[Show abstract][Hide abstract] ABSTRACT: Convolvulus arvensis is traditionally used as laxative. Its decoction is used in cough, flu, jaundice and in skin diseases. It is also used to treat the painful joints, inflammation and swelling. The current study was conducted to determine its hepatoprotective activity. The results showed that extract of C. arvensis (200 mg/kg and 500 mg/kg) produced significant (p<0.05) decrease in paracetamol induced increased levels of liver enzymes and total bilirubin. Histopathological investigation and detection of active constituent, qurecetin by HPLC also supported the results. So the current study showed that ethanolic extract of C. arvensis possess hepatoprotective activity.
[Show abstract][Hide abstract] ABSTRACT: Objective: The aim of this study was to investigate the hypoglycemic activity of Eugenia jambolana Lam. Materials and Methods: (Myrtaceae) root extracts. 100 mg/kg of body weight of the extracts were orally administered to streptozotocin-induced diabetic rabbits and to nicotinamide-streptozotocin-induced diabetic rabbits. Results: Our results showed that aqueous and alcoholic extract of Eugenia jambolana roots have no effect on fasting blood glucose levels of streptozotocin-induced diabetic rabbits as well as nicotinamide-streptozotocin-induced diabetic rabbits. Conclusion: Eugenia jambolana root lacks the hypoglycaemic activity.
[Show abstract][Hide abstract] ABSTRACT: Hydrogels are water-swollen, cross-linked polymeric structures. The objective of this study was to synthesize a new pH-sensitive copolymer, which shows no water uptake at lower pH values but a maximum water uptake at higher pH values. Methyl methacrylate-co-itaconic acid [P(MMA/IA)] hydrogels cross-linked with methylene bis-acrylamide were synthesized. To determine the effect of monomeric composition, copolymers were prepared with different proportions of methyl methacrylate and itaconic acid i.e. 100:0, 90:10, 85:15, 80:20 and 75:25 keeping the degree of cross-linking constant i.e. 0.30 mol %. It was concluded from this study that the MMA/IA 75:25 (x = 0.3 mol %) polymer fulfilled our objective. It seems suitable for delivering the drug above pH 6.
Journal of Drug Delivery Science and Technology 05/2011; 21(3):249-255. DOI:10.1016/S1773-2247(11)50034-6 · 0.48 Impact Factor