Hee-Jin Kim

CHA University, Sŏul, Seoul, South Korea

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Publications (294)799.88 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present study was to determine the reliability of optical coherence tomography (OCT) in detecting cracked teeth and its relative clinical effectiveness by comparing it with other diagnostic methods including conventional visual inspection, trans-illumination, and micro-computed tomography (micro-CT). The reliability of swept source OCT (SS-OCT) was verified by comparing the number of detected crack lines on 109 surfaces of 61 teeth with those detected with other conventional methods. One to one comparison revealed that crack lines that were invisible with naked eyes could be found in SS-OCT images. The detection ability of SS-OCT was superior or similar to those of micro-CT (100.0 %) and trans-illumination. Crack lines shown in the SS-OCT images had distinct characteristics, and structural crack lines and craze lines could be distinguished in SS-OCT images. Thus, the detection ability of SS-OCT renders it an acceptable diagnostic device for cracked-tooth syndrome.
    Anatomia Clinica 07/2015; DOI:10.1007/s00276-015-1514-8 · 1.33 Impact Factor
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    ABSTRACT: Severe congenital neutropenia (SCN) is a bone marrow failure disease with an autosomal dominant inheritance from mutations in ELANE. Here, we report a 7-week-old Korean male with SCN. His elder sister died from pneumonia at 2 years. Direct sequencing of ELANE in the proband identified a heterozygous novel frameshift mutation: c.658delC (p.Arg220Glyfs20*). Family study involving his asymptomatic parents with normal cell counts revealed that his father had the same mutation, but at a lower burden than expected in a typical heterozygous state. Further molecular investigation demonstrated somatic mosaicism with ∼18% mutant alleles. We concluded the proband inherited the mutation from his somatic mosaic father. Pediatr Blood Cancer. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Pediatric Blood & Cancer 07/2015; DOI:10.1002/pbc.25654 · 2.56 Impact Factor
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    ABSTRACT: The gastrointestinal (GI) tract often becomes involved in patients with systemic amyloidosis. As few GI amyloidosis data have been reported, we describe the clinical features and outcomes of patients with pathologically proven GI amyloidosis. We identified 155 patients diagnosed with systemic amyloidosis between April 1995 and April 2013. Twenty-four patients (15.5%) were diagnosed with GI amyloidosis using associated symptoms, and the diagnoses were confirmed by direct biopsy. Among the 24 patients, 20 (83.3%) had amyloidosis light chain (AL), three (12.5%) had amyloid A, and one (4.2%) had transthyretin-related type amyloidosis. Their median age was 57 years (range, 37 to 72), and 10 patients were female (41.7%). The most common symptoms of GI amyloidosis were diarrhea (11 patients, 45.8%), followed by anorexia (nine patients, 37.5%), weight loss, and nausea and/or vomiting (seven patients, 29.2%). The histologically confirmed GI tract site in AL amyloidosis was the stomach in 11 patients (55.0%), the colon in nine (45.0%), the rectum in seven (35.0%), and the small bowel in one (5.0%). Patients with GI involvement had a greater frequency of organ involvement (p = 0.014). Median overall survival (OS) in patients with GI involvement was shorter (7.95 months; range, 0.3 to 40.54) than in those without GI involvement (15.84 months; range, 0.0 to 114.53; p = 0.069) in a univariate analysis. A multivariate analysis of prognostic factors for AL amyloidosis revealed that GI involvement was not a significant predictor of OS (p = 0.447). The prognosis of patients with AL amyloidosis and GI involvement was poorer than those without GI involvement, and they presented with more organ involvement and more advanced disease than those without organ involvement.
    The Korean Journal of Internal Medicine 07/2015; 30(4):496. DOI:10.3904/kjim.2015.30.4.496
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    ABSTRACT: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hemolytic anemia caused by a mutation in the G6PD gene on Xq28. Herein, we describe a Korean boy with G6PD deficiency resulting from a novel mutation in G6PD. A 20-month-old boy with hemolytic anemia was referred for molecular diagnosis. He had no relevant family history. The G6PD activity was severely decreased at 0.2 U/g Hb (severe deficiency). Direct sequencing analyses on the G6PD gene revealed that he was hemizygous for a novel missense variant, c.1187C>G (p.Pro396Arg), in exon 10 of G6PD. Family study involving his parents revealed the de novo occurrence of the mutation. This is the first report of genetically confirmed G6PD deficiency in Korea. © 2015 by the Association of Clinical Scientists, Inc.
    Annals of clinical and laboratory science 07/2015; 45(4):446-8. · 0.84 Impact Factor
  • Leukemia & lymphoma 06/2015; DOI:10.3109/10428194.2015.1065982 · 2.89 Impact Factor
  • British Journal of Haematology 06/2015; DOI:10.1111/bjh.13564 · 4.96 Impact Factor
  • Hun-Mu Yang · Sung-Yoon Won · Hee-Jin Kim · Kyung-Seok Hu
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    ABSTRACT: Various surgical interventions including esthetic surgery, salivary gland excision, and open reduction of fracture have been performed in the area around the mandibular angle and condyle. This study aimed to comprehensively review the anatomy of the neurovascular structures on the angle and condyle with recent anatomic and clinical research. We provide detailed information about the branching and distributing patterns of the neurovascular structures at the mandibular angle and condyle, with reported data of measurements and proportions from previous anatomical and clinical research. Our report should serve to help practitioners gain a better understanding of the area in order or reduce potential complications during local procedures. Reckless manipulation during mandibular angle reduction could mutilate arterial branches, not only from the facial artery, but also from the external carotid artery. The transverse facial artery and superficial temporal artery could be damaged during approach and incision in the condylar area. The marginal mandibular branch of the facial nerve can be easily damaged during submandibular gland excision or facial rejuvenation treatment. The main trunk of the facial nerve and its upper and lower distinct divisions have been damaged during parotidectomy, rhytidectomy, and open reductions of condylar fractures. By revisiting the information in the present study, surgeons will be able to more accurately prevent procedure-related complications, such as iatrogenic vascular accidents on the mandibular angle and condyle, complete and partial facial palsy, gustatory sweating (Frey syndrome), and traumatic neuroma after parotidectomy.
    Anatomia Clinica 05/2015; DOI:10.1007/s00276-015-1482-z · 1.33 Impact Factor
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    ABSTRACT: This study was done to evaluate the effect of recombinant human bone morphogenic protein-2 (RhBMP-2) on enhancing the quality and quantity of regenerated bone when injected into distracted alveolar bone. Sixteen adult beagle dogs were assigned to either the control or rhBMP-2 group. After distraction was completed, an rhBMP-2 dose of 330µg in 0.33ml was slowly injected into the distracted alveolar crest of the mesial, middle, and distal parts of the alveolar bone in the experimental group. Histological and micro-computed tomography analyses of regenerated bone were done after 2 and 6 weeks of consolidation. After 6 weeks of consolidation, the vertical defect height of regenerated bone was significantly lower in the rhBMP-2 group (2.2 mm) than in the control group (3.4 mm) (P<0.05). Additionally, the width of the regenerated bone was significantly greater in the rhBMP-2 group (4.3 mm) than in the control group (2.8 mm) (P<0.05). The bone density and volume of regenerated bone in the rhBMP-2 group were denser and greater, respectively, than in the control group after 6 weeks of consolidation (P<0.001). Injection of rhBMP-2 into regenerated bone after a distraction osteogenesis procedure significantly increased bone volume in the dentoalveolar distraction site and improved both the width and height of the alveolar ridge and increased the bone density.
    Journal of Periodontology 05/2015; DOI:10.1902/jop.2015.140697 · 2.57 Impact Factor
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    ABSTRACT: The topography of the facial muscles differs between males and females and among individuals of the same gender. To explain the unique expressions that people can make, it is important to define the shapes of the muscle, their associations with the skin, and their relative functions. Three-dimensional (3D) motion-capture analysis, often used to study facial expression, was used in this study to identify characteristic skin movements in males and females when they made six representative basic expressions. The movements of 44 reflective markers (RMs) positioned on anatomical landmarks were measured. Their mean displacement was large in males [ranging from 14.31 mm (fear) to 41.15 mm (anger)], and 3.35-4.76 mm smaller in females [ranging from 9.55 mm (fear) to 37.80 mm (anger)]. The percentages of RMs involved in the ten highest mean maximum displacement values in making at least one expression were 47.6% in males and 61.9% in females. The movements of the RMs were larger in males than females but were more limited. Expanding our understanding of facial expression requires morphological studies of facial muscles and studies of related complex functionality. Conducting these together with quantitative analyses, as in the present study, will yield data valuable for medicine, dentistry, and engineering, for example, for surgical operations on facial regions, software for predicting changes in facial features and expressions after corrective surgery, and the development of face-mimicking robots. Clin. Anat., 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Clinical Anatomy 04/2015; 28(6). DOI:10.1002/ca.22542 · 1.16 Impact Factor
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    ABSTRACT: Abstract Mantle cell lymphoma has features of both indolent and aggressive non-Hodgkin lymphomas. Repeated relapses leading to treatment failure in mantle cell lymphoma patients might suggest the presence of cancer stem cells. A small cell population with CD45(+)/CD19(-) was previously reported to represent cancer stem cells. We evaluated the clinical relevance of CD45(+)/CD19(-) cells in bone marrow of patients with mantle cell lymphoma (n = 20). A CD45(+)/CD19(-) cell population was observed in newly diagnosed mantle cell lymphoma, and its percentage correlated with tumor cells in bone marrow (r = 0.832, P = 0.001), and the score on the simplified mantle cell lymphoma prognostic index (r = 0.675, P = 0.016). After treatment, CD45(+)/CD19(-) cells decreased (mean: 0.012%), and CD45(+)/CD19(-) cells (0.276%) was higher at relapse or progression than at diagnosis. In conclusion, a CD45(+)/CD19(-) cell population in bone marrow aspirates correlated with clinical outcome of patients with mantle cell lymphoma.
    Leukemia and Lymphoma 03/2015; DOI:10.3109/10428194.2015.1025391 · 2.89 Impact Factor
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    03/2015; 50(1):58-61. DOI:10.5045/br.2015.50.1.58
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    Annals of Laboratory Medicine 03/2015; 35(2):257-9. DOI:10.3343/alm.2015.35.2.257 · 1.48 Impact Factor
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    Borahm Kim · Seung-Tae Lee · Hee-Jin Kim · Sun Hee Kim
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    ABSTRACT: Bone marrow biopsies are routinely performed for staging patients with B-cell non-Hodgkin lymphoma (NHL). In addition to histomorphological studies, ancillary tools may be needed for accurate diagnosis. We investigated the clinical utility of multiparameter flow cytometric examination of bone marrow aspirates. A total of 248 bone marrow specimens from 232 patients diagnosed with B-cell NHL were examined. Monoclonal antibodies directed against CD19, CD20, CD10 (or CD5), and κ and λ immunoglobulins were used. Multi-stage sequential gating was performed to select specific cells of interest, and the results were compared with bone marrow histology. The concordance rate between histomorphology and flow cytometry was 91.5% (n=227). Eight cases (3.2%) were detected by flow cytometry alone and were missed by histomorphology analysis, and 6 of these 8 cases showed minimal bone marrow involvement (0.09-2.2%). The diagnosis in these cases included large cell lymphoma (n=3), mantle cell lymphoma (n=3), and mucosa-associated lymphoid tissue (MALT) lymphoma (n=2). Thirteen cases were histopathologically positive and immunophenotypically negative, and the diagnoses in these cases included diffuse large cell lymphoma (n=7), T-cell/histiocyte-rich large B-cell lymphoma (n=2), anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (n=1), follicular lymphoma (n=1), MALT lymphoma (n=1), and unclassifiable lymphoma (n=1). Multi-color flow cytometry can be a useful method for assessing bone marrow in staging NHL and also plays a complementary role, especially in detecting small numbers of lymphoma cells.
    Annals of Laboratory Medicine 03/2015; 35(2):187-93. DOI:10.3343/alm.2015.35.2.187 · 1.48 Impact Factor
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    ABSTRACT: The inferior labial artery (ILA) and horizontal labiomental artery (HLA) can be regarded as the main arteries used in the lower lip pedicle for the perioral reconstruction. However, the courses of the ILA and HLA are described in diverse ways, and there is no obvious standard for distinguishing between them. The aim of this study was to elucidate the distribution patterns of the ILA and HLA, and the significance of the HLA in the vascularization of the lower lip. Sixty-three hemifaces from 18 Korean and 19 Thai cadavers were used in this study. The distribution patterns of the arteries of the lower lip area were classified based on the assumption that the HLA travels in the middle of the lower lip area, while the ILA runs along the lower lip border. The arterial distribution pattern of the HLA was classified into three types (I-III): type I, where the HLA ran horizontally in the lower lip area; type II, where the HLA curved upward to the vermilion border of the lower lip; and type III, where the HLA bifurcated into two branches. The ILA was also classified into three types (A-C): type A, where the ILA was not observed; type B, ILA was ramified from facial artery at the level of mouth corner; and type C, ILA arose from the superior labial artery (SLA) and supplied the lower lip vermillion border. Types I, II, and III were observed in 52.4 % (33/63), 39.7 % (25/63), and 7.9 % (5/63) of cases, respectively; and types A, B, and C were observed in 52.4 % (33/63), 36.5 % (23/63), and 11.1 % (7/63) of cases. Consideration of the two artery classifications together revealed seven types: type IA (14.3 %, 9/63), type IB (28.6 %, 18/63), type IC (9.5 %, 6/63), type IIA (30.2 %, 19/63), type IIB (7.9 %, 5/63), type IIC (1.6 %, 1/63), and type III (7.9 %, 5/63). The distance between the HLA and the midpoint between the mouth corner and the inferior mandibular margin was 0.4 ± 3.1 mm (mean ± SD) inferior to this point. The ILA and HLA should be differentiated according to the location of their origin rather than their terminating areas. The HLA could be considered as the main artery supplying the lower lip mucosa.
    Surgical and Radiologic Anatomy 02/2015; DOI:10.1007/s00276-015-1447-2 · 1.33 Impact Factor
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    ABSTRACT: Previous studies have revealed a variation in the origin and distribution patterns of the facial artery. However, the relationship between the facial artery and the facial muscles has not been well described. The purpose of this study was to determine the facial artery depth and relationship with the facial musculature layer, which represents critical information for dermal filler injection and oral and maxillofacial surgery. Fifty-four embalmed adult faces from Korean cadavers (36 male and 18 female cadavers; mean age, 73.3 years) were used in this study. A detailed dissection was performed, with great care being taken to avoid damaging the facial artery underlying the facial skin and muscle. The facial artery was first categorized according to the patterns of its final arterial branches. The branching pattern was classified simply into three types: type I, nasolabial pattern (51.8 percent); type II, nasolabial pattern with an infraorbital trunk (29.6 percent); and type III, forehead pattern (18.6 percent). Each type was further subdivided according to the facial artery depth and relationship with the facial musculature layer as types Ia (37.0 percent), Ib (14.8 percent), IIa (16.7 percent), IIb (12.9 percent), IIIa (16.7 percent), and IIIb (1.9 percent). This study provides new anatomical insight into the relationships between the facial artery branches and the facial muscles, including providing useful information for clinical applications in the fields of oral and maxillofacial surgery.
    Plastic &amp Reconstructive Surgery 02/2015; 135(2):437-44. DOI:10.1097/PRS.0000000000000991 · 3.33 Impact Factor
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    ABSTRACT: The superior labial artery, which is a branch of the facial artery, supplies the upper lip area. The aim of this study was to determine the distribution pattern of the superior labial artery and provide precise topographic information of the artery for dermal filler injection. Sixty hemifaces from 18 Korean and 18 Thai cadavers were used for this study. The various distribution patterns of the superior labial artery were classified according to its relationship with the facial artery. The course of the superior labial artery was classified into four types: type I (56.7 percent), in which the artery and the alar branch both arise directly and independently from the facial artery; type II (21.7 percent), in which the superior labial artery branches off from the facial artery and then gives off an alar branch; type III (15.0 percent), in which it is the terminal branch of the facial artery; and type IV (6.7 percent), in which the artery is absent. The origin of the superior labial artery was located 12.1 ± 3.1 mm (mean ± SD) lateral and at a variable angle of 42.8 ± 26.9 degrees relative to the mouth corner. The superior labial artery proceeded from the origin of the artery located within a 1.5-cm-side square superolateral to the mouth corner as running along the vermilion border of the upper lip to the facial sagittal midline at a depth of 3 mm. Thus, clinicians should be careful when injecting dermal filler into this area.
    Plastic &amp Reconstructive Surgery 02/2015; 135(2):445-50. DOI:10.1097/PRS.0000000000000858 · 3.33 Impact Factor
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    ABSTRACT: The purpose of this study was to clarify the anatomic variation of the dorsalis pedis and first metatarsal arteries and to define the trabecular-to-cortical bone ratio (TBR) of the second metatarsal bone to ascertain their suitability as implants. Fifty-two specimens were prepared for this study. Each specimen was dissected on the dorsal side of the foot to search for the dorsalis pedis artery. Three types of dorsalis pedis artery were found: in type A, which was the most common, the artery continuously formed the first metatarsal artery; in type C, which was the second most common, the artery coursed below the first dorsal interosseous muscle; and in type B, the artery coursed from the lateral side. Five variations of the first metatarsal artery were identified: the most common was type IIb, in which the artery coursed below the first dorsal interosseous muscle; followed by type Ib, in which the artery coursed obliquely through the muscle; type Ic, in which the artery coursed parallel to the muscle; type IIa, in which the artery coursed above and below the muscle; and type Ia, in which the artery coursed only above the muscle. The second metatarsal bone was divided into 5 regions. There was no trabecular bone in regions 1 and 5. The TBR appeared to be lower in region 3 than in regions 2 and 4 and highest in region 2. All regions of the second metatarsal bone appear to be suitable as implants, but when placing the implant in the proximal end, care should be taken not to overheat the bone and to be wary of perforation when placing it on the middle side. Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
    Journal of Oral and Maxillofacial Surgery 02/2015; DOI:10.1016/j.joms.2015.02.007 · 1.28 Impact Factor
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    ABSTRACT: The aim of this study was to clarify the definition of the anterior wall of the ulnar tunnel and to reveal the topographical characteristics of the various components of the ulnar tunnel. Twenty-two forearms from 11 embalmed cadavers (7 males, 4 females; mean age, 67.8 years) were carefully dissected. In all cases, the anterior wall of the ulnar tunnel comprised the hypothenar fascia, which originated from the tendon of the flexor carpi ulnaris muscle. The palmar carpal ligament, the distal extent of the antebrachial fascia, was located deep to the anterior wall and formed only the anterior boundary of the proximal hiatus of the ulnar tunnel. The hypothenar fascia was attached to the flexor retinaculum at 15.2 mm lateral to the pisiform bone. However, the palmar carpal ligament was attached to the flexor retinaculum just lateral to the ulnar artery; the distance between the attachment of the palmar carpal ligament and the pisiform bone was 8.7 mm. Anatomical variations potentially associated with ulnar nerve compression were observed. The accessory abductor digiti minimi muscle and the fibrous band crossing the ulnar nerve in the ulnar tunnel were found in 27 and 23 % of forearms, respectively. A more detailed description of the anterior wall of the ulnar tunnel than was previously available is presented herein, and topographic and metric data regarding each structure of the tunnel are reported.
    Surgical and Radiologic Anatomy 01/2015; DOI:10.1007/s00276-014-1415-2 · 1.33 Impact Factor
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    Annals of Laboratory Medicine 01/2015; 35(1):159-61. DOI:10.3343/alm.2015.35.1.159 · 1.48 Impact Factor
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    Annals of Laboratory Medicine 01/2015; 35(1):155-8. DOI:10.3343/alm.2015.35.1.155 · 1.48 Impact Factor

Publication Stats

2k Citations
799.88 Total Impact Points

Institutions

  • 2015
    • CHA University
      • School of Medicine
      Sŏul, Seoul, South Korea
  • 2003–2015
    • Sungkyunkwan University
      • Samsung Medical Center
      Sŏul, Seoul, South Korea
  • 2014
    • Chulalongkorn University
      Krung Thep, Bangkok, Thailand
    • Asan Medical Center
      • Department of Nuclear Medicine
      Sŏul, Seoul, South Korea
  • 2010–2014
    • Korea Research Institute of Bioscience and Biotechnology KRIBB
      • Medical Genomics Research Center
      Anzan, Gyeonggi Province, South Korea
    • Pusan National University
      • School of Dentistry
      Pusan, Busan, South Korea
  • 2003–2014
    • Yonsei University
      • • Department of Oral Biology
      • • Department of Anatomy
      Sŏul, Seoul, South Korea
  • 2013
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
  • 2012
    • Ewha Womans University
      • Department of Laboratory Medicine
      Sŏul, Seoul, South Korea
  • 2009–2012
    • Chung-Ang University
      Sŏul, Seoul, South Korea
  • 2007–2012
    • Samsung Medical Center
      • • Department of Hematology and Oncology
      • • Department of Laboratory Medicine
      Sŏul, Seoul, South Korea
  • 2011
    • Kwandong University
      Gangneung, Gangwon, South Korea
  • 2006–2010
    • Tokyo Dental College
      • Department of Anatomy
      Tiba, Chiba, Japan
  • 2007–2008
    • Konkuk University
      • School of Medicine
      Sŏul, Seoul, South Korea