H. Tsuji

Kyushu University, Fukuoka-shi, Fukuoka-ken, Japan

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Publications (263)291.49 Total impact

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    ABSTRACT: Effects of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on thyroid hormone and immune response systems were examined in 16 Yusho patients at about 30 years after the outbreak of the Yusho accident. Their toxic equivalent (TEQ) levels in the blood were 27.8-1048.5 pg/g fat with the median level of 222.4 pg/g fat, which was about seven times higher than that of healthy Japanese people. Even at such high blood TEQ concentrations, they seemed not to affect the serum levels of thyroid hormones, thyroid stimulating hormone (TSH), immunoglobulins (A, G and M), autoantibodies (antinuclear antibody, rheumatoid and lupus erythematosus (LE) factors), and lymphocyte subsets in the blood. However, positive rates of rheumatoid factor were considered to increase in higher blood TEQ groups. This investigation was done using rather small number of Yusho patients, so further large-scale investigations are needed to get more conclusive findings concerning their effects on thyroid hormone and immune response systems.
    Chemosphere 01/2001; 43(4-7):1005-10. · 3.14 Impact Factor
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    ABSTRACT: The ITER-CS model coil was fabricated and its performance test was successfully carried out. The assembling technique by using indium wires was developed for the terminal joints. The short samples were fabricated to establish the technique and their joint resistance was low enough (∼4 nΩ at 4.5 T, 50 kA). This technique was applied to the assembling of seven joints in the CS model coils and the assembling was successfully completed. It has been confirmed in the performance test that the resistance of these joints is lower than 5 nΩ. According to these results, it can be concluded that the developed assembling technique by using indium wires is applicable and useful to the terminal joints of superconducting coils with the large-current conductors.
    Fusion Engineering and Design - FUSION ENG DES. 01/2001; 58:93-97.
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    ABSTRACT: Frequencies of sister chromatid exchanges (SCEs) of human lymphocytes in control (DMSO treated) and 7,8-benzoflavone (ANF) treated cultures were measured in 39 healthy Japanese people and examined in connection with donor age. Both the control (baseline) and ANF induced SCE rates were significantly enhanced with age and highly positive correlation was observed between them. Therefore, in vivo aging seemed to have some effects on the frequencies of SCEs in human lymphocytes cultured in vitro. Concentrations of PCDDs, PCDFs and Co-PCBs in the blood and sebum of face were determined in the same Japanese subjects. Significantly positive correlation was observed between the blood and sebum in their total TEQ levels. Hence, PCDDs, PCDFs and Co-PCBs, which have been contaminating human bodies, are considered proportionally excreted from the sebum of face or body. Their total TEQ concentrations were also meaningfully increased with donor age in the sebum of face as well as in the blood. Either the baseline or ANF induced SCE frequencies was not enhanced with the total TEQ levels in the blood. Therefore, background levels of their contamination seem not to affect the SCE rates of the lymphocytes in the control and ANF treated cultures.
    Chemosphere 01/2001; 43(4-7):845-9. · 3.14 Impact Factor
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    ABSTRACT: Highly toxic organochlorine chemicals such as polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (CoPCBs) were determined in the peripheral blood and sebum from the face of 16 "Yusho" patients of about 27 yr after the outbreak of Yusho accident, and 39 healthy Japanese people. The mean total toxic equivalent (TEQ) levels of PCDDs, PCDFs and CoPCBs in the blood were still about seven times higher in Yusho patients than in healthy Japanese at the age of 45 yr and more. The sebum excretion of these chemicals seemed proportional to their blood levels in Yusho patients. These toxic chemicals, however, did not enhance frequencies of sister chromatid exchanges (SCEs) in the control and 7,8-benzoflavone (ANF) treated cultures in Yusho patients. Hence, no significant difference was observed in the mean SCE rates between the Yusho patients and general Japanese people of more than 45 yr of age. In this study, the number of Yusho patients examined is limited, so further large-scale investigations are needed to get more conclusive results concerning the genotoxic potency such as SCE induction.
    Chemosphere 01/2001; 43(4-7):931-6. · 3.14 Impact Factor
  • Fusion Engineering and Design 01/2001; 55(2):153-170. · 0.84 Impact Factor
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    ABSTRACT: A 13 T-46 kA Nb3Al conductor with steel jacket has been developed in the framework of ITER-EDA. The thermal strain will appear on the Nb3Al strands after heat treatment, when the steel jacket is used because of difference in their thermal expansion. The conductor critical current performance is degraded by this process. The critical current performance of this conductor was then studied to verify no degradation during the fabrication and small deterioration in the critical current performance even when the steel jacket is used. The thermal strain is evaluated to be < 0.4% for the developed Nb3Al conductor. The critical current deterioration for this case is < 10%. Also, the critical current of the conductor without the thermal strain shows good agreement with that calculated by the critical current of a strand multiplied by its number, 1152. Consequently, no degradation during the conductor fabrication process can be verified. Moreover, the critical current is expected to be more than 90 kA for the thermal strain of 0.4%, resulting in a large margin against the nominal current, 46 kA. <(c)> 2001 Elsevier Science B.V. All rights reserved.
    01/2001;
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    ABSTRACT: Advanced Steady State Tokamak Reactor2 (A-SSTR2) which meets both economical and environmental requirements, has been designed with the thermal fusion power of 2 GW. The toroidal field (TF) coil has a maximum magnetic field of 23 T at conductor and a magnetic stored energy of 181 GJ. For the realization of this coil, large in size and with high magnetic field, the application of high Tc superconductor has been considered.
    Fusion Engineering and Design. 01/2001;
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    ABSTRACT: The largest pulsed superconducting coils ever built, the Central Solenoid (CS) Model Coil and Central Solenoid Insert Coil were successfully developed and tested by international collaboration under the R&D activity of the International Thermonuclear Experimental Reactor (ITER), demonstrating and validating the engineering design criteria of the ITER Central Solenoid coil. The typical achievement is to charge the coil up to the operation current of 46 kA, and the maximum magnetic field to 13 T with a swift rump rate of 0.6 T/s without quench. The typical stored energy of the coil reached during the tests was 640 MJ that is 21 times larger than any other superconducting pulsed coils ever built. The test have shown that the high current cable in conduit conductor technology is indeed applicable to the ITER coils and could accomplish all the requirements of current sharing temperature, AC losses, ramp rate limitation, quench behavior and 10 000-cycle operation.
    Fusion Engineering and Design. 01/2001;
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    ABSTRACT: The effect of helium due to nuclear transmutation reactions during neutron irradiation on low cycle fatigue life of type 304 stainless steel was investigated. The specimens were irradiated in spectrally tailored capsules in the Japan Materials Testing Reactor (JMTR) at a temperature of 823 K to a neutron fluence of approximately 1×1025n/m2(E>1MeV) and helium levels of 0.8, 2.5 and 8.1 appm. The low cycle fatigue tests were performed in total axial strain ranges of 0.8–1.6% at 823 K. A laser extensometer was used for controlling the axial strain of a specimen under cyclic testing. The difference between unirradiated and irradiated specimens is quite clear and appears to be a reduction by a factor of 2–5 in fatigue life. The helium concentration of the specimen is not the main factor to shorten fatigue life in the present experimental condition.
    Journal of Nuclear Materials 12/2000; 283:440-445. · 2.02 Impact Factor
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    ABSTRACT: A 74-year-old man was admitted to our hospital with frequent right flank pain. The multiple multilocular hepatic abscesses were revealed by computed tomography. Radiographs following a barium meal showed a linear filling defect in the ileum consistent with ascariasis. One day after treatment with pyrantel pamoate, an Ascaris was passed in the stool. The pyogenic hepatic abscesses gradually healed with both antibiotics and continuous drainage. After 2 months, he was discharged. In this case, the pyogenic hepatic abscesses were thus considered to have been caused by an inflammation which spread through the portal vein.
    Internal Medicine 04/2000; 39(3):228-30. · 0.97 Impact Factor
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    ABSTRACT: The conductor joint is one of the key technologies for superconducting coils. A butt type joint has been successfully developed for the ITER magnets. The 46 kA Nb<sub>3</sub>Sn conductors are connected by the diffusion bonding technique in vacuum, after the reaction of Nb<sub>3</sub>Sn. The advantage of this joint is low losses against pulse field, because the compacted part is very small compared with other types of joint. 15 butt joints have already been fabricated in the ITER CS Model Coil. According to the test results of the full-size conductor samples, these butt joints will be operated stably in the pulse operation, because the temperature increase due to ac losses and Joule heating by joint resistance is very small and the joint has a sufficiently high temperature margin
    IEEE Transactions on Applied Superconductivity 04/2000; · 1.20 Impact Factor
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    ABSTRACT: The fabrication of the outer module has been completed, which is one of the central solenoid (CS) model coils being developed as the most important R&D for ITER construction. The inner and outer diameters are 2.8 m and 3.6 m, respectively. The weight is 63 tons. The conductor is a Nb<sub>3</sub>Sn cable-in-conduit conductor with a square Incoloy 908 conduit. The coil that consists of 8 layers was fabricated with a solenoid winding with two conductors-in-hand. The outer module will be connected with the inner module coil in series and contribute to the generation of 13 T at 46 kA. The test will be started in November 1999
    IEEE Transactions on Applied Superconductivity 04/2000; · 1.20 Impact Factor
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    ABSTRACT: The central solenoid (CS) model coil program is in progress with an international collaboration under the frame of the ITER-EDA. The purpose of the CS insert coil is to test the performance of the ITER-CS conductor. The CS insert coil is installed in the bore of the CS model coil and tested at a magnetic flux density of 13 T. The installation work is underway with the inner and outer module of the CS model coil. The superconducting characteristics of the CS conductor, the critical current and the current sharing temperature are evaluated under the operating load. The AC loss characteristics of the conductor are also evaluated under pulsed magnetic field. The fabrication of the CS insert coil was completed on May 1999. The winding tools and the results of the winding of CS insert coil are reported. The heat treatment for Nb<sub>3 </sub>Sn processing was performed successfully with no SAGBO (stress accelerated grain boundary oxidation). The procedure of the heat treatment is also reported
    IEEE Transactions on Applied Superconductivity 04/2000; · 1.20 Impact Factor
  • Internal Medicine - INTERNAL MED. 01/2000; 39(3):228-230.
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    ABSTRACT: We herein describe a patient with autoimmune cholangiopathy complicated with rheumatoid arthritis. A 58-year-old female was admitted to our hospital due to complications of arthralgia in her fingers, shoulders, elbows, knees and ankles. She presented with abnormally elevated levels of transaminases, alkaline phosphatase and was also negative for hepatitis B virus, hepatitis C virus and the serum mitochondrial antibody test, but had high titers of serum antinuclear antibody, rheumatoid factor and rheumatoid arthritis hemagglutination. A liver biopsy specimen showed chronic non-suppurative destructive cholangitis. She was thus diagnosed to have autoimmune cholangiopathy and rheumatoid arthritis. She began treatment with prednisolone 40 mg per day. After 20 days of steroid therapy, her hepatic function tests improved and the arthralgia symptoms disappeared. This is, to our knowledge, the first case of autoimmune cholangiopathy associated with rheumatoid arthritis, in which both symptoms improved with steroid therapy.
    Hepato-gastroenterology 01/2000; 47(36):1533-4. · 0.77 Impact Factor
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    Diabetes Care 09/1999; 22(8):1382-4. · 7.74 Impact Factor
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    ABSTRACT: A 64-year old man was admitted to our hospital with multiple hepatocellular carcinoma (HCC) lesions in the liver, lung and bone. Three weeks after admission, the patient became complicated with right upper chest pain. A chest radiograph showed a marked increase in right pleural effusion. Thoracentesis demonstrated a hemothorax. Despite treatment with a continuous pleural tap and blood transfusions, the patient's clinical status worsened and he developed severe dyspnea. His right pleural effusion might be considered to be caused by a rupture of the HCC metastasis in the right 2nd rib. The patient died due to respiratory and hepatic failure 26 hours after his occurring the pleural effusion. An autopsy revealed moderately differentiated HCC in the liver, lung and bone. The HCC metastasis of the right 2nd rib was found to have torn the nearby pleura. We described a rare case in which hemothorax was caused by a ruptured rib-based HCC.
    Fukuoka igaku zasshi = Hukuoka acta medica 09/1999; 90(8):342-6.
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    ABSTRACT: The fabrication of the center solenoid (CS) insert is under way in the engineering design activity (EDA) of International Thermonuclear Experimental Reactor (ITER), the purpose of the CS insert is to measure the performance of Nb<sub>3</sub>Sn conductor for ITER, the R&D activities of the strain accelerated grain boundary oxidation (SAGBO) avoidance was carried out for the CS insert fabrication. The shot peening and the flow control were established for the heat treatment of Nb<sub>3</sub>Sn processing. The effect of the chromium plating on the Nb<sub>3</sub>Sn strands was clarified by the several specimens
    IEEE Transactions on Applied Superconductivity 07/1999; · 1.20 Impact Factor
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    ABSTRACT: The central solenoid (CS) model coil-outer module being fabricated to demonstrate the justification of the CS design for the ITER, was almost completed except for epoxy impregnation to concrete whole layers. All the wound and heat treated layers have been assembled symmetrically with the insulation on the same axis, and for layer-to-layer joints the newly developed butt joint, has been installed
    IEEE Transactions on Applied Superconductivity 07/1999; · 1.20 Impact Factor
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    ABSTRACT: In the International Thermonuclear Experimental Reactor project, the Nb<sub>3</sub>Al superconductor has been recognized as one of the candidates for the Toroidal Field Coil superconductor. An Nb<sub>3</sub>Al Insert will be tested in the bore of the Central Solenoid Model Coil under ITER Engineering Design Activities. The authors developed the copper stabilized multifilamentary strand using the jelly-roll process for the Nb<sub>3</sub>Al Insert. The strand had Jc above 600 A/mm<sup>2</sup> at 12 T under the bending strain of 0.4%, the hysteresis loss density lower than the 410 mJ/cc in the alternative magnetic field of +/- 3 T parallel to the wire axial direction and the residual resistivity lower than 1.6×10<sup>-10</sup> Ωm. We have developed a large scale multifilamentary billet from which a 16 km wire could be obtained. Total 230 km strands were manufactured from the large scale billet. A yield of 90% was obtained for the wire longer than 500 m and 70% for the wire longer than 1500 m. The maximum unit length reached 4600 m
    IEEE Transactions on Applied Superconductivity 07/1999; · 1.20 Impact Factor

Publication Stats

987 Citations
291.49 Total Impact Points

Institutions

  • 1988–2007
    • Kyushu University
      • • Graduate School of Medical Sciences
      • • Faculty of Medical Sciences
      • • Division of Internal Medicine
      Fukuoka-shi, Fukuoka-ken, Japan
  • 2002
    • National Institute of Advanced Industrial Science and Technology
      Tsukuba, Ibaraki, Japan
    • Japan Atomic Energy Agency
      • Quantum Beam Science Directorate
      Muramatsu, Niigata, Japan
  • 2001
    • St.Mary's Hospital (Fukuoka - Japan)
      Hukuoka, Fukuoka, Japan
  • 1988–1997
    • Toshiba Corporation
      Edo, Tōkyō, Japan
  • 1995
    • Seikei University
      Edo, Tōkyō, Japan
  • 1985
    • Nihon University
      Edo, Tōkyō, Japan
  • 1981–1985
    • Obninsk Institute of Atomic Energy
      Moskva, Moscow, Russia