H Sugino

Publications (2)6.14 Total impact

• Source

  Available from: jbc.org

  Article: Follistatin is a developmentally regulated cytokine in neural differentiation.

  M Hashimoto, T Nakamura, S Inoue, T Kondo, R Yamada, Y Eto, H Sugino, M Muramatsu
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  ABSTRACT: Activin acts mitogenically on P19 cells as well as being inhibitory of the differentiation of retinoic acid-treated P19 cells and some neuroblastoma cell lines. Here, we show some lines of evidence that follistatin, an activin-binding protein, is also involved in neural differentiation. Counteracting the activity of activin, addition of follistatin suppresses the anchorage-independent growth of P19 cells in soft agar and stimulates neurite outgrowth of a neuroblastoma cell line, IMR-32 cells. While activin does not seem to be expressed significantly, follistatin is demonstrated in the conditioned medium of these cells. Furthermore, the expression of follistatin in P19 cells is subject to dynamic fluctuations in response to retinoic acid treatment. These neural cells may produce follistatin in a cell stage-specific manner in order to interact with exogenously derived activin.
  Journal of Biological Chemistry 05/1992; 267(11):7203-6. · 4.77 Impact Factor
• Article: Non-contact linear displacement sensors using amorphous-core multivibrators for mechanocardiography

  K. Mohri, T. Kondo, H. Sugino, J. Yamasaki, K. Yoshino
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  ABSTRACT: New non-contact type linear-displacement sensors are constructed using a magnetometer combined with a small magnet. The magnetometer contains an amorphous-wire-core multivibrator bridge. High linearity of the sensor output versus the magnet displacement is realized by cancelling the nonlinearity of the field versus displacement of the magnet using the saturation curve of the magnetometer. These sensors detect magnet displacements of 1 μm - 6 mm at frequencies 0 - 4 kHz. Mechano-cardiograph, that is, Phonocardiograph and Sphygmograph use a new non-contact sensors by attaching a small magnet to the chest wall without disturbances that have been a problem when using conventional microphone type sensors. These non-contact type sensors are expected to add easy manipulation to the mechanocardiograph, similar to the electrocardiograph, and become an effective tool for diagnosis of cardial functions.
  IEEE Transactions on Magnetics 10/1985; · 1.36 Impact Factor