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Publications (3)2.83 Total impact

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    ABSTRACT: In this study, a stable red pigment was prepared from Lithospermum erythrorhizon via supercritical carbon dioxide extraction. The optimal extraction conditions were 400 bar and 60 degrees C. The patch tests indicated that up to 10% of the red pigment was acceptable from a skin irritation standpoint. According to the results of the CIE LAB chromaticity test, the color difference was acceptable when compared to commercial synthetic red pigments. The light-illuminated color stability test indicated that the pigment was more stable than the red pigment extracted with ethanol. The higher stability was also demonstrated in the DPPH antioxidant activity test. The supercritical red pigment harbored elevated amounts of shikonin and derivatives, and appears to be usable as a stable red pigment for cosmetic color products.
    Journal of cosmetic science 01/2008; 59(5):431-40. · 0.28 Impact Factor
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    ABSTRACT: Matrix metalloproteinases (MMPs) are the proteases involved in the degradation of the extracellular matrix. MMP-1 is thought to be one of the key enzymes acting in fibrolysis, a process closely related to tissue remodeling. In this study, we found that emodin, an anthraquinone which has been isolated from the rhizome of Rheum palmatum, significantly inhibited TNF alpha-induced MMP-1 gene expression in a concentration-dependent manner. Therefore, we have attempted to characterize the inhibitory mechanism of emodin in TNF alpha-induced MMP-1 expression. Emodin was determined to inhibit TNF alpha-induced activation of AP-1 promoter, an important nuclear transcription factor in MMP-1 expression. Additionally, we detected that emodin suppressed the TNF alpha-induced phosphorylation of two mitogen-activated protein kinases, extracellular signal-regulated protein kinase and c-Jun N-terminal kinase, but it did not suppress the TNF alpha-induced phosphorylation of p38 kinase. In a consistent result, the TNF alpha-induced MMP-1 expression was inhibited by PD98059 (MEK/ERK inhibitor) and SP600125 (JNK inhibitor), but was not inhibited by SB203580, a p38 MAPK inhibitor. Taken together, these results show that emodin suppresses TNF alpha-induced MMP-1 expression through the inhibition of the AP-1 signaling pathway.
    Life Sciences 12/2006; 79(26):2480-5. · 2.56 Impact Factor
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    ABSTRACT: Using optimized standard methods, which were previously done by sensory tests, many factors have been analyzed and their significance were determined according to gloss and gloss-lasting capability in lipstick. Analyzing some factors we could conclude that the effective factors were the kind of wax, amount of volatile silicone oil, and stick hardness in the aspect of lipstick's gloss. And in the point of lipstick's gloss-lasting properties, vital few X's were quantity of volatile silicone oil stick hardness, and polymer contents and so on. We successfully have tried new analytical approach, 6-sigma to general property of lipstick. Furthermore this study will be a base on the prescription design in gloss-enhanced products.
    Journal of the Society of Cosmetic Scientists of Korea. 01/2005; 31(4).