      • College of Medicine
      Sŏul, Seoul, South Korea
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2007–2015
    • Yonsei University
      • • Division of Biological Science and Technology
      • • Department of Biochemistry
      • • Department of Biotechnology
      Sŏul, Seoul, South Korea
    • International Vaccine Institute
      Sŏul, Seoul, South Korea
  • 2005–2015
    • Ewha Womans University
      • • Department of Nutritional Science and Food Management
      • • College of Health Sciences
      • • College of Pharmacy
      Sŏul, Seoul, South Korea
    • University of Pittsburgh
      Pittsburgh, Pennsylvania, United States
    • Dong-A College
      Tsau-liang-hai, Busan, South Korea
  • 2004–2015
    • Seoul National University
      • • Department of Pharmacy
      • • Dental Research Institute
      • • Department of Internal Medicine
      • • Department of Food and Nutrition
      • • College of Veterinary Medicine
      Sŏul, Seoul, South Korea
  • 2003–2015
    • Kyungpook National University
      • • School of Medicine
      • • Department of Microbiology
      Daikyū, Daegu, South Korea
  • 2014
    • University of Oregon
      Eugene, Oregon, United States
    • Korea University
      • Department of Electrical Engineering
      Sŏul, Seoul, South Korea
    • Chungnam National University Hospital
      Sŏul, Seoul, South Korea
  • 2013–2014
    • Samsung Medical Center
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
    • Kongju National University
      Gongju, Chungcheongnam-do, South Korea
  • 2011–2014
    • Sookmyung Women's University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
  • 2005–2014
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2004–2014
    • University of Ulsan
      • • College of Medicine
      • • Department of Surgery
      Ulsan, Ulsan, South Korea
  • 2003–2014
    • Sungkyunkwan University
      • Institute of Basic Science
      Sŏul, Seoul, South Korea
  • 2010–2013
    • Asan Medical Center
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2009–2013
    • University of North Carolina at Charlotte
      • Department of Mechanical Engineering and Engineering Science
      Charlotte, North Carolina, United States
    • Korea Basic Science Institute KBSI
      • Busan Center
      Sŏul, Seoul, South Korea
  • 2012
    • Korea University of Science and Technology
      Sŏul, Seoul, South Korea
    • National Institute of Crop Science
      성남시, Gyeonggi-do, South Korea
    • Hanyang University
      • Department of Nursing
      Sŏul, Seoul, South Korea
    • Hankuk University of Foreign Studies
      • Department of Environmental Science
      Sŏul, Seoul, South Korea
    • Texas Tech University
      • Department of Community, Family, and Addiction Services
      Lubbock, Texas, United States
  • 2006–2012
    • Korea Advanced Institute of Science and Technology
      • • Department of Materials Science and Engineering
      • • Department of Biological Sciences
      Sŏul, Seoul, South Korea
  • 2008–2011
    • Seoul National University Hospital
      • • Department of Family Medicine
      • • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2004–2011
    • Chungnam National University
      • • Department of Microbiology
      • • School of Bioscience and Biotechnology
      • • College of Pharmacy
      Sŏngnam, Gyeonggi Province, South Korea
  • 2005–2009
    • Seoul Veterans Hospital
      Sŏul, Seoul, South Korea
  • 2002
    • Dong-A University
      • Department of Cardiology
      Tsau-liang-hai, Busan, South Korea
  • 1999–2002
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2001
    • Dong-Pusan College
      Tsau-liang-hai, Busan, South Korea
    • Korea Food and Drug Administration
      Seishō-gun, Gyeongsangbuk-do, South Korea