H Koike

Toyama Medical and Pharmaceutical University, Тояма, Toyama, Japan

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Publications (17)37.8 Total impact

  • Teruhiro Nakada · Hiroshi Koike · Takashi Katayama ·
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    ABSTRACT: A twenty-one-year-old virilized woman with Cushing syndrome due to a huge adrenocortical carcinoma was successively treated with trilostane (3 beta-hydroxysteroid dehydrogenase inhibitor), subsequent adrenalectomy, and postoperative cis-platinum. Clinical or biochemical abnormalities peculiar to Cushing syndrome gradually subsided, and three and one-half years after the adrenal surgery, the patient delivered a normal female infant. This study points out some of the clinical and biochemical responses of each treatment.
    Urology 11/1990; 36(4):359-63. DOI:10.1016/0090-4295(90)80249-M · 2.19 Impact Factor
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    ABSTRACT: Forty-three patients with essential haematuria were studied for 35 days to determine the efficacy of hyperbaric oxygen (OHP) exposure on haemostatic ability. Out of 15 untreated patients, haematuria persisted for the study period in all but one patient (6.7%). Out of 11 patients who received 90 mg/day of carbazochrome sodium sulfate and 750 mg/day of tranexanic acid excellent haemostatic results had been obtained in 2 (18.2%). Results of exposure of 17 patients to 2 atm. pressure of OHP for 90 min daily were excellent in 10 (58.8%) and good in one (5.9%). No serious adverse effects had been noted following OHP treatment. These results indicate that OHP can be applied for the treatment of essential haematuria if routine haemostatic drugs fail to improve the condition.
    International Urology and Nephrology 02/1989; 21(1):3-8. DOI:10.1007/BF02549895 · 1.52 Impact Factor
  • T Nakada · H Furuta · H Koike · T Katayama · H Teranishi ·
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    ABSTRACT: A case of Itai-itai (ouch-ouch) disease with reduced urinary kallikrein excretion and slightly enhanced renin-angiotensin-aldosterone system is described. Although it is well known that cadmium toxicity frequently affects the renal tubular lesions, this report is the first to demonstrate the impaired urine concentrating ability in this disease.
    International Urology and Nephrology 02/1989; 21(2):201-9. DOI:10.1007/BF02550809 · 1.52 Impact Factor
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    T Nakada · H Furuta · H Koike · T Akiya · T Katayama · K Wakaki ·
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    ABSTRACT: Renal tissue was obtained from 36 patients with renal cell carcinoma, some of whom received renal arterial embolization. The removed specimens was examined histopathologically and the concentration of some vasoactive substances in these patients was measured. Nephrectomy alone produced no discernible changes in blood pressure, vasoactive substances determined or histopathological findings of the kidney. Renal arterial embolization raised the blood pressure in association with the elevation of plasma renin activity (PRA) and urinary prostaglandin (PG) E2 excretion. A linear relationship was found to exist between PRA and mean blood pressure (r = 0.70, p less than 0.001). Hyperplasia of the juxtaglomerular (JG) apparatus, and high granularity of sudan black B granules in renomedullary interstitial cells were confirmed in removed kidneys of patients who had received embolization alone. Subsequently high renin production would be anticipated to influence overproduction of renal PG E2 in acute ischemic kidney in patients with renal cell carcinoma, and hypertension following renal arterial embolization appears to be caused by the hyperplasia of the JG apparatus.
    Hinyokika kiyo. Acta urologica Japonica 10/1988; 34(9):1561-8.
  • T Nakada · H Koike · T Katayama ·
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    ABSTRACT: Renal arterial embolization and subsequent nephrectomy or nephrectomy alone were performed in 34 patients with renal cell carcinoma. Renal arterial embolization caused a blood pressure elevation concomitant with an increase in plasma renin activity (PRA), urinary aldosterone excretion or urinary prostaglandin (PGE2) excretion. Subsequent nephrectomy normalized hypertension and reduced the levels of these vasoactive substances. There were significant relationships between the increase in mean blood pressure and the increase in PRA, the increment in mean blood pressure and the increment in urinary aldosterone excretion, and the increase in PRA and increase in log urinary PGE2 excretion following embolization. These evidences suggest that enhancement of the renin-angiotensin-aldosterone system participates in the development of hypertension following embolization, and increased PRA may play an important role in the release of urinary PGE2.
    International Urology and Nephrology 02/1988; 20(6):569-76. DOI:10.1007/BF02549489 · 1.52 Impact Factor
  • T Nakada · H Koike · T Katayama ·
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    ABSTRACT: Rats had been given intraventricular injection of 6-hydroxydopamine (6-OHDA) before clipping the unilateral renal artery (2K-1C) that caused selective ablation of the central noradrenergic neurons. Central catecholamines and the in vivo incorporation of 3H-proline into vascular non-collagen protein were determined in 2K-1C rats in the acute hypertensive stage. It is suggested that increased non-collagen protein synthesis in the mesenteric artery and the low level of hypothalamic norepinephrine concentration may participate in the development of 2K-1C hypertension in rats.
    International Urology and Nephrology 02/1988; 20(4):439-47. DOI:10.1007/BF02549578 · 1.52 Impact Factor
  • T Nakada · T Akiya · H Koike · T Katayama ·
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    ABSTRACT: Both Cu-Zn- and Mn-superoxide dismutase (SOD) activities were determined in renal cell carcinoma and tumor-uninvolved renal tissues in 25 patients with renal cancer. These enzymatic activities were similar in tumor and tumor-uninvolved renal tissues. The age of the patients, grade or stage of tumors had no apparent effect on SOD activities. Renal arterial embolization caused a slight decrease (p less than 0.05) in Cu-Zn-SOD activity in tumor tissues, but none in other enzymes in the same tissues, while renal arterial embolization reduced each SOD activity in tumor-uninvolved renal tissues (p less than 0.01 - p less than 0.001). Therefore the development of renal cell carcinoma is probably not related to the abnormality of renal SOD, but renal ischemic changes appear to lower each SOD activity in normal renal tissues.
    European Urology 02/1988; 14(1):50-5. · 13.94 Impact Factor
  • T Nakada · H Koike · T Akiya · T Katayama · M Takata · H Iida · Y Mizumura ·
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    ABSTRACT: A study was made of 9 patients with primary aldosteronism due to aldosterone-producing adenoma (APA) and 8 subjects with idiopathic adrenal hyperplasia (IHA) to clarify the pathogenesis of sustained hypertension after surgical or non-surgical treatment. Following each treatment, a complete improvement of hypertension was obtained in 12 patients (6 APA, 6 IHA), while 5 (3 APA, 2 IHA) showed still hypertensive status. Renal or renovascular lesions were prominent only in the hypertension-unchanged group. Under regular sodium diet, the ratio of urinary excretion of sodium to creatinine of this hypertensive group was significantly lower than that of the hypertension-improved group. However, the results of other renal function tests were similar in both groups. After respective treatments, suppressed plasma renin activity and elevated plasma aldosterone concentration were improved in all patients. In addition, patients of both groups showed normal response of the renin-aldosterone system following diuretic and dietary induced sodium and volume depletion. Based on these findings, renal or renovascular lesions appear to play an important role in the pathogenesis of maintenance of hypertension in this disorder after respective treatments.
    International Urology and Nephrology 02/1988; 20(1):67-76. DOI:10.1007/BF02583034 · 1.52 Impact Factor
  • H Furuta · T Nakada · H Koike · T Katayama ·
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    ABSTRACT: A clinical study was made on 26 patients with renal cell carcinoma, who visited our department between October, 1979 and April, 1984. There were 21 men and 5 women. As the major initial symptoms, hematuria and flank pain were observed in 14 cases (53.8%), followed by symptoms of metastatic tumors in 7 cases (26.9%). Four cases of malignant renal masses which showed no abnormality on the excretory urogram were diagnosed by chance at the time of examination of the abdominal computed tomography (CT). CT was especially useful in diagnosing the renal cell carcinomas.
    Hinyokika kiyo. Acta urologica Japonica 05/1987; 33(4):579-84.
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    ABSTRACT: Liddle's syndrome was diagnosed in a 72-year-old man who presented clinically with hypertension and muscle weakness. This disorder has been characterized by hyporeninemic hypoaldosteronism, hypertension, hypokalemia and enhanced erythrocyte sodium influx. Administration of spironolactone failed to correct the hypertension and electrolyte abnormality, which subsequently improved with triamterene therapy and a low salt diet. However, suppression of the renin-angiotensin-aldosterone system remained unchanged after this treatment. In addition, an atrophic juxtaglomerular apparatus and hypertensive lesions in the arterioles were confirmed by kidney biopsy after triamterene therapy. Therefore, a process of intrinsic hyperactive distal sodium reabsorption, probably affected by aldosterone-independent sodium transport into erythrocytes, appears to be important in the pathogenesis of this syndrome. Triamterene therapy, which usually is performed in patients with this disease, might not be the ultimate therapy in the future even if electrolyte abnormalities were to be improved temporarily.
    The Journal of Urology 05/1987; 137(4):636-40. · 4.47 Impact Factor
  • T Nakada · K Umeda · H Koike · T Akiya · T Katayama ·
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    ABSTRACT: Twelve patients with ureteral tumours with or without ipsilateral renal pelvic neoplasms were retrospectively analysed. Haematuria was the most common symptom. Location of all tumours was preoperatively detected by conventional diagnostic methods, such as intravenous or retrograde pyelography, washing cytology of the upper urinary tract, computed tomography, echogram and abdominal aortography. Cumulative proportion survivals of 1, 3 and 5 years were 81.9%, 68.2% and 45.5%, respectively. Patients with high Karnovsky rating survived longer (p less than 0.05) than those with low rating. Patients with low-stage tumours (T1, T2) showed longer survival rate (p less than 0.001) than those with high-stage tumours (T3, T4). Vascular invasion of tumour cells was present in removed specimens in 4 out of 7 patients who died or are alive with cancer, but none in those who survived without disease. Good therapeutic response could not be achieved unless surgery was performed.
    International Urology and Nephrology 02/1987; 19(4):377-84. DOI:10.1007/BF02550354 · 1.52 Impact Factor
  • Teruhiro Nakada · Hiroshi Koike · Takashi Katayama ·
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    ABSTRACT: Of 15 patients with primary aldosteronism, 7 had idiopathic adrenal hyperplasia (IHA) and 8 had aldosterone-producing adenoma (APA). In order to determine any renal problems involved in the treatment, the renal clearance of these patients was analyzed and the results compared with those obtained from 12 patients with essential hypertension. With water diuresis or under antidiuresis status, levels of urine volume, Cosm and CH2O in patients with APA were greater (p less than 0.05-p less than 0.001) than those of patients with essential hypertension, while the fractional tubular sodium delivery of the former patients was lower than that of the latter patients (p less than 0.001 or less than 0.05). A similar tendency was observed in clearance studies in patients with IHA, although to a lesser extent. Adrenal surgery for patients with APA normalized these values, but administration of trilostane (3 beta-hydrosteroid dehydrogenase inhibitor) to patients with IHA failed to improve these values. These results indicate that impaired urinary concentrating ability as well as reduced urinary diluting capability is a common feature of primary aldosteronism. Such impaired renal function was improved only in patients with APA after adrenal surgery.
    Urologia Internationalis 02/1987; 42(4):295-301. DOI:10.1159/000281962 · 1.43 Impact Factor
  • T Nakada · T Akiya · M Yoshikawa · H Koike · T Kayayama ·
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    ABSTRACT: We studied single dose intravesical doxorubicin instillation (50 mg. dissolved in 30 ml. saline) in 29 patients with bladder tumor and 2 with dysplasia of the bladder. The results demonstrated that 1) the levels of doxorubicin hydrochloride in extracts of tumors were significantly higher than those of histologically normal bladder tissues in all regions examined except the dome, 2) the incorporation concentration of the drug into the smallest tumor was 3-fold greater than that of larger tumors, 3) tissue concentration of the drug in histologically normal bladder tissues was 2.4-fold greater in patients with recurrent than with primary bladder tumors, and 4) a high concentration of the agent was noted in unifocal, multifocal and primary tumors classified as papillary noninvasive or invasive transitional cell carcinoma. These findings indicate that intravesical installation of doxorubicin hydrochloride can be incorporated to a high degree by relatively small papillary noninvasive or invasive transitional cell carcinoma located in almost all regions except the bladder dome.
    The Journal of Urology 08/1985; 134(1):54-7. · 4.47 Impact Factor
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    ABSTRACT: The practicability and tolerability of trilostane, a competitive inhibitor of 3β-hydroxysteroid-Δ5-dehydrogenase, for the therapy of primary aldosteronism was assessed in 1 patient with aldosterone-producing adenoma (APA) and 3 subjects with idiopathic adrenal hyperplasia (IHA). Trilostane afforded reduction of plasma levels of aldosterone, progesterone, deoxycorticosterone, 17-OH progesterone, cortisol, Δ4-androstenedione, and urinary excretion of 17-hydroxycorticosteroid. Conversely, circulating levels of dehydroepiandrosterone, dehydroepiandrosterone sulfate, and urinary excretion of 17-ketosteroids were increased following this drug therapy. Suppression of mineralo- or glucocorticoid biosynthesis was accompanied by an increase in plasma renin activity. One patient with APA or 3 subjects with IHA showed slight or remarkable improvement of hypertension and hypokalemia. Based on these findings, efficacy and tolerability of trilostane appear to aid in the treatment of IHA.
    Urology 02/1985; 25(2):207-214. DOI:10.1016/0090-4295(85)90548-5 · 2.19 Impact Factor
  • T Nakada · H Koike · T Akiya · T Katayama ·

    Nippon Jinzo Gakkai shi 11/1984; 26(10):1379-87.

  • Nippon Jinzo Gakkai shi 03/1983; 25(2):189-97.
  • T Nakada · N Yamazaki · H Koike · T Akiya · T Katayama · H Watanabe ·

    Nippon Hinyōkika Gakkai zasshi. The japanese journal of urology 12/1982; 73(11):1458-63.