Hye Jin Kim

Columbia University, New York, New York, United States

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Publications (273)609.85 Total impact

  • Annals of Laboratory Medicine 01/2016; 36(1):15. DOI:10.3343/alm.2016.36.1.15 · 1.48 Impact Factor
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    ABSTRACT: Objective: Distal myopathy is a heterogeneous group of muscle diseases characterized by predominant distal muscle weakness. A study was done to identify the underlying cause of autosomal recessive adolescent-onset distal myopathy. Methods: Four patients from two unrelated Korean families were evaluated. To isolate the genetic cause, exome sequencing was performed. In vitro and in vivo assays using myoblast cells and zebrafish models were performed to examine the ADSSL1 mutation causing myopathy pathogenesis. Results: Patients had an adolescent-onset distal myopathy phenotype which included distal dominant weakness, facial muscle weakness, rimmed vacuole, and mild elevation of serum creatine kinase. Exome sequencing identified completely cosegregating compound heterozygous mutations (p.D304N and p.I350fs) in ADSSL1 which encodes a muscle-specific adenylosuccinate synthase in both families. None of the controls had both mutations, and the mutation sites were located in well conserved regions. Both the D304N and I350fs mutations in ADSSL1 led to decreased enzymatic activity. The knock-down of the adssl1 gene significantly inhibited the proliferation of mouse myoblast cells, and the addition of human wild-type ADSSL1 reversed the reduced viability. In an adssl1 knock-downed zebrafish model, muscle fibers were severely disrupted, which was evaluated by myosin expression and birefringence. In these conditions, supplementing wild-type ADSSL1 protein reversed the muscle defect. Interpretation: We suggest that mutations in ADSSL1 are the novel genetic cause of the autosomal recessive adolescent-onset distal myopathy. This study broadens the genetic and clinical spectrum of distal myopathy and will be useful for exact molecular diagnostics. This article is protected by copyright. All rights reserved.
    Annals of Neurology 10/2015; DOI:10.1002/ana.24550 · 9.98 Impact Factor
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    ABSTRACT: Objective: The goal of this study was to ascertain optimal assisted hatching (AH) method in frozen embryo transfer. We compared the effect of depending on whether mechanical or laser-AH was performed before or after the vitrification of embryo development rate and blastocyst cell numbers. Methods: In order to induce superovulation, pregnant mare's serum gonadotropin followed by human chorionic gonadotropin were injected into 4- to 5-week-old female mice. 2-cell embryos were then collected by flushing out the oviducts. The Expanded blastocysts were recovered after the collected embryos were incubated for 48 hours, and were then subjected to artificial shrinkage (AS) and cross-mechanical AH (cMAH) or quarter-laser zona thinning-AH (qLZT-AH) were carried out using the expanded blastocysts before or after vitrification. After 48 hours of incubation, followed by vitrification and thawing (V-T), and blastocysts were fluorescence stained and observed. Results: The rate of formation of hatched blastocysts after 24 and 72 hours of incubation was significantly higher in the AS/qLZT-AH/V-T group than in the other groups (p<0.05). The cell number of the inner cell mass was higher in AS/V-T/non-AH and AS/V-T/cMAH groups than those of others (p<0.05). In the control group, the number of trophectoderm and the total cell number were higher than in the AS-AH group (p<0.05). Conclusion: The above results suggest that AS and AH in vitrification of expanded blastocysts lead to the more efficient formation of hatched blastocysts in mice.
    Clinical and Experimental Reproductive Medicine 10/2015; 42(3):94-100. DOI:10.5653/cerm.2015.42.3.94
  • Ghilsuk Yoon · Sol-Min Kim · Hye Jin Kim · An Na Seo ·
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    ABSTRACT: We evaluated the clinical influence of cancer stem cells (CSCs) on residual disease after preoperative chemoradiotherapy (CRT) in patients with rectal cancer. The surgical specimens of 145 patients with residual rectal cancer after preoperative CRT were assessed. To identify CSCs, immunohistochemistry was performed using their surrogate makers (CD44 and aldehyde dehydrogenase 1 [ALDH1]) in full section tissues. Of the 145 cases, ALDH1 and CD44 positivity was found in 80.0 % (n = 116) and 47.6 % (n = 69), respectively; ALDH1 positivity showed weakly positive correlation with CD44 (r s = 0.269, P = 0.002). ALDH1 and CD44 positivity was related to lower tumor regression grade (TRG) (P = 0.009 and 0.003, respectively). Additionally, ALDH1 positivity was associated with positive circumferential resection margin (P = 0.019). However, ALDH1 and CD44 positivity showed no relationship with KRAS or BRAF mutation. In univariate analysis, ALDH1 positivity was associated with short recurrence-free survival (RFS) (P = 0.005) and rectal cancer-specific survival (RCSS) (P = 0.043), but not CD44 positivity (RFS, P = 0.725; RCSS, P = 0.280). In multivariate analysis, ALDH1 positivity was an independent prognostic factor for poor RFS (P = 0.039; hazard ratio = 2.997; 95 % confidence interval = 1.059-8.478), but not RCSS (P = 0.571). The expression of ALDH1 assessment independently predicts RFS in patients with residual disease after CRT. These results suggest that targeting CSCs could be an effective therapeutic approach to rectal cancer patients receiving preoperative CRT.
    Tumor Biology 10/2015; DOI:10.1007/s13277-015-4201-9 · 3.61 Impact Factor
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    ABSTRACT: Purpose: Recently, enzymes of the serine synthetic pathway (SSP) have been suggested as key player in the metabolic adaptation of oncogenesis. We assessed the expression of enzymes of the SSP in colonic tumor tissue (TT) and paired normal tissue (pNT) and the prognostic implications. Methods: From 2006 to 2010, we included 486 patients with colon cancer who underwent curative surgery at Kyungpook National University Hospital. Phosphoglycerate dehydrogenase (PHGDH), pyruvate dehydrogenase kinase (PDK) 1, PDK2, pyruvate kinase M2 (PKM2), and phosphoserine aminotransferase (PSAT) expression were investigated by immunohistochemical staining (IHC) in TT and pNT. The IHC values were calculated by multiplying intensity by proportion. The final score was classified as follows: 0-2 as negative and 3-12 as positive. Results: During the median follow-up duration of 55.5 months (37.4-90.6), 78 patients experienced recurrence. The expression of PHGDH, PDK1, and PSAT was significantly higher in TT than pNT (p < 0.001 for each). The univariate analysis for relapse-free survival revealed that TT PDK2 positivity was the only positive prognostic factor (p = 0.023). However, the expression of TT PDK2 did not represent a prognostic value in multivariate analysis. Conclusions: In conclusion, PHGDH, PDK1, and PSAT were significantly increased in colonic TT compared with pNT. The prognostic implication of these enzymes needs to be further investigated.
    Oncology 10/2015; 89(6). DOI:10.1159/000439571 · 2.42 Impact Factor
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    Zhao Liu · Keiko Ueda · Hye Jin Kim · Janet R Sparrow ·
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    ABSTRACT: The autofluorescence of the retina that originates primarily from lipofuscin fluorophores in retinal pigment epithelial cells, is observed to undergo photobleaching during the acquisition of fundus autofluorescence images. Bisretinoid fluorophores isolated from retinal pigment epithelial cells have the spectral characteristics consistent with their being the source of fundus autofluorescence. Clinically relevant experiments were designed to better understand conditions in the micromilieu of bisretinoid fluorophores that can influence fluorescence efficiencies, photobleaching, and subsequent fluorescence recovery of this fluorophore. The consumption of the bisretinoid A2E due to photooxidation-induced degradation was quantified in solvent systems of variable relative permittivity (formerly called dielectric constant), in micelles, and in phospholipid vesicles of varying composition. Reorganization within biphasic systems was also examined. A2E content was measured by high performance liquid chromatography (HPLC) and fluorescence intensity was quantified spectroscopically. As solvent polarity was increased, A2E fluorescent spectra exhibited red-shifted maxima and reduced intensity. A2E was depleted by light irradiation and the loss was more pronounced in less polar solvents, lower concentrations of anionic surfactant, and in gel- versus fluid-ordered phospholipid liposomes. Conditions that permit A2E aggregation promoted photooxidation/photodegradation, while movement of A2E between bisphasic systems was associated with fluorescence recovery after photobleaching. The fluorescence characteristics of A2E are subject to environmental modulation. Photooxidation and photodegradation of bisretinoid can account for fundus autofluorescence photobleaching. Return of fluorescence intensity after photobleaching likely occurs due to redistribution of A2E fractions amongst co-existing heterogeneous microdomains of the lysosomal compartment.
    PLoS ONE 09/2015; 10(9):e0138081. DOI:10.1371/journal.pone.0138081 · 3.23 Impact Factor
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    ABSTRACT: Charcot-Marie-Tooth disease type 4H (CMT4H) is an autosomal recessive demyelinating subtype of peripheral enuropathies caused by mutations in the FGD4 gene. Most CMT4H patients are in consanguineous Mediterranean families characterized by early onset and slow progression. We identified two CMT4H patients from a Korean CMT cohort, and performed a detailed genetic and clinical analysis in both cases. Both patients from nonconsanguineous families showed characteristic clinical manifestations of CMT4H including early onset, scoliosis, areflexia, and slow disease progression. Exome sequencing revealed novel compound heterozygous mutations in FGD4 as the underlying cause in both families (p.Arg468Gln and c.1512-2A>C in FC73, p.Met345Thr and c.2043+1G>A (p.Trp663Trpfs*30) in FC646). The missense mutations were located in highly conserved RhoGEF and PH domains which were predicted to be pathogenic in nature by in silico modeling. The CMT4H occurrence frequency was calculated to 0.7% in the Korean demyelinating CMT patients. This study is the first report of CMT4H in Korea. FGD4 assay could be considered as a means of molecular diagnosis for sporadic cases of demyelinating CMT with slow progression.
    Annals of Human Genetics 09/2015; 79(6). DOI:10.1111/ahg.12134 · 2.21 Impact Factor

  • Wonye kwahak kisulchi = Korean journal of horticultural science and technology / 08/2015; 33(4):585-590. DOI:10.7235/hort.2015.14058 · 0.34 Impact Factor

  • 08/2015; 18(3):179-188. DOI:10.7846/JKOSMEE.2015.18.3.179
  • Hye Jin Kim · Eun-Jung Lee · Sena Moon · Jae Young Lee · Jin Han Kang ·

    Pediatrics International 08/2015; 57(4):802-804. DOI:10.1111/ped.12735 · 0.73 Impact Factor
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    ABSTRACT: Chronic graft-versus-host disease (cGvHD) is the major source of late phase morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Humanized acute GvHD (aGvHD) in vivo models using NOD-SCID il2rγ-/- (NSG) mice are well described and are important tools for investigating pathogenicity of human cells in vivo. However, there have been only few reported humanized cGvHD mouse models. We evaluated if prolonged inflammation driven by low dose G-CSF-mobilized human PBMCs (G-hPBMCs) would lead to cGvHD following cyclophosphamide (CTX) administration and total body irradiation (TBI) in NSG mice. Engraftment was assessed in peripheral blood (PB) and in specific target organs by either flow cytometry or immunohistochemistry (IHC). Tissue samples were harvested 56 days post transplantation and were evaluated by a pathologist. Some mice were kept for up to 84 days to evaluate the degree of fibrosis. Mice that received CTX at 20mg/kg did not show aGvHD with stable expansion of human CD45+ CD3+ T-cells in PB (mean; 5.8 to 23.2%). The pathology and fibrosis scores in the lung and the liver were significantly increased with aggregation of T-cells and hCD68+ macrophages. There was a correlation between liver pathology score and the percentage of hCD68+ cells, suggesting the role of macrophage in fibrogenesis in NSG mice. In order to study long-term survival, 6/9 mice who survived more than 56 days showed increased fibrosis in the lung and liver at the endpoint, which suggests the infiltrating hCD68+ macrophages may be pathogenic. It was shown that the combination of CTX and TBI with a low number of G-hPBMCs (1x106) leads to chronic lung and liver inflammation driven by a high infiltration of human macrophage and mature human T cells from the graft, resulting in fibrosis of lung and liver in NSG mice. In conclusion this model may serve as an important pre-clinical model to further current understanding of the roles of human macrophages in cGvHD.
    PLoS ONE 07/2015; 10(7):e0133216. DOI:10.1371/journal.pone.0133216 · 3.23 Impact Factor

  • 06/2015; 6(1):38-41. DOI:10.17241/smr.2015.6.1.38
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    ABSTRACT: Vibrio cholerae can cause severe diarrhea and dehydration leading to high mortality and morbidity. Current cholera vaccines are formulated with KVC. Although the innate immune responses following vaccination deeply influence the induction of adaptive immunity, the initial recognition of cholera vaccines by the host innate immune system is not well characterized. In this study, the ability of KVC to induce innate immune responses was investigated. Unlike typical Gram-negative bacteria stimulating TLR2 and TLR4, KVC activated TLR2 but hardly TLR4. However, purified V. cholerae LPS preferentially stimulated TLR4, although not as potently as LPS of other Gram-negative bacteria, implying that LPS is not a major immunostimulatory component of KVC. Instead, MPFs were similar to KVC in the capacity to activate TLR2, transcription factors, and cytokine expression. Furthermore, OmpU is an abundant membrane protein of V. cholerae and could interact with TLR2 for inducing cytokine expression. Notably, cholera vaccine-induced immune responses are impaired in TLR2(-/-) mice. Conclusively, TLR2 is essential for the immune responses to cholera vaccination, and OmpU is the major immunostimulatory component of cholera vaccines. © Society for Leukocyte Biology.
    Journal of leukocyte biology 06/2015; 98(4). DOI:10.1189/jlb.4A1014-498R · 4.29 Impact Factor
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    ABSTRACT: Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision is considered the standard of care for patients with locally advanced adenocarcinoma of the middle/low rectum. The present study evaluated the feasibility of using modified FOLFOX6 regimen as an adjuvant treatment for high-risk patients with locally advanced rectal cancer (LARC) treated with neoadjuvant CRT. Forty patients with LARC (ypT3-4 or N+) treated with neoadjuvant CRT were enrolled at Kyungpook National University Medical Center (Daegu, Korea) between December 2011 and December 2012. All the patients underwent rectal surgery with curative intent 8 weeks after the end of the neoadjuvant treatment. Adjuvant chemotherapy using modified FOLFOX6 regimen was then delivered for 3 months. The treatments were generally well tolerated. Dose reduction was recorded in 11 of the 40 patients (27.5 %). The incidence of febrile neutropenia was 5 %, the incidence of grade 3 or 4 asthenia was 10 %, and the incidence of grade 3 gastrointestinal adverse events was 5 % during treatment. Treatment discontinuation caused by toxic effects or any other reasons was observed in six patients (15 %). The reasons for discontinuation were asthenia (n = 2, 5 %), diarrhea (n = 2, 5 %), acute renal failure (n = 1, 2.5 %), and relapse during chemotherapy (n = 1, 2.5 %). With a median follow-up duration of 18 months, six patients (15 %) relapsed and one patient (2.5 %) died of disease progression. The estimated 3-year disease-free survival and overall survival rates were 84.2 and 97.3 %, respectively. Postoperative adjuvant modified FOLFOX6 regimen was found to be feasible for patients with LARC treated with neoadjuvant CRT.
    Cancer Chemotherapy and Pharmacology 05/2015; 76(1). DOI:10.1007/s00280-015-2764-1 · 2.77 Impact Factor
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    ABSTRACT: In the seventh TNM classification, stage IIIA includes tumors with early stage of bowel wall invasion and regional lymph node metastasis. We investigated the validity of the current TNM classification of patients with stage IIIA colorectal cancer and identified prognostic factors of them for ameliorating treatment strategies for them. This study included the participation of four tertiary hospitals. A total of 4,236 patients with Stages I-IIIB colorectal cancer were analyzed. The primary end point was the 5-year relapse-free survival. The 5-year relapse-free survival of patients with stage IIIA disease was similar to that of patients with stage IIA. The 5-year relapse-free survival was 88.9% in the chemotherapy group (n = 152) and 82.3% in the no-chemotherapy group (n = 36, P = 0.111). Tumor differentiation (moderate or poor) and venous invasion were independent prognostic factors of relapse-free survival. The relapse-free survival of patients with stage IIIA tumors was similar to that of patients with stage IIA tumors, and the prognosis of stage IIIA tumors varied significantly by the tumor factors identified. These factors can be used to predict the risk of disease recurrence and to optimize the use of adjuvant chemotherapy. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Journal of Surgical Oncology 04/2015; 111(7). DOI:10.1002/jso.23892 · 3.24 Impact Factor
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    Sang A Oh · Hyang Mok Ok · Hye Jin Kim · Won Jun Lee · Oran Kwon ·
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    ABSTRACT: Purpose: There is a fair amount of evidence indicating that increased risk of obesity and insulin resistance is associated with postmenopausal state, but can be modulated by diet and exercise. In this study, we explored whether a Pueraria lobata root-based supplement containing Rehmannia glutinosa (PR) and/or aerobic treadmill exercise can modify the metabolic changes associated with estrogen deficiency. Methods: Seventy rats were randomly assigned to the following groups for 8 weeks (n=10 per group): SHAM, sham-operated; PR0, ovariectomized (OVX) control; PR200, OVX with PR200 mg/kg B.W; PR400, OVX with PR400 mg/kg B.W; EPR0, OVX with exercise; EPR200, OVX with exercise and PR200 mg/kg B.W; EPR400, OVX with exercise and PR400 mg/kg B.W. Results: OVX induced significant increases in body weight, food intake, fat mass, LDL-cholesterol, and fasting blood glucose, confirming induction of menopausal symptoms. PR supplementation or exercise significantly suppressed the above mentioned changes through different regulatory elements in adipose tissue: PR supplement upregulated adiponectin gene expression and aerobic exercise upregulated adiponectin and insulin receptor gene expression and a combination of PR supplement and aerobic exercise showed an additive effect on adiponectin gene expression. Conclusion: Taken together, the results of this study suggest that PR supplement has a potential to provide health benefits in OVX rats through leptin and adiponectin secretion. In addition, the data suggest that combination of exercise and PR would have additive effects on metabolic dysfunction associated with estrogen deficiency.
    Journal of Nutrition and Health 04/2015; 48(2):133. DOI:10.4163/jnh.2015.48.2.133
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    ABSTRACT: Noninvasive imaging has become the standard for hepatocellular carcinoma (HCC) diagnosis in cirrhotic livers. In this review paper, we go over the basics of MR imaging in cirrhotic livers and describe the imaging appearance of a spectrum of hepatic nodules marking the progression from regenerative nodules to low- and high-grade dysplastic nodules, and ultimately to HCCs. We detail and illustrate the typical imaging appearances of different types of HCC including focal, multi-focal, massive, diffuse/infiltrative, and intra-hepatic metastases; with emphasis on the diagnostic value of MR in imaging these lesions. We also shed some light on liver imaging reporting and data system, and the role of different magnetic resonance imaging (MRI) contrast agents and future MRI techniques including the use of advanced MR pulse sequences and utilization of hepatocyte-specific MRI contrast agents, and how they might contribute to improving the diagnostic performance of MRI in early stage HCC diagnosis.
    World Journal of Hepatology 03/2015; 7(3):468-87. DOI:10.4254/wjh.v7.i3.468
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    ABSTRACT: This study was aimed at assessing left ventricular torsion (LVtor) mechanics using speckle tracking echocardiography (STE), establishing normal reference values of principal LVtor parameters, and analyzing the age-related changes in normal children. Eighty children (aged 3 months to 15 years) with normal cardiac function and rhythm were recruited. LVtor parameters including rotations, twist and untwist, torsion, and their rate indices were measured using STE. Age and heart rate related changes of the parameters were analyzed. Speckle tracking echocardiography analyses for LVtor parameters had excellent reliability in 64 of 80 subjects (80%) (intraclass correlation coefficients; 0.93-0.97). Early systolic twist (EST) motions (-8.4--0.1°) were observed in all subjects during an early 20±7% of systolic time intervals. The peak systolic twist and torsion were 17.0±6.5° and 2.9±1.3°/cm, respectively. The peak twist velocity was recorded at 51±13% of systolic time and the peak untwist velocity at 13.8±11.5% of diastolic time intervals. Multivariate analysis showed that heart rate change was an independent predictor of changes in torsion parameters; significantly decreasing LV length-normalized apical and basal rotation, torsion, and twist and untwist rate with increasing age. Isovolumetric recoil rate was independent of change in age and heart rate. Left ventricle showed unique torsion mechanics in children with EST, torsion, and untwists. Heart rate was an independent predictor of the change in torsion parameters with aging.
    Korean Circulation Journal 03/2015; 45(2):131-40. DOI:10.4070/kcj.2015.45.2.131 · 0.75 Impact Factor
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    ABSTRACT: The sweet potato is an important industrial crop and a source of food that contains useful dietary fiber and vitamins. Recently, orange- and purple-fleshed varieties have come under the spotlight due to their healthful components, carotenoids and anthocyanins, respectively. In this study, an HPLC-DAD method was applied to determine the carotenoid composition and content in nine Korean cultural varieties of sweet potato. Changes in carotenoid contents and composition were also observed during home-processing of an orange-fleshed cultivar with high carotenoid content (530 ± 60 μg/g of dry weight, DW as all-trans-β-carotene). A loss of the carotenoids was observed for all of the home-processing methods examined; the baked or boiled or steamed sweet potatoes had higher amounts of all-trans-β-carotene (246 ± 34, 253 ± 29 and 240 ± 21 μg/g DW, respectively) than pressure-cooked, sautéed and fried ones (194 ± 21, 201 ± 28 and 111 ± 19 μg/g DW, respectively). Interestingly, cis-isomer of the all-trans-β-carotene, 13Z-β-carotene was found in elevated amounts in all of the processed samples, particularly in baked, pressure-cooked and steamed sweet potatoes compared to control. Variations in anthocyanin content in the nine cultural varieties and home-processed sweet potatoes were also determined by an HPLC-DAD method.
    Journal of Food Composition and Analysis 02/2015; 41. DOI:10.1016/j.jfca.2015.01.012 · 1.99 Impact Factor
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    ABSTRACT: Objectives: The clinical significance of aquaporin-1 (AQP1), aquaporin-3 (AQP3), and aquaporin-5 (AQP5) expression was analyzed in a large number of patients with colon cancer. Methods: AQP1, AQP3, and AQP5 expression was investigated based on the immunohistochemistry of tissue microarray specimens from 486 colon cancer patients who underwent curative surgery. Scores were given to the staining intensity and percentage of positive cells, and the staining score was defined as the sum of these scores then used to categorize the AQP expression as negative, weakly AQP-positive, or strongly AQP-positive. Results: A total of 298 (61.3%) patients were identified as strongly AQP1-positive (staining score ≥ 6), while 38 (7.8%) were strongly AQP3-positive and 145 (29.8%) were strongly AQP5-positive. The overexpression of AQP1, AQP3, and AQP5 was significantly correlated with lymph node metastasis in a multivariate logistic analysis (AQP1, p = 0.026; AQP3, p = 0.023; AQP5, p = 0.003). While the multivariate survival analysis, which included age, histology, TNM stage, and CEA level showed that the expression of AQP1, AQP3, and AQP5 had no effect on the overall survival and disease-free survival. Conclusions: The current study found a significant correlation between AQP1, AQP3, and AQP5 expression and lymph node metastasis in patients with surgically resected colon cancer.
    Oncology 02/2015; 88(6). DOI:10.1159/000369073 · 2.42 Impact Factor

Publication Stats

3k Citations
609.85 Total Impact Points


  • 2015
    • Columbia University
      New York, New York, United States
    • SickKids
      • Division of Hematology/Oncology
      Toronto, Ontario, Canada
    • University of North Carolina at Chapel Hill
      North Carolina, United States
  • 2011-2015
    • Gyeongsang National University
      • • Division of Applied Life Science
      • • Institute of Agriculture and Life Science
      Shinshū, Gyeongsangnam-do, South Korea
    • National Cancer Center Korea
      • Division of Cancer Biology
      Kōyō, Gyeonggi Province, South Korea
  • 2010-2015
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
  • 2009-2015
    • Kyung Hee University
      • • College of Pharmacy
      • • Oriental Pharmaceutical Science Division
      Sŏul, Seoul, South Korea
  • 2008-2015
    • Catholic University of Korea
      • • Department of Pediatrics
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2007-2015
    • Yonsei University
      • • Division of Biological Science and Technology
      • • Department of Biochemistry
      • • Department of Biotechnology
      Sŏul, Seoul, South Korea
    • International Vaccine Institute
      Sŏul, Seoul, South Korea
    • Pusan National University
      • College of Medicine
      Busan, Busan, South Korea
  • 2005-2015
    • Ewha Womans University
      • • Department of Nutritional Science and Food Management
      • • College of Health Sciences
      • • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Dong-A College
      Tsau-liang-hai, Busan, South Korea
    • University of Pittsburgh
      Pittsburgh, Pennsylvania, United States
    • Gwangju Institute of Science and Technology
      • Department of Life Sciences
      Gwangju, Gwangju, South Korea
  • 2003-2015
    • Kyungpook National University
      • • School of Medicine
      • • Department of Microbiology
      Daikyū, Daegu, South Korea
  • 2001-2015
    • Seoul National University
      • • Department of Pharmacy
      • • Dental Research Institute
      • • Department of Internal Medicine
      • • Department of Food and Nutrition
      • • College of Veterinary Medicine
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Dong-Pusan College
      Tsau-liang-hai, Busan, South Korea
    • Korea Food and Drug Administration
      Seishō-gun, Gyeongsangbuk-do, South Korea
  • 2014
    • Eulji University
      • Department of Radiology
      Sŏul, Seoul, South Korea
    • Korea University
      • Department of Electrical Engineering
      Sŏul, Seoul, South Korea
    • University of Oregon
      Eugene, Oregon, United States
  • 2013-2014
    • Samsung Medical Center
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
    • Kongju National University
      Gongju, Chungcheongnam-do, South Korea
    • Soonchunhyang University
      Onyang, Chungcheongnam-do, South Korea
    • Seoul National University of Science and Technology
      Sŏul, Seoul, South Korea
  • 2012-2014
    • National Institute of Crop Science
      성남시, Gyeonggi-do, South Korea
    • Hankuk University of Foreign Studies
      • Department of Environmental Science
      Sŏul, Seoul, South Korea
    • Korea University of Science and Technology
      Sŏul, Seoul, South Korea
    • Hanyang University
      • Department of Nursing
      Sŏul, Seoul, South Korea
    • Texas Tech University
      • Department of Community, Family, and Addiction Services
      Lubbock, Texas, United States
  • 2011-2014
    • Sookmyung Women's University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Chungnam National University Hospital
      Sŏul, Seoul, South Korea
  • 2007-2014
    • University of Ulsan
      • College of Medicine
      Ulsan, Ulsan, South Korea
  • 2005-2014
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2003-2014
    • Sungkyunkwan University
      • Institute of Basic Science
      Sŏul, Seoul, South Korea
  • 2010-2013
    • Asan Medical Center
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2009-2013
    • University of North Carolina at Charlotte
      • Department of Mechanical Engineering and Engineering Science
      Charlotte, North Carolina, United States
    • Korea Basic Science Institute KBSI
      • Busan Center
      Sŏul, Seoul, South Korea
  • 2004-2013
    • Chungnam National University
      • • Department of Internal Medicine
      • • Department of Microbiology
      • • School of Bioscience and Biotechnology
      • • College of Pharmacy
      Daiden, Daejeon, South Korea
    • Sejong University
      • Faculty of Bioscience and Biotechnology
      Sŏul, Seoul, South Korea
  • 2006-2012
    • Korea Advanced Institute of Science and Technology
      • • Department of Materials Science and Engineering
      • • Department of Biological Sciences
      Sŏul, Seoul, South Korea
  • 2008-2011
    • Seoul National University Hospital
      • • Department of Family Medicine
      • • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2005-2009
    • Seoul Veterans Hospital
      Sŏul, Seoul, South Korea
  • 2007-2008
    • CHA University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2002
    • Dong-A University
      • Department of Cardiology
      Tsau-liang-hai, Busan, South Korea
  • 1999-2002
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea