H Li

Publications (5)9.77 Total impact

• Article: Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice.

  H C Dow, A S Kreibich, K A Kaercher, G M V Sankoorikal, E D Pauley, F W Lohoff, T N Ferraro, H Li, E S Brodkin
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  ABSTRACT: Aggressive behaviors are disabling, treatment refractory, and sometimes lethal symptoms of several neuropsychiatric disorders. However, currently available treatments for patients are inadequate, and the underlying genetics and neurobiology of aggression is only beginning to be elucidated. Inbred mouse strains are useful for identifying genomic regions, and ultimately the relevant gene variants (alleles) in these regions, that affect mammalian aggressive behaviors, which, in turn, may help to identify neurobiological pathways that mediate aggression. The BALB/cJ inbred mouse strain exhibits relatively high levels of intermale aggressive behaviors and shows multiple brain and behavioral phenotypes relevant to neuropsychiatric syndromes associated with aggression. The A/J strain shows very low levels of aggression. We hypothesized that a cross between BALB/cJ and A/J inbred strains would reveal genomic loci that influence the tendency to initiate intermale aggressive behavior. To identify such loci, we conducted a genomewide scan in an F2 population of 660 male mice bred from BALB/cJ and A/J inbred mouse strains. Three significant loci on chromosomes 5, 10 and 15 that influence aggression were identified. The chromosome 5 and 15 loci are completely novel, and the chromosome 10 locus overlaps an aggression locus mapped in our previous study that used NZB/B1NJ and A/J as progenitor strains. Haplotype analysis of BALB/cJ, NZB/B1NJ and A/J strains showed three positional candidate genes in the chromosome 10 locus. Future studies involving fine genetic mapping of these loci as well as additional candidate gene analysis may lead to an improved biological understanding of mammalian aggressive behaviors.
  Genes Brain and Behavior 02/2011; 10(1):57-68. · 3.48 Impact Factor
• Article: Enhanced sensitivity to rare, emotion-irrelevant stimuli in females: neural correlates.

  J J Yuan, J M Yang, J Chen, X X Meng, H Li
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  ABSTRACT: Numerous studies showed enhanced sensitivity of females to emotional stimuli relative to males using multiple tasks. However, in the present study, two event-related potential (ERP) experiments targeting the impact of gender on rare stimulus processing both showed enhanced sensitivity of females to rare stimulus that is neutral, irrelevant to emotion. Subjects were required to press different keys for standard and rare pictures in Experiment 1, and to do nothing but to passively view the pictures in Experiment 2. Rare pictures elicited more intense pop-out effects in females, at both neuroelectrical (multiple levels of ERP analyses) and behavioral (response latencies and pop-out assessment) levels across experiments. Thus, females are equipped with enhanced sensitivity to rare, emotion-irrelevant stimuli relative to males, probably as a result of evolutionary adaptation. This effect is ought to be considered in studies that use an oddball paradigm.
  Neuroscience 09/2010; 169(4):1758-67. · 3.38 Impact Factor
• Source

  Available from: Robert Ritch

  Article: Comparisons of anterior segment biometry between Chinese and Caucasians using anterior segment optical coherence tomography.

  C K Leung, P-M Palmiero, R N Weinreb, H Li, Z Sbeity, S Dorairaj, D Leung, S Liu, J M Liebmann, N Congdon, D S Lam, R Ritch
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  ABSTRACT: To compare anterior segment parameters between eyes of Chinese and Caucasians using anterior segment optical coherence tomography and to evaluate the association between these parameters and anterior chamber angle width between the two ethnic groups. 60 Chinese and 60 Caucasians, 30 with open angles and 30 with narrow angles (defined as Shaffer grade < or =2 in > or =3 quadrants during dark room gonioscopy) in each group, were consecutively enrolled. One eye of each subject was randomly selected for imaging in a completely darkened room. Measurements, including anterior chamber depth (ACD), scleral spur-to-scleral spur distance (anterior chamber width (ACW)), anterior chamber angle width, iris convexity and iris thickness, were compared between the groups. The associations between angle opening distance and biometric measurements were evaluated with univariate and multivariate regression analyses. There were no differences in age, axial length, anterior chamber angle measurements, pupil diameter and iris convexity between Chinese and Caucasians in both open-angle and narrow-angle groups. However, the ACD and ACW were smaller and the iris was thicker in Chinese. In the multivariate analysis, the ACD was the most influential biometric parameter for angle opening distance in both Chinese and Caucasians. After adjusting the effects of axial length, age and sex, ACD and ACW were significantly smaller in Chinese. Chinese eyes had smaller ACD, smaller ACW and greater iris thickness than Caucasians. ACD was the most influential parameter in determining the angle width in both ethnic groups.
  The British journal of ophthalmology 09/2010; 94(9):1184-9. · 2.92 Impact Factor
• Article: The valence strength of negative stimuli modulates visual novelty processing: Electrophysiological evidence from an event-related potential study

  J.J. Yuan, J.M. Yang, X.X. Meng, F.Q. Yu, H. Li
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  ABSTRACT: In natural settings, the occurrence of unpredictable infrequent events is often associated with emotional reactions in the brain. Previous research suggested a special sensitivity of the brain to valence differences in emotionally negative stimuli. Thus, the present study hypothesizes that valence changes in infrequent negative stimuli would have differential effects on visual novelty processing. Event-related potentials (ERPs) were recorded for highly negative (HN), moderately negative (MN) and Neutral infrequent stimuli, and for the frequent standard stimulus while subjects performed a frequent/infrequent categorization task, irrespective of the emotional valence of the infrequent stimuli. The infrequent–frequent difference waves, which index visual novelty processing, displayed larger N2 amplitudes during HN condition than during MN condition which, in turn, elicited greater N2 amplitude than the Neutral condition. Similarly, in the infrequent–frequent difference waves, the frontocentral P3a and parietal LPC (late positive complex) elicited by the HN condition were more negative than those by MN stimuli, which elicited more negative amplitudes than the Neutral condition. This suggests that negative emotions of diverse strength, as induced by negative stimuli of varying valences, are clearly different in their impact on visual novelty processing. Novel stimuli of increased negativity elicited more attentional resources during the early novelty detection, and recruited increased inhibitive and evaluative processing during the later stages of response decision and reaction readiness, relative to novel stimuli of reduced negativity.
  Neuroscience.
• Article: Enhanced sensitivity to rare, emotion-irrelevant stimuli in females: neural correlates

  J.J. Yuan, J.M. Yang, J. Chen, X.X. Meng, H. Li
  [show abstract] [hide abstract]
  ABSTRACT: Numerous studies showed enhanced sensitivity of females to emotional stimuli relative to males using multiple tasks. However, in the present study, two event-related potential (ERP) experiments targeting the impact of gender on rare stimulus processing both showed enhanced sensitivity of females to rare stimulus that is neutral, irrelevant to emotion. Subjects were required to press different keys for standard and rare pictures in Experiment 1, and to do nothing but to passively view the pictures in Experiment 2. Rare pictures elicited more intense pop-out effects in females, at both neuroelectrical (multiple levels of ERP analyses) and behavioral (response latencies and pop-out assessment) levels across experiments. Thus, females are equipped with enhanced sensitivity to rare, emotion-irrelevant stimuli relative to males, probably as a result of evolutionary adaptation. This effect is ought to be considered in studies that use an oddball paradigm.
  Neuroscience.