Hee-Jin Kim

CHA University, Sŏul, Seoul, South Korea

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Publications (304)768.19 Total impact

  • The Korean Journal of Internal Medicine 10/2015; 30(6):771-788. DOI:10.3904/kjim.2015.30.6.771 · 1.43 Impact Factor

  • Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 10/2015; DOI:10.1093/asj/sjv190 · 1.84 Impact Factor
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    ABSTRACT: Introduction: To identify the ideal sites for botulinum toxin injection by examining the intramuscular nerve patterns of the ankle invertors. Method: A modified Sihler method was performed on the flexor hallucis longus, tibialis posterior, and flexor digitorum longus muscles (10 specimens each). The muscle origins, nerve entry points, and intramuscular arborization areas were measured as a percentage of the total distance from the most prominent point of the lateral malleolus (0%) to the fibular head (100%). Results: Intramuscular arborization patterns were observed at 20-50% for the flexor hallucis longus, 70-80% for the tibialis posterior, and 30-40% for the flexor digitorum longus. Discussion: These findings suggest that treatment of muscle spasticity of the ankle invertors involves botulinum toxin injections at specific areas. These areas, corresponding to the areas of maximum arborization, are recommended as the most effective and safest points for botulinum toxin injection. This article is protected by copyright. All rights reserved.
    Muscle & Nerve 10/2015; DOI:10.1002/mus.24939 · 2.28 Impact Factor
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    ABSTRACT: Recent evidence has shown that the level of 5-hydroxymethylcytosine (5hmC) in chromosomal DNA is aberrantly decreased in a variety of cancers, but whether this decrease is a cause or a consequence of tumorigenesis is unclear. Here we show that, in gastric cancers, the 5hmC decrease correlates with a decrease in ten-eleven translocation 1 (TET1) expression, which is strongly associated with metastasis and poor survival in patients with gastric cancer. In gastric cancer cells, TET1-targeted siRNA induced a decrease in 5hmC, whereas TET1 overexpression induced an increase in 5hmC and reduced cell proliferation, thus correlating decreased 5hmC with gastric carcinogenesis. We also report the epigenetic signatures responsible for regulating TET1 transcription. Methyl-CpG Binding Domain Sequencing and Reduced Representation Bisulfite Sequencing identified unique CpG methylation signatures at the CpG island 3'-shore region located 1.3 kb from the transcription start site of TET1 in gastric tumor cells but not in normal mucosa. The luciferase activity of constructs with a methylated 3'-shore sequence was greatly decreased compared with that of an unmethylated sequence in transformed gastric cancer cells. In gastric cancer cells, dense CpG methylation in the 3'-shore was strongly associated with TET1 silencing and bivalent histone marks. Thus, a decrease in 5hmC may be a cause of gastric tumorigenesis owing to a decrease in TET1 expression through DNA methylation coupled with bivalent marks in the 3'-shore of TET1.
    Oncotarget 10/2015; DOI:10.18632/oncotarget.6069 · 6.36 Impact Factor
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    ABSTRACT: Bone marrow hemophagocytosis is a frequently observed but not mandatory finding for the diagnosis of hemophagocytic lymphohistiocytosis (HLH). However, the impact of bone marrow hemophagocytosis on the diagnosis of HLH is still not clear in adult patients. Thus, we retrospectively analyzed adult patients with bone marrow hemophagocytosis between 2000 and 2014 to determine its clinical significance. Among 264 patients with bone marrow hemophagocytosis, malignant disorders were the predominant underlying cause (n = 170, 64 %), especially T/NK-cell (n = 88) and B-cell (n = 45) lymphomas compared to infectious disease (48/264, 18 %). The data for HLH-2004 diagnostic criteria was available in 182 patients, and only 29 % (77/264) of patients with ≥ five positive criteria could be diagnosed with HLH. Among the criteria for the diagnosis of HLH, increased serum ferritin (89 %) was more common than hypofibrinogenemia, hypertriglyceridemia, and bicytopenia (<40 %). The median overall survival was worse in patients with malignancy (9.0 months, 95 % confidence interval [CI] 5.6-12.5) than in those with non-malignant disorders (71.8 months, 95 % CI 56.5-87.1, P < 0.001). In patients with malignancy, the overall survival of patients fulfilling the HLH-2004 criteria was significantly worse than patients who did not (P < 0.001). In conclusion, our results suggest that bone marrow hemophagocytosis might be an important finding in the diagnosis of HLH in adult patients. Considering the high incidence of malignancy as a predisposing disorder for HLH, immediate evaluation should be performed in adult patients with bone marrow hemophagocytosis.
    Annals of Hematology 10/2015; DOI:10.1007/s00277-015-2523-8 · 2.63 Impact Factor
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    ABSTRACT: Familial hemophagocytic lymphohistiocytosis (F-HLH or FHL) is a potentially fatal immune dysregulation syndrome with a heterogeneous genetic background. Most recently, STXBP2 has been identified as the causative gene of type 5 FHL (FHL5) with a worldwide distribution. In this study, we investigated the prevalence of FHL5 in Korea. Fifty Korean pediatric patients with HLH who lacked pathogenic mutations in PRF1, UNC13D, or in STX11 from the previous series of 72 patients with HLH were analyzed for STXBP2 mutations by conventional sequencing analyses. As a result, we found 1 patient with 2 novel mutations of STXBP2: c.184A>G and c.577A>C. c.184A>G (p.Asn62Asp) was located within a highly conserved region of the STXBP2 protein and predicted to be deleterious. c.577A>C in exon 7 resulted in incomplete splicing mutation with exon 7 skipping concurrent with exon 7-retained transcript with p.Lys193Gln substitution. The frequency of FHL5 was ~1% (1/72) in Korean pediatric patients with HLH. This is the first study on FHL5 in Korea, and the data from a nationwide patient cohort provides another piece of genetic profiles of FHL.
    Clinical Genetics 10/2015; DOI:10.1111/cge.12682 · 3.93 Impact Factor
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    ABSTRACT: Chronic migraine has been related to the entrapment of the supratrochlear nerve within the corrugator supercilii muscle. Recently, research has shown that people who have undergone botulinum neurotoxin A injection in frontal regions reported disappearance or alleviation of their migraines. There have been numerous anatomical studies conducted on Caucasians revealing possible anatomical problems leading to migraine; on the other hand, relatively few anatomical studies have been conducted on Asians. Thus, the aim of the present study was to determine the topographic relationship between the supratrochlear nerve and corrugator supercilii muscle in the forehead that may be the cause of migraine. Fifty-eight hemifaces from Korean and Thai cadavers were used for this study. The supratrochlear nerve entered the corrugator supercilii muscle in every case. Type I, in which the supratrochlear nerve emerged separately from the supraorbital nerve at the medial one-third portion of the orbit, was observed in 69% (40/58) of cases. Type II, in which the supratrochlear nerve emerged from the orbit at the same location as the supraorbital nerve, was observed in 31% (18/58) of cases.
    Toxins 07/2015; 7(7):2629-38. DOI:10.3390/toxins7072629 · 2.94 Impact Factor
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    ABSTRACT: The aim of the present study was to determine the reliability of optical coherence tomography (OCT) in detecting cracked teeth and its relative clinical effectiveness by comparing it with other diagnostic methods including conventional visual inspection, trans-illumination, and micro-computed tomography (micro-CT). The reliability of swept source OCT (SS-OCT) was verified by comparing the number of detected crack lines on 109 surfaces of 61 teeth with those detected with other conventional methods. One to one comparison revealed that crack lines that were invisible with naked eyes could be found in SS-OCT images. The detection ability of SS-OCT was superior or similar to those of micro-CT (100.0 %) and trans-illumination. Crack lines shown in the SS-OCT images had distinct characteristics, and structural crack lines and craze lines could be distinguished in SS-OCT images. Thus, the detection ability of SS-OCT renders it an acceptable diagnostic device for cracked-tooth syndrome.
    Anatomia Clinica 07/2015; DOI:10.1007/s00276-015-1514-8 · 1.05 Impact Factor
  • Hee-Jung Kim · Min-Jung Song · Ki-O Lee · Sun-Hee Kim · Hee-Jin Kim ·
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    ABSTRACT: Severe congenital neutropenia (SCN) is a bone marrow failure disease with an autosomal dominant inheritance from mutations in ELANE. Here, we report a 7-week-old Korean male with SCN. His elder sister died from pneumonia at 2 years. Direct sequencing of ELANE in the proband identified a heterozygous novel frameshift mutation: c.658delC (p.Arg220Glyfs20*). Family study involving his asymptomatic parents with normal cell counts revealed that his father had the same mutation, but at a lower burden than expected in a typical heterozygous state. Further molecular investigation demonstrated somatic mosaicism with ∼18% mutant alleles. We concluded the proband inherited the mutation from his somatic mosaic father. Pediatr Blood Cancer. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Pediatric Blood & Cancer 07/2015; 62(12). DOI:10.1002/pbc.25654 · 2.39 Impact Factor
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    ABSTRACT: The gastrointestinal (GI) tract often becomes involved in patients with systemic amyloidosis. As few GI amyloidosis data have been reported, we describe the clinical features and outcomes of patients with pathologically proven GI amyloidosis. We identified 155 patients diagnosed with systemic amyloidosis between April 1995 and April 2013. Twenty-four patients (15.5%) were diagnosed with GI amyloidosis using associated symptoms, and the diagnoses were confirmed by direct biopsy. Among the 24 patients, 20 (83.3%) had amyloidosis light chain (AL), three (12.5%) had amyloid A, and one (4.2%) had transthyretin-related type amyloidosis. Their median age was 57 years (range, 37 to 72), and 10 patients were female (41.7%). The most common symptoms of GI amyloidosis were diarrhea (11 patients, 45.8%), followed by anorexia (nine patients, 37.5%), weight loss, and nausea and/or vomiting (seven patients, 29.2%). The histologically confirmed GI tract site in AL amyloidosis was the stomach in 11 patients (55.0%), the colon in nine (45.0%), the rectum in seven (35.0%), and the small bowel in one (5.0%). Patients with GI involvement had a greater frequency of organ involvement (p = 0.014). Median overall survival (OS) in patients with GI involvement was shorter (7.95 months; range, 0.3 to 40.54) than in those without GI involvement (15.84 months; range, 0.0 to 114.53; p = 0.069) in a univariate analysis. A multivariate analysis of prognostic factors for AL amyloidosis revealed that GI involvement was not a significant predictor of OS (p = 0.447). The prognosis of patients with AL amyloidosis and GI involvement was poorer than those without GI involvement, and they presented with more organ involvement and more advanced disease than those without organ involvement.
    The Korean Journal of Internal Medicine 07/2015; 30(4):496. DOI:10.3904/kjim.2015.30.4.496 · 1.43 Impact Factor
  • Mi-Ae Jang · Ji-Yoon Kim · Ki-O Lee · Sun-Hee Kim · Hong Hoe Koo · Hee-Jin Kim ·
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    ABSTRACT: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hemolytic anemia caused by a mutation in the G6PD gene on Xq28. Herein, we describe a Korean boy with G6PD deficiency resulting from a novel mutation in G6PD. A 20-month-old boy with hemolytic anemia was referred for molecular diagnosis. He had no relevant family history. The G6PD activity was severely decreased at 0.2 U/g Hb (severe deficiency). Direct sequencing analyses on the G6PD gene revealed that he was hemizygous for a novel missense variant, c.1187C>G (p.Pro396Arg), in exon 10 of G6PD. Family study involving his parents revealed the de novo occurrence of the mutation. This is the first report of genetically confirmed G6PD deficiency in Korea. © 2015 by the Association of Clinical Scientists, Inc.
    Annals of clinical and laboratory science 07/2015; 45(4):446-8. · 0.91 Impact Factor

  • Leukemia & lymphoma 06/2015; DOI:10.3109/10428194.2015.1065982 · 2.89 Impact Factor
  • Hyun-Young Kim · Ki-O Lee · Keon Hee Yoo · Sun-Hee Kim · Doyeun Oh · Hee-Jin Kim ·

    British Journal of Haematology 06/2015; DOI:10.1111/bjh.13564 · 4.71 Impact Factor
  • Hun-Mu Yang · Sung-Yoon Won · Hee-Jin Kim · Kyung-Seok Hu ·
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    ABSTRACT: Various surgical interventions including esthetic surgery, salivary gland excision, and open reduction of fracture have been performed in the area around the mandibular angle and condyle. This study aimed to comprehensively review the anatomy of the neurovascular structures on the angle and condyle with recent anatomic and clinical research. We provide detailed information about the branching and distributing patterns of the neurovascular structures at the mandibular angle and condyle, with reported data of measurements and proportions from previous anatomical and clinical research. Our report should serve to help practitioners gain a better understanding of the area in order or reduce potential complications during local procedures. Reckless manipulation during mandibular angle reduction could mutilate arterial branches, not only from the facial artery, but also from the external carotid artery. The transverse facial artery and superficial temporal artery could be damaged during approach and incision in the condylar area. The marginal mandibular branch of the facial nerve can be easily damaged during submandibular gland excision or facial rejuvenation treatment. The main trunk of the facial nerve and its upper and lower distinct divisions have been damaged during parotidectomy, rhytidectomy, and open reductions of condylar fractures. By revisiting the information in the present study, surgeons will be able to more accurately prevent procedure-related complications, such as iatrogenic vascular accidents on the mandibular angle and condyle, complete and partial facial palsy, gustatory sweating (Frey syndrome), and traumatic neuroma after parotidectomy.
    Anatomia Clinica 05/2015; 37(9). DOI:10.1007/s00276-015-1482-z · 1.05 Impact Factor
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    ABSTRACT: This study was done to evaluate the effect of recombinant human bone morphogenic protein-2 (RhBMP-2) on enhancing the quality and quantity of regenerated bone when injected into distracted alveolar bone. Sixteen adult beagle dogs were assigned to either the control or rhBMP-2 group. After distraction was completed, an rhBMP-2 dose of 330µg in 0.33ml was slowly injected into the distracted alveolar crest of the mesial, middle, and distal parts of the alveolar bone in the experimental group. Histological and micro-computed tomography analyses of regenerated bone were done after 2 and 6 weeks of consolidation. After 6 weeks of consolidation, the vertical defect height of regenerated bone was significantly lower in the rhBMP-2 group (2.2 mm) than in the control group (3.4 mm) (P<0.05). Additionally, the width of the regenerated bone was significantly greater in the rhBMP-2 group (4.3 mm) than in the control group (2.8 mm) (P<0.05). The bone density and volume of regenerated bone in the rhBMP-2 group were denser and greater, respectively, than in the control group after 6 weeks of consolidation (P<0.001). Injection of rhBMP-2 into regenerated bone after a distraction osteogenesis procedure significantly increased bone volume in the dentoalveolar distraction site and improved both the width and height of the alveolar ridge and increased the bone density.
    Journal of Periodontology 05/2015; 86(9):1-16. DOI:10.1902/jop.2015.140697 · 2.71 Impact Factor
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    ABSTRACT: The topography of the facial muscles differs between males and females and among individuals of the same gender. To explain the unique expressions that people can make, it is important to define the shapes of the muscle, their associations with the skin, and their relative functions. Three-dimensional (3D) motion-capture analysis, often used to study facial expression, was used in this study to identify characteristic skin movements in males and females when they made six representative basic expressions. The movements of 44 reflective markers (RMs) positioned on anatomical landmarks were measured. Their mean displacement was large in males [ranging from 14.31 mm (fear) to 41.15 mm (anger)], and 3.35-4.76 mm smaller in females [ranging from 9.55 mm (fear) to 37.80 mm (anger)]. The percentages of RMs involved in the ten highest mean maximum displacement values in making at least one expression were 47.6% in males and 61.9% in females. The movements of the RMs were larger in males than females but were more limited. Expanding our understanding of facial expression requires morphological studies of facial muscles and studies of related complex functionality. Conducting these together with quantitative analyses, as in the present study, will yield data valuable for medicine, dentistry, and engineering, for example, for surgical operations on facial regions, software for predicting changes in facial features and expressions after corrective surgery, and the development of face-mimicking robots. Clin. Anat., 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Clinical Anatomy 04/2015; 28(6). DOI:10.1002/ca.22542 · 1.33 Impact Factor
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    ABSTRACT: Abstract Mantle cell lymphoma has features of both indolent and aggressive non-Hodgkin lymphomas. Repeated relapses leading to treatment failure in mantle cell lymphoma patients might suggest the presence of cancer stem cells. A small cell population with CD45(+)/CD19(-) was previously reported to represent cancer stem cells. We evaluated the clinical relevance of CD45(+)/CD19(-) cells in bone marrow of patients with mantle cell lymphoma (n = 20). A CD45(+)/CD19(-) cell population was observed in newly diagnosed mantle cell lymphoma, and its percentage correlated with tumor cells in bone marrow (r = 0.832, P = 0.001), and the score on the simplified mantle cell lymphoma prognostic index (r = 0.675, P = 0.016). After treatment, CD45(+)/CD19(-) cells decreased (mean: 0.012%), and CD45(+)/CD19(-) cells (0.276%) was higher at relapse or progression than at diagnosis. In conclusion, a CD45(+)/CD19(-) cell population in bone marrow aspirates correlated with clinical outcome of patients with mantle cell lymphoma.
    Leukemia and Lymphoma 03/2015; 56(11):1-12. DOI:10.3109/10428194.2015.1025391 · 2.89 Impact Factor
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    Borahm Kim · Seung-Tae Lee · Hee-Jin Kim · Sun Hee Kim ·
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    ABSTRACT: Bone marrow biopsies are routinely performed for staging patients with B-cell non-Hodgkin lymphoma (NHL). In addition to histomorphological studies, ancillary tools may be needed for accurate diagnosis. We investigated the clinical utility of multiparameter flow cytometric examination of bone marrow aspirates. A total of 248 bone marrow specimens from 232 patients diagnosed with B-cell NHL were examined. Monoclonal antibodies directed against CD19, CD20, CD10 (or CD5), and κ and λ immunoglobulins were used. Multi-stage sequential gating was performed to select specific cells of interest, and the results were compared with bone marrow histology. The concordance rate between histomorphology and flow cytometry was 91.5% (n=227). Eight cases (3.2%) were detected by flow cytometry alone and were missed by histomorphology analysis, and 6 of these 8 cases showed minimal bone marrow involvement (0.09-2.2%). The diagnosis in these cases included large cell lymphoma (n=3), mantle cell lymphoma (n=3), and mucosa-associated lymphoid tissue (MALT) lymphoma (n=2). Thirteen cases were histopathologically positive and immunophenotypically negative, and the diagnoses in these cases included diffuse large cell lymphoma (n=7), T-cell/histiocyte-rich large B-cell lymphoma (n=2), anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (n=1), follicular lymphoma (n=1), MALT lymphoma (n=1), and unclassifiable lymphoma (n=1). Multi-color flow cytometry can be a useful method for assessing bone marrow in staging NHL and also plays a complementary role, especially in detecting small numbers of lymphoma cells.
    Annals of Laboratory Medicine 03/2015; 35(2):187-93. DOI:10.3343/alm.2015.35.2.187 · 1.48 Impact Factor
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    Blood Research 03/2015; 50(1):58-61. DOI:10.5045/br.2015.50.1.58
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    Annals of Laboratory Medicine 03/2015; 35(2):257-9. DOI:10.3343/alm.2015.35.2.257 · 1.48 Impact Factor

Publication Stats

2k Citations
768.19 Total Impact Points


  • 2015
    • CHA University
      • School of Medicine
      Sŏul, Seoul, South Korea
  • 2003-2015
    • Sungkyunkwan University
      • Samsung Medical Center
      Sŏul, Seoul, South Korea
  • 2001-2015
    • Yonsei University
      • • Human identification research center
      • • Department of Oral Biology
      • • Oral Science Research Center
      • • Department of Anatomy
      • • College of Dentistry
      Sŏul, Seoul, South Korea
  • 2014
    • Chulalongkorn University
      Krung Thep, Bangkok, Thailand
    • Asan Medical Center
      • Department of Nuclear Medicine
      Sŏul, Seoul, South Korea
  • 2010-2014
    • Korea Research Institute of Bioscience and Biotechnology KRIBB
      • Medical Genomics Research Center
      Anzan, Gyeonggi Province, South Korea
    • Tokyo Dental College
      • Department of Anatomy
      Tiba, Chiba, Japan
  • 2013
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
  • 2004-2013
    • Samsung Medical Center
      • • Department of Hematology and Oncology
      • • Department of Laboratory Medicine
      Sŏul, Seoul, South Korea
  • 2012
    • Catholic University of Korea
      Sŏul, Seoul, South Korea
  • 2009-2012
    • Chung-Ang University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2002-2008
    • Konkuk University
      • School of Medicine
      Sŏul, Seoul, South Korea