Hiroaki Kiyokawa

Publications (2)7.78 Total impact

• Article: Cdk6-dependent regulation of G(1) length controls adult neurogenesis.

  Pierre Beukelaers, Renaud Vandenbosch, Nicolas Caron, Laurent Nguyen, Shibeshih Belachew, Gustave Moonen, Hiroaki Kiyokawa, Mariano Barbacid, David Santamaria, Brigitte Malgrange
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  ABSTRACT: The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here, we unravel the major contribution of the G(1) regulator cyclin-dependent kinase 6 (Cdk6) to adult neurogenesis. We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Specifically, Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons. Altogether, our data support G(1) length as an essential regulator of the switch between proliferation and neuronal differentiation in the adult brain and Cdk6 as one intrinsic key molecular regulator of this process.
  Stem Cells 02/2011; 29(4):713-24. · 7.78 Impact Factor
• Article: Cdk4 promotes adipogenesis through PPARγ activation

  Anna Abella, Pierre Dubus, Marcos Malumbres, Sushil G. Rane, Hiroaki Kiyokawa, Audrey Sicard, Françoise Vignon, Dominique Langin, Mariano Barbacid, Lluis Fajas
  Cell Metabolism - CELL METAB. 01/2005; 2(4):239-249.