H C Shin

Hallym University, Sŏul, Seoul, South Korea

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Publications (25)45.66 Total impact

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    ABSTRACT: This paper presents a low-cost bidirectional (BiDi) wavelength-division-multiplexed passive optical network (WDM-PON) employing colorless uncooled BiDi transceivers (TRxs) and superluminescent diode (SLD)-based broadband light sources (BLSs). The C band is allocated for upstream and the E+ band for downstream in consideration of BiDi packaging, SLD development, and wavelength alignment of dual-window arrayed waveguide gratings (AWGs). The BiDi TRx integrates an uncooled Fabry-Perot laser diode (FP-LD), a p-i-n photodiode (PD), and a 45°-angled thin-film filter in a small-form-factor (SFF) package. The SLD-based BLSs provide 13-dBm amplified spontaneous emissions (ASEs) with spectral ripples of < 3 dB and polarization dependencies of <1 dB. Colorless operations over 32 100-GHz-spaced channels are demonstrated from -20 to 80°C in 155-Mb/s BiDi transmissions over 25 km.
    Journal of Lightwave Technology 02/2006; DOI:10.1109/JLT.2005.861122 · 2.86 Impact Factor
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    ABSTRACT: We developed polarization-independent high-power superluminescent diodes (SLDs) for wavelength division multiplexed-passive optical network (WDM-PON) applications. The SLD presents CW output power of 150 mW, spectral bandwidth of 40 nm, polarization-dependent power variation of less than 1 dB, and spectral ripple of 3 dB at current of 1.47 A and temperature of 25 degC
    Lasers and Electro-Optics Society, 2005. LEOS 2005. The 18th Annual Meeting of the IEEE; 11/2005
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    ABSTRACT: We present a low-cost C/S-band WDM-PON employing colorless uncooled bidirectional transceivers and SOA-based broadband light sources. Colorless operations over 32 DWDM channels are demonstrated from -20 to 80°C in 155-Mb/s bidirectional transmissions over 25 km.
    Optical Fiber Communication Conference, 2005. Technical Digest. OFC/NFOEC; 04/2005
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    ABSTRACT: We present R-SOAs with improved modulation bandwidth of ∼1.35 GHz as WDM sources in 1.25 Gbit/s WDM-PONs. In back-to-back transmission using the R-SOA seeded by 0.6 nm-wide ASE of -20 dBm, receiver sensitivity at a 10<sup>-9 </sup>BER was - 25.3 dBm.
    Lasers and Electro-Optics Society, 2004. LEOS 2004. The 17th Annual Meeting of the IEEE; 12/2004
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    ABSTRACT: Cellular and biochemical responses of the pectoral muscle to variation in seasonal activity were studied in the bat, Murina leucogaster ognevi. We collected bats in mid-hibernation (February), end-hibernation (April), and mid-summer (August) to track major activity periods in their annual cycle. Our findings indicated that myofiber cross-sectional area decreased to 68% between mid- and end-hibernation, but returned to the winter level in mid-summer. Total soluble protein and total RNA concentrations were not altered over these sampling periods. Oxidative potential gauged by citrate synthase activity increased 1.47-fold from mid- to end-hibernation and then remained at the similar level in mid-summer. Glycolytic potential gauged by lactate dehydrogenase activity changed little between mid- and end-hibernation but increased 1.42-fold in summer, compared with the winter level. Thus, the myofibers underwent disuse atrophy during hibernation, while enzymatic catalytic function recovered towards the level of mid-summer.
    Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology 07/2000; 126(2):245-50. DOI:10.1016/S1095-6433(00)00203-8 · 2.37 Impact Factor
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    ABSTRACT: Administration of the excitotoxin kainate produces seizure activity and selective neuronal death in various brain areas. We examined the degeneration pattern of hippocampal neurons following systemic injections of kainate in the hamster and the rat. As reported, treatment with kainate resulted in severe neuronal loss in the hilus and CA3 in the rat. While the hilar neurons were also highly vulnerable to kainate in the hamster, neurons in the CA1 area, but not CA3, were highly sensitive to kainate. In both animals, immunoreactivity to anti-p50 nuclear factor kappa B antibody was increased in nuclei of the hilar neurons within 4 h following administration of kainate. Kainate treatment also increased the nuclear factor kappa B immunoreactivity in hamster CA1 neurons and rat CA3 neurons 24 h later. Neurons showing intense nuclear factor kappa B signal were stained with acid fuchsin. Kainate also increased DNA binding activity of p50 and p65 nuclear factor kappa B in the nuclear extract of the hippocampal formation as analysed by electrophoretic mobility shift assay in the hamster, suggesting that activation of nuclear factor kappa B may contribute to kainate-induced hippocampal degeneration. Administration of 100 nmol dizocilpine maleate 3 h prior to kainate attenuated kainate-induced activation of nuclear factor kappa B and neuronal death in CA1 in the hamster. The present study provides evidence that the differential vulnerability of neurons in the rat and the hamster hippocampus to kainate is partly mediated by mechanisms involving N-methyl-D-aspartate-dependent activation of nuclear factor kappa B.
    Neuroscience 09/1999; 94(1):83-91. DOI:10.1016/S0306-4522(99)00196-7 · 3.33 Impact Factor
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    ABSTRACT: Activity-dependent changes of conduction velocity (CV) and conduction block in single A(delta) fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of A(delta) DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.
    Neuroreport 11/1997; 8(15):3201-5. DOI:10.1097/00001756-199710200-00004 · 1.64 Impact Factor
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    ABSTRACT: The effects of topical application of interleukin-6 (IL-6) on the short and long latency evoked unit responses of the neurones in the primary somatosensory (SI) cortex were determined quantitatively in anaesthetized rats. IL-6 (0.01, 0.1, 1.0 units) significantly suppressed (-15.13 +/- 3.4%) short latency afferent sensory responses, while it induced profound facilitation (+464.74 +/- 132.7%) of long latency responses in a dose-dependent manner. IL-6-induced afferent modulations fully recovered by 60 min after drug administration. In control experiments, saline solution containing 0.2% bovine serum albumin, used as a vehicle, did not affect afferent sensory transmission. Implications of these results are discussed with reference to the different somatosensory functions of short and long latency response components in the SI cortex.
    Neuroreport 10/1997; 8(13):2841-4. DOI:10.1097/00001756-199709080-00007 · 1.64 Impact Factor
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    ABSTRACT: Activity-dependent changes of the conduction latency of single A beta fibers of primary afferent neurons were characterized in both neuropathic (L4 and L6 ligated) and normal rats. Activity-dependent increases in conduction latency of dorsal root fibers in neuropathic rats were significantly stronger than those in normal rats. Different profiles of activity dependence were also observed between injured and adjacent intact dorsal root fibers of neuropathic rats. However, activity-dependent latency changes in sciatic nerves distal to the dorsal root ganglion were not different between neuropathic and normal rats. These results suggest that partial nerve injury induces activity-dependent excitability changes in the dorsal root fibers of neuropathic rat and that these changes may be responsible for the altered sensory processing such as those seen in allodynia.
    Neuroreport 09/1997; 8(12):2813-6. · 1.64 Impact Factor
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    ABSTRACT: Single unit responses of the primary somatosensory (SI) cortical neurons to the stimulation of the forepaw single digit were monitored in anesthetized rats before and after subcutaneous injection of lidocaine to an ipsilateral homologous receptive field (IHRF). Quantitative determination of the temporal changes of afferent sensory transmission was done by analyzing poststimulus time histograms of unit responses. Temporary deafferentation to the IHRF induced immediate, but reversible suppression of afferent sensory transmission in the SI cortex and this suppression lasts up to 35 min post-deafferentation period (during 10-15 min, -21.81 +/- 5.9%, P < 0.01). This result suggests that temporary absence of afferent inflow from the digit to the SI cortex may exert interhemispheric modulation of afferent sensory transmission in the opposite somatosensory cortex of anesthetized rats.
    Neuroscience Letters 07/1997; 230(2):137-9. DOI:10.1016/S0304-3940(97)00486-2 · 2.06 Impact Factor
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    ABSTRACT: The effects of acute lowering of body temperature on afferent sensory transmission to the primary somatosensory cortex were determined quantitatively in anaesthetized rats and hamsters. Rats showed no change in afferent sensory transmission until 27 degrees C, but dramatic suppression between 26 degrees C and 22 degrees C, reaching 100% inhibition at 21 degrees C. Hamsters exhibited gradual suppression of sensory transmission from 34 degrees C to 18 degrees C, reaching 95% inhibition at 18 degrees C. Differential effects were also observed during rewarming up to 37 degrees C. Response latencies were also differentially affected during hypothermia in rats and hamsters. These results suggest the presence of inherently different neural mechanisms to process somatosensory information during transient lowering of body temperature between hibernators and non-hibernators.
    Neuroreport 01/1997; 8(1):41-4. DOI:10.1097/00001756-199612200-00009 · 1.64 Impact Factor
  • M H Won, Y S Oh, H C Shin
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    ABSTRACT: The presence of somatostatin-like immunoreactive neurons was examined in the rabbit vestibular ganglion by using immunohistochemical techniques. About 22% (n = 153) of the total ganglion cells (n = 699) examined were somatostatin-immunoreactive and they were diffusely present throughout the ganglion. Majority of the somatostatin-immunoreactive cells were large (long diameter, 23-31 microns, 74%; short diameter, 20-25 microns, 76%) and they had oval or spherical cell bodies with well developed Nissl's body. However, about 78% (n = 546) of the total ganglion cells examined were not immunoreactive to the somatostatin. The presence of the somatostatin-immunoreactive neurons in the vestibular ganglion suggests a possibility that somatostatin may be involved in the modulation of afferent sensory transmission from the vestibular organ of the rabbit.
    Neuroscience Letters 11/1996; 217(2-3):129-32. DOI:10.1016/0304-3940(96)13088-3 · 2.06 Impact Factor
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    ABSTRACT: Single unit recordings were made from the ventral posterior lateral thalamus of anaesthetized rats to characterize responses to the activation of new receptive fields induced by either local anaesthesia or amputation. Receptive fields confined to single digits were identified and evoked unit responses to the stimulation of single digits were quantitated before and after deafferentation. Although both methods of denervation rapidly induced similar new receptive fields from the adjacent single digit, they exhibited quite different temporal changes of the evoked unit responses from new receptive fields. This difference in the evoked unit responses from the new receptive fields may be related to either the different nature or the outcome of the two types of deafferentation.
    Neuroreport 01/1996; 7(1):33-6. DOI:10.1097/00001756-199512000-00007 · 1.64 Impact Factor
  • Chungkil Won, H J Park, H C Shin
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    ABSTRACT: The effect of topical application of human recombinant interleukin-1 beta (IL-1) on afferent sensory transmission to the neurones in the primary somatosensory (SI) cortex was determined in anesthetized rats. Quantitative determination of the effect of IL-1 was made by generating post-stimulus time histograms of unit responses to the stimulation of receptive field. IL-1 (0.01, 0.1, 1.0 U) significantly facilitated afferent sensory transmission in SI cortical neurones (n = 22). IL-1-induced facilitation fully recovered by 60 min after drug. In control experiments (n = 10), saline solution containing 0.2 bovine serum albumin, used as a vehicle, did not affect afferent sensory transmission. Our results suggest that IL-1 may be involved in the processing of afferent sensory information in the SI cortex of rats.
    Neuroscience Letters 01/1996; 201(3):255-8. DOI:10.1016/0304-3940(95)12185-4 · 2.06 Impact Factor
  • H J Park, C K Won, K H Pyun, H C Shin
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    ABSTRACT: The effect of topical application of interleukin 2 (IL-2) on afferent sensory transmission to the neurones in the primary somatosensory (SI) cortex was determined quantitatively in anaesthetized rats. IL-2 (0.1, 1.0, 5.0 units) significantly suppressed afferent sensory transmission in SI cortical neurones (n = 19) in a dose-dependent manner. IL-2-induced suppression fully recovered by 60 min after drug. In control experiments, saline solution containing 0.2% bovine serum albumin, used as a vehicle, did not affect afferent sensory transmission. Our results suggest that IL-2 and its receptor present in the SI cortex may be involved in the processing of afferent sensory information.
    Neuroreport 06/1995; 6(7):1018-20. DOI:10.1097/00001756-199505090-00017 · 1.64 Impact Factor
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    ABSTRACT: Compound action potentials (CAPs) of A- and C-fibres were recorded from isolated sciatic nerves of the rat to determine whether lidocaine-induced phasic impulse block was affected by low doses of capsaicin. Preceding impulse activity produced phasic reductions of the amplitudes of both A- (5.7 +/- 1.3%) and C-CAPs (20.7 +/- 7.0%) in drug-free solution. Capsaicin alone (50 microM) did not change the activity-induced reductions of the heights of both CAPs (A-CAP: 6.2 +/- 1.7%, C-CAP: 22.3 +/- 8.0%). Lidocaine (100 microM) caused differential phasic blocks between the A-CAP (20.1 +/- 3.7%; n = 7) and the C-CAP (33.8 +/- 4.9% n = 7). Lidocaine's phasic impulse block was potentiated after 30 min of subsequent capsaicin administration (A-CAP: 40.6 +/- 4.7%, n = 7; C-CAP: 48.8 +/- 5.5% n = 9). Capsaicin's phasic potentiating effects were reversed after 30 min of washing. These results suggest that capsaicin may be a useful agent for the reversible potentiation of phasic impulse blockade by lidocaine.
    Pharmacological Research 08/1994; 30(1):73-9. DOI:10.1016/1043-6618(94)80089-8 · 3.98 Impact Factor
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    ABSTRACT: Compound action potentials (CAPs) of A- and C-fibers were recorded from isolated sciatic nerves of the rat to determine whether tonic block of impulse conduction induced by lidocaine was affected by low doses of capsaicin. Capsaicin alone (50 microM) did not change the CAPs of either A- or C-fibers. Although the lower concentrations of capsaicin (5-30 microM) caused no change of the tonic blocking action of lidocaine, 30 min of 50 microM capsaicin administration did induce a significant potentiation of tonic block. Capsaicin's potentiating effects were partially reversed after 30 min of wash. These results suggest that capsaicin may be a useful agent for the potentiation of impulse blockade by lidocaine.
    Neuroscience Letters 07/1994; 174(1):14-6. DOI:10.1016/0304-3940(94)90107-4 · 2.06 Impact Factor
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    ABSTRACT: Single neurons were recorded in the forepaw area of the primary somatosensory (SI) cortex of awake rats during rest and running behavior. Locomotor step cycle dependent changes of the transmission of the short (4.5 +/- 0.1-10.5 +/- 0.1 ms, SEURs) and the long (10.6 +/- 0.6-28.5 +/- 2.3 ms, LEURs) latency evoked unit responses were tested by generating post-stimulus time histograms of these neurons' responses to stimulation through electrodes chronically implanted under the skin of the forepaw. Times of footfall were determined by way of frame-by-frame analyses of video recordings, and peri-footfall histograms were generated to differentiate a total of 55 SI cortical neurons into two types: footfall responsive (n = 37) and footfall unresponsive (n = 18) neurons. Peri-footfall gating patterns were determined for both types of cells. The SEURs and the LEURs showed significantly different phasic sensory modulation patterns. A major difference in sensory modulations between footfall responsive and footfall unresponsive cells was noted during the swing phase of the locomotor step cycle. In footfall responsive cells, the SEURs were suppressed most strongly just after footfall, while the LEURs were phasically suppressed following both footfall and footoff. The SEURs were disinhibited during the swing phase. In footfall unresponsive cells, the SEURs were tonically suppressed during the whole locomotor step cycle phases. However, the LEURs were phasically facilitated during the early swing phase.(ABSTRACT TRUNCATED AT 250 WORDS)
    Neuroscience Research 07/1994; 19(4):419-25. DOI:10.1016/0168-0102(94)90083-3 · 2.15 Impact Factor
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    ABSTRACT: Single neurons were recorded in the forepaw area of the ventroposterolateral (VPL) thalamus of awake rats during rest and running behaviors. Locomotor step cycle dependent changes of the transmission of the short (4.0 +/- 0.1-10.1 +/- 0.3 ms, SEURs) and the long (10.2 +/- 0.2-26.0 +/- 2.1 ms, LEURs) latency somatic sensory responses were tested by generating post-stimulus time histograms of these neurons' responses to stimulation through electrodes chronically implanted under the skin of the forepaw. The magnitudes of firing during these responses were measured and normalized as percent increases over background firing. Times of footfall were determined through frame-by-frame analyses of video recordings and peri-footfall histograms were generated to differentiate a total of 40 VPL thalamic neurons into two types, footfall responsive (n = 21) and unresponsive (n = 19) neurons. Perifootfall gating patterns were determined for both types of cells. The SEURs and the LEURs showed significantly different phasic sensory modulation patterns across the locomotor step cycle. Major difference of the sensory modulations between footfall responsive and footfall unresponsive cells was noted during swing phase of the locomotor step cycle. In footfall responsive cells, the SEURs were suppressed most strongly just after footfall, while the LEURs were tonically suppressed during late stance and swing phases. The SEURs were disinhibited during the swing phase, while the LEURs were disinhibited during the middle stance phase. In footfall unresponsive cells, the LEURs were suppressed more strongly around footfall event than the SEURs were.(ABSTRACT TRUNCATED AT 250 WORDS)
    Neuroscience Research 08/1993; 17(2):117-25. DOI:10.1016/0168-0102(93)90089-9 · 2.15 Impact Factor
  • H C Shin, John K. Chapin
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    ABSTRACT: Single unit recordings were used to map the spatial distribution of motor (MI) cortical influences on thalamic somatosensory relay nuclei in the rat. A total of 215 microelectrode penetrations were made to record single neurons in tracks through the medial and lateral ventroposterior (VPM and VPL), ventrolateral (VL), reticular (nRt), and posterior (Po) thalamic nuclei. Single units were classified according to their: 1) location within the nuclei, 2) receptive fields, and 3) response to standardized microstimulation in deep layers of the forepaw-forelimb areas of MI cortex. For mapping purposes, only short latency (1-7 msec) excitatory neuronal responses to the MI cortex stimulation were considered. Percentages of recorded thalamic neurons responsive to the MI stimulation varied considerably across nuclei: VL: 42.6%, nRt: 23.0%, VPL: 15.7%, VPM: 9.3%, and Po: 3.9%. Within the VPL, most responsive neurons were found in "border" regions, i.e., areas adjacent to the VL, and (to a lesser extent) the nRt and Po thalamic nuclei. The same parameters of MI cortical stimulation were used in studies of corticofugal modulation of afferent transmission through the VPL thalamus. A condition-test (C-T) paradigm was implemented in which the cortical stimulation (C) was delivered at a range of time intervals before test (T) mechanical vibratory stimulation was applied to digit No. 4 of the contralateral forepaw. The time course of MI cortical effects was analyzed by measuring the averaged evoked unit responses of the thalamic neurons to the T stimuli, and plotting them as a function of C-T intervals from 5-50 msec. Of the 30 VPL neurons tested during MI stimulation, the average response to T stimulation was decreased a mean 43%, with the suppression peaking at about 30 msec after the C stimulus. This suppression was more pronounced in the VPL border areas (-52% in areas adjacent to VL and nRt) than in the VPL center (-25%).
    Brain Research Bulletin 03/1990; 24(2):257-65. DOI:10.1016/0361-9230(90)90213-J · 2.97 Impact Factor

Publication Stats

378 Citations
45.66 Total Impact Points

Institutions

  • 1993–2000
    • Hallym University
      • • College of Medicine
      • • Department of Medicine
      Sŏul, Seoul, South Korea
  • 1997
    • Yonsei University
      Sŏul, Seoul, South Korea
  • 1990
    • Harvard Medical School
      • Department of Anesthesia
      Boston, Massachusetts, United States
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, Massachusetts, United States