H Ito

Kagoshima University, Kagosima, Kagoshima, Japan

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Publications (2)3.27 Total impact

  • S Matsunaga · H Ito · T Sakou ·
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    ABSTRACT: This study was designed to assess the effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Female Sprague-Dawley rats aged 8-9 months were ovariectomized (OVX) or sham operated and divided into five experimental groups: (1) ovariectomy (OVX), (2) OVX plus vitamin K supplementation, (3) OVX plus vitamin D supplementation, (4) OVX plus vitamin K and vitamin D supplementation, and (5) sham operation. The trabecular bone area was estimated by bone histomorphometry by microradiography and histological examination. Bone loss in OVX plus vitamin K and vitamin D group was significantly reduced at both 7 and 14 weeks compared with the OVX group. No significant bone loss in OVX plus vitamin K or OVX plus vitamin D groups was found. A similar effect of vitamin K and D supplementation on ovariectomy-induced bone loss was recognized in histological examination. Our findings indicate that vitamins K and D may have a synergistic effect on reducing bone loss. This is valuable information for the treatment of bone loss in postmenopausal women with osteoporosis.
    Calcified Tissue International 11/1999; 65(4):285-9. DOI:10.1007/s002239900700 · 3.27 Impact Factor
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    K Hayashi · K Yone · H Ito · M Yanase · T Sakou ·
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    ABSTRACT: We investigated the usefulness of magnetic resonance imaging (MRI) in assessing cervical spinal cord injury in patients where there was no evidence of bone injury on radiographs, and examined the relationship between the MRI findings and the clinical prognosis of this injury. MRI allowed us to confirm directly the cause and severity of spinal cord compression in 30 of 31 cases. The patients with severe spinal cord compression demonstrated by MRI showed poor neurological improvement. In regard to the signal changes in the spinal cord, the patients who showed no signal change on T1- and T2-weighted images had a better prognosis. MRI is a very useful non-invasive adjunctive imaging modality for diagnosis of this injury and for the evaluation of the compressed spinal cord. It also demonstrates potential in predicting neurological recovery.
    Paraplegia 05/1995; 33(4):212-5. DOI:10.1038/sc.1995.47

Publication Stats

69 Citations
3.27 Total Impact Points


  • 1995-1999
    • Kagoshima University
      • Department of Orthopaedic Surgery
      Kagosima, Kagoshima, Japan